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<title>Re: [Fis] 10 Principles</title>
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<p class=MsoNormal><font size=3 face="Lucida Sans Unicode"><span lang=EN-GB
style='font-size:12.0pt;font-family:"Lucida Sans Unicode"'>Dear Pedro and FIS Colleagues,<o:p></o:p></span></font></p>
<p class=MsoNormal><font size=3 face="Lucida Sans Unicode"><span lang=EN-GB
style='font-size:12.0pt;font-family:"Lucida Sans Unicode"'>I endorse this
latest statement of principles. I suggest only that in 4, the phrase “among
adaptive life-cycles” be deleted or replaced by “organisms”. A
‘life-cycle’ is an abstraction that cannot and does not in and of
itself exchange information.<o:p></o:p></span></font></p>
<p class=MsoNormal><font size=3 face="Lucida Sans Unicode"><span lang=EN-GB
style='font-size:12.0pt;font-family:"Lucida Sans Unicode"'><o:p> </o:p></span></font></p>
<p class=MsoNormal><font size=3 face="Lucida Sans Unicode"><span lang=EN-GB
style='font-size:12.0pt;font-family:"Lucida Sans Unicode"'>As to Koichiro’s
comment, I propose restating it positively as follows: </span></font><font
size=2 face=游ゴシック><span lang=EN-US
style='font-size:11.0pt;font-family:\6E38\30B4\30B7\30C3\30AF'>This observation
can never stand alone since “all colleagues” ARE inhabitants INSIDE
the LIFE sphere.<u14:p></u14:p><o:p></o:p></span></font></p>
<p class=MsoNormal><font size=3 face="ＭＳ Ｐゴシック"><span
lang=EN-US style='font-size:12.0pt'><o:p> </o:p></span></font></p>
<p class=MsoNormal><font size=3 face="Lucida Sans Unicode"><span lang=EN-US
style='font-size:12.0pt;font-family:"Lucida Sans Unicode"'>Thank you and kind
regards,<o:p></o:p></span></font></p>
<p class=MsoNormal><font size=3 face="Lucida Sans Unicode"><span lang=EN-US
style='font-size:12.0pt;font-family:"Lucida Sans Unicode"'><o:p> </o:p></span></font></p>
<p class=MsoNormal><font size=3 face="Lucida Sans Unicode"><span lang=EN-US
style='font-size:12.0pt;font-family:"Lucida Sans Unicode"'>Joseph<o:p></o:p></span></font></p>
<p class=MsoNormal><font size=3 color="#3366ff" face="Lucida Sans Unicode"><span
lang=EN-US style='font-size:12.0pt;font-family:"Lucida Sans Unicode";
color:#3366FF'><u14:p> </span></font><font color="#3366ff"
face="Lucida Sans Unicode"><span lang=EN-GB style='font-family:"Lucida Sans Unicode";
color:#3366FF'><o:p></o:p></span></font></p>
<p class=MsoNormal><font size=3 color=navy face="Lucida Sans Unicode"><span
lang=EN-GB style='font-size:12.0pt;font-family:"Lucida Sans Unicode";
color:navy'> <o:p></o:p></span></font></p>
<p class=MsoNormal><font size=2 color=navy face=Arial><span lang=EN-GB
style='font-size:10.0pt;font-family:Arial;color:navy'><o:p> </o:p></span></font></p>
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<p class=MsoNormal><b><font size=2 face=Tahoma><span lang=EN-US
style='font-size:10.0pt;font-family:Tahoma;font-weight:bold'>From:</span></font></b><font
size=2 face=Tahoma><span lang=EN-US style='font-size:10.0pt;font-family:Tahoma'>
Fis [mailto:fis-bounces@listas.unizar.es] <b><span style='font-weight:bold'>On
Behalf Of </span></b>Pedro C. Marijuan<br>
<b><span style='font-weight:bold'>Sent:</span></b> mardi, 14 juillet 2020 14:30<br>
<b><span style='font-weight:bold'>To:</span></b> 'fis'<br>
<b><span style='font-weight:bold'>Subject:</span></b> Re: [Fis] 10 Principles</span></font><font
