<div dir="ltr"><p class="MsoNormal" style="margin:0cm 0cm 0.0001pt;line-height:normal;font-size:11pt;font-family:Calibri,"sans-serif""><span lang="BG" style="font-size:12pt;font-family:"Times New Roman","serif"">Dear
Xueshan,</span></p>

<p class="MsoNormal" style="margin:0cm 0cm 0.0001pt;line-height:normal;font-size:11pt;font-family:Calibri,"sans-serif""><span lang="BG" style="font-size:12pt;font-family:"Times New Roman","serif""> </span></p>

<p class="MsoNormal" style="margin:0cm 0cm 0.0001pt;line-height:normal;font-size:11pt;font-family:Calibri,"sans-serif""><span lang="BG" style="font-size:12pt;font-family:"Times New Roman","serif"">Regarding
your question in section</span></p>

<p class="MsoNormal" style="margin:0cm 0cm 0.0001pt;line-height:normal;font-size:11pt;font-family:Calibri,"sans-serif""><span lang="BG" style="font-size:12pt;font-family:"Times New Roman","serif""> </span></p>

<p class="MsoNormal" style="margin:0cm 0cm 0.0001pt;line-height:normal;font-size:11pt;font-family:Calibri,"sans-serif""><b><span lang="BG" style="font-size:12pt;font-family:"Times New Roman","serif"">Cloud 2.
Brain Informatics or Animal Informatics</span></b><span lang="BG" style="font-size:12pt;font-family:"Times New Roman","serif"">:</span></p>

<p class="MsoNormal" style="margin:0cm 0cm 0.0001pt;line-height:normal;font-size:11pt;font-family:Calibri,"sans-serif""><span lang="BG" style="font-size:12pt;font-family:"Times New Roman","serif"">Can we
assume that there are as many types of animal informatics as there are animal
species?</span></p>

<p class="MsoNormal" style="margin:0cm 0cm 0.0001pt;line-height:normal;font-size:11pt;font-family:Calibri,"sans-serif""><span lang="BG" style="font-size:12pt;font-family:"Times New Roman","serif""> </span></p>

<p class="MsoNormal" style="margin:0cm 0cm 0.0001pt;line-height:normal;font-size:11pt;font-family:Calibri,"sans-serif""><span lang="BG" style="font-size:12pt;font-family:"Times New Roman","serif"">I would
like to note that there must obviously be a difference in the models that we
build for different animal species, since the structure of the brain differs,
for example, there is a neocortex in mammals, while in other animals it is not.</span></p>

<p class="MsoNormal" style="margin:0cm 0cm 0.0001pt;line-height:normal;font-size:11pt;font-family:Calibri,"sans-serif""><span lang="BG" style="font-size:12pt;font-family:"Times New Roman","serif""> </span></p>

<p class="MsoNormal" style="margin:0cm 0cm 0.0001pt;line-height:normal;font-size:11pt;font-family:Calibri,"sans-serif""><span lang="BG" style="font-size:12pt;font-family:"Times New Roman","serif"">A very
important distinguishing feature of humans, in relation to other animals, is
the presence of writing and specific only to humans written information
interaction, part of which is this letter.</span></p>

<p class="MsoNormal" style="margin:0cm 0cm 0.0001pt;line-height:normal;font-size:11pt;font-family:Calibri,"sans-serif""><span lang="BG" style="font-size:12pt;font-family:"Times New Roman","serif""> </span></p>

<p class="MsoNormal" style="margin:0cm 0cm 0.0001pt;line-height:normal;font-size:11pt;font-family:Calibri,"sans-serif""><span lang="BG" style="font-size:12pt;font-family:"Times New Roman","serif"">There is
no other animal that uses e-mail :-) !!!</span></p>

<p class="MsoNormal" style="margin:0cm 0cm 0.0001pt;line-height:normal;font-size:11pt;font-family:Calibri,"sans-serif""><span lang="BG" style="font-size:12pt;font-family:"Times New Roman","serif""> </span></p>

<p class="MsoNormal" style="margin:0cm 0cm 0.0001pt;line-height:normal;font-size:11pt;font-family:Calibri,"sans-serif""><span lang="BG" style="font-size:12pt;font-family:"Times New Roman","serif"">In
connection with</span></p>

<p class="MsoNormal" style="margin:0cm 0cm 0.0001pt;line-height:normal;font-size:11pt;font-family:Calibri,"sans-serif""><span lang="BG" style="font-size:12pt;font-family:"Times New Roman","serif""> </span></p>

<p class="MsoNormal" style="margin:0cm 0cm 0.0001pt;line-height:normal;font-size:11pt;font-family:Calibri,"sans-serif""><b><span lang="BG" style="font-size:12pt;font-family:"Times New Roman","serif"">Cloud 5.
Exploration of Fundamental Information Science</span></b></p>

<p class="MsoNormal" style="margin:0cm 0cm 0.0001pt;line-height:normal;font-size:11pt;font-family:Calibri,"sans-serif""><span lang="BG" style="font-size:12pt;font-family:"Times New Roman","serif"">and your
question: Does Fundamental Information Science (FIS) exist at all?</span></p>

<p class="MsoNormal" style="margin:0cm 0cm 0.0001pt;line-height:normal;font-size:11pt;font-family:Calibri,"sans-serif""><span lang="BG" style="font-size:12pt;font-family:"Times New Roman","serif""> </span></p>

