[Fis] Informational Bookkeeping

[Pedro C. Marijuan]

 Dear Koichiro,

Nice that you have left your hibernation for a while!
I quite agree with your excellent comment. On the one side the 
bookkeeping of molecules has plenty of tools to ascertain what is 
happening with each other in an uncorrelated way (state variables, 
force/mass/ energy, entropy, enthalpy, Helmholtz free energy, Gibbs free 
energy, etc.). But trying to synchronize their happenstances becomes 
daunting: tough external constraints have to be entered in order to keep 
a decent bookkeeping and make useful workings. And this is where the 
bookkeeping of life starts: building upon cycles as basic functional 
constraints: the work cycle of the individual enzyme, the multiple 
reaction cycles, the life cycle of the whole bacterium or the 
unicellular. In aggregate, the life cycle is the great referent of 
biological information, and the source of its "meaning". It is this 
different inner reference what makes invalid the maximum entropy 
principle for life--sometimes it is followed, sometimes it is just the 
opposite. It depends on the intertwining of external "signals" and on 
the advancement of the self-production process.
And with this I have already spent my "two cents" for the week...

best

--Pedro

PS. After the crash the list has more complex management (that I cannot 
handle very well) and message processing. People willing to check 
whether their messages have passed or not may directly check at:  
http://listas.unizar.es/pipermail/fis/

Koichiro Matsuno wrote:
> At 9:14 PM 09/05/2014, Pedro wrote:
>
> Who knows, focusing on varieties of bookkeeping might be quite productive!
>
> [KM] Pedro, your kick was loud enough to waken me up from my long
> hibernation. Suppose there are many things popping up here and there
> concurrently with no synchronization among them on the spot. Then, we would
> be totally at a loss what to do when asked to tell what is going on there.
> One plan as a last resort would be to make an appeal to a scheme of
> synchronization even if conceivable out of the blue. One candidate would be
> Bob U's energy, in reference to which we can safely say which are
> synchronized and which are sequential. One more candidate of this sort might
> be a reaction cycle of a natural origin, since any component reaction going
> round the cycle is ipso facto made synchronous with the occurrence of the
> cycle itself.    
>
>    Koichiro
>
>
>
>
>
>   


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Pedro C. Marijuán
Grupo de Bioinformación / Bioinformation Group
Instituto Aragonés de Ciencias de la Salud
Centro de Investigación Biomédica de Aragón (CIBA)
Avda. San Juan Bosco, 13, planta X
50009 Zaragoza, Spain
Tfno. +34 976 71 3526 (& 6818)
pcmarijuan.iacs at aragon.es
http://sites.google.com/site/pedrocmarijuan/
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