<html><head><meta http-equiv="Content-Type" content="text/html; charset=utf-8"></head><body style="word-wrap: break-word; -webkit-nbsp-mode: space; line-break: after-white-space;" class=""><div class="">Dear Folks,</div>A key question for this discussion is: What is a machine?<div class="">One working definition of a machine is that it is an instantiation in physical processes of a specified system of rules and procedures.<div class="">In other words a machine is a realization of a formal system in the sense of mathematical logic. Thus realized Turing machines are machines in this sense.</div><div class="">Note that behaviors of such machines, happening recursively, are not mathematically predictable in general. Machine behaviours go beyond the possibilities of mathematical prediction to processes unfolding in time.</div><div class=""><br class=""></div><div class="">One may want to extend this definition to at least machines that are self-modifying in terms of their own rules and procedures, and one may want to discuss the extent to which a biological organism's behaviours can be “captured” by such a set of rules, and how our finding such rules is a reflection of our interaction/observation leading to knowledge of the organism.</div><div class="">Best,</div><div class="">Lou Kauffman</div><div class=""> </div><div class=""><div><br class=""><blockquote type="cite" class=""><div class="">On May 13, 2025, at 8:27 AM, Pedro C. Marijuán <<a href="mailto:pedroc.marijuan@gmail.com" class="">pedroc.marijuan@gmail.com</a>> wrote:</div><br class="Apple-interchange-newline"><div class="">
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<div class=""><p class=""><font size="5" class="">Mind, Life & Machines</font></p><p class=""><b class=""><font size="4" class="">From Mike Levin: Living Things Are Not Machines
(Also, They<br class="">
Totally Are)</font></b><br class="">
</p><p class="">To start with, different contexts require us to adopt diverse
perspectives as to<br class="">
how much mind, or mechanism, is before us. The continuing battle
over whether<br class="">
living beings are or are not machines is based on two mistaken but
pervasive<br class="">
beliefs. First, the belief that we can objectively and uniquely
nail down what<br class="">
something is. And second, that our formal models of life,
computers or materials<br class="">
tell the entire story of their capabilities and limitations.<br class="">
</p><p class="">Despite the continued expansion and mainstream prominence of
molecular<br class="">
biology, and its reductionist machine metaphors, or likely because
of it, there has<br class="">
been an increasing upsurge of papers and science social media
posts arguing that<br class="">
“living things are not machines” (LTNM). There are thoughtful,
informative,<br class="">
nuanced pieces exploring this direction, such as this exploration
of “new post-<br class="">
genomic biology” and others, masterfully reviewed and analyzed by
cognitive<br class="">
scientist and historian Ann-Sophie Barwich and historian Matthew
James<br class="">
Rodriguez at Indiana University Bloomington. (A non-exhaustive
list includes<br class="">
engineer Perry Marshall’s look at how biology transcends the
limits of<br class="">
computation, computer scientist Alexander Ororbia’s discussion of
“mortal<br class="">
computation,” biologist Stuart Kauffman and computer scientist
Andrea Roli’s<br class="">
look at the evolution of the biosphere, and the works of
philosophers like Daniel<br class="">
Nicholson, George Kampis and Günther Witzani.)</p><p class="">Many others, however, use the siren song of biological
exceptionalism and<br class="">
outdated or poorly defined notions of “machines” to push a view
that misleads lay<br class="">
readers and stalls progress in fields such as evolution, cell
biology, biomedicine,<br class="">
cognitive science (and basal cognition), computer science,
bioengineering,<br class="">
philosophy and more. All of these fields are held back by hidden
assumptions<br class="">
within the LTNM-lens that are better shed in favor of a more
fundamental framework.</p>
