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<p><font size="1">Thanks, Nikita and Andrei, for your text and the
very intriguing special issue. The personal figure of Efim
Liberman is fascinating.</font></p>
<font size="1"> </font>
<p><font size="1">Currently I am working in AI, in the field of
sentiment analysis (using big data from social networks). In
this field we have a bottleneck in the way data are processed
and stored, for the classical von Neumann architecture keeps
them separately and processors have to spend most of their time
and energy moving data back and forth. There are some partial
achievements and special processors have been developed, but
clearly it is not enough for the current needs of AI and IoT.
So, the interest, or at least the need, for exploring
bio-inspired and brain-inspired computing is growing
substantially.</font></p>
<font size="1"> </font>
<p><font size="1"><br>
</font></p>
<p><font size="1">In this sense, I have two questions. Those
theoretical schemes of MCC and QMR from Liberman have they been
explored in the sense of suggesting alternative architectures of
data processing? And further, I have curiosity on what
relationship could be established between QMR and Hameroff and
Penrose's quantum computation in the microtubules? I have not
heard that the "tubulin qubit" had any feasibility within the
cellular environment... Could the hypothesis of hypersound
quasiparticles be more feasible cellularly? <br>
</font> </p>
<font size="1"> </font>
<p><font size="1">Thanks again for the kickoff.<br>
</font> </p>
<font size="1"> </font>
<p><font size="1"><br>
</font></p>
<p><font size="1">Regards,</font></p>
<font size="1"> </font>
<p><font size="1">Jorge Navarro</font></p>
<p><font size="1"><br>
</font></p>
<div class="moz-cite-prefix">El 13/06/2022 a las 17:36, Andrei
Igamberdiev escribió:<br>
</div>
<blockquote type="cite"
cite="mid:MWHPR15MB1551C73322AF651332C3218898AB9@MWHPR15MB1551.namprd15.prod.outlook.com">
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<p class="MsoNormal" style="margin:0in 0in
8pt;font-size:11pt;font-family:"Calibri", sans-serif">
<span class="elementToProof">Dear Colleagues, </span></p>
<p class="MsoNormal elementToProof" style="margin:0in 0in
8pt;font-size:11pt;font-family:"Calibri", sans-serif">
<span class="elementToProof">here is the text to start the
session on natural computation devoted to Efim Liberman
(1925-2011).</span></p>
<p class="MsoNormal elementToProof" style="margin:0in 0in
8pt;font-size:11pt;font-family:"Calibri", sans-serif">
<span class="elementToProof">We look forward for discussing this
important topic. It became the basis of the special issue of
the journal BioSystems:
<br>
</span></p>
<p class="MsoNormal elementToProof" style="margin:0in 0in
8pt;font-size:11pt;font-family:"Calibri", sans-serif">
<span class="elementToProof"><a
href="https://www.sciencedirect.com/journal/biosystems/special-issue/107NLGRSL8M"
id="LPNoLPOWALinkPreview" moz-do-not-send="true"
class="moz-txt-link-freetext">https://www.sciencedirect.com/journal/biosystems/special-issue/107NLGRSL8M</a></span><br>
</p>
<br>
<p class="MsoNormal elementToProof" style="margin:0in 0in
8pt;font-size:11pt;font-family:"Calibri", sans-serif">
<span class="elementToProof">With best regards,<br>
</span></p>
<p class="MsoNormal elementToProof" style="margin:0in 0in
8pt;font-size:11pt;font-family:"Calibri", sans-serif">
<span class="elementToProof">Nikita Shklovskiy-Kordi and Andrei
Igamberdiev<br>
</span></p>
<p class="MsoNormal elementToProof" style="margin:0in 0in
8pt;font-size:11pt;font-family:"Calibri", sans-serif">
<span class="elementToProof"></span><b class="elementToProof">Natural
computation (Biological computation)<o:p
class="elementToProof"> </o:p></b></p>
<p class="MsoNormal elementToProof" style="margin:0in 0in
8pt;font-size:11pt;font-family:"Calibri", sans-serif">
Following the pioneering works of Efim A. Liberman (1972, 1979),
Koichiro Matsuno (1995), and Michael Conrad (1999), it became
apparent that computability is generated internally in evolving
biological systems. While quantum computation in human
technology is still in early stages and does not go beyond the
simplest realizations, it develops in biological systems in a
complex way starting from the origin of life to the
sophistication of enzymes’ work. A thorough search of the
appropriate conceptual tools and mathematical language is
needed, so that it will help theoretical biologists to provide
new insights on the apparent goal-directedness, biological
complexity, and human consciousness—it is an important task for
the future. The biological computation concept became a basis of
the powerful scientific paradigm that is currently acquiring new
important developments.<o:p> </o:p></p>
<p class="MsoNormal elementToProof" style="margin:0in 0in
8pt;font-size:11pt;font-family:"Calibri", sans-serif">
Professor Efim A. Liberman (1925-2011) pioneered the paradigm of
biological computation and developed the concepts of the
molecular cell computer and the computational operation of
neuron. He published several important papers in BioSystems from
1979 to 1996, in close collaboration with the editor-in-chief
Michael Conrad. His concept of biological cell as a molecular
computer was published in 1972 (Liberman, 1972) followed by the
series of papers where he developed this concept in more detail
and made further advancement.