face="Times New Roman"><span lang=EN-US style='font-family:"Times New Roman"'><o:p></o:p></span></font></p>
</div>
<p class=MsoNormal><font size=3 face="ＭＳ Ｐゴシック"><span
style='font-size:12.0pt'><o:p> </o:p></span></font></p>
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<p class=MsoNormal><font size=3 face="ＭＳ Ｐゴシック"><span
style='font-size:12.0pt'>Dear List, <o:p></o:p></span></font></p>
</div>
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<p class=MsoNormal><font size=3 face="ＭＳ Ｐゴシック"><span
style='font-size:12.0pt'><o:p> </o:p></span></font></p>
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<p class=MsoNormal><font size=3 face="ＭＳ Ｐゴシック"><span
style='font-size:12.0pt'>Thanks for the comments. I have tried to be more
inclusive in the new point 2. <o:p></o:p></span></font></p>
</div>
<div>
<p class=MsoNormal><font size=3 face="ＭＳ Ｐゴシック"><span
style='font-size:12.0pt'>Also, Point 1 has been slightly modified reminding an
old comment from Lars (that info always goes "by contact")<o:p></o:p></span></font></p>
</div>
<p class=MsoNormal><font size=3 face="ＭＳ Ｐゴシック"><span
style='font-size:12.0pt'>Other changes, in point 3 now, can be justified as
follows: <o:p></o:p></span></font></p>
<div>
<p class=MsoNormal><font size=3 face="ＭＳ Ｐゴシック"><span
style='font-size:12.0pt'>The fact that biological self-production either in
bacteria or in organisms is accompanied respectively by a "bacterial
signaling system" or by a "central nervous system" tells us that
the way of life, the adaptation to the niche, always needs the development of
ad hoc informational detectors. Otherwise the life cycle becomes
"blind", truncated and unable to advance towards completion. At the
same time, inside every cell, inside every organism, there is an internal
information flow related to its own self-production. For instance <!--[if gte mso 9]><xml>
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</xml><![endif]-->in a living cell, the self-production may imply: expression,
copying, translation, genetic code, modification codes, degradation... While
the signaling flow may imply: signal generation, emission, transmission
channel, reception, decoding/processing, meaning elaboration, response...
Both information flows, the external and the internal, become intertwined,
densely mixed, at all scales of biological organization. Let us further
emphasize point 1, for all these information processes imply a physical
contact, as they always have to impinge on the system receptors or sensory
surfaces. <o:p></o:p></span></font></p>
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<p class=MsoNormal><font size=3 face="ＭＳ Ｐゴシック"><span
style='font-size:12.0pt'>So, points 1 to 5 could read as follows:<o:p></o:p></span></font></p>
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<p class=MsoNormal><font size=3 face="ＭＳ Ｐゴシック"><span
style='font-size:12.0pt'>1. Information as such: distinction of an "adjacent"
difference.<o:p></o:p></span></font></p>
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<p class=MsoNormal><font size=3 face="ＭＳ Ｐゴシック"><span
lang=EN-US style='font-size:12.0pt'>2. Information processes: organized action
upon distinctions collected into structures, patterns, sequences, messages, or
flows.</span><o:p></o:p></font></p>
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<p class=MsoNormal><font size=3 face="ＭＳ Ｐゴシック"><span
