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<title>Re: [Fis] Fwd: Contingency biological signals: -Sex and Being</title>
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<p>Dear John and FIS Colleagues,</p>
<p>Thanks for the well crafted, dense bio paragraphs. Although I
agree with most of the comments --not with all-- the main problem
I see that it is a really too condensed a summary. It reminds me
the great little book by French biologist Max Pavans de Ceccatty
"La vie: de la cellule à l'homme" (1962), put in just half page.
Given the brevity needed, I will just point to three extra themes
that for my taste are relevant: signaling and the life cycle, role
of the "virome" in eukaryotic complexity and multicellular life,
and the tangled threads of Anthropogenesis. </p>
<p>The former one, signaling and the life cycle, represents "the
path not taken" about the deep meaning of cellular signaling. From
the beginning it was conceived within the input-processing-output
paradigm of techno-computer and artificial systems. It did not
help the concept of signaling as "structural coupling" with the
milieu, from the thought of Maturana and Varela. In any event, the
information flow (signaling) necessary interrelationship with the
energy flow (metabolism) has not been properly integrated with the
great sink and source for both flows: the life cycle. Perhaps
making the cycle "modular", and susceptible to be maintained
conveniently "frozen" along its different phases, represented the
basis of cell differentiation & specialized tissues via
signaling codes... Further, any complex form of life has had to
maintain the same openness to the info flows of its niche in order
to propel the advancement of its own life cycle. And let me stop
here.</p>
<p>About the virome, following Villareal, Witzany, and many others,
the motto "Ex virus omnia" means that
a new, forgotten realm of life has to be added to Margulis’
endosymbiotic
theory (Margulis, 1981, 1970), so incorporating viruses’ essential
evolutionary role within the present
discussions around the renewal or replacement of evolutionary
theory (Noble, 2016). In fact, one
the most important genome modifications of eukaryotes has come
from the
systematic activity of components of viral provenance: mobile
elements,
transposons, retrotransposons, repetitive elements and so on.
Seemingly (Shapiro) our species has counted with around 4 million
mobile insertion events. As a result, ancestral viral proteins can
be found in signaling pathways of all kind, and all across the
mammalian and human proteomes. </p>
<p>And finally about Anthropogenesis, let me copy from a recent
study: "By employing 471 whole-genome sequence samples, including
archaic humans (Neanderthals, Denisovans and more), modern humans,
other vertebrates (fish, amphibians, reptiles, birds, rodents,
mammals) plus four coelacanth and three lungfish samples, together
with 18 human cognition-related genes and their total of 223 SNVs
(Single-Nucleotide Variations),comparative analyses revealed that
the CGPPs (cognition gene polymorphism patterns) of both
coelacanths and lungfish are evolutionarily closer to those of
archaic humans than those of most other animal groups. The CGPP
appears to occupy an evolutionary inflection point, bridging
diverse animal lineages to archaic hominoids. Our observational
results suggest a hypothesis (to be validated in the future) that
<b>the genetic architecture underlying human cognition seems to
have been established during the evolutionary stage of fish,
predating the emergence of tetrapods</b>..." Amazing!! (From
Zhizhou Zhang et al., 2025,
<a class="moz-txt-link-freetext" href="https://urldefense.com/v3/__https://doi.org/10.20935/AcadMolBioGen8001__;!!D9dNQwwGXtA!UusxFDTBk3ZUgkvJ1A6efTRkbVH1ghY7Hqm_3tckntBOt0NwXJpwRR3yOZ0vQsEj9vRbkhxP9L0TnovknBDPEK5Ao7cg$">https://doi.org/10.20935/AcadMolBioGen8001</a>). By the way, there is
a special issue on Anthropogenesis to appear soon in BioSystems,
where brain evolution, sexual selection, social niche, emergence
of language, cognition, etc. are updated and discussed (editors
Marijuan, Igamberdiev, Iurato, 2025)--great job by Andrei. We will
send soon the link.</p>
<p>Best regards,</p>
<p>--Pedro</p>
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Name="List Continue 5"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="Message Header"/>
