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</o:shapelayout></xml><![endif]--></head><body lang=EN-US link="#0563C1" vlink="#954F72" style='word-wrap:break-word'><div class=WordSection1><p class=MsoNormal><span style='font-size:11.0pt;font-family:"Calibri",sans-serif;mso-fareast-language:EN-US'>Dear Koichiro,<o:p></o:p></span></p><p class=MsoNormal><span style='font-size:11.0pt;font-family:"Calibri",sans-serif;mso-fareast-language:EN-US'><o:p> </o:p></span></p><p class=MsoNormal><span style='font-size:11.0pt;font-family:"Calibri",sans-serif;mso-fareast-language:EN-US'>This statement is certainly valid. What Andrei and I have been trying to say is that Heisenberg uncertainty is one of a larger group of process descriptions characterized by uncertainty, imprecision, ‘diversity’, <i>etc.</i> Their elements, however. are always dual, instantiating actuality and potentiality in a changing, reciprocal relation. “Integration”, e.g., of symbolical and indexical is not necessary if this would mean that the terms lose their identity. The logic is a logic of dynamic coexistence.<o:p></o:p></span></p><p class=MsoNormal><span style='font-size:11.0pt;font-family:"Calibri",sans-serif;mso-fareast-language:EN-US'><o:p> </o:p></span></p><p class=MsoNormal><span style='font-size:11.0pt;font-family:"Calibri",sans-serif;mso-fareast-language:EN-US'>It is, at least for me, a measure of the validity of your approach that what others might consider an oxymoron applies: <i>uncertainty</i> at the origin of the <i>precision</i> of macromolecules as computing devices”. I think Lupasco would have appreciated this formulation.<o:p></o:p></span></p><p class=MsoNormal><span style='font-size:11.0pt;font-family:"Calibri",sans-serif;mso-fareast-language:EN-US'><o:p> </o:p></span></p><p class=MsoNormal><span style='font-size:11.0pt;font-family:"Calibri",sans-serif;mso-fareast-language:EN-US'>Best,<o:p></o:p></span></p><p class=MsoNormal><span style='font-size:11.0pt;font-family:"Calibri",sans-serif;mso-fareast-language:EN-US'><o:p> </o:p></span></p><p class=MsoNormal><span style='font-size:11.0pt;font-family:"Calibri",sans-serif;mso-fareast-language:EN-US'>Joseph <o:p></o:p></span></p><p class=MsoNormal><span style='font-size:11.0pt;font-family:"Calibri",sans-serif;mso-fareast-language:EN-US'><o:p> </o:p></span></p><p class=MsoNormal><span style='font-size:11.0pt;font-family:"Calibri",sans-serif;mso-fareast-language:EN-US'><o:p> </o:p></span></p><div><div style='border:none;border-top:solid #E1E1E1 1.0pt;padding:3.0pt 0in 0in 0in'><p class=MsoNormal><b><span style='font-size:11.0pt;font-family:"Calibri",sans-serif;mso-fareast-language:EN-US'>From:</span></b><span style='font-size:11.0pt;font-family:"Calibri",sans-serif;mso-fareast-language:EN-US'> Fis <fis-bounces@listas.unizar.es> <b>On Behalf Of </b>Koichiro Matsuno<br><b>Sent:</b> Sunday, June 26, 2022 10:06 AM<br><b>To:</b> 'Andrei Igamberdiev' <a_igamberdiev@hotmail.com>; 'Gordana Dodig Crnkovic' <gordana.dodig-crnkovic@chalmers.se>; 'Nikita Shklovsky' <nikitashk@gmail.com>; joe.brenner@bluewin.ch; fis@listas.unizar.es<br><b>Subject:</b> Re: [Fis] Summarising this weeks discussion<o:p></o:p></span></p></div></div><p class=MsoNormal><o:p> </o:p></p><p class=MsoNormal><span style='font-size:11.0pt;font-family:"Yu Gothic",sans-serif;color:#1F497D;mso-fareast-language:JA'>Saturday, June 25, 2022 3:54 AM, Andrei Igamberdiev </span><a href="mailto:a_igamberdiev@hotmail.com"><span style='font-size:11.0pt;font-family:"Yu Gothic",sans-serif;mso-fareast-language:JA'>a_igamberdiev@hotmail.com</span></a><span style='font-size:11.0pt;font-family:"Yu Gothic",sans-serif;color:#1F497D;mso-fareast-language:JA'> wrote;<o:p></o:p></span></p><p class=MsoNormal><span style='font-size:11.0pt;font-family:"Calibri",sans-serif;color:black'>I suggested the idea that the Heisenberg uncertainty ratio “energy-time” can explain the precision of operation of macromolecules