<div dir="ltr"><p class="MsoNormal" style="margin:0cm 0cm 8pt;line-height:107%;font-size:12pt;font-family:"Times New Roman",serif"><span lang="EN-US">Dear Andrei
and Colleagues,</span></p><p class="MsoNormal" style="margin:0cm 0cm 8pt;line-height:107%;font-size:12pt;font-family:"Times New Roman",serif"><span lang="EN-US"><br></span></p>
<p class="MsoNormal" style="margin:0cm 0cm 8pt;line-height:107%;font-size:12pt;font-family:"Times New Roman",serif"><span lang="EN-US">Thank you
for summarizing last week's discussion. Please allow me to draw your attention
to the fact that I have also contributed, twice, to those proceedings. </span></p>
<p class="MsoNormal" style="margin:0cm 0cm 8pt;line-height:107%;font-size:12pt;font-family:"Times New Roman",serif"><span lang="EN-US">So, <b><u>for
the record, </u></b>let me summarize what I have tried to bring to your
attention.</span></p><p class="MsoNormal" style="margin:0cm 0cm 8pt;line-height:107%;font-size:12pt;font-family:"Times New Roman",serif"><span lang="EN-US"><br></span></p>
<p class="gmail-MsoListParagraph" style="margin:0cm 0cm 8pt 36pt;line-height:107%;font-size:12pt;font-family:"Times New Roman",serif"><b><span lang="EN-US">1.<span style="font-variant-numeric:normal;font-variant-east-asian:normal;font-weight:normal;font-stretch:normal;font-size:7pt;line-height:normal;font-family:"Times New Roman""> </span></span></b><b><span lang="EN-US">Epistemological, meta-communicational
differences</span></b></p>
<p class="MsoNormal" style="margin:0cm 0cm 8pt;line-height:107%;font-size:12pt;font-family:"Times New Roman",serif"><span lang="EN-US">To me, the process
of our non-dialogue has stark similarities to how I imagine the process <i>Holy
Congregation vs. Galileo Galilei</i> to have taken place. The two sides have
absolutely no common ground and consider each other to be subject to irrational
phantasmagories. </span></p>
<p class="MsoNormal" style="margin:0cm 0cm 8pt;line-height:107%;font-size:12pt;font-family:"Times New Roman",serif"><span lang="EN-US">The similarities
cover also:</span></p>
<p class="gmail-MsoListParagraphCxSpFirst" style="margin:0cm 0cm 0cm 36pt;line-height:107%;font-size:12pt;font-family:"Times New Roman",serif"><span lang="EN-US">a.<span style="font-variant-numeric:normal;font-variant-east-asian:normal;font-stretch:normal;font-size:7pt;line-height:normal;font-family:"Times New Roman""> </span></span><span lang="EN-US">Your side has tradition, publicity,
establishment on its side,</span></p>
<p class="gmail-MsoListParagraphCxSpLast" style="margin:0cm 0cm 8pt 36pt;line-height:107%;font-size:12pt;font-family:"Times New Roman",serif"><span lang="EN-US">b.<span style="font-variant-numeric:normal;font-variant-east-asian:normal;font-stretch:normal;font-size:7pt;line-height:normal;font-family:"Times New Roman""> </span></span><span lang="EN-US">My side is an individual with no
backing from establishment figures.</span></p>
<p class="MsoNormal" style="margin:0cm 0cm 8pt;line-height:107%;font-size:12pt;font-family:"Times New Roman",serif"><span lang="EN-US">You can refer
to the community of Cardinals giving a reasoned judgement reinforcing each
other’s opinion by referring to each other’s valuable and much-renowned
publications in the most respected journals, books and at conferences. I can
only point to e.g. Learn to Count in Twelve Easy Steps and De Ordinibus
Naturalibus.</span></p><p class="MsoNormal" style="margin:0cm 0cm 8pt;line-height:107%;font-size:12pt;font-family:"Times New Roman",serif"><span lang="EN-US"><br></span></p>
<p class="gmail-MsoListParagraph" style="margin:0cm 0cm 8pt 36pt;line-height:107%;font-size:12pt;font-family:"Times New Roman",serif"><b><span lang="EN-US">2.<span style="font-variant-numeric:normal;font-variant-east-asian:normal;font-weight:normal;font-stretch:normal;font-size:7pt;line-height:normal;font-family:"Times New Roman""> </span></span></b><b><span lang="EN-US">What you need to understand</span></b></p>
<p class="MsoNormal" style="margin:0cm 0cm 8pt;line-height:107%;font-size:12pt;font-family:"Times New Roman",serif"><span lang="EN-US"> In the present discussion about <b><i><u>Biological</u>
</i></b><i>Mathematics, </i>the only person who has anything to do with Biology
is me. With all due respect, this is again comparable to<i> Cardinals vs Galileo
