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<p>Dear All,</p>
<p>The exchanges below have been taken from Plamen's authors list
about immune overreaction to COVID-19. I think it is of general
interest. </p>
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<div>Best--Pedro</div>
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<div dir="auto">Dear Plamen,
<div dir="auto">Cytokine storm is still a big
therapeutic problem similar to sepsis. It's been known
to arise in SARS patients. Here is a good summary:</div>
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<div dir="auto"><span style="font-family:sans-serif"><a
href="https://www.sinobiological.com/cytokine-storm-cytokine-storms-a-5800.html"
moz-do-not-send="true">https://www.sinobiological.com/cytokine-storm-cytokine-storms-a-5800.html</a></span><br>
</div>
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<div dir="auto"><font face="sans-serif">Treatment in
infection related cytokine storm is like walking on
thin ice. One needs to turn down the lymphocytes'
overreaction without harming the immune defense.
That is why corticosteroids are actually counter
indicated. Using standard immunosuppressants would
be similar unless they are carefully targeted like
the OX40 inhibition. Nevertheless, I am curious what
exactly was done and how does it differ from
corticosteroid action (e.g. - Cyclosporine also
blocks immune signaling very much upstream and
antiproliferative drugs kill off protective
lymphocytes).</font></div>
<div dir="auto"><font face="sans-serif"><br>
</font></div>
<div dir="auto"><font face="sans-serif">Best regards,</font></div>
<div dir="auto"><font face="sans-serif">Anastas</font></div>
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<div style="font-family: Tahoma, Geneva, sans-serif;
font-size: 10pt; color: rgb(0, 0, 0); font-weight:
bold;"> One can try curcumin for a start. See <a
href="http://iv.iiarjournals.org/content/29/1/1.full"
id="LPlnk757221" moz-do-not-send="true">
http://iv.iiarjournals.org/content/29/1/1.full</a><br>
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<div style="font-family: Tahoma, Geneva, sans-serif;
font-size: 10pt; color: rgb(0, 0, 0); font-weight:
bold;"> Best,</div>
Arran</div>
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<div dir="ltr" class="gmail_attr">On Sun, Mar 15, 2020,
1:27 AM Plamen <<a
href="mailto:plamen.l.simeonov@gmail.com"
target="_blank" rel="noreferrer"
moz-do-not-send="true">plamen.l.simeonov@gmail.com</a>>
wrote:<br>
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.8ex;border-left:1px #ccc solid;padding-left:1ex">
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Dear All,
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</div>
<div>just briefly: </div>
<div>here is what Bob Ulanowitz just shared with me.
You may also share this with others who may find
it helpful. <br>
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<span></span><br>
<span>I'm very excited right now by something
I just heard on NPR. Italian</span><br>
<span>doctors are reporting some success with
saving grave,elderly patients</span><br>
<span>by giving them auto-immune suppressant
drugs. Three days ago I wrote</span><br>
<span>to my sister (a pathologist) that is
exactly what should be tried.</span><br>
<span></span><br>
<span>About 15 years ago the frozen remains of
young explorers who had died</span><br>
<span>of the 1918 flu were discovered and
autopsied. It was revealed that</span><br>
<span>they were killed by their own healthy
immune systems run amok.</span><br>
<span></span><br>
<span>Now last week a fellow by the name of
Menachery ran some experiments</span><br>
<span>on mice that were exposed to COVID-19
like virus. He discovered that</span><br>
<span>young mice were not affected much, but
mortality was high with old</span><br>
<span>mice. Furthermore, the immune systems of
the old mice had run wild and</span><br>
<span>killed them.</span><br>
<span></span><br>
<span>So why not try treating old human
patients with auto-immune suppressant drugs?</span><br>
<span></span><br>
<span>Voila!</span><br>
<span></span><br>
<span>More later,</span><br>
<span></span><br>
<span>Bob</span><br>
<br>
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