[Fis] Fwd: Re: Fis Digest, Vol 85, Issue 16. Onti and Epistemic Perspectives

Wed Feb 2 09:42:57 CET 2022

Dear Youri, Pedro and All,

I have very much welcomed this exchange which I hope will continue past the "closing". One possible area for discussion is the relatiion of information to ontology and epistemology. Youri wrote:

>In this respect, I have the impression that an epistemological perspective
>on one's own activity is more conducive to a form of humour,
>relativity and makes people less rigid and therefore less aggressive ?

I beg to differ with Youri on this point. In my view, it has been the neglect of the ontological aspects of complex phenomena, of which humor and information are prime examples, that has led to reductionist, non-humanistic interpretations. I would look forward to the views of others on this issue, in which science and philosophy are conjoined.

Best wishes,

Joe

>
>----Message d'origine----
>De : youri.timsit at mio.osupytheas.fr
>Date : 31/01/2022 - 11:42 (E)
>À : fis at listas.unizar.es
>Objet : Re: [Fis] Fis Digest, Vol 85, Issue 16
>
>about Information, Editors, Humour and Life Metaphors
>
>
>Dear all,
>
> 
>Thanks again to Pedro for allowing these interesting exchanges and thanks
>to all for
>your comments around the new year lecture.
>
> 
>First of all, I would like to point out that I am not an information
>specialist at all,
>nor am I a mathematician: I look modestly at the structure of biological
>macromolecules. And by chance, I simply observed protein networks in the
>ribosome that were analogous to neural networks. By transitivity, I
>wondered if
>these networks could also transmit signals and integrate them, like neural
>networks: is it information? I don't know Š.
>
> 
>But that¹s how I came to ask the question, can the architecture of the
>networks tell us
>what they do? Can we deduce the 'function' of a network by the way it is
>connected? If you look through the literature, you can find, for example,
>these
>famous "small world networks", the "scale-free" networks,
>Uri Alon's FFL motifs, but if you look a little deeper, you can see that
>it's
>not that simple... the answer is not clear.
>
>I also asked myself a stupid question: is there a kind of
>'proportionality' between the difficulty of
>the tasks to be accomplished and the complexity of the networks that are
>supposed to process them? If we look at the nervous system, from the
>simplest
>organisms to the most complex (which Cajal has started to do), we can see
>that
>the more complex the behaviour of organisms is, the more complex their
>nervous
>system is... but is there a simple law to describe this phenomenon? and do
>things start from the ribosome, from LUCA (last universal common ancestor)?
>
> 
>This is why I called on my mathematical colleagues Daniel Bennequin, who
>is also a nervous
>system specialist, and his student Grégoire Sergeant-Perthuis. Ribosome
>networks
>and their properties have been described but, of course, this does not
>allow us
>to understand how they work. The famous 'structure-function relationships'
>that
>serve as the scaffolding for all modern biology have serious limitations.
>
> 
>And to answer Jerry's question, normally, if we knew the properties of
>atoms and
>molecules perfectly, the crystallographic structure of a bacterial ribosome
>(take for example pdb code: 4y4p which contains 3 tRNAs and is very high
>resolution): normally, this structure which contains "all the
>information" should allow us to understand the ribosome completely... But
>this is not the case. It also requires thousands of tedious biochemical
>studies, the design of hundreds of mutants in various areas of the rRNA and
>ribosomal proteins to test their 'functional' roles. And with all this work
>over half a century, we have painfully arrived at a very mechanistic view
>of
>the ribosome and the whole of life... and the essentials still elude us.
>The
>conclusion of a recent review by one of the leading experts in the field
>(Harry
>Noller) on ribosome dynamics is: "an important unanswered question is: how
>are intersubunit and head rotations coordinated with all of the other
>dynamic
>events of the ribosome during translocation?" (Noller et al., 2017,
>https://doi.org/10.1017/S0033583517000117).
>
> 
>Thus, a purely mechanistic vision does not allow us to understand either
>the ribosome
>or living organisms in their entirety and misses entirely the "information
>flow" that Pedro talks about.
>
>When we see that the entire human genome has been sequenced, that the PDB
>is filled
>with hundreds of thousands of macromolecule structures, that the
>pharmaceutical
>industry 'excels' in the design of targeted medicines and the belief in the
>effectiveness of drug design, and that on the other hand, a tiny
>coronavirus or
>even an ebola virus containing only 6 genes can wipe out the whole of
>mankind,
>we have the right to ask ourselves whether we are not missing something
>essential in our understanding of living organisms?
> 
>
>In my opinion, this is where the crucial question of living metaphors,
>humour,
>seriousness and aggressiveness of scientific editors comes in...
