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<u>Mssg. from Jerry Chandler</u></div>
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<div class="moz-forward-container">List, Pedro, Youri, <br class="">
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<blockquote type="cite" class="">
<div class="">On Jan 19, 2022, at 12:55 PM, Pedro C. Marijuán
<<a href="mailto:pedroc.marijuan@gmail.com" class=""
moz-do-not-send="true">pedroc.marijuan@gmail.com</a>>
wrote:</div>
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<div class="moz-cite-prefix" style="caret-color: rgb(0, 0,
0); font-family: Helvetica; font-size: 18px; font-style:
normal; font-variant-caps: normal; font-weight: normal;
letter-spacing: normal; text-align: start; text-indent:
0px; text-transform: none; white-space: normal;
word-spacing: 0px; -webkit-text-stroke-width: 0px;
text-decoration: none;">So, my contention is that a new
filed like bio-chemistry or bio-physics would be needed
concerning the biological-informational themes, a
bio-information discipline comparable to those just
mentioned. According to several authors (me included),
the prokaryotic cell should be considered as the
fundamental, basic unit of biological cognition.
Thereafter, there would be different ways to characterize
its informational processes, particularly along the
"information flow" conceptualization... interested parties
may go to the recent contribution of Jorge Navarro and
mine:<a class="moz-txt-link-freetext"
href="https://www.mdpi.com/1422-0067/22/21/11965"
moz-do-not-send="true">https://www.mdpi.com/1422-0067/22/21/11965</a><span
class="Apple-converted-space"> </span>, it is in the
special issue coordinated by Youri. I also discuss that
the from the informational thinking one could find the
ways and means to renew the outdated Modern Synthesis.<span
class="Apple-converted-space"> </span><br class="">
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<div class="moz-cite-prefix" style="caret-color: rgb(0, 0,
0); font-family: Helvetica; font-size: 18px; font-style:
normal; font-variant-caps: normal; font-weight: normal;
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</div>
<div class="moz-cite-prefix" style="caret-color: rgb(0, 0,
0); font-family: Helvetica; font-size: 18px; font-style:
normal; font-variant-caps: normal; font-weight: normal;
letter-spacing: normal; text-align: start; text-indent:
0px; text-transform: none; white-space: normal;
word-spacing: 0px; -webkit-text-stroke-width: 0px;
text-decoration: none;">Otherwise, without a clearer
disciplinary framework, am afraid the new biology will be
reduced to bioinformatics and experimental "omic"
disciplines. Just another (advanced, "very advanced")
technology.</div>
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<div>Pedro: Your comments are often intriguing and these
sentences are no exception. </div>
<div>I do not grasp what either your scientific or personal
objectives are. One consistent theme in somehow tied to
expectations about “biologic codes” in relation to forms of
communication. Can you be more explicit about what sorts of
meaning you are seeking to understand? </div>
<div>Youri has presented the FIS with an encoded diagram of one of
the central apparati of all living organisms. Roughly speaking,
the role of the ribosome is well-understood although finer
structuring of the apparatus and its dynamics will continue to
be studied ad infinitum. <span style="caret-color: rgb(0, 0, 0);
color: rgb(0, 0, 0);" class="">The logical role of the
ribosome in transducing information into alternative dynamic
forms has been clear for more than 40 years.</span></div>
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<div> This encoded diagram is based on the epistemology of the
chemical code of life, the physical codes of mass and
electricity and the mathematical codes of permutation groups,
space groups, number theory, and so forth. </div>
<div>Is it not clear that Youri’s work generates a diagram that is
a logical constant of form? </div>
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<div>Somehow, I suspect that the epistemic gaps between
mathematics and physics and chemistry lie at the root of your
search for biological codes. Perhaps the effort is guided by a
believe that the genesis of living dynamics, involving thousands
of variables and literally hundreds of millions of <b class=""><u
class="">unique</u></b> biochemical reactions must
necessarily be expressible in simplistic and other scientific,
syntactical symbol systems? (Hundreds of millions of reactions
BECAUSE every DNA base occupies a logically unique sequential
position and undergoes unique reactions during transcription and
duplication.)</div>
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<div> Is the concern semantics or semeoius? The syntax of Youri’s
work is not seriously questioned, is it? Is the problem that
Youri’s work does not fit into alternative theories of
“information” that can not be distorted to fit the biological
codes? </div>
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<div>Youri - Can you refer to a data source that lists the
physical-chemical data of an E coli ribosome in terms of the
parts of the whole? (I am not referring x-ray data, just the
chemical parameters used to compute the structure.). As time
allows, I may do a few calculations to unconceal aspects of the
scientific information content of a ribosome. </div>
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<div>Cheers</div>
<div><br class="">
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<div>Jerry </div>
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