<w:LsdException Locked="false" Priority="11" QFormat="true" Name="Subtitle"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="Salutation"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="Date"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="Body Text First Indent"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="Body Text First Indent 2"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="Note Heading"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="Body Text 2"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="Body Text 3"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="Body Text Indent 2"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="Body Text Indent 3"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="Block Text"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="Hyperlink"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="FollowedHyperlink"/>
<w:LsdException Locked="false" Priority="22" QFormat="true" Name="Strong"/>
<w:LsdException Locked="false" Priority="20" QFormat="true" Name="Emphasis"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="Document Map"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="Plain Text"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="E-mail Signature"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="HTML Top of Form"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="HTML Bottom of Form"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="Normal (Web)"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="HTML Acronym"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="HTML Address"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="HTML Cite"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="HTML Code"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="HTML Definition"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="HTML Keyboard"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="HTML Preformatted"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="HTML Sample"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="HTML Typewriter"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="HTML Variable"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="Normal Table"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="annotation subject"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="No List"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="Outline List 1"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="Outline List 2"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="Outline List 3"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="Table Simple 1"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="Table Simple 2"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="Table Simple 3"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="Table Classic 1"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="Table Classic 2"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="Table Classic 3"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="Table Classic 4"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="Table Colorful 1"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="Table Colorful 2"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="Table Colorful 3"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="Table Columns 1"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="Table Columns 2"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="Table Columns 3"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="Table Columns 4"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="Table Columns 5"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="Table Grid 1"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="Table Grid 2"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="Table Grid 3"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="Table Grid 4"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="Table Grid 5"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="Table Grid 6"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="Table Grid 7"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="Table Grid 8"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="Table List 1"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="Table List 2"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="Table List 3"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="Table List 4"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="Table List 5"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="Table List 6"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="Table List 7"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="Table List 8"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="Table 3D effects 1"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="Table 3D effects 2"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="Table 3D effects 3"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="Table Contemporary"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="Table Elegant"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="Table Professional"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="Table Subtle 1"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="Table Subtle 2"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="Table Web 1"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="Table Web 2"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="Table Web 3"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="Balloon Text"/>