<o:p> </o:p></p>
<p class="MsoNormal" style="margin:0in 0in
8pt;font-size:11pt;font-family:"Calibri", sans-serif">
Efim Liberman suggested the existence of a quantum computing
system of life based on an estimate of the proximity to the
minimum possible of the energy spend by living organisms on the
calculations necessary to control macroscopic bodies with many
degrees of freedom in real time, as well as on the calculations
that ensure the existence of our consciousness.<o:p> </o:p></p>
<p class="MsoNormal" style="margin:0in 0in
8pt;font-size:11pt;font-family:"Calibri", sans-serif">
Liberman gave these quantum computing systems the names -
"quantum molecular regulator" - QMR and - "extreme quantum
regulator" - EQR.
<o:p> </o:p></p>
<p class="MsoNormal elementToProof" style="margin:0in 0in
8pt;font-size:11pt;font-family:"Calibri", sans-serif">
Liberman proposed the available for experimental verification
connection between the "molecular cell computer" - MCC and the
quantum computer system of the cell, in the work of enzymes and
ion channels of a living cell, functioning as input devices for
transmitting information from the MСС to quantum regulators, and
the cytoskeleton as a computing environment for quantum
calculations. The implementation of these experiments and the
search for suitable conceptual tools and mathematical language
are needed to help theoretical biologists take a fresh look at
the apparent feasibility or teleonomic basis of living systems,
the development of biological complexity, and the basis of human
consciousness.<o:p> </o:p></p>
<p class="MsoNormal elementToProof" style="margin:0in 0in
8pt;font-size:11pt;font-family:"Calibri", sans-serif">
The virtual special issue of BioSystems “Fundamental principles
of biological computation: From molecular computing to
biological complexity” commemorates the first publication of
Efim Liberman on biological computation at its 50th anniversary.
It was edited by Nikita Shklovskiy-Kordi, Koichiro Matsuno,
Pedro Marijuan and Andrei Igamberdiev. The webpage of this
special issue is:<o:p> </o:p></p>
<p class="MsoNormal elementToProof" style="margin:0in 0in
8pt;font-size:11pt;font-family:"Calibri", sans-serif">
<a
href="https://www.sciencedirect.com/journal/biosystems/special-issue/107NLGRSL8M"
moz-do-not-send="true" class="moz-txt-link-freetext">https://www.sciencedirect.com/journal/biosystems/special-issue/107NLGRSL8M</a><o:p> </o:p></p>
<p class="MsoNormal elementToProof" style="margin:0in 0in
8pt;font-size:11pt;font-family:"Calibri", sans-serif">
Some papers of this issue have free access, and for other
papers, you can send a request to the editors to receive a copy.
The biographical essay of Efim Liberman “On the way to a new
science” (<a
href="https://www.sciencedirect.com/science/article/pii/S0303264722000399"
moz-do-not-send="true" class="moz-txt-link-freetext">https://www.sciencedirect.com/science/article/pii/S0303264722000399</a>)
represents an autobiographic courageous creative story of life
in science. Efim Liberman presented in this essay not only the
story of his life but also his thoughts about the role of
science and its future development and unification, with the
ultimate goal to unite and harmonize our understanding of life
and nature. Nikita Shklovskiy-Kordi and Andrei (Abir)
igamberdiev review the contributions of Liberman in
understanding the mechanisms of intracellular processing of
information (<a
href="https://www.sciencedirect.com/science/article/pii/S0303264722000454"
moz-do-not-send="true" class="moz-txt-link-freetext">https://www.sciencedirect.com/science/article/pii/S0303264722000454</a>).<span
style="mso-spacerun:yes">
</span>It can be considered as an overview of Liberman’s efforts
to create an integrative theory of natural computation that aims
to unite biology, physics and mathematics, which he called
Chaimatics.
<o:p> </o:p></p>
<p class="MsoNormal elementToProof" style="margin:0in 0in
8pt;font-size:11pt;font-family:"Calibri", sans-serif">
In other papers of the issue, different aspects of biological
computations are discussed including Physical foundations of
biology; Quantum computation in biological organization;
Molecular recognition; Cellular control; Neuromolecular
computing; Molecular computing processes; Self-organizing and
self-replicating systems; Computational principles in biological
development; Origins and evolution of the genetic mechanism;
Fundamental nature of biological information processing.
<o:p> </o:p></p>
<div style="font-family: Calibri, Helvetica, sans-serif;
font-size: 12pt; color: rgb(0, 0, 0);" class="elementToProof">
Nikita Sklovskiy-Kordi and Andrei Igamberdiev<br>
</div>
<br>
<fieldset class="moz-mime-attachment-header"></fieldset>
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