In arguing against LTNM, I use cognitive science-based <br class="">
approaches to understand and manipulate biological substrates.<br class="">
I have claimed that cognition goes all the way down to the molecular
level; after all,<br class="">
we find memory and learning in small networks of mutually
interacting<br class="">
chemicals, and studies show that molecular circuits can act as
agential materials.<br class="">
I take the existence of goals, preferences, problem-solving skills,
attention,<br class="">
memories, etc., in biological substrates such as cells and tissues
so seriously that<br class="">
I’ve staked my entire laboratory career on this approach.<br class="">
<br class="">
Some molecular biology colleagues consider my views — that bottom-up<br class="">
molecular approaches simply won’t suffice, and must be augmented
with the tools<br class="">
and concepts of cognitive science — to be an extreme form of
animism. Thus, my<br class="">
quarrel with LTNM is not coming from a place of sympathy with
molecular<br class="">
reductionism; I consider myself squarely within the organicist
tradition of<br class="">
theoretical biologists like Denis Noble, Brian Goodwin, Robert
Rosen, Francisco<br class="">
Varela and Humberto Maturana, whose works all focus on the
irreducible,<br class="">
creative, agential quality of life; however, I want to push this
view further than<br class="">
many of its adherents might.<br class="">
<br class="">
LTNM must go, but we should not replace this concept with its
opposite, <br class="">
the dreaded presumption that living things are machines;<br class="">
that is equally wrong and also holds back progress.<br class="">
Still, it is easy to see why the LTNM-lens persists. The LTNM
framing gives the<br class="">
feeling that one has said something powerful — cut nature at its
joints with<br class="">
respect to the most important thing there is, life and mind, by
establishing a<br class="">
fundamental category that separates life from the rest of the cold,
inanimate<br class="">
universe. It feels as if it forestalls the constant, pernicious
efforts to reduce the<br class="">
majesty of life to predictable mechanisms with no ability to drive
consideration or<br class="">
the first-person experiences that make life worth living.<br class="">
“Many use the siren song of biological exceptionalism and outdated<br class="">
or poorly defined notions of ‘machines’ to push a view that misleads<br class="">
lay readers and stalls progress.”<br class="">
<br class="">
But this is all smoke and mirrors, from an idea that took hold as a
bulwark against<br class="">
reductionism and mechanism; it refuses to go away even though we
have<br class="">
outgrown it. The approach I am advocating for is anchored by the
principles of<br class="">
pluralism and pragmatism: no system definitively is our formal model
of it, but if<br class="">
we move beyond expecting everything to be a nail for one particular
favorite<br class="">
hammer, we are freed up to do the important work of actually
characterizing the<br class="">
sets of tools that may open new frontiers.<br class="">
<br class="">
As scientists and philosophers, we owe everyone realistic stories of
scaling and<br class="">
gradual metamorphosis along a continuum — not of magical and sharp<br class="">
transitions — and a description of the tools we propose to use to
interact with a<br class="">
wide range of systems, along with a commitment to empirical
evaluation of those<br class="">
tools. We must battle our innate mind-blindness with new theories in
the field of<br class="">
Diverse Intelligence and the facilitating technology it enables,
much as a theory<br class="">
and apparatus for electromagnetism enabled access to an enormous,
unifying<br class="">
spectrum of phenomena of which we had previously had only narrow,
disparate-<br class="">
seeming glimpses. We must resist the urge to see the limits of
reality in the limits<br class="">
of our formal models. Everything, even things that look simple to
us, are a lot<br class="">
more than we think they are because we, too, are finite observers —