</i>insofar as none of the Cardinals has ever looked thru a telescope. None of
you have ever dealt with anankastic syndrome, manic-depressive processes, dysthymia,
or surges of urges. These observations are highly educative, as educative as
seeing the moons of Jupiter.</span></p>
<p class="MsoNormal" style="margin:0cm 0cm 8pt;line-height:107%;font-size:12pt;font-family:"Times New Roman",serif"><span lang="EN-US">If you want
to understand how Biology functions and model that what you observe, you have
to learn some basic concepts, which I can teach you. The situation is
completely different to how you see it: not you are in the know and I talk
about stuff I have no idea about, but rather you are completely out of your
depth and have no idea about what you pontificate about, this made worse by you
believing that you are the champions, because you congratulate each other how
well you are making progress. If you are not ready to learn, you will never
understand (said Galileo to the Cardinals).</span></p><p class="MsoNormal" style="margin:0cm 0cm 8pt;line-height:107%;font-size:12pt;font-family:"Times New Roman",serif"><span lang="EN-US"><br></span></p>
<p class="gmail-MsoListParagraph" style="margin:0cm 0cm 8pt 36pt;line-height:107%;font-size:12pt;font-family:"Times New Roman",serif"><span lang="EN-US">3.<span style="font-variant-numeric:normal;font-variant-east-asian:normal;font-stretch:normal;font-size:7pt;line-height:normal;font-family:"Times New Roman""> </span></span><span lang="EN-US"> <b>Basics to learn</b></span></p>
<p class="MsoNormal" style="margin:0cm 0cm 8pt;line-height:107%;font-size:12pt;font-family:"Times New Roman",serif"><span lang="EN-US">It takes
about 7 years to get a PhD in Psychology. Zero chances of instructing you how
to approach <b><u>Biologic</u> Mathematics. </b> For a start, let me tell you two of the most fundamental
principles, to help you avoid the most horrible nonsense. These principles are:
thresholds and individuality of symbols.</span></p><p class="MsoNormal" style="margin:0cm 0cm 8pt;line-height:107%;font-size:12pt;font-family:"Times New Roman",serif"><span lang="EN-US"><br></span></p>
<p class="gmail-MsoListParagraph" style="margin:0cm 0cm 8pt 36pt;line-height:107%;font-size:12pt;font-family:"Times New Roman",serif"><span lang="EN-US">4.<span style="font-variant-numeric:normal;font-variant-east-asian:normal;font-stretch:normal;font-size:7pt;line-height:normal;font-family:"Times New Roman""> </span></span><b><span lang="EN-US">Eddington and the 136 ~ 137 upper
limit</span></b><span lang="EN-US"></span></p>
<p class="MsoNormal" style="margin:0cm 0cm 8pt;line-height:107%;font-size:12pt;font-family:"Times New Roman",serif"><span lang="EN-US">This guy
Eddington must have been a real genius. How he figured out the upper limit of
consistent assemblies without having any idea about the mathematics behind it
is truly marvelous. Fact is that he did, even though he could not withstand the
pressure of his ignorant contemporaries and avoided stating loud and clear that
the <b>essence of the idea of a threshold is that it is impossible to keep on
counting above a threshold, because the results of the counting become
self-contradictory. </b></span></p>
<p class="MsoNormal" style="margin:0cm 0cm 8pt;line-height:107%;font-size:12pt;font-family:"Times New Roman",serif"><span lang="EN-US">We imagine
an assembly made up <i>n </i>parts which assembly is consistent and coherent, that
is: in which the parts have relations among each other. It is self-evident that
this assembly can contain only a limited number of parts (otherwise we had an
infinite number of relations among objects, which is evidently not the case,
see e.g. that not every object is subject to magnetism). </span></p>
<p class="MsoNormal" style="margin:0cm 0cm 8pt;line-height:107%;font-size:12pt;font-family:"Times New Roman",serif"><span lang="EN-US">If
Eddington had been able to use the terms <i>‘foreground – background’ </i>and <i>‘similarity
– diversity’, </i>he would have established that there are differently many
similarity relations observable on a background of diversity than there are
diversity relations observable on a background of similarity. Using these concepts,
he would have entered <i>A242615 </i>into <i><a href="http://www.oeis.org" style="color:rgb(5,99,193)">www.oeis.org</a>.