<w:LsdException Locked="false" Priority="39" Name="Table Grid"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="Table Theme"/>
<w:LsdException Locked="false" SemiHidden="true" Name="Placeholder Text"/>
<w:LsdException Locked="false" Priority="1" QFormat="true" Name="No Spacing"/>
<w:LsdException Locked="false" Priority="60" Name="Light Shading"/>
<w:LsdException Locked="false" Priority="61" Name="Light List"/>
<w:LsdException Locked="false" Priority="62" Name="Light Grid"/>
<w:LsdException Locked="false" Priority="63" Name="Medium Shading 1"/>
<w:LsdException Locked="false" Priority="64" Name="Medium Shading 2"/>
<w:LsdException Locked="false" Priority="65" Name="Medium List 1"/>
<w:LsdException Locked="false" Priority="66" Name="Medium List 2"/>
<w:LsdException Locked="false" Priority="67" Name="Medium Grid 1"/>
<w:LsdException Locked="false" Priority="68" Name="Medium Grid 2"/>
<w:LsdException Locked="false" Priority="69" Name="Medium Grid 3"/>
<w:LsdException Locked="false" Priority="70" Name="Dark List"/>
<w:LsdException Locked="false" Priority="71" Name="Colorful Shading"/>
<w:LsdException Locked="false" Priority="72" Name="Colorful List"/>
<w:LsdException Locked="false" Priority="73" Name="Colorful Grid"/>
<w:LsdException Locked="false" Priority="60" Name="Light Shading Accent 1"/>
<w:LsdException Locked="false" Priority="61" Name="Light List Accent 1"/>
<w:LsdException Locked="false" Priority="62" Name="Light Grid Accent 1"/>
<w:LsdException Locked="false" Priority="63" Name="Medium Shading 1 Accent 1"/>
<w:LsdException Locked="false" Priority="64" Name="Medium Shading 2 Accent 1"/>
<w:LsdException Locked="false" Priority="65" Name="Medium List 1 Accent 1"/>
<w:LsdException Locked="false" SemiHidden="true" Name="Revision"/>
<w:LsdException Locked="false" Priority="34" QFormat="true"
Name="List Paragraph"/>
<w:LsdException Locked="false" Priority="29" QFormat="true" Name="Quote"/>
<w:LsdException Locked="false" Priority="30" QFormat="true"
Name="Intense Quote"/>
<w:LsdException Locked="false" Priority="66" Name="Medium List 2 Accent 1"/>
<w:LsdException Locked="false" Priority="67" Name="Medium Grid 1 Accent 1"/>
<w:LsdException Locked="false" Priority="68" Name="Medium Grid 2 Accent 1"/>
<w:LsdException Locked="false" Priority="69" Name="Medium Grid 3 Accent 1"/>
<w:LsdException Locked="false" Priority="70" Name="Dark List Accent 1"/>
<w:LsdException Locked="false" Priority="71" Name="Colorful Shading Accent 1"/>
<w:LsdException Locked="false" Priority="72" Name="Colorful List Accent 1"/>
<w:LsdException Locked="false" Priority="73" Name="Colorful Grid Accent 1"/>
<w:LsdException Locked="false" Priority="60" Name="Light Shading Accent 2"/>
<w:LsdException Locked="false" Priority="61" Name="Light List Accent 2"/>
<w:LsdException Locked="false" Priority="62" Name="Light Grid Accent 2"/>
<w:LsdException Locked="false" Priority="63" Name="Medium Shading 1 Accent 2"/>
<w:LsdException Locked="false" Priority="64" Name="Medium Shading 2 Accent 2"/>
<w:LsdException Locked="false" Priority="65" Name="Medium List 1 Accent 2"/>
<w:LsdException Locked="false" Priority="66" Name="Medium List 2 Accent 2"/>
<w:LsdException Locked="false" Priority="67" Name="Medium Grid 1 Accent 2"/>
<w:LsdException Locked="false" Priority="68" Name="Medium Grid 2 Accent 2"/>
<w:LsdException Locked="false" Priority="69" Name="Medium Grid 3 Accent 2"/>
<w:LsdException Locked="false" Priority="70" Name="Dark List Accent 2"/>
<w:LsdException Locked="false" Priority="71" Name="Colorful Shading Accent 2"/>
<w:LsdException Locked="false" Priority="72" Name="Colorful List Accent 2"/>
<w:LsdException Locked="false" Priority="73" Name="Colorful Grid Accent 2"/>
<w:LsdException Locked="false" Priority="60" Name="Light Shading Accent 3"/>
<w:LsdException Locked="false" Priority="61" Name="Light List Accent 3"/>
<w:LsdException Locked="false" Priority="62" Name="Light Grid Accent 3"/>
<w:LsdException Locked="false" Priority="63" Name="Medium Shading 1 Accent 3"/>
<w:LsdException Locked="false" Priority="64" Name="Medium Shading 2 Accent 3"/>
<w:LsdException Locked="false" Priority="65" Name="Medium List 1 Accent 3"/>
<w:LsdException Locked="false" Priority="66" Name="Medium List 2 Accent 3"/>
<w:LsdException Locked="false" Priority="67" Name="Medium Grid 1 Accent 3"/>
<w:LsdException Locked="false" Priority="68" Name="Medium Grid 2 Accent 3"/>
<w:LsdException Locked="false" Priority="69" Name="Medium Grid 3 Accent 3"/>