wondrous<br class="">
embodied minds with limited perspectives but massive potential and
the moral<br class="">
responsibility to get this (at least somewhat) right.<br class="">
<i class=""><br class="">
</i><br class="">
<i class="">See an enlarged version of this text at: </i><br class=""><p class=""><i class=""><span style="left: 4.32%; top: 97.04%; font-size: calc(var(--scale-factor)*8.00px); font-family: serif; transform: scaleX(0.914424);" role="presentation" dir="ltr" class=""><a class="moz-txt-link-freetext" href="https://urldefense.com/v3/__https://www.noemamag.com/living-things-are-not-machines-also-they-totally-are/__;!!D9dNQwwGXtA!TuRf27kMqxXb6vn61GDuY5SQFOpW-2bJsv9g_xjpV95LAvd4KXEvjSvlYJyKOCwm5VRzNhHx_qeJdN1pix7IJbKTwFLX$">https://www.noemamag.com/living-things-are-not-machines-also-they-totally-are/</a></span></i></p><p class=""><i class=""><span style="left: 4.32%; top: 97.04%; font-size: calc(var(--scale-factor)*8.00px); font-family: serif; transform: scaleX(0.914424);" role="presentation" dir="ltr" class="">-------------------------------------------------------------------------------------------------------------<br class="">
</span><span style="left: 47.29%; top: 97.04%; font-size: calc(var(--scale-factor)*8.00px); font-family: serif;" role="presentation" dir="ltr" class=""> </span></i></p>
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/* Style Definitions */
table.MsoNormalTable
{mso-style-name:"Tabla normal";
mso-tstyle-rowband-size:0;
mso-tstyle-colband-size:0;
mso-style-noshow:yes;
mso-style-priority:99;
mso-style-parent:"";
mso-padding-alt:0cm 5.4pt 0cm 5.4pt;
mso-para-margin:0cm;
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<![endif]--><p class="MsoNormal" style="text-align:justify;tab-stops:21.3pt"><span lang="EN-US" class=""><font size="4" class=""><b class=""> From William B. Miller, Jr. : </b></font></span><font size="4" class=""><b class=""><span lang="EN-US" class="">Information in a cellular
framework</span></b><span lang="EN-US" class=""> –
abstract for discussion</span></font></p><p class="MsoNormal" style="text-align:justify;tab-stops:21.3pt"><font size="4" class=""><span lang="EN-US" class="">See in the accompanying attached
file (for technical reasons)<br class="">
</span></font></p>
<div align="left" class="">
<blockquote class=""><div style="text-align: center;" class=""><font size="5" class=""><span lang="EN-US" class=""> </span></font><br class="webkit-block-placeholder"></div>
</blockquote>
</div>
<br class=""><div style="text-align: justify;" class=""><span lang="EN-US" class=""> </span><br class="webkit-block-placeholder"></div><div style="text-align: justify;" class=""><span lang="EN-US" class=""> </span><br class="webkit-block-placeholder"></div>
<span style="left: 47.29%; top: 97.04%; font-size: calc(var(--scale-factor)*8.00px); font-family: serif;" role="presentation" dir="ltr" class=""> </span>
</div>
<span id="cid:47CD06F7-FD49-44BD-88F5-6D7C30D846B1"><Information in a cellular framework - FIS.doc></span>_______________________________________________<br class="">Fis mailing list<br class=""><a href="mailto:Fis@listas.unizar.es" class="">Fis@listas.unizar.es</a><br class=""><a href="http://listas.unizar.es/cgi-bin/mailman/listinfo/fis">http://listas.unizar.es/cgi-bin/mailman/listinfo/fis</a><br class="">----------<br class="">INFORMACI�N SOBRE PROTECCI�N DE DATOS DE CAR�CTER PERSONAL<br class=""><br class="">Ud. recibe este correo por pertenecer a una lista de correo gestionada por la Universidad de Zaragoza.<br class="">Puede encontrar toda la informaci�n sobre como tratamos sus datos en el siguiente enlace: <a href="https://sicuz.unizar.es/informacion-sobre-proteccion-de-datos-de-caracter-personal-en-listas">https://sicuz.unizar.es/informacion-sobre-proteccion-de-datos-de-caracter-personal-en-listas</a><br class="">Recuerde que si est� suscrito a una lista voluntaria Ud. puede darse de baja desde la propia aplicaci�n en el momento en que lo desee.<br class=""><a href="http://listas.unizar.es">http://listas.unizar.es</a><br class="">----------<br class=""></div></blockquote></div><br class=""></div></div></body></html>