</i></span></p>
<p class="MsoNormal" style="margin:0cm 0cm 8pt;line-height:107%;font-size:12pt;font-family:"Times New Roman",serif"><span lang="EN-US"> Reading the relations published in <i>A242615 </i>one
understands that </span><i><span lang="EN-US" style="font-family:Cambria,serif">Δ</span></i><i><span lang="EN-US"> ( f<sub>1</sub>(n), f<sub>2</sub>(n) ) > </span></i><i><span lang="EN-US" style="font-family:Cambria,serif">Δ</span></i><i><span lang="EN-US"> ( f(n+1), f(n) ) for n > Limit, </span></i><span lang="EN-US">where the term <i>Limit </i>refers to <i>n =
136 </i>in one case and to <i>n = 137 </i>in the other case. This is not that
complicated to understand, one needs only to look at the numbers (but one needs
to look at the numbers, in order to understand the Eddington threshold).</span></p>
<p class="MsoNormal" style="margin:0cm 0cm 8pt;line-height:107%;font-size:12pt;font-family:"Times New Roman",serif"><span lang="EN-US">In Biology,
one hits thresholds right and left, the whole contraption would not work
without the existence, contributions of thresholds.</span></p>
<p class="MsoNormal" style="margin:0cm 0cm 8pt;line-height:107%;font-size:12pt;font-family:"Times New Roman",serif"><span lang="EN-US">You must
use a kind of Mathematics that is full of thresholds, in order to be able to
create a picture of how Biology works. Otherwise, you are as lost as the
Cardinals discussing with Galileo.</span></p><p class="MsoNormal" style="margin:0cm 0cm 8pt;line-height:107%;font-size:12pt;font-family:"Times New Roman",serif"><span lang="EN-US"><br></span></p>
<p class="gmail-MsoListParagraph" style="margin:0cm 0cm 8pt 36pt;line-height:107%;font-size:12pt;font-family:"Times New Roman",serif"><span lang="EN-US">5.<span style="font-variant-numeric:normal;font-variant-east-asian:normal;font-stretch:normal;font-size:7pt;line-height:normal;font-family:"Times New Roman""> </span></span><b><span lang="EN-US">Individuated symbols</span></b><span lang="EN-US"></span></p>
<p class="MsoNormal" style="margin:0cm 0cm 8pt;line-height:107%;font-size:12pt;font-family:"Times New Roman",serif"><span lang="EN-US">Below the
threshold, the action takes place. For historical reasons (and for the fact of
not having computers at their disposal), the Founding Fathers of Mathematics
have simplified the task of counting by declaring the symbols one conducts
counting on to be <b>non-distinguishable, non-individual, all similar in all
respects. </b></span></p>
<p class="MsoNormal" style="margin:0cm 0cm 8pt;line-height:107%;font-size:12pt;font-family:"Times New Roman",serif"><span lang="EN-US">This is a time-honored
tradition, like the Teachings of the Prophets, First Disciples, Founding Fathers
in the case of the Cardinals. It is downright heretic to suggest that symbols
should be distinguished among each other, and one plays with his life if one
suggests to the Cardinals that they should move their purple-clothed bodies and
actually look at what the experiments show: in the case of Galileo, be so
revolutionary and heretic as to look thru a telescope, in my case to be so revolutionary
and heretic as to take some few (any number above say 21 should do, needs not
be more than 136) symbols (assembled from <i>a,b; a,b </i></span><i><span lang="EN-US">≤</span></i><i><span lang="EN-US"> 16; a </span></i><i><span lang="EN-US">≤ b), </span></i><span lang="EN-US">sort them in any order and then resort them in a
different order. The exercise should open your eyes like the exercise of
looking thru the telescope would have opened the eyes of those Cardinals. As
fat a chance of you being conductive to pledges to reason as there was in the
case then, one may bet. If one is a Cardinal, one will not lower himself to
observations of experiments, one is secure enough in the knowledge that the
other Cardinals are supportive of one’s convictions.</span></p><p class="MsoNormal" style="margin:0cm 0cm 8pt;line-height:107%;font-size:12pt;font-family:"Times New Roman",serif"><span lang="EN-US"><br></span></p>
<p class="gmail-MsoListParagraph" style="margin:0cm 0cm 8pt 36pt;line-height:107%;font-size:12pt;font-family:"Times New Roman",serif"><b><span lang="EN-US">6.<span style="font-variant-numeric:normal;font-variant-east-asian:normal;font-weight:normal;font-stretch:normal;font-size:7pt;line-height:normal;font-family:"Times New Roman""> </span></span></b><b><span lang="EN-US">Summary</span></b></p>
<p class="MsoNormal" style="margin:0cm 0cm 8pt;line-height:107%;font-size:12pt;font-family:"Times New Roman",serif"><span lang="EN-US">This addition to the summary of last week's discussions
is <b><u>for the record. </u></b>Whatever happens, future historians will know that <b><u>you have been told.</u></b> </span><span lang="EN-US"> </span></p>