style='font-size:12.0pt'>3. Integrated information processes of life: </span></font><span
lang=EN-US>information flows, both from the external signaling environment and
from the internal productive environment, are tightly integrated along
the advancement of the adaptive life cycle --they regularly anticipate, shape,
and mix up with the accompanying energy flows.</span><span lang=EN-US> </span><o:p></o:p></p>
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<p class=MsoNormal><font size=3 face="ＭＳ Ｐゴシック"><span
lang=EN-US style='font-size:12.0pt'>4. Biological complexity: communication/information
exchanges among adaptive life-cycles underlie the complexity of biological
organization at all scales.</span><o:p></o:p></font></p>
</div>
<div>
<p class=MsoNormal><font size=3 face="ＭＳ Ｐゴシック"><span
style='font-size:12.0pt'><o:p> </o:p></span></font></p>
</div>
<div>
<p class=MsoNormal><font size=3 face="ＭＳ Ｐゴシック"><span
lang=EN-US style='font-size:12.0pt'>5. Biological cognition: cognition, meaning
and knowledge can be identified within the integrated signaling/productive
molecular mechanisms that adaptively transform the cell-cycle trajectory as
well as in the action/perception cycle of central nervous systems. </span><o:p></o:p></font></p>
</div>
<div>
<p class=MsoNormal><font size=3 face="ＭＳ Ｐゴシック"><span
style='font-size:12.0pt'><o:p> </o:p></span></font></p>
</div>
<div>
<p class=MsoNormal><font size=3 face="ＭＳ Ｐゴシック"><span
lang=EN-US style='font-size:12.0pt'>The other 5 points regarding human &
social aspects may be discussed later on. </span><o:p></o:p></font></p>
</div>
<div>
<p class=MsoNormal><font size=3 face="ＭＳ Ｐゴシック"><span
style='font-size:12.0pt'><o:p> </o:p></span></font></p>
</div>
<div>
<p class=MsoNormal><font size=3 face="ＭＳ Ｐゴシック"><span
lang=EN-US style='font-size:12.0pt'>All the best</span><o:p></o:p></font></p>
</div>
<div>
<p class=MsoNormal><font size=3 face="ＭＳ Ｐゴシック"><span
lang=EN-US style='font-size:12.0pt'>--Pedro</span><o:p></o:p></font></p>
<p class=MsoNormal style='margin-left:2.0cm;text-align:justify;line-height:
14.0pt'><font size=3 face="ＭＳ Ｐゴシック"><span
lang=EN-US style='font-size:12.0pt'> </span><o:p></o:p></font></p>
<p class=MsoNormal><font size=3 face="ＭＳ Ｐゴシック"><span
style='font-size:12.0pt'><o:p> </o:p></span></font></p>
</div>
<div>
<p class=MsoNormal><font size=3 face="ＭＳ Ｐゴシック"><span
style='font-size:12.0pt'>El 13/07/2020 a las 2:01, Koichiro Matsuno escribió:<o:p></o:p></span></font></p>
</div>
<blockquote style='margin-top:5.0pt;margin-bottom:5.0pt' type=cite
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<p class=MsoNormal><font size=2 color="#1f497d" face=游ゴシック><span
lang=EN-US style='font-size:11.0pt;font-family:\6E38\30B4\30B7\30C3\30AF;
color:#1F497D'>On Monday, July 13, 2020 5:14 AM, Krassimir Markov wrote: </span></font><font
size=4 color=black face=Calibri><span lang=EN-US style='font-size:13.5pt;
font-family:Calibri;color:black'>I am not sure that all colleagues agree that
information does not exist out of the LIFE sphere.<u14:p></u14:p></span></font><o:p></o:p></p>
<p class=MsoNormal><font size=4 color=black face=Calibri><span lang=EN-US
style='font-size:13.5pt;font-family:Calibri;color:black'><u14:p> </u14:p></span></font><o:p></o:p></p>
<p class=MsoNormal style='text-indent:16.5pt'><font size=2 color="#1f497d"
face=游ゴシック><span lang=EN-US