<w:LsdException Locked="false" Priority="70" Name="Dark List Accent 3"/>
<w:LsdException Locked="false" Priority="71" Name="Colorful Shading Accent 3"/>
<w:LsdException Locked="false" Priority="72" Name="Colorful List Accent 3"/>
<w:LsdException Locked="false" Priority="73" Name="Colorful Grid Accent 3"/>
<w:LsdException Locked="false" Priority="60" Name="Light Shading Accent 4"/>
<w:LsdException Locked="false" Priority="61" Name="Light List Accent 4"/>
<w:LsdException Locked="false" Priority="62" Name="Light Grid Accent 4"/>
<w:LsdException Locked="false" Priority="63" Name="Medium Shading 1 Accent 4"/>
<w:LsdException Locked="false" Priority="64" Name="Medium Shading 2 Accent 4"/>
<w:LsdException Locked="false" Priority="65" Name="Medium List 1 Accent 4"/>
<w:LsdException Locked="false" Priority="66" Name="Medium List 2 Accent 4"/>
<w:LsdException Locked="false" Priority="67" Name="Medium Grid 1 Accent 4"/>
<w:LsdException Locked="false" Priority="68" Name="Medium Grid 2 Accent 4"/>
<w:LsdException Locked="false" Priority="69" Name="Medium Grid 3 Accent 4"/>
<w:LsdException Locked="false" Priority="70" Name="Dark List Accent 4"/>
<w:LsdException Locked="false" Priority="71" Name="Colorful Shading Accent 4"/>
<w:LsdException Locked="false" Priority="72" Name="Colorful List Accent 4"/>
<w:LsdException Locked="false" Priority="73" Name="Colorful Grid Accent 4"/>
<w:LsdException Locked="false" Priority="60" Name="Light Shading Accent 5"/>
<w:LsdException Locked="false" Priority="61" Name="Light List Accent 5"/>
<w:LsdException Locked="false" Priority="62" Name="Light Grid Accent 5"/>
<w:LsdException Locked="false" Priority="63" Name="Medium Shading 1 Accent 5"/>
<w:LsdException Locked="false" Priority="64" Name="Medium Shading 2 Accent 5"/>
<w:LsdException Locked="false" Priority="65" Name="Medium List 1 Accent 5"/>
<w:LsdException Locked="false" Priority="66" Name="Medium List 2 Accent 5"/>
<w:LsdException Locked="false" Priority="67" Name="Medium Grid 1 Accent 5"/>
<w:LsdException Locked="false" Priority="68" Name="Medium Grid 2 Accent 5"/>
<w:LsdException Locked="false" Priority="69" Name="Medium Grid 3 Accent 5"/>
<w:LsdException Locked="false" Priority="70" Name="Dark List Accent 5"/>
<w:LsdException Locked="false" Priority="71" Name="Colorful Shading Accent 5"/>
<w:LsdException Locked="false" Priority="72" Name="Colorful List Accent 5"/>
<w:LsdException Locked="false" Priority="73" Name="Colorful Grid Accent 5"/>
<w:LsdException Locked="false" Priority="60" Name="Light Shading Accent 6"/>
<w:LsdException Locked="false" Priority="61" Name="Light List Accent 6"/>
<w:LsdException Locked="false" Priority="62" Name="Light Grid Accent 6"/>
<w:LsdException Locked="false" Priority="63" Name="Medium Shading 1 Accent 6"/>
<w:LsdException Locked="false" Priority="64" Name="Medium Shading 2 Accent 6"/>
<w:LsdException Locked="false" Priority="65" Name="Medium List 1 Accent 6"/>
<w:LsdException Locked="false" Priority="66" Name="Medium List 2 Accent 6"/>
<w:LsdException Locked="false" Priority="67" Name="Medium Grid 1 Accent 6"/>
<w:LsdException Locked="false" Priority="68" Name="Medium Grid 2 Accent 6"/>
<w:LsdException Locked="false" Priority="69" Name="Medium Grid 3 Accent 6"/>
<w:LsdException Locked="false" Priority="70" Name="Dark List Accent 6"/>
<w:LsdException Locked="false" Priority="71" Name="Colorful Shading Accent 6"/>
<w:LsdException Locked="false" Priority="72" Name="Colorful List Accent 6"/>
<w:LsdException Locked="false" Priority="73" Name="Colorful Grid Accent 6"/>
<w:LsdException Locked="false" Priority="19" QFormat="true"
Name="Subtle Emphasis"/>
<w:LsdException Locked="false" Priority="21" QFormat="true"
Name="Intense Emphasis"/>
<w:LsdException Locked="false" Priority="31" QFormat="true"
Name="Subtle Reference"/>
<w:LsdException Locked="false" Priority="32" QFormat="true"
Name="Intense Reference"/>
<w:LsdException Locked="false" Priority="33" QFormat="true" Name="Book Title"/>
<w:LsdException Locked="false" Priority="37" SemiHidden="true"
UnhideWhenUsed="true" Name="Bibliography"/>
<w:LsdException Locked="false" Priority="39" SemiHidden="true"
UnhideWhenUsed="true" QFormat="true" Name="TOC Heading"/>
<w:LsdException Locked="false" Priority="41" Name="Plain Table 1"/>
<w:LsdException Locked="false" Priority="42" Name="Plain Table 2"/>
<w:LsdException Locked="false" Priority="43" Name="Plain Table 3"/>
<w:LsdException Locked="false" Priority="44" Name="Plain Table 4"/>
<w:LsdException Locked="false" Priority="45" Name="Plain Table 5"/>
<w:LsdException Locked="false" Priority="40" Name="Grid Table Light"/>
<w:LsdException Locked="false" Priority="46" Name="Grid Table 1 Light"/>
<w:LsdException Locked="false" Priority="47" Name="Grid Table 2"/>
<w:LsdException Locked="false" Priority="48" Name="Grid Table 3"/>