<p class="MsoNormal" style="margin:0cm 0cm 8pt;line-height:107%;font-size:12pt;font-family:"Times New Roman",serif"><b><span lang="EN-US"> </span></b></p></div><br><div class="gmail_quote"><div dir="ltr" class="gmail_attr">Am Do., 30. Juni 2022 um 05:15 Uhr schrieb Nikita Shklovskiy <<a href="mailto:nikitashk@gmail.com">nikitashk@gmail.com</a>>:<br></div><blockquote class="gmail_quote" style="margin:0px 0px 0px 0.8ex;border-left:1px solid rgb(204,204,204);padding-left:1ex"><div><div dir="auto">Thanks! GREAT! </div></div><div><br><div class="gmail_quote"><div dir="ltr" class="gmail_attr">Чт, 30 июня 2022 г. в 04:21, Andrei Igamberdiev <<a href="mailto:a_igamberdiev@hotmail.com" target="_blank">a_igamberdiev@hotmail.com</a>>:<br></div><blockquote class="gmail_quote" style="margin:0px 0px 0px 0.8ex;border-left:1px solid rgb(204,204,204);padding-left:1ex">
<div dir="ltr">
<div style="font-family:Calibri,Helvetica,sans-serif;font-size:12pt;color:rgb(0,0,0)">
<span style="font-size:12pt">Dear Plamen, Koichiro and All,</span></div>
<div><span style="font-size:12pt;font-family:Calibri,Helvetica,sans-serif">Thank you Plamen for your important messages. I think, the Heisenberg uncertainty ratio "energy-time" can be named, in relation to the internal measurement
and following Liberman's principle of "minimum price of action", as the principle of "precision of action". It can be considered as a sub-principle of the first principle and in biological computation it determines the balance between the precision of action
and its duration. It can be the basis of optimality in biosystems that determines the choice between the fast and less precise reaction and slow and highly precise. All this is controlled through the achievement of maximum efficiency of the system in concrete
conditions (environment, etc.). Long conformational relaxation of macromolecules corresponds to holding coherent state and providing the precision of the output. This is the model of quantum non-demolition (QND) measurement, which corresponds to the internal
measurement with a high precision.</span><span style="font-size:12pt"> </span>
<span style="font-size:12pt;font-family:Calibri,sans-serif" lang="EN-GB">The sensitivity of detector is determined by its relaxation properties. The QND measurements are characterized by low energy dissipation and provide the basis for quantum computation
in biosystems. Actual energy dissipation in the course of measurement proceeds by emitting quanta carrying energy E at the time interval t. Calculation of this energy was done, e.g., in the paper of Matsuno and Paton (2000). Thus,
</span><span style="font-size:11pt;font-family:Calibri,sans-serif" lang="EN-GB">these ideas can be experimentally verified.<br>
</span></div>
<br>
<div style="font-family:Calibri,Helvetica,sans-serif;font-size:12pt;color:rgb(0,0,0)">
<span style="font-size:12pt">All the best,</span></div>
<div style="font-family:Calibri,Helvetica,sans-serif;font-size:12pt;color:rgb(0,0,0)">
<span style="font-size:12pt">Andrei </span><br>
</div>
<div style="font-family:Calibri,Helvetica,sans-serif;font-size:12pt;color:rgb(0,0,0)">
<br>
</div>
<div id="gmail-m_3530641183182496616m_5158162040538708158signature_bookmark"></div>
<div id="gmail-m_3530641183182496616m_5158162040538708158appendonsend"></div>
<div style="font-family:Calibri,Helvetica,sans-serif;font-size:12pt;color:rgb(0,0,0)">
<br>
</div>
<hr style="display:inline-block;width:98%">
<div id="gmail-m_3530641183182496616m_5158162040538708158divRplyFwdMsg" dir="ltr"><font style="font-size:11pt" face="Calibri, sans-serif" color="#000000"><b>From:</b> Plamen <<a href="mailto:plamen.l.simeonov@gmail.com" target="_blank">plamen.l.simeonov@gmail.com</a>><br>
<b>Sent:</b> June 26, 2022 10:12 AM<br>
<b>To:</b> Koichiro Matsuno <<a href="mailto:CXQ02365@nifty.com" target="_blank">CXQ02365@nifty.com</a>><br>
<b>Cc:</b> Andrei Igamberdiev <<a href="mailto:a_igamberdiev@hotmail.com" target="_blank">a_igamberdiev@hotmail.com</a>>; Gordana Dodig Crnkovic <<a href="mailto:gordana.dodig-crnkovic@chalmers.se" target="_blank">gordana.dodig-crnkovic@chalmers.se</a>>; Nikita Shklovsky <<a href="mailto:nikitashk@gmail.com" target="_blank">nikitashk@gmail.com</a>>; <a href="mailto:joe.brenner@bluewin.ch" target="_blank">joe.brenner@bluewin.ch</a> <<a href="mailto:joe.brenner@bluewin.ch" target="_blank">joe.brenner@bluewin.ch</a>>; <a href="mailto:fis@listas.unizar.es" target="_blank">fis@listas.unizar.es</a> <<a href="mailto:fis@listas.unizar.es" target="_blank">fis@listas.unizar.es</a>><br>
<b>Subject:</b> Re: [Fis] Summarising this weeks discussion</font>
<div> </div>
</div></div><div dir="ltr">
<div dir="auto">This is an interesting idea I like, Koichiro and Andrei.