as computing devices in living systems</span><span style='font-size:11.0pt;font-family:"Yu Gothic",sans-serif;color:#1F497D;mso-fareast-language:JA'><o:p></o:p></span></p><p class=MsoNormal><span style='font-size:11.0pt;font-family:"Yu Gothic",sans-serif;color:#1F497D;mso-fareast-language:JA'><o:p> </o:p></span></p><p class=MsoNormal><span style='font-size:11.0pt;font-family:"Yu Gothic",sans-serif;color:#1F497D;mso-fareast-language:JA'>Quantum mechanics has been an attempt for preventing us from falling into a helpless abyss in case symbolical and indexical languages simply got mixed up. QM regulation integrating both the symbolical and indexical, e.g., conservation laws and measurements, as epitomized in the uncertainty relation, is an instance of quantum computation, and relevant to biology also.<o:p></o:p></span></p><p class=MsoNormal><span style='font-size:11.0pt;font-family:"Yu Gothic",sans-serif;color:#1F497D;mso-fareast-language:JA'><o:p> </o:p></span></p><p class=MsoNormal><span style='font-size:11.0pt;font-family:"Yu Gothic",sans-serif;color:#1F497D;mso-fareast-language:JA'> Best,<o:p></o:p></span></p><p class=MsoNormal><span style='font-size:11.0pt;font-family:"Yu Gothic",sans-serif;color:#1F497D;mso-fareast-language:JA'> Koichiro<o:p></o:p></span></p><p class=MsoNormal><span style='font-size:11.0pt;font-family:"Yu Gothic",sans-serif;color:#1F497D;mso-fareast-language:JA'><o:p> </o:p></span></p><p class=MsoNormal><span style='font-size:11.0pt;font-family:"Yu Gothic",sans-serif;color:#1F497D;mso-fareast-language:JA'><o:p> </o:p></span></p><p class=MsoNormal><span style='font-size:11.0pt;font-family:"Yu Gothic",sans-serif;color:#1F497D;mso-fareast-language:JA'><o:p> </o:p></span></p><div><div style='border:none;border-top:solid #E1E1E1 1.0pt;padding:3.0pt 0in 0in 0in'><p class=MsoNormal><b><span style='font-size:11.0pt;font-family:"Calibri",sans-serif;mso-fareast-language:JA'>From:</span></b><span style='font-size:11.0pt;font-family:"Calibri",sans-serif;mso-fareast-language:JA'> Andrei Igamberdiev <</span><a href="mailto:a_igamberdiev@hotmail.com"><span style='font-size:11.0pt;font-family:"Calibri",sans-serif;mso-fareast-language:JA'>a_igamberdiev@hotmail.com</span></a><span style='font-size:11.0pt;font-family:"Calibri",sans-serif;mso-fareast-language:JA'>> <br><b>Sent:</b> Saturday, June 25, 2022 3:54 AM<br><b>To:</b> Gordana Dodig Crnkovic <</span><a href="mailto:gordana.dodig-crnkovic@chalmers.se"><span style='font-size:11.0pt;font-family:"Calibri",sans-serif;mso-fareast-language:JA'>gordana.dodig-crnkovic@chalmers.se</span></a><span style='font-size:11.0pt;font-family:"Calibri",sans-serif;mso-fareast-language:JA'>>; Nikita Shklovsky <</span><a href="mailto:nikitashk@gmail.com"><span style='font-size:11.0pt;font-family:"Calibri",sans-serif;mso-fareast-language:JA'>nikitashk@gmail.com</span></a><span style='font-size:11.0pt;font-family:"Calibri",sans-serif;mso-fareast-language:JA'>>; Koichiro Matsuno <</span><a href="mailto:cxq02365@nifty.com"><span style='font-size:11.0pt;font-family:"Calibri",sans-serif;mso-fareast-language:JA'>cxq02365@nifty.com</span></a><span style='font-size:11.0pt;font-family:"Calibri",sans-serif;mso-fareast-language:JA'>>; </span><a href="mailto:joe.brenner@bluewin.ch"><span style='font-size:11.0pt;font-family:"Calibri",sans-serif;mso-fareast-language:JA'>joe.brenner@bluewin.ch</span></a><span style='font-size:11.0pt;font-family:"Calibri",sans-serif;mso-fareast-language:JA'>; </span><a href="mailto:fis@listas.unizar.es"><span style='font-size:11.0pt;font-family:"Calibri",sans-serif;mso-fareast-language:JA'>fis@listas.unizar.es</span></a><span style='font-size:11.0pt;font-family:"Calibri",sans-serif;mso-fareast-language:JA'><br><b>Subject:</b> Re: Summarising this weeks discussion<o:p></o:p></span></p></div></div><p class=MsoNormal><o:p> </o:p></p><div><p class=MsoNormal style='margin-bottom:8.0pt'><span