<w:LsdException Locked="false" Priority="49" Name="Grid Table 4"/>
<w:LsdException Locked="false" Priority="50" Name="Grid Table 5 Dark"/>
<w:LsdException Locked="false" Priority="51" Name="Grid Table 6 Colorful"/>
<w:LsdException Locked="false" Priority="52" Name="Grid Table 7 Colorful"/>
<w:LsdException Locked="false" Priority="46"
Name="Grid Table 1 Light Accent 1"/>
<w:LsdException Locked="false" Priority="47" Name="Grid Table 2 Accent 1"/>
<w:LsdException Locked="false" Priority="48" Name="Grid Table 3 Accent 1"/>
<w:LsdException Locked="false" Priority="49" Name="Grid Table 4 Accent 1"/>
<w:LsdException Locked="false" Priority="50" Name="Grid Table 5 Dark Accent 1"/>
<w:LsdException Locked="false" Priority="51"
Name="Grid Table 6 Colorful Accent 1"/>
<w:LsdException Locked="false" Priority="52"
Name="Grid Table 7 Colorful Accent 1"/>
<w:LsdException Locked="false" Priority="46"
Name="Grid Table 1 Light Accent 2"/>
<w:LsdException Locked="false" Priority="47" Name="Grid Table 2 Accent 2"/>
<w:LsdException Locked="false" Priority="48" Name="Grid Table 3 Accent 2"/>
<w:LsdException Locked="false" Priority="49" Name="Grid Table 4 Accent 2"/>
<w:LsdException Locked="false" Priority="50" Name="Grid Table 5 Dark Accent 2"/>
<w:LsdException Locked="false" Priority="51"
Name="Grid Table 6 Colorful Accent 2"/>
<w:LsdException Locked="false" Priority="52"
Name="Grid Table 7 Colorful Accent 2"/>
<w:LsdException Locked="false" Priority="46"
Name="Grid Table 1 Light Accent 3"/>
<w:LsdException Locked="false" Priority="47" Name="Grid Table 2 Accent 3"/>
<w:LsdException Locked="false" Priority="48" Name="Grid Table 3 Accent 3"/>
<w:LsdException Locked="false" Priority="49" Name="Grid Table 4 Accent 3"/>
<w:LsdException Locked="false" Priority="50" Name="Grid Table 5 Dark Accent 3"/>
<w:LsdException Locked="false" Priority="51"
Name="Grid Table 6 Colorful Accent 3"/>
<w:LsdException Locked="false" Priority="52"
Name="Grid Table 7 Colorful Accent 3"/>
<w:LsdException Locked="false" Priority="46"
Name="Grid Table 1 Light Accent 4"/>
<w:LsdException Locked="false" Priority="47" Name="Grid Table 2 Accent 4"/>
<w:LsdException Locked="false" Priority="48" Name="Grid Table 3 Accent 4"/>
<w:LsdException Locked="false" Priority="49" Name="Grid Table 4 Accent 4"/>
<w:LsdException Locked="false" Priority="50" Name="Grid Table 5 Dark Accent 4"/>
<w:LsdException Locked="false" Priority="51"
Name="Grid Table 6 Colorful Accent 4"/>
<w:LsdException Locked="false" Priority="52"
Name="Grid Table 7 Colorful Accent 4"/>
<w:LsdException Locked="false" Priority="46"
Name="Grid Table 1 Light Accent 5"/>
<w:LsdException Locked="false" Priority="47" Name="Grid Table 2 Accent 5"/>
<w:LsdException Locked="false" Priority="48" Name="Grid Table 3 Accent 5"/>
<w:LsdException Locked="false" Priority="49" Name="Grid Table 4 Accent 5"/>
<w:LsdException Locked="false" Priority="50" Name="Grid Table 5 Dark Accent 5"/>
<w:LsdException Locked="false" Priority="51"
Name="Grid Table 6 Colorful Accent 5"/>
<w:LsdException Locked="false" Priority="52"
Name="Grid Table 7 Colorful Accent 5"/>
<w:LsdException Locked="false" Priority="46"
Name="Grid Table 1 Light Accent 6"/>
<w:LsdException Locked="false" Priority="47" Name="Grid Table 2 Accent 6"/>
<w:LsdException Locked="false" Priority="48" Name="Grid Table 3 Accent 6"/>
<w:LsdException Locked="false" Priority="49" Name="Grid Table 4 Accent 6"/>
<w:LsdException Locked="false" Priority="50" Name="Grid Table 5 Dark Accent 6"/>
<w:LsdException Locked="false" Priority="51"
Name="Grid Table 6 Colorful Accent 6"/>
<w:LsdException Locked="false" Priority="52"
Name="Grid Table 7 Colorful Accent 6"/>
<w:LsdException Locked="false" Priority="46" Name="List Table 1 Light"/>
<w:LsdException Locked="false" Priority="47" Name="List Table 2"/>
<w:LsdException Locked="false" Priority="48" Name="List Table 3"/>
<w:LsdException Locked="false" Priority="49" Name="List Table 4"/>
<w:LsdException Locked="false" Priority="50" Name="List Table 5 Dark"/>
<w:LsdException Locked="false" Priority="51" Name="List Table 6 Colorful"/>
<w:LsdException Locked="false" Priority="52" Name="List Table 7 Colorful"/>
<w:LsdException Locked="false" Priority="46"
Name="List Table 1 Light Accent 1"/>
<w:LsdException Locked="false" Priority="47" Name="List Table 2 Accent 1"/>
<w:LsdException Locked="false" Priority="48" Name="List Table 3 Accent 1"/>
<w:LsdException Locked="false" Priority="49" Name="List Table 4 Accent 1"/>
<w:LsdException Locked="false" Priority="50" Name="List Table 5 Dark Accent 1"/>
<w:LsdException Locked="false" Priority="51"
Name="List Table 6 Colorful Accent 1"/>
<w:LsdException Locked="false" Priority="52"
Name="List Table 7 Colorful Accent 1"/>
<w:LsdException Locked="false" Priority="46"
Name="List Table 1 Light Accent 2"/>