<div>Are there any other (anticipated) forms of biocomputation languages beyond the symbolical and indexing ones that can get mixed up at a later point in time? I think we should keep in mind Gödel‘s inheritance avoid repeating Hilbert‘s mistake, which is a
biological one at its core. </div>
<div><br>
</div>
<div>Best,</div>
<div><br>
</div>
<div>Plamen<br>
<div>
<div dir="ltr"><br>
<blockquote type="cite">On Jun 26, 2022, at 11:07 AM, Koichiro Matsuno <<a href="mailto:CXQ02365@nifty.com" target="_blank">CXQ02365@nifty.com</a>> wrote:<br>
<br>
</blockquote>
</div>
<blockquote type="cite">
<div dir="ltr">
<div>
<p style="margin:0mm;font-size:12pt;font-family:SimSun">
<span style="font-size:11pt;font-family:游ゴシック;color:rgb(31,73,125)" lang="EN-US">Saturday, June 25, 2022 3:54 AM, Andrei Igamberdiev
<a href="mailto:a_igamberdiev@hotmail.com" target="_blank">a_igamberdiev@hotmail.com</a> wrote;</span></p>
<p style="margin:0mm;font-size:12pt;font-family:SimSun">
<span style="font-size:11pt;font-family:Calibri,sans-serif;color:black" lang="EN-US">I suggested the idea that the Heisenberg uncertainty ratio “energy-time” can explain the precision of operation of macromolecules as computing devices in living systems</span><span style="font-size:11pt;font-family:游ゴシック;color:rgb(31,73,125)" lang="EN-US"></span></p>
<p style="margin:0mm;font-size:12pt;font-family:SimSun">
<span style="font-size:11pt;font-family:游ゴシック;color:rgb(31,73,125)" lang="EN-US"> </span></p>
<p style="margin:0mm;font-size:12pt;font-family:SimSun">
<span style="font-size:11pt;font-family:游ゴシック;color:rgb(31,73,125)" lang="EN-US">Quantum mechanics has been an attempt for preventing us from falling into a helpless abyss in case symbolical and indexical languages simply got mixed up. QM regulation integrating
both the symbolical and indexical, e.g., conservation laws and measurements, as epitomized in the uncertainty relation, is an instance of quantum computation, and relevant to biology also.</span></p>
<p style="margin:0mm;font-size:12pt;font-family:SimSun">
<span style="font-size:11pt;font-family:游ゴシック;color:rgb(31,73,125)" lang="EN-US"> </span></p>
<p style="margin:0mm;font-size:12pt;font-family:SimSun">
<span style="font-size:11pt;font-family:游ゴシック;color:rgb(31,73,125)" lang="EN-US"> Best,</span></p>
<p style="margin:0mm;font-size:12pt;font-family:SimSun">
<span style="font-size:11pt;font-family:游ゴシック;color:rgb(31,73,125)" lang="EN-US"> Koichiro</span></p>
<p style="margin:0mm;font-size:12pt;font-family:SimSun">
<span style="font-size:11pt;font-family:游ゴシック;color:rgb(31,73,125)" lang="EN-US"> </span></p>
<p style="margin:0mm;font-size:12pt;font-family:SimSun">
<span style="font-size:11pt;font-family:游ゴシック;color:rgb(31,73,125)" lang="EN-US"> </span></p>
<p style="margin:0mm;font-size:12pt;font-family:SimSun">
<span style="font-size:11pt;font-family:游ゴシック;color:rgb(31,73,125)" lang="EN-US"> </span></p>
<div>
<div style="border-right:none;border-bottom:none;border-left:none;border-top:1pt solid rgb(225,225,225);padding:3pt 0mm 0mm">
<p style="margin:0mm;font-size:12pt;font-family:SimSun">
<b><span style="font-size:11pt;font-family:Calibri,sans-serif" lang="EN-US">From:</span></b><span style="font-size:11pt;font-family:Calibri,sans-serif" lang="EN-US"> Andrei Igamberdiev <</span><span lang="EN-US"><a href="mailto:a_igamberdiev@hotmail.com" target="_blank"><span style="font-size:11pt;font-family:Calibri,sans-serif">a_igamberdiev@hotmail.com</span></a></span><span style="font-size:11pt;font-family:Calibri,sans-serif" lang="EN-US">>
<br>
<b>Sent:</b> Saturday, June 25, 2022 3:54 AM<br>
<b>To:</b> Gordana Dodig Crnkovic <</span><span lang="EN-US"><a href="mailto:gordana.dodig-crnkovic@chalmers.se" target="_blank"><span style="font-size:11pt;font-family:Calibri,sans-serif">gordana.dodig-crnkovic@chalmers.se</span></a></span><span style="font-size:11pt;font-family:Calibri,sans-serif" lang="EN-US">>;
Nikita Shklovsky <</span><span lang="EN-US"><a href="mailto:nikitashk@gmail.com" target="_blank"><span style="font-size:11pt;font-family:Calibri,sans-serif">nikitashk@gmail.com</span></a></span><span style="font-size:11pt;font-family:Calibri,sans-serif" lang="EN-US">>;
Koichiro Matsuno <</span><span lang="EN-US"><a href="mailto:cxq02365@nifty.com" target="_blank"><span style="font-size:11pt;font-family:Calibri,sans-serif">cxq02365@nifty.com</span></a></span><span style="font-size:11pt;font-family:Calibri,sans-serif" lang="EN-US">>;
</span><span lang="EN-US"><a href="mailto:joe.brenner@bluewin.ch" target="_blank"><span style="font-size:11pt;font-family:Calibri,sans-serif">joe.brenner@bluewin.ch</span></a></span><span style="font-size:11pt;font-family:Calibri,sans-serif" lang="EN-US">;
</span><span lang="EN-US"><a href="mailto:fis@listas.unizar.es" target="_blank"><span style="font-size:11pt;font-family:Calibri,sans-serif">fis@listas.unizar.es</span></a></span><span style="font-size:11pt;font-family:Calibri,sans-serif" lang="EN-US"><br>
<b>Subject:</b> Re: Summarising this weeks discussion</span></p>
</div>
</div>
<p style="margin:0mm;font-size:12pt;font-family:SimSun">
<span lang="EN-US"> </span></p>
<div>
<p style="margin:0mm 0mm 8pt;font-size:12pt;font-family:SimSun">
<span style="font-size:11pt;font-family:Calibri,sans-serif;color:black" lang="EN-US">Dear Gordana, Joseph, Koichiro and Nikita, </span></p>
<p style="margin:0mm 0mm 8pt;font-size:12pt;font-family:SimSun">