style='font-size:11.0pt;font-family:"Calibri",sans-serif;color:black'>Dear Gordana, Joseph, Koichiro and Nikita, <o:p></o:p></span></p><p class=MsoNormal style='margin-bottom:8.0pt'><span style='font-size:11.0pt;font-family:"Calibri",sans-serif;color:black'>In my opinion, the exchange between Joseph and Koichiro regarding the transitions between the potential and the actual is very important as this is the point where we can approach closer to the nature of macromolecular (and biological) computation. The whole process of computation is directly related to the aspects of “potentiality in reality”. The advanced systems that developed complex behavior are able to hold the potential for a prolonged time to make precise outputs based on the choice of particular result that help the system to navigate in the external world. This means that such holding the potential corresponds to the abstracting capacity, which was clarified in recent papers of Koichiro. This also corresponds to the duality of actual entity and of abstract entity in the philosophy of A.N. Whitehead. <o:p></o:p></span></p><p class=MsoNormal style='margin-bottom:8.0pt'><span style='font-size:11.0pt;font-family:"Calibri",sans-serif;color:black'>Many years ago, in my first paper of BioSystems (1993) I suggested the idea that the Heisenberg uncertainty ratio “energy-time” can explain the precision of operation of macromolecules as computing devices in living systems in a way that the prolonged time of quantum measurement corresponds to the minimum dissipation of energy in it, i.e. to the precise result and thus represents the basis of natural computation performed by macromolecular devices. These devices operate as molecular automata of the extremal quantum computer, and their set maintains highly ordered robust coherent state, which precisely directs actualizations in the course of natural computational process. During this process, single events corresponding to realization of interacting individual programs form a percolating network, and this leads to concrete spatial patterns constructed using optimal coordinate scales. <o:p></o:p></span></p><p class=MsoNormal style='margin-bottom:8.0pt'><span style='font-size:11.0pt;font-family:"Calibri",sans-serif;color:black'>I am confident that this concept has a potential for development, and it is grounded in the ideas expressed by Efim Liberman in his conceptual approach to natural computation. Several concrete aspects of the quantum biological computation were outlined in the works of Koichiro Matsuno, including the estimation of actual energy dissipation in the course of measurement accompanied by emitting quanta, each carrying energy E at every time interval τ (Matsuno and Paton, 2000, BioSystems 55: 39-46). The works of Yukio Gunji, of Andrei Khrennikov, also earlier works of Howard Pattee and others, are particularly important in this development, although we are still at the beginning of this important paradigm of the “new science”. In this development, the paradigm of the new science will incorporate the ideas of relational biology formulated by Robert Rosen, which will result in overcoming their too abstract original representation. Summarizing, I would say that we have all prerequisites for the concept of natural computation that can be applied to the real world, and the logic of potentiality in reality is in the core of this paradigm. The real world is <i>tantot libre, tantot recherché </i>(Beethoven words), and this is a pledge of freedom, which is the basis of the existence of the world and its evolution. <o:p></o:p></span></p><p class=MsoNormal style='margin-bottom:8.0pt'><span style='font-size:11.0pt;font-family:"Calibri",sans-serif;color:black'>All the best, <o:p></o:p></span></p><p class=MsoNormal style='margin-bottom:8.0pt'><span style='font-size:11.0pt;font-family:"Calibri",sans-serif;color:black'>Andrei <o:p></o:p></span></p></div><p class=MsoNormal><o:p> </o:p></p></div></body></html>