style='font-size:11.0pt;font-family:\6E38\30B4\30B7\30C3\30AF;color:#1F497D'>This
observation should stand alone only when “all colleagues” are the
inhabitants outside the LIFE sphere.<u14:p></u14:p></span></font><o:p></o:p></p>
<p class=MsoNormal style='text-indent:16.5pt'><font size=2 color="#1f497d"
face=游ゴシック><span lang=EN-US
style='font-size:11.0pt;font-family:\6E38\30B4\30B7\30C3\30AF;color:#1F497D'><u14:p> </u14:p></span></font><o:p></o:p></p>
<p class=MsoNormal style='text-indent:16.5pt'><font size=2 color="#1f497d"
face=游ゴシック><span lang=EN-US
style='font-size:11.0pt;font-family:\6E38\30B4\30B7\30C3\30AF;color:#1F497D'>Best
regards,<u14:p></u14:p></span></font><o:p></o:p></p>
<p class=MsoNormal style='text-indent:16.5pt'><font size=2 color="#1f497d"
face=游ゴシック><span lang=EN-US
style='font-size:11.0pt;font-family:\6E38\30B4\30B7\30C3\30AF;color:#1F497D'>Koichiro
Matsuno</span></font><o:p></o:p></p>
<u14:p></u14:p>
<p class=MsoNormal><font size=2 color="#1f497d" face=游ゴシック><span
lang=EN-US style='font-size:11.0pt;font-family:\6E38\30B4\30B7\30C3\30AF;
color:#1F497D'><u14:p></u14:p> <u14:p></u14:p></span></font><o:p></o:p></p>
<p class=MsoNormal><font size=2 color="#1f497d" face=游ゴシック><span
lang=EN-US style='font-size:11.0pt;font-family:\6E38\30B4\30B7\30C3\30AF;
color:#1F497D'><u14:p> </u14:p></span></font><o:p></o:p></p>
<div>
<div style='border:none;border-top:solid #E1E1E1 1.0pt;padding:3.0pt 0cm 0cm 0cm'>
<p class=MsoNormal><b><font size=2 face=Calibri><span lang=EN-US
style='font-size:11.0pt;font-family:Calibri;font-weight:bold'>From:</span></font></b><font
size=2 face=Calibri><span lang=EN-US style='font-size:11.0pt;font-family:Calibri'>
Fis <a href="mailto:fis-bounces@listas.unizar.es"><fis-bounces@listas.unizar.es></a>
<b><span style='font-weight:bold'>On Behalf Of </span></b>Krassimir Markov<br>
<b><span style='font-weight:bold'>Sent:</span></b> Monday, July 13, 2020 5:14 AM<br>
<b><span style='font-weight:bold'>To:</span></b> 'fis' <a
href="mailto:fis@listas.unizar.es"><fis@listas.unizar.es></a><br>
<b><span style='font-weight:bold'>Subject:</span></b> Re: [Fis] 10 Principles<u14:p></u14:p></span></font><o:p></o:p></p>
</div>
</div>
<p class=MsoNormal><font size=3 face="ＭＳ Ｐゴシック"><span
lang=EN-US style='font-size:12.0pt'><u14:p> </u14:p></span><o:p></o:p></font></p>
<div>
<div>
<div>
<p class=MsoNormal><font size=4 color=black face=Calibri><span lang=EN-US
style='font-size:13.5pt;font-family:Calibri;color:black'>Dear Pedro and FIS
Colleagues,</span></font><o:p></o:p></p>
</div>
<u14:p></u14:p>
<div>
<p class=MsoNormal><font size=4 color=black face=Calibri><span lang=EN-US
style='font-size:13.5pt;font-family:Calibri;color:black'>I see that maybe
INFORMATION and LIFE are interconnected.</span></font><o:p></o:p></p>
</div>
<u14:p></u14:p>
<div>
<p class=MsoNormal><font size=4 color=black face=Calibri><span lang=EN-US
style='font-size:13.5pt;font-family:Calibri;color:black'>Unfortunately, I am
not sure that all colleagues agree that information does not exist out of the
LIFE sphere.</span></font><o:p></o:p></p>
</div>
<u14:p></u14:p>
<div>
<p class=MsoNormal><font size=4 color=black face=Calibri><span lang=EN-US
style='font-size:13.5pt;font-family:Calibri;color:black'>Because of this, the
first point I expect to reflect the correspondence between information and life.</span></font><o:p></o:p></p>