> 
>It seems to me that certain forms of thought, and in particular the choice
>of metaphors,
>are more conducive to poetry, humour, and that humour, art and poetry, can
>often mitigate the aggressive impulses, war and, among other things, the
>implacable authority of scientific editors (this is in response to the
>editor's
>comments on Joe's article). I think S. Freud would not contradict me...
>sublimation in art, is the last bastion against barbarism...
> 
>
>In biology, for the moment, it is very comfortable for the community of
>biologists (and the
>pharmaceutical industry that controls it) to compare living beings to
>machines:
>the whole edifice of molecular biology is based on this reductive analogy
>that
>simplifies living beings and their constituents to a mechanistic
>functioning
>drawn from analogies with engineering and industry. Genetic 'codes and
>programmes',
>and the notions of the famous 'structure/function' relationships that have
>structured biological thinking since the death of Stalin, Prokofiev in
>1953 and
>the concomitant publication of the structure of the DNA double helix. Each
>molecule has a specific function and its structure is responsible for it!
>Of
>course, there is some truth in this paradigm, but it is not so simple...
>But
>one prefers this simple system of thought to wandering in still ill-defined
>spheres... wandering is very badly tolerated by science although it is its
>deepest essence....
> 
>
>If we look at the literature on antibiotics, for example, we realise that
>many
>"antimicrobial molecules" are also neuromodulators ... ! We also
>realise that proteins can have multiple functions, that others have no
>structure.... etc: there is a huge task to be carried out in biology:
>redefine
>the notion of function!
> 
>
>On the subject of seriousness in science, there are few philosophical
>works that
>address this question: what is really serious? It is, however, a serious
>question... Nietzche had already asked himself about humour and philosophy
>when
>he published his "gai savoir"... more recently, we find "en
>quête du sérieux" by J.LH. Thomas. Rare are the philosophers and
>scientists who question the seriousness of their approaches... is
>sequencing
>the entire human genome really serious? (this question is provocative... I
>am aware of it) but one can ask the question in
>view of what this project has really brought?
>
>In this respect, I have the impression that an epistemological perspective
>on one's own activity is more conducive to a form of humour,
>relativity and makes people less rigid and therefore less aggressive ?
>
>About competition between living beings (and researchers) ... the famous
>"struggle for life"..., there are other systems of thought which are
>still very much in the minority... see "la manifestation de soi" by
>Jacques Dewitte (édition la découverte..; I don't know if it's translated
>into
>English?). Despite the dominant view, we know that ecosystems are based on
>many
>other laws than the prey/predator relationship... You only have to look at
>how
>a large whale can protect penguins, sea lions and its calf under its fins
>against the attack of orcas.
>
> 
>This machine metaphor and all the simplifying ideology about living beings
>that goes with it
>is nevertheless dominant and authoritarian today: in my opinion, it
>guarantees
>the functioning of a biology at the mercy of the pharmaceutical industry,
>which
>wants to reduce living beings to obedient objects.
>
>It is based on a misunderstood Darwinian vision that exalts the survival
>of the strongest
>and the best adapted... see the "Darwinian programme for French
>science" proposed by the president of the CNRS, A. Petit: we are not far
>from the notion of degenerate art that was hunted down not so long ago by
>certain regimes.
> 
>
>In short,there is a whole arsenal of concepts that are the pillars of a
>neo-liberal
>reductionist ideology, which, instead of understanding and contemplating
>the
>living, seeks to exploit it, if not destroy it. With the machine metaphor,
>we
>are not joking, there is no room for humour, we are 'efficient' and
>'performing' and we assimilate ourselves to our object of study... we
>ourselves
>become machines for producing scientific facts... and multiple guardians
>ambush
>everywhere, making sure that this gigantic machine called science works
>well...
>That's why it took me a while to answer you, I was transformed for several
>weeks into a machine asking for money to be able to do science...
> 
>
>Like any authoritarian system, it comes with a repressive apparatus to
>enforce it, and
>I'm taking the risk of proposing here that the main inquisitors are the
>"scientific editors" and also a large part of our colleagues who
>"know" where "right and wrong", "true and false",
>lie on the basis of a supposed rationality.
> 
>
>One can imagine that showing Chaplin's film "Modern Times", having the
>Milgram test or
>listening to a Bach fugue to the editors of major scientific journals could
>help them better understand the limits of the machine metaphor, understand
>the