<span style="font-size:11pt;font-family:Calibri,sans-serif;color:black" lang="EN-US">In my opinion, the exchange between Joseph and Koichiro regarding the transitions between the potential and the actual is very important as this is the point where we
can approach closer to the nature of macromolecular (and biological) computation. The whole process of computation is directly related to the aspects of “potentiality in reality”. The advanced systems that developed complex behavior are able to hold the potential
for a prolonged time to make precise outputs based on the choice of particular result that help the system to navigate in the external world. This means that such holding the potential corresponds to the abstracting capacity, which was clarified in recent
papers of Koichiro. This also corresponds to the duality of actual entity and of abstract entity in the philosophy of A.N. Whitehead. </span></p>
<p style="margin:0mm 0mm 8pt;font-size:12pt;font-family:SimSun">
<span style="font-size:11pt;font-family:Calibri,sans-serif;color:black" lang="EN-US">Many years ago, in my first paper of BioSystems (1993) I suggested the idea that the Heisenberg uncertainty ratio “energy-time” can explain the precision of operation
of macromolecules as computing devices in living systems in a way that the prolonged time of quantum measurement corresponds to the minimum dissipation of energy in it, i.e. to the precise result and thus represents the basis of natural computation performed
by macromolecular devices. These devices operate as molecular automata of the extremal quantum computer, and their set maintains highly ordered robust coherent state, which precisely directs actualizations in the course of natural computational process. During
this process, single events corresponding to realization of interacting individual programs form a percolating network, and this leads to concrete spatial patterns constructed using optimal coordinate scales. </span></p>
<p style="margin:0mm 0mm 8pt;font-size:12pt;font-family:SimSun">
<span style="font-size:11pt;font-family:Calibri,sans-serif;color:black" lang="EN-US">I am confident that this concept has a potential for development, and it is grounded in the ideas expressed by Efim Liberman in his conceptual approach to natural computation.
Several concrete aspects of the quantum biological computation were outlined in the works of Koichiro Matsuno, including the estimation of actual energy dissipation in the course of measurement accompanied by emitting quanta, each carrying energy E at every
time interval τ (Matsuno and Paton, 2000, BioSystems 55: 39-46). The works of Yukio Gunji, of Andrei Khrennikov, also earlier works of Howard Pattee and others, are particularly important in this development, although we are still at the beginning of this
important paradigm of the “new science”. In this development, the paradigm of the new science will incorporate the ideas of relational biology formulated by Robert Rosen, which will result in overcoming their too abstract original representation. Summarizing,
I would say that we have all prerequisites for the concept of natural computation that can be applied to the real world, and the logic of potentiality in reality is in the core of this paradigm. The real world is
<i>tantot libre, tantot recherché </i>(Beethoven words), and this is a pledge of freedom, which is the basis of the existence of the world and its evolution. </span></p>
<p style="margin:0mm 0mm 8pt;font-size:12pt;font-family:SimSun">
<span style="font-size:11pt;font-family:Calibri,sans-serif;color:black" lang="EN-US">All the best, </span></p>
<p style="margin:0mm 0mm 8pt;font-size:12pt;font-family:SimSun">
<span style="font-size:11pt;font-family:Calibri,sans-serif;color:black" lang="EN-US">Andrei </span></p>
</div>
<p style="margin:0mm;font-size:12pt;font-family:SimSun">
<span lang="EN-US"> </span></p>
</div>
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<div id="gmail-m_3530641183182496616m_5158162040538708158signature_bookmark"></div>
<div id="gmail-m_3530641183182496616m_5158162040538708158appendonsend"></div>
<div style="font-family:Calibri,Helvetica,sans-serif;font-size:12pt;color:rgb(0,0,0)">
<br>
</div>
<hr style="display:inline-block;width:98%">
<div id="gmail-m_3530641183182496616m_5158162040538708158divRplyFwdMsg" dir="ltr"><font style="font-size:11pt" face="Calibri, sans-serif" color="#000000"><b>From:</b> Plamen <<a href="mailto:plamen.l.simeonov@gmail.com" target="_blank">plamen.l.simeonov@gmail.com</a>><br>
<b>Sent:</b> June 26, 2022 10:12 AM<br>
<b>To:</b> Koichiro Matsuno <<a href="mailto:CXQ02365@nifty.com" target="_blank">CXQ02365@nifty.com</a>><br>
<b>Cc:</b> Andrei Igamberdiev <<a href="mailto:a_igamberdiev@hotmail.com" target="_blank">a_igamberdiev@hotmail.com</a>>; Gordana Dodig Crnkovic <<a href="mailto:gordana.dodig-crnkovic@chalmers.se" target="_blank">gordana.dodig-crnkovic@chalmers.se</a>>; Nikita Shklovsky <<a href="mailto:nikitashk@gmail.com" target="_blank">nikitashk@gmail.com</a>>; <a href="mailto:joe.brenner@bluewin.ch" target="_blank">joe.brenner@bluewin.ch</a> <<a href="mailto:joe.brenner@bluewin.ch" target="_blank">joe.brenner@bluewin.ch</a>>; <a href="mailto:fis@listas.unizar.es" target="_blank">fis@listas.unizar.es</a> <<a href="mailto:fis@listas.unizar.es" target="_blank">fis@listas.unizar.es</a>><br>
<b>Subject:</b> Re: [Fis] Summarising this weeks discussion</font>
<div> </div>
</div>
<div dir="auto">This is an interesting idea I like, Koichiro and Andrei.
