<div dir="ltr">Dear Steve,<br>Thank you for the opportunity to read your publications.<br>In this regard, I will allow myself a few brief remarks.<br>While autopoiesis offers a revolutionary framework for understanding self-sustaining systems, systematic research, including your publications, reveals critical gaps in accounting for:<br>(1) the genesis of recursive systems,<br>(2) their termination and death,<br>(3) metabolic dependencies and predation,<br>(4) the material substratum beneath operations, and<br>(5) political transformation.<br>Autopoietic theory suffers from a transcendental organizational perspective—privileging operations over objects, closure over consumption, and modulation over material constraints. Furthermore, your attempts to formalize autopoiesis through category theory introduce additional problems by ignoring fundamental categorical principles, notably duality.<br>I see a possible development in a synthesis integrating autopoiesis with dissipative structures (Prigozhin), trophic ecology (Lindemann) and agential realism (Barad), allowing a transition to a complete ecology capable of dealing with birth, death and metabolic predation.<br>Finally, I will note that your formula O=F(O) is the formula of the perpetual motion machine, which we all know is impossible.<br>With respect,<br>Krassimir<br></div><div id="DAB4FAD8-2DD7-40BB-A1B8-4E2AA1F9FDF2"><br><table style="border-top:1px solid #d3d4de"><tr><td style="width:55px;padding-top:13px"><a href="https://urldefense.com/v3/__https://www.avast.com/sig-email?utm_medium=email&utm_source=link&utm_campaign=sig-email&utm_content=webmail__;!!D9dNQwwGXtA!Rbc6UICtGq21X8lsol5u67WQbt8i-VNtG7c8pb302-3bxzXQR10Tx4ZUULGAbYF0MG1fX2_ApmPBkx2iqXo$" target="_blank"><img src="https://s-install.avcdn.net/ipm/preview/icons/icon-envelope-tick-round-orange-animated-no-repeat-v1.gif" alt="" width="46" height="29" style="width: 46px; height: 29px;"></a></td><td style="width:470px;padding-top:12px;color:#41424e;font-size:13px;font-family:Arial,Helvetica,sans-serif;line-height:18px">Virus-free.<a href="https://urldefense.com/v3/__https://www.avast.com/sig-email?utm_medium=email&utm_source=link&utm_campaign=sig-email&utm_content=webmail__;!!D9dNQwwGXtA!Rbc6UICtGq21X8lsol5u67WQbt8i-VNtG7c8pb302-3bxzXQR10Tx4ZUULGAbYF0MG1fX2_ApmPBkx2iqXo$" target="_blank" style="color:#4453ea">www.avast.com</a></td></tr></table><a href="#DAB4FAD8-2DD7-40BB-A1B8-4E2AA1F9FDF2" width="1" height="1"></a></div>