<w:LsdException Locked="false" Priority="47" Name="List Table 2 Accent 2"/>
<w:LsdException Locked="false" Priority="48" Name="List Table 3 Accent 2"/>
<w:LsdException Locked="false" Priority="49" Name="List Table 4 Accent 2"/>
<w:LsdException Locked="false" Priority="50" Name="List Table 5 Dark Accent 2"/>
<w:LsdException Locked="false" Priority="51"
Name="List Table 6 Colorful Accent 2"/>
<w:LsdException Locked="false" Priority="52"
Name="List Table 7 Colorful Accent 2"/>
<w:LsdException Locked="false" Priority="46"
Name="List Table 1 Light Accent 3"/>
<w:LsdException Locked="false" Priority="47" Name="List Table 2 Accent 3"/>
<w:LsdException Locked="false" Priority="48" Name="List Table 3 Accent 3"/>
<w:LsdException Locked="false" Priority="49" Name="List Table 4 Accent 3"/>
<w:LsdException Locked="false" Priority="50" Name="List Table 5 Dark Accent 3"/>
<w:LsdException Locked="false" Priority="51"
Name="List Table 6 Colorful Accent 3"/>
<w:LsdException Locked="false" Priority="52"
Name="List Table 7 Colorful Accent 3"/>
<w:LsdException Locked="false" Priority="46"
Name="List Table 1 Light Accent 4"/>
<w:LsdException Locked="false" Priority="47" Name="List Table 2 Accent 4"/>
<w:LsdException Locked="false" Priority="48" Name="List Table 3 Accent 4"/>
<w:LsdException Locked="false" Priority="49" Name="List Table 4 Accent 4"/>
<w:LsdException Locked="false" Priority="50" Name="List Table 5 Dark Accent 4"/>
<w:LsdException Locked="false" Priority="51"
Name="List Table 6 Colorful Accent 4"/>
<w:LsdException Locked="false" Priority="52"
Name="List Table 7 Colorful Accent 4"/>
<w:LsdException Locked="false" Priority="46"
Name="List Table 1 Light Accent 5"/>
<w:LsdException Locked="false" Priority="47" Name="List Table 2 Accent 5"/>
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<p><span> </span></p>
<blockquote type="cite"
cite="mid:CAGyb-D1aNDcBKO7BnuOwYOxcjFjRrHL2s9pu0u1yQ3-LrQ3fSA@mail.gmail.com">
<div dir="ltr">
<div>
<div dir="ltr" class="gmail_signature"
data-smartmail="gmail_signature">
<div>
<div>El 23/11/2025 a las 18:20, JOHN TORDAY escribió:<br>
</div>
<blockquote type="cite">
<div dir="ltr">
<div><font size="4">Dear Eric, I am afraid you have
misunderstood my allusion to the role gravity
plays in evolution, in my opinion, based totally
on experimental evidence. It becomes most apparent
and relevant in the vertebrate transition from
water to land, when fish adapted to land (a known
fact). During that transition there were three
hormone receptors that duplicated- the Parathyroid
Hormone Receptor (PTHrP), the Glucocorticoid
Receptor (GR) and the beta-adrenergic receptor
(beta-AR). Which came first is the question I have
pondered for many years, only recently coming to
the realization that it must have been the PTHrP
receptor that duplicated first, given that it
determines bone 'stiffness', and the skeleton
would have been under stress due to the effective
force of gravity on land versus in water. Those
members of the species that were able to
'up-regulate' their PTHrP receptor most readily
for bone would have done so successively in the
swim bladder to drive its evolution in becoming
the lung, as evidenced by the fact that in the
absence of PTHrP the lung does not alveolarize
(Rubin et al, 2004), followed by the role of PTHrP
in forming kidney glomeruli from the fish kidney
glomus, and the augmentation of the stress signal
from pituitary to adrenal cortex to produce
adrenaline and cortisol. We know that there must
have been such a scenario since fish attempted to
breech land on at least 5 separate occasions (see
Clack, J.A., Gaining Ground, 2012). The relevance
of these physiologic adaptations can be seen in
astronauts who experience osteoporosis due to
PTHrP deficiency (see Torday, 2003 for evidence of
such) as well as kidney complications due to
down-regulation of PTHrP control of salt and water
balance. So in the aggregate, in reply to
your comment that "gravity would not directly
control the growth of a bilateral gynandromorph
that is half female and half male down the
middle", I would beg to differ based on</font><span
style="font-size:large"> the hormonal adaptations
for land life, which are fundamental to land
vertebrate physiologic adaptations for skeletal
integrity, breathing, salt and water balance, if
you get my point. And all of these physiologic
traits are essential for the bipedalism that freed
our forelimbs for tool-making, including speaking,
and locomotion, all of which are under the control
of the FoxP2 gene and are 'housed' within the Area
of Broca (</span><font size="4">see <span
style="color:rgb(33,33,33);font-family:system-ui,-apple-system,"Segoe UI",Roboto,Oxygen,Ubuntu,Cantarell,"Fira Sans","Droid Sans","Helvetica Neue",sans-serif">Torday
JS. A central theory of biology. Med Hypotheses.