<div>Are there any other (anticipated) forms of biocomputation languages beyond the symbolical and indexing ones that can get mixed up at a later point in time? I think we should keep in mind Gödel‘s inheritance avoid repeating Hilbert‘s mistake, which is a
biological one at its core. </div>
<div><br>
</div>
<div>Best,</div>
<div><br>
</div>
<div>Plamen<br>
<div>
<div dir="ltr"><br>
<blockquote type="cite">On Jun 26, 2022, at 11:07 AM, Koichiro Matsuno <<a href="mailto:CXQ02365@nifty.com" target="_blank">CXQ02365@nifty.com</a>> wrote:<br>
<br>
</blockquote>
</div>
<blockquote type="cite">
<div dir="ltr">
<div>
<p style="margin:0mm;font-size:12pt;font-family:SimSun">
<span style="font-size:11pt;font-family:游ゴシック;color:rgb(31,73,125)" lang="EN-US">Saturday, June 25, 2022 3:54 AM, Andrei Igamberdiev
<a href="mailto:a_igamberdiev@hotmail.com" target="_blank">a_igamberdiev@hotmail.com</a> wrote;</span></p>
<p style="margin:0mm;font-size:12pt;font-family:SimSun">
<span style="font-size:11pt;font-family:Calibri,sans-serif;color:black" lang="EN-US">I suggested the idea that the Heisenberg uncertainty ratio “energy-time” can explain the precision of operation of macromolecules as computing devices in living systems</span><span style="font-size:11pt;font-family:游ゴシック;color:rgb(31,73,125)" lang="EN-US"></span></p>
<p style="margin:0mm;font-size:12pt;font-family:SimSun">
<span style="font-size:11pt;font-family:游ゴシック;color:rgb(31,73,125)" lang="EN-US"> </span></p>
<p style="margin:0mm;font-size:12pt;font-family:SimSun">
<span style="font-size:11pt;font-family:游ゴシック;color:rgb(31,73,125)" lang="EN-US">Quantum mechanics has been an attempt for preventing us from falling into a helpless abyss in case symbolical and indexical languages simply got mixed up. QM regulation integrating
both the symbolical and indexical, e.g., conservation laws and measurements, as epitomized in the uncertainty relation, is an instance of quantum computation, and relevant to biology also.</span></p>
<p style="margin:0mm;font-size:12pt;font-family:SimSun">
<span style="font-size:11pt;font-family:游ゴシック;color:rgb(31,73,125)" lang="EN-US"> </span></p>
<p style="margin:0mm;font-size:12pt;font-family:SimSun">
<span style="font-size:11pt;font-family:游ゴシック;color:rgb(31,73,125)" lang="EN-US"> Best,</span></p>
<p style="margin:0mm;font-size:12pt;font-family:SimSun">
<span style="font-size:11pt;font-family:游ゴシック;color:rgb(31,73,125)" lang="EN-US"> Koichiro</span></p>
<p style="margin:0mm;font-size:12pt;font-family:SimSun">
<span style="font-size:11pt;font-family:游ゴシック;color:rgb(31,73,125)" lang="EN-US"> </span></p>
<p style="margin:0mm;font-size:12pt;font-family:SimSun">
<span style="font-size:11pt;font-family:游ゴシック;color:rgb(31,73,125)" lang="EN-US"> </span></p>
<p style="margin:0mm;font-size:12pt;font-family:SimSun">
<span style="font-size:11pt;font-family:游ゴシック;color:rgb(31,73,125)" lang="EN-US"> </span></p>
<div>
<div style="border-right:none;border-bottom:none;border-left:none;border-top:1pt solid rgb(225,225,225);padding:3pt 0mm 0mm">
<p style="margin:0mm;font-size:12pt;font-family:SimSun">
<b><span style="font-size:11pt;font-family:Calibri,sans-serif" lang="EN-US">From:</span></b><span style="font-size:11pt;font-family:Calibri,sans-serif" lang="EN-US"> Andrei Igamberdiev <</span><span lang="EN-US"><a href="mailto:a_igamberdiev@hotmail.com" target="_blank"><span style="font-size:11pt;font-family:Calibri,sans-serif">a_igamberdiev@hotmail.com</span></a></span><span style="font-size:11pt;font-family:Calibri,sans-serif" lang="EN-US">>
<br>
<b>Sent:</b> Saturday, June 25, 2022 3:54 AM<br>
<b>To:</b> Gordana Dodig Crnkovic <</span><span lang="EN-US"><a href="mailto:gordana.dodig-crnkovic@chalmers.se" target="_blank"><span style="font-size:11pt;font-family:Calibri,sans-serif">gordana.dodig-crnkovic@chalmers.se</span></a></span><span style="font-size:11pt;font-family:Calibri,sans-serif" lang="EN-US">>;
Nikita Shklovsky <</span><span lang="EN-US"><a href="mailto:nikitashk@gmail.com" target="_blank"><span style="font-size:11pt;font-family:Calibri,sans-serif">nikitashk@gmail.com</span></a></span><span style="font-size:11pt;font-family:Calibri,sans-serif" lang="EN-US">>;
Koichiro Matsuno <</span><span lang="EN-US"><a href="mailto:cxq02365@nifty.com" target="_blank"><span style="font-size:11pt;font-family:Calibri,sans-serif">cxq02365@nifty.com</span></a></span><span style="font-size:11pt;font-family:Calibri,sans-serif" lang="EN-US">>;
</span><span lang="EN-US"><a href="mailto:joe.brenner@bluewin.ch" target="_blank"><span style="font-size:11pt;font-family:Calibri,sans-serif">joe.brenner@bluewin.ch</span></a></span><span style="font-size:11pt;font-family:Calibri,sans-serif" lang="EN-US">;
</span><span lang="EN-US"><a href="mailto:fis@listas.unizar.es" target="_blank"><span style="font-size:11pt;font-family:Calibri,sans-serif">fis@listas.unizar.es</span></a></span><span style="font-size:11pt;font-family:Calibri,sans-serif" lang="EN-US"><br>
