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<div class="moz-cite-prefix">Dear Youri and All,</div>
<div class="moz-cite-prefix"><br>
</div>
<div class="moz-cite-prefix">Gojng back to the Lecture theme, one of
the things that worries me is the biological disarray when having
to deal with "the informational." I mean, when you work with the
relational properties of these fascinating ribosomal proteins,
apart of mathematical-statistical techniques and algorithms to
make sense of their interactions and evolutionary co-adaptations,
you have nothing else but to recur to the metaphor, "molecular
brains", neural like", etc. It is fine, as you do not have any
consisting framework to refer to. It already happened to the
proponents of "bacterial intelligence", also forced to the
metaphor (Bray, Armitage...). <br>
</div>
<div class="moz-cite-prefix"><br>
</div>
<div class="moz-cite-prefix">In my view, tools from maths,
statistics, computer science, etc. are just that, tools.
Ironically some of these tools themselves had biological origins
(genetic algorithms, neural networks, perceptrons). So, my
contention is that a new filed like bio-chemistry or bio-physics
would be needed concerning the biological-informational themes, a
bio-information discipline comparable to those just mentioned.
According to several authors (me included), the prokaryotic cell
should be considered as the fundamental, basic unit of biological
cognition. Thereafter, there would be different ways to
characterize its informational processes, particularly along the
"information flow" conceptualization... interested parties may go
to the recent contribution of Jorge Navarro and mine:
<a class="moz-txt-link-freetext" href="https://www.mdpi.com/1422-0067/22/21/11965">https://www.mdpi.com/1422-0067/22/21/11965</a> , it is in the special
issue coordinated by Youri. I also discuss that the from the
informational thinking one could find the ways and means to renew
the outdated Modern Synthesis. <br>
</div>
<div class="moz-cite-prefix"><br>
</div>
<div class="moz-cite-prefix">Otherwise, without a clearer
disciplinary framework, am afraid the new biology will be reduced
to bioinformatics and experimental "omic" disciplines. Just
another (advanced, "very advanced") technology.</div>
<div class="moz-cite-prefix"><br>
</div>
<div class="moz-cite-prefix">Best wishes to All,</div>
<div class="moz-cite-prefix">--Pedro<br>
</div>
<div class="moz-cite-prefix"><br>
</div>
<div class="moz-cite-prefix"><br>
</div>
<div class="moz-cite-prefix"><br>
</div>
<div class="moz-cite-prefix">El 11/01/2022 a las 17:04, Youri Timsit
escribió:<br>
</div>
<blockquote type="cite"
cite="mid:DE03641D.3529C%25youri.timsit@mio.osupytheas.fr">
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<div>Dear Joseph and pedro</div>
<div><br>
</div>
<div>thank you very much for your mail…</div>
<div><br>
</div>
<div><br>
</div>
<div>
<div>I also think that humour and poetry are indeed not
incompatible with science… </div>
<div>(I still don't know what good science is, since to detect
it, we probably need a certain amount of hindsight ..., and
although I passed my sixties recently, it still doesn't seem
sufficient)</div>
<div><br>
</div>
<div>There was a more favourable time for the marriage of arts
and sciences, with for example Diderot's "D'alembert's dream",
but this luminous time seems very far away today…</div>
<div><br>
</div>
<div>this bL20 protein was truly subversive by refusing to
crystallize for 4 years... and it was the uncontrolled rise in
temperature of the crystallization room that finally coaxed
it... </div>
<div>the hazards of the climate and the cooling circuits came to
my aid and it was about time: the CNRS evaluation committee,
faced with a 4-year publication gap, was getting impatient</div>
<div><br>
</div>
<div>especially as a "competitor"/colleague had just solved this
« same" structure by NMR in a few months!!! his secret: he had
cut the long flexible extension and had only kept the small
globular domain… </div>
<div>this colleague has moreover made a meteoric rise and has
even become president of a Parisian university and former
right-hand man of the minister of research....</div>
<div><br>