>immeasurable complexity of life and its information flows and make
>relations
>between researchers more harmonious....
> 
> 
> 
> 
>
>
>all the best
>
>Youri
>
>
>
>Le 27/01/2022 12:00, « fis-bounces at listas.unizar.es on behalf of
>fis-request at listas.unizar.es » <fis-bounces at listas.unizar.es on behalf of
>fis-request at listas.unizar.es> a écrit :
>
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>>Today's Topics:
>>
>>   1. Fwd:  NEW YEAR LECTURE--from Jerry Chandler (Pedro C. Mariju?n)
>>   2. Test Message No Content (Jerry LR Chandler)
>>
>>
>>----------------------------------------------------------------------
>>
>>Message: 1
>>Date: Wed, 26 Jan 2022 13:45:57 +0100
>>From: Pedro C. Mariju?n <pedroc.marijuan at gmail.com>
>>To: "'fis'" <fis at listas.unizar.es>
>>Subject: [Fis] Fwd:  NEW YEAR LECTURE--from Jerry Chandler
>>Message-ID: <54419d99-ed1b-3da4-384e-845765c1917e at gmail.com>
>>Content-Type: text/plain; charset="utf-8"; Format="flowed"
>>
>>_Mssg. from Jerry Chandler_
>>
>>List, Pedro, Youri,
>>
>>> On Jan 19, 2022, at 12:55 PM, Pedro C. Mariju?n
>>> <pedroc.marijuan at gmail.com <mailto:pedroc.marijuan at gmail.com>> wrote:
>>>
>>> So, my contention is that a new filed like bio-chemistry or
>>> bio-physics would be needed concerning the biological-informational
>>> themes, a bio-information discipline comparable to those just
>>> mentioned. According to several authors? (me included), the
>>> prokaryotic cell should be considered as the fundamental, basic unit
>>> of biological cognition. Thereafter, there would be different ways to
>>> characterize its informational processes, particularly along the
>>> "information flow" conceptualization... interested parties may go to
>>> the recent contribution of Jorge Navarro and
>>> mine:https://www.mdpi.com/1422-0067/22/21/11965, it is in the special
>>> issue coordinated by Youri.? I also discuss that the from the
>>> informational thinking one could find the ways and means to renew the
>>> outdated Modern Synthesis.
>>>
>>> Otherwise, without a clearer disciplinary framework, am afraid the new
>>> biology will be reduced to bioinformatics and experimental "omic"
>>> disciplines. Just another (advanced, "very advanced") technology.
>>
>>Pedro: ?Your comments are often intriguing and these sentences are no
>>exception.
>>I do not grasp what either your scientific or personal objectives are.
>> ?One consistent theme in somehow tied to expectations about ?biologic
>>codes? in relation to forms of communication. ?Can you be more explicit
>>about what sorts of meaning you are seeking to understand?
>>Youri has presented the FIS with an encoded diagram of one of the
>>central apparati of all living organisms. ?Roughly speaking, the role of
>>the ribosome is well-understood although finer structuring of the
>>apparatus and its dynamics will continue to be studied ad infinitum. The
>>logical role of the ribosome in transducing information into alternative
>>dynamic forms has been clear for more than 40 years.
>>
>> ?This encoded diagram is based on the epistemology of the chemical code
>>of life, the physical codes of mass and electricity and the mathematical
>>codes of permutation groups, space groups, number theory, and so forth.
>>Is it not clear that Youri?s work generates a diagram that is a logical
>>constant of form?
>>
>>Somehow, I suspect that the epistemic gaps between mathematics and
>>physics and chemistry lie at the root of your search for biological
>>codes. ?Perhaps the effort is guided by a believe that the genesis of
>>living dynamics, involving thousands of variables and literally hundreds
>>of millions of *_unique_* biochemical reactions must necessarily be
>>expressible in simplistic and other scientific, syntactical symbol
>>systems? ?(Hundreds of millions of reactions BECAUSE every DNA base
>>occupies a logically unique sequential position and undergoes unique
>>reactions during transcription and duplication.)
>>
>> ?Is the concern semantics or semeoius? ?The syntax of Youri?s work is
>>not seriously questioned, is it? ?Is the problem that Youri?s work does
>>not fit into alternative theories of ?information? that can not be
>>distorted to fit the biological codes?
>>
>>Youri - Can you refer to a data source that lists the physical-chemical
>>data of an E coli ribosome in terms of the parts of the whole? ?(I am
>>not referring x-ray data, just the chemical parameters used to compute
>>the structure.). As time allows, I may do a few calculations to
>>unconceal aspects of the scientific information content of a ribosome.
>>
>>Cheers
>>
>>Jerry
>>
>>
>>
>>
>>
>>-- 
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>>Message: 2
>>Date: Wed, 26 Jan 2022 22:30:45 -0600
>>From: Jerry LR Chandler <jerry_lr_chandler at me.com>
>>To: fis <fis at listas.unizar.es>
>>Subject: [Fis] Test Message No Content
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>>   
>>
>>
>>------------------------------
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>>End of Fis Digest, Vol 85, Issue 16
>>***********************************
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