<p class="MsoNormal" style="margin:0cm 0cm 0.0001pt;line-height:normal;font-size:11pt;font-family:Calibri,"sans-serif""><span lang="BG" style="font-size:12pt;font-family:"Times New Roman","serif"">I would
like to note that at the moment I do not see a clear definition of FIS as an independent
science, but in my opinion it is possible that such a scientific direction will
appear in the future.</span><span style="font-size:12pt;font-family:"Times New Roman","serif""></span></p>

<p class="MsoNormal" style="margin:0cm 0cm 0.0001pt;line-height:normal;font-size:11pt;font-family:Calibri,"sans-serif""><span style="font-size:12pt;font-family:"Times New Roman","serif""> </span></p>

<p class="MsoNormal" style="margin:0cm 0cm 0.0001pt;line-height:normal;font-size:11pt;font-family:Calibri,"sans-serif""><span lang="BG" style="font-size:12pt;font-family:"Times New Roman","serif"">The
interdisciplinarity that exists within our community prevents the formation of
a relatively separate direction. </span></p><p class="MsoNormal" style="margin:0cm 0cm 0.0001pt;line-height:normal;font-size:11pt;font-family:Calibri,"sans-serif""><span lang="BG" style="font-size:12pt;font-family:"Times New Roman","serif""><br></span></p><p class="MsoNormal" style="margin:0cm 0cm 0.0001pt;line-height:normal;font-size:11pt;font-family:Calibri,"sans-serif""><span lang="BG" style="font-size:12pt;font-family:"Times New Roman","serif"">This is also evident from the discussions in
the FIS list, which are usually superficial without the possibility of in-depth
insight into the problems, due to the unpreparedness of the audience regarding
the necessary special knowledge on each of the discussed issues, as well as the
unwillingness of the presenters to answer “simple” questions, which leads to a
huge burden on the listeners, who need to deal with tons of specialized
literature from new areas for them.</span><span style="font-size:12pt;font-family:"Times New Roman","serif""></span></p>

<p class="MsoNormal" style="margin:0cm 0cm 0.0001pt;line-height:normal;font-size:11pt;font-family:Calibri,"sans-serif""><span style="font-size:12pt;font-family:"Times New Roman","serif""> </span></p>

<p class="MsoNormal" style="margin:0cm 0cm 0.0001pt;line-height:normal;font-size:11pt;font-family:Calibri,"sans-serif""><span lang="BG" style="font-size:12pt;font-family:"Times New Roman","serif"">I
consider it an inappropriate approach to say a few words and throw a list of
literature for “acquaintance” at the reader</span><span style="font-size:12pt;font-family:"Times New Roman","serif"">!</span></p>

<p class="MsoNormal" style="margin:0cm 0cm 0.0001pt;line-height:normal;font-size:11pt;font-family:Calibri,"sans-serif""><span style="font-size:12pt;font-family:"Times New Roman","serif""> </span></p>

<p class="MsoNormal" style="margin:0cm 0cm 0.0001pt;line-height:normal;font-size:11pt;font-family:Calibri,"sans-serif""><span lang="BG" style="font-size:12pt;font-family:"Times New Roman","serif"">At the
same time, small teams of highly qualified scientists who have in-depth
knowledge of more than one or two scientific directions would achieve
significant success. This is evidenced by a number of publications whose
authors are part of well-prepared interdisciplinary teams.</span></p>

<p class="MsoNormal" style="margin:0cm 0cm 0.0001pt;line-height:normal;font-size:11pt;font-family:Calibri,"sans-serif""><span lang="BG" style="font-size:12pt;font-family:"Times New Roman","serif""> </span></p>

<p class="MsoNormal" style="margin:0cm 0cm 0.0001pt;line-height:normal;font-size:11pt;font-family:Calibri,"sans-serif""><span lang="BG" style="font-size:12pt;font-family:"Times New Roman","serif"">I will
refrain from commenting on <b>Cloud 3</b>, as I am not an expert in the field
of genetics, as well as <b>Cloud 1</b> and <b>Cloud 4</b> for the opposite
reason. The latter requires a long conversation and small comments would do more
harm than help to clarify the issues. For me</span><span style="font-size:12pt;font-family:"Times New Roman","serif"">,</span><span lang="BG" style="font-size:12pt;font-family:"Times New Roman","serif""> they are of particular
importance, which is also evident from the main theme of the IS4SI Summit 2025:
“The Key Role of Information Interaction” (<a href="https://urldefense.com/v3/__https://is4si.org/summit-2025/__;!!D9dNQwwGXtA!TdrWSw6KLuOFyYhAWXj-5GOp3i80kymnaej420hAyORTgf5T6vU34In2sg0Omx7L-756LSyRJPgaNfDE6vI$">https://is4si.org/summit-2025/</a>).</span></p>

<p class="MsoNormal" style="margin:0cm 0cm 0.0001pt;line-height:normal;font-size:11pt;font-family:Calibri,"sans-serif""><span lang="BG" style="font-size:12pt;font-family:"Times New Roman","serif""> </span></p>

<p class="MsoNormal" style="margin:0cm 0cm 0.0001pt;line-height:normal;font-size:11pt;font-family:Calibri,"sans-serif""><span lang="BG" style="font-size:12pt;font-family:"Times New Roman","serif"">With
respect,</span></p>

<p class="MsoNormal" style="margin:0cm 0cm 0.0001pt;line-height:normal;font-size:11pt;font-family:Calibri,"sans-serif""><span lang="BG" style="font-size:12pt;font-family:"Times New Roman","serif"">Krassimir</span><span style="font-size:12pt;font-family:"Times New Roman","serif""></span></p></div>