</div>
<div>thank you again for your kind email, and thank you to Pedro
for allowing these exchanges and reflexions </div>
<div><br>
</div>
<div>all the best </div>
</div>
<div><br>
</div>
<div>Youri</div>
<div><br>
</div>
<span id="OLK_SRC_BODY_SECTION">
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BORDER-RIGHT: medium none; PADDING-TOP: 3pt"><span
style="font-weight:bold">De : </span> "<a
href="mailto:joe.brenner@bluewin.ch" moz-do-not-send="true">joe.brenner@bluewin.ch</a>"
<<a href="mailto:joe.brenner@bluewin.ch"
moz-do-not-send="true">joe.brenner@bluewin.ch</a>><br>
<span style="font-weight:bold">Répondre à : </span> <<a
href="mailto:joe.brenner@bluewin.ch" moz-do-not-send="true">joe.brenner@bluewin.ch</a>><br>
<span style="font-weight:bold">Date : </span> dimanche 9
janvier 2022 12:54<br>
<span style="font-weight:bold">À : </span> Pedro <<a
href="mailto:pedroc.marijuan@gmail.com"
moz-do-not-send="true">pedroc.marijuan@gmail.com</a>>,
Youri Timsit <<a
href="mailto:youri.timsit@mio.osupytheas.fr"
moz-do-not-send="true">youri.timsit@mio.osupytheas.fr</a>>,
"\"fis\"" <<a href="mailto:fis@listas.unizar.es"
moz-do-not-send="true">fis@listas.unizar.es</a>><br>
<span style="font-weight:bold">Objet : </span> Fwd: [Fis] NEW
YEAR LECTURE (Youri Timsit)<br>
</div>
<div><br>
</div>
<font size="3">Dear Youri, Dear Pedro, and All,</font>
<div><font size="3"><br>
</font></div>
<div><font size="3">The same to you in spades, as we used to say
in school in the U.S.!</font></div>
<div><font size="3"><br>
</font></div>
<div><span style="font-size: medium;">I see again in your work,
Youri, how good science can be enjoyable as well as
thought-provoking. The lines which particularly struck me
were the following:</span></div>
<div><span style="font-family: Times; font-size: 10pt;"><br>
</span></div>
<div><span style="font-family: Times; font-size: 10pt;">This
r-protein had a kind of subversive and unique behaviour in
deciding
to crystallize in both a folded and an unfolded form within
the same
crystal </span><sup style="font-family: Times;">20</sup><span
style="font-family: Times; font-size: 10pt;">.</span></div>
<div><br>
</div>
<div><font size="3">I see here the underlying "dynamic dualism"
of the universe for whose expressions I have tried to find
the logic, my Logic in Reality. Although touching on the
essence of mind, Youri avoids any anti-scien</font><span
style="font-size: medium;">tific panpsychism. I look forward
to learning more about this "brain" and its informational
dynamics.</span></div>
<div><span style="font-size: medium;"><br>
</span></div>
<div><span style="font-size: medium;">Best,</span></div>
<div><span style="font-size: medium;"><br>
</span></div>
<div><span style="font-size: medium;">Joseph</span></div>
<div>
<blockquote style="margin-right: 0px; margin-left:15px;">----Message
d'origine----<br>
De : <a href="mailto:pcmarijuan.iacs@aragon.es"
moz-do-not-send="true">pcmarijuan.iacs@aragon.es</a><br>
Date : 08/01/2022 - 20:49 (E)<br>
À : <a href="mailto:fis@listas.unizar.es"
moz-do-not-send="true">fis@listas.unizar.es</a><br>
Objet : [Fis] NEW YEAR LECTURE (Youri Timsit)<br>
<br>
<div class="moz-forward-container">
<table class="moz-email-headers-table" cellspacing="0"
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<tbody>
<tr>
<th valign="BASELINE" nowrap="nowrap" align="RIGHT">Asunto:
</th>
<td> NEW YEAR LECTURE<br>
</td>
</tr>
<tr>
<th valign="BASELINE" nowrap="nowrap" align="RIGHT">Fecha:
</th>
<td>Thu, 06 Jan 2022 15:09:26 +0100</td>
</tr>
<tr>
<th valign="BASELINE" nowrap="nowrap" align="RIGHT">De:
</th>
<td>Youri Timsit <a class="moz-txt-link-rfc2396E"
style="cursor:pointer;
text-decoration:underline; color:blue"
onclick="javascript:handleMailto('mailto:youri.timsit@mio.osupytheas.fr');"
moz-do-not-send="true"><youri.timsit@mio.osupytheas.fr></a></td>
</tr>
<tr>
<th valign="BASELINE" nowrap="nowrap" align="RIGHT">Para:
</th>
<td>Pedro C. Marijuán <a
class="moz-txt-link-rfc2396E"
style="cursor:pointer;
text-decoration:underline; color:blue"
onclick="javascript:handleMailto('mailto:pedroc.marijuan@gmail.com');"
moz-do-not-send="true"><pedroc.marijuan@gmail.com></a></td>
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