[Fis] Fwd: Covid-19 immune therapy

Pedro C. Marijuan pcmarijuan.iacs at aragon.es
Sun Mar 15 21:22:31 CET 2020

Dear All,

The exchanges below have been taken from Plamen's authors list about 
immune overreaction to COVID-19. I think it is of general interest.


> Dear Plamen,
> Cytokine storm is still a big therapeutic problem similar to sepsis. 
> It's been known to arise in SARS patients. Here is a good summary:
> https://www.sinobiological.com/cytokine-storm-cytokine-storms-a-5800.html
> Treatment in infection related cytokine storm is like walking on thin 
> ice. One needs to turn down the lymphocytes' overreaction without 
> harming the immune defense. That is why corticosteroids are actually 
> counter indicated. Using standard immunosuppressants would be similar 
> unless they are carefully targeted like the OX40 inhibition. 
> Nevertheless, I am curious what exactly was done and how does it 
> differ from corticosteroid action (e.g. - Cyclosporine also blocks 
> immune signaling very much upstream and antiproliferative drugs  kill 
> off protective lymphocytes).
> Best regards,
> Anastas

> One can try curcumin for a start. See 
> http://iv.iiarjournals.org/content/29/1/1.full 
> <http://iv.iiarjournals.org/content/29/1/1.full>
> Best,
> Arran

> On Sun, Mar 15, 2020, 1:27 AM Plamen <plamen.l.simeonov at gmail.com 
> <mailto:plamen.l.simeonov at gmail.com>> wrote:
>     Dear All,
>     just briefly:
>     here is what Bob Ulanowitz just shared with me. You may also share
>     this with others who may find it helpful.
>>     I'm very excited right now by something I just heard on NPR. Italian
>>     doctors are reporting some success with saving grave,elderly patients
>>     by giving them auto-immune suppressant drugs. Three days ago I wrote
>>     to my sister (a pathologist) that is exactly what should be tried.
>>     About 15 years ago the frozen remains of young explorers who had died
>>     of the 1918 flu were discovered and autopsied. It was revealed that
>>     they were killed by their own healthy immune systems run amok.
>>     Now last week a fellow by the name of Menachery ran some experiments
>>     on mice that were exposed to COVID-19 like virus. He discovered that
>>     young mice were not affected much, but mortality was high with old
>>     mice. Furthermore, the immune systems of the old mice had run
>>     wild and
>>     killed them.
>>     So why not try treating old human patients with auto-immune
>>     suppressant drugs?
>>     Voila!
>>     More later,
>>     Bob

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