<b>Subject:</b> Re: Summarising this weeks discussion</span></p>
</div>
</div>
<p style="margin:0mm;font-size:12pt;font-family:SimSun">
<span lang="EN-US"> </span></p>
<div>
<p style="margin:0mm 0mm 8pt;font-size:12pt;font-family:SimSun">
<span style="font-size:11pt;font-family:Calibri,sans-serif;color:black" lang="EN-US">Dear Gordana, Joseph, Koichiro and Nikita, </span></p>
<p style="margin:0mm 0mm 8pt;font-size:12pt;font-family:SimSun">
<span style="font-size:11pt;font-family:Calibri,sans-serif;color:black" lang="EN-US">In my opinion, the exchange between Joseph and Koichiro regarding the transitions between the potential and the actual is very important as this is the point where we
can approach closer to the nature of macromolecular (and biological) computation. The whole process of computation is directly related to the aspects of “potentiality in reality”. The advanced systems that developed complex behavior are able to hold the potential
for a prolonged time to make precise outputs based on the choice of particular result that help the system to navigate in the external world. This means that such holding the potential corresponds to the abstracting capacity, which was clarified in recent
papers of Koichiro. This also corresponds to the duality of actual entity and of abstract entity in the philosophy of A.N. Whitehead. </span></p>
<p style="margin:0mm 0mm 8pt;font-size:12pt;font-family:SimSun">
<span style="font-size:11pt;font-family:Calibri,sans-serif;color:black" lang="EN-US">Many years ago, in my first paper of BioSystems (1993) I suggested the idea that the Heisenberg uncertainty ratio “energy-time” can explain the precision of operation
of macromolecules as computing devices in living systems in a way that the prolonged time of quantum measurement corresponds to the minimum dissipation of energy in it, i.e. to the precise result and thus represents the basis of natural computation performed
by macromolecular devices. These devices operate as molecular automata of the extremal quantum computer, and their set maintains highly ordered robust coherent state, which precisely directs actualizations in the course of natural computational process. During
this process, single events corresponding to realization of interacting individual programs form a percolating network, and this leads to concrete spatial patterns constructed using optimal coordinate scales. </span></p>
<p style="margin:0mm 0mm 8pt;font-size:12pt;font-family:SimSun">
<span style="font-size:11pt;font-family:Calibri,sans-serif;color:black" lang="EN-US">I am confident that this concept has a potential for development, and it is grounded in the ideas expressed by Efim Liberman in his conceptual approach to natural computation.
Several concrete aspects of the quantum biological computation were outlined in the works of Koichiro Matsuno, including the estimation of actual energy dissipation in the course of measurement accompanied by emitting quanta, each carrying energy E at every
time interval τ (Matsuno and Paton, 2000, BioSystems 55: 39-46). The works of Yukio Gunji, of Andrei Khrennikov, also earlier works of Howard Pattee and others, are particularly important in this development, although we are still at the beginning of this
important paradigm of the “new science”. In this development, the paradigm of the new science will incorporate the ideas of relational biology formulated by Robert Rosen, which will result in overcoming their too abstract original representation. Summarizing,
I would say that we have all prerequisites for the concept of natural computation that can be applied to the real world, and the logic of potentiality in reality is in the core of this paradigm. The real world is
<i>tantot libre, tantot recherché </i>(Beethoven words), and this is a pledge of freedom, which is the basis of the existence of the world and its evolution. </span></p>
<p style="margin:0mm 0mm 8pt;font-size:12pt;font-family:SimSun">
<span style="font-size:11pt;font-family:Calibri,sans-serif;color:black" lang="EN-US">All the best, </span></p>
<p style="margin:0mm 0mm 8pt;font-size:12pt;font-family:SimSun">
<span style="font-size:11pt;font-family:Calibri,sans-serif;color:black" lang="EN-US">Andrei </span></p>
</div>
<p style="margin:0mm;font-size:12pt;font-family:SimSun">
<span lang="EN-US"> </span></p>
</div>
<span>_______________________________________________</span><br>
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</blockquote></div></div>-- <br><div dir="ltr"><div dir="ltr"><div>Никита Ефимович Шкловский-Корди<div>Гематологический центр.</div><div><a href="http://WWW.AI-VOROBIEV.RU" target="_blank">WWW.AI-VOROBIEV.RU</a> - сайт Андрея Ивановича Воробьева</div></div></div></div>
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