2015 Jul;85(1):49-57)</span></font><span
style="font-size:large">. It is this transition
from crawling on all fours to standing on two legs
due to the advent of endothermy that marks the
evolution of our over-seized central nervous
system....and as a consequence, at some point in
human evolution our heads became too large to fit
in the birth canal so we are born prematurely,
with only 25% of brain capacity, requiring decades
of nurturing by family and society in order to
effectively mature as a species, if ever (I note
my current President). </span></div>
<div><span style="font-size:large"><br>
</span></div>
<div><span style="font-size:large">As for your glib
comment abou</span><font size="4">t "The issue is
more understanding the information that makes a
difference (Oh dear I have slipped into Spencer
Brown"......In this regard, I think you
misunderstand Spencer-Brown too in that what he
was telling us is that we are fractals of a
'holism' as the unmarked space.</font></div>
<div><font size="4"><br>
</font></div>
<div><font size="4">And as for your flippant comment
about "gravity does not make the difference
between a whale and a dog" I again beg your
pardon, but gravity is exactly what makes the
difference between a whale and a dog, referring
again to gravity's effects on the physiologic
traits of each on land (dog) and in water (whale)
given that seals are thought to have evolved back
to water from dogs......</font></div>
<div><font size="4"><br>
</font></div>
<div><font size="4">But you may take exception to what
I am saying, so have at it. I am of the opinion
that the way I have traced evolution from cell to
our 'selves' accounts for the evolution of
consciousness from the former to the latter as I
have expressed in numerous peer-reviewed articles,
and 14 monographs.</font></div>
<div><font size="4"><br>
</font></div>
<div><font size="4">Best, John</font></div>
<div><span style="font-size:large"> </span></div>
<br>
</div>
<br>
<div class="gmail_quote">
<div dir="ltr" class="gmail_attr">On Sun, Nov 23, 2025
at 11:11 AM OARF <<a
href="mailto:eric.werner@oarf.org" target="_blank"
moz-do-not-send="true"
class="moz-txt-link-freetext">eric.werner@oarf.org</a>>
wrote:<br>
</div>
<blockquote class="gmail_quote"
style="margin:0px 0px 0px 0.8ex;border-left:1px solid rgb(204,204,204);padding-left:1ex">
<div dir="auto">Dear john,
<div>There is a difference between necessary
conditions that are just that and offer no
information that controls the growth of detailed
structure in multicellular organisms that
differentiates one from another and conditions
like gravity that apply to all such
developmental processes. Thus, for example,
gravity would not directly control the growth of
a bilateral gynandromorph that is half female
and half male down the middle. See: <a href="https://urldefense.com/v3/__https://arxiv.org/abs/1212.5439__;!!D9dNQwwGXtA!UusxFDTBk3ZUgkvJ1A6efTRkbVH1ghY7Hqm_3tckntBOt0NwXJpwRR3yOZ0vQsEj9vRbkhxP9L0TnovknBDPEDwcoYq4$" target="_blank" moz-do-not-send="true" class="moz-txt-link-freetext">https://arxiv.org/abs/1212.5439</a> for
more details. </div>
<div><br>
</div>
<div>But I agree that gravity and oxygen
certainly have their effects on development. </div>
<div> </div>
<div>The issue is more understanding the
information that makes a difference (Oh dear I
have slipped into Spencer Brown ;-) ).</div>
<div>and gravity does not make the difference
between a whale and a dog.</div>
<div><br>
</div>
<div>Best,</div>
<div>Eric</div>
<div><br>
</div>
<div>
<div dir="ltr">Sent from my iPad</div>
<div dir="ltr"><br>
<blockquote type="cite">On Nov 23, 2025, at
3:05 PM, JOHN TORDAY <<a
href="mailto:jtorday@ucla.edu"
target="_blank" moz-do-not-send="true"
class="moz-txt-link-freetext">jtorday@ucla.edu</a>>
wrote:<br>
<br>
</blockquote>
</div>
<blockquote type="cite">
<div dir="ltr">
<div dir="ltr">
<div><font size="4">To Eric, Gordana,
Howard, regarding the role of sex in
evolution, I would like to point out
that the role of gravity in evolution
also entails sex in the following way.
In the study of the effect of
microgravity on yeast, the simplest
eukaryote, they cannot 'bud' as form
of asexual reproduction in
microgravitational conditions (<span
style="color:rgb(33,33,33);font-family:system-ui,-apple-system,"Segoe UI",Roboto,Oxygen,Ubuntu,Cantarell,"Fira Sans","Droid Sans","Helvetica Neue",sans-serif">Purevdorj-Gage
B, Sheehan KB, Hyman LE. Effects of
low-shear modeled microgravity on
cell function, gene expression, and
phenotype in Saccharomyces
cerevisiae. Appl Environ Microbiol.
2006 Jul;72(7):4569-75). I am of the
opinion that it is only in
addressing the evolutionary ontology
as it corresponds with the
epistemology that an adaptive trait
can be understood, as in the case of
sex as a means of adapting to an
ever-changing environment. In the
case of yeast, budding is a means of
epigenetic inheritance of
environmental factors relevant to
its adaptation, and the force of
gravity affects that process. These
authors also observed that the yeast
could not conduct a calcium flux
under microgravity, rendering them
unconscious 'zombies'. I share this
information with you in an attempt
to find a final common pathway for
the process of evolution, ultimately
referring to the elements in the
Cosmos as the latter's 'logic', as I
expressed it in an accompanying
email earlier today....Best, John</span></font></div>
<br>
</div>
<br>
<div class="gmail_quote">
<div dir="ltr" class="gmail_attr">On Sun,
Nov 23, 2025 at 8:13 AM OARF <<a
href="mailto:eric.werner@oarf.org"
target="_blank" moz-do-not-send="true"
class="moz-txt-link-freetext">eric.werner@oarf.org</a>>
wrote:<br>
</div>
<blockquote class="gmail_quote"
style="margin:0px 0px 0px 0.8ex;border-left:1px solid rgb(204,204,204);padding-left:1ex">
<div dir="auto"><span
style="color:rgb(0,0,0);background-color:rgb(255,255,255)">Hi Gordana,</span>
<div style="color:rgb(0,0,0)"><br>
</div>
<div style="color:rgb(0,0,0)">I was
just responding to Howard’s more
general point beyond bacteria.
Eukaryotes have sex an inherently
social process. Sexuality is
fundamentally a cooperative process,
at many levels of organization. Even
social at the level of the genome:
See my theory of meta-genome
interactions between the sexes. It
is particularly clear in the case
physically mixed sex organisms (this
can be neurological as well). See
the theory applied to mixed sex
organisms or gynandropmorphs: </div>
<div style="color:rgb(0,0,0)"><a
href="https://urldefense.com/v3/__https://arxiv.org/abs/1212.5439__;!!D9dNQwwGXtA!XLF-Q-SqJ-AuvQ-dic9ptw82Ooe57dI4UX6ePa7CTWADakJMPTruAnfSd0yTCHhsfb-S3Rv04mCA4h3ClsatzQ4$"
style="color:rgb(37,37,255)"
target="_blank"
moz-do-not-send="true">https://arxiv.org/abs/1212.5439</a></div>
<div style="color:rgb(0,0,0)"> </div>
<div style="color:rgb(0,0,0)">So the
sexuality of being is inherently
social. </div>
<div style="color:rgb(0,0,0)"><br>
</div>
<div style="color:rgb(0,0,0)">-Eric</div>
<div style="color:rgb(0,0,0)"><br>
</div>
<div style="color:rgb(0,0,0)"><a
href="https://urldefense.com/v3/__https://www.ericwerner.com/__;!!D9dNQwwGXtA!XLF-Q-SqJ-AuvQ-dic9ptw82Ooe57dI4UX6ePa7CTWADakJMPTruAnfSd0yTCHhsfb-S3Rv04mCA4h3CaUt82MM$"
target="_blank"
moz-do-not-send="true">https://www.ericwerner.com/</a></div>
<div style="color:rgb(0,0,0)"><br>
</div>
<div dir="ltr">Sent from my iPad</div>
<div dir="ltr"><br>
</div>
<div dir="ltr"><br>
</div>
</div>
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