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<p class=MsoNormal><font size=4 color=black face=Calibri><span lang=EN-US
style='font-size:13.5pt;font-family:Calibri;color:black'>Friendly greetings</span></font><o:p></o:p></p>
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<p class=MsoNormal><font size=4 color=black face=Calibri><span lang=EN-US
style='font-size:13.5pt;font-family:Calibri;color:black'>Krassimir</span></font><o:p></o:p></p>
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<p class=MsoNormal><font size=4 color=black face=Calibri><span lang=EN-US
style='font-size:14.0pt;font-family:Calibri;color:black'> <u14:p></u14:p></span></font><o:p></o:p></p>
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<p class=MsoNormal><font size=4 color=black face=Calibri><span lang=EN-US
style='font-size:14.0pt;font-family:Calibri;color:black'> <u14:p></u14:p></span></font><o:p></o:p></p>
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<p class=MsoNormal><font size=2 color=black face=Tahoma><span lang=EN-US
style='font-size:10.0pt;font-family:Tahoma;color:black'> </span></font><o:p></o:p></p>
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<p class=MsoNormal><font size=3 face="Times New Roman"><span style='font-size:
12.0pt;font-family:"Times New Roman"'><br>
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<o:p></o:p></span></font></p>
<fieldset class="mimeAttachmentHeader"></fieldset><pre><font size=2
face="Courier New"><span style='font-size:10.0pt'>_______________________________________________<o:p></o:p></span></font></pre><pre><font
size=2 face="Courier New"><span style='font-size:10.0pt'>Fis mailing list<o:p></o:p></span></font></pre><pre><font
size=2 face="Courier New"><span style='font-size:10.0pt'><a
href="mailto:Fis@listas.unizar.es">Fis@listas.unizar.es</a><o:p></o:p></span></font></pre><pre><font
size=2 face="Courier New"><span style='font-size:10.0pt'><a
href="http://listas.unizar.es/cgi-bin/mailman/listinfo/fis">http://listas.unizar.es/cgi-bin/mailman/listinfo/fis</a><o:p></o:p></span></font></pre><pre><font
size=2 face="Courier New"><span style='font-size:10.0pt'>----------<o:p></o:p></span></font></pre><pre><font
size=2 face="Courier New"><span style='font-size:10.0pt'>INFORMACIÓN SOBRE PROTECCIÓN DE DATOS DE CARÁCTER PERSONAL<o:p></o:p></span></font></pre><pre><font
size=2 face="Courier New"><span style='font-size:10.0pt'><o:p> </o:p></span></font></pre><pre><font
size=2 face="Courier New"><span style='font-size:10.0pt'>Ud. recibe este correo por pertenecer a una lista de correo gestionada por la Universidad de Zaragoza.<o:p></o:p></span></font></pre><pre><font
size=2 face="Courier New"><span style='font-size:10.0pt'>Puede encontrar toda la información sobre como tratamos sus datos en el siguiente enlace: <a
href="https://sicuz.unizar.es/informacion-sobre-proteccion-de-datos-de-caracter-personal-en-listas">https://sicuz.unizar.es/informacion-sobre-proteccion-de-datos-de-caracter-personal-en-listas</a><o:p></o:p></span></font></pre><pre><font
size=2 face="Courier New"><span style='font-size:10.0pt'>Recuerde que si está suscrito a una lista voluntaria Ud. puede darse de baja desde la propia aplicación en el momento en que lo desee.<o:p></o:p></span></font></pre><pre><font
size=2 face="Courier New"><span style='font-size:10.0pt'><a
href="http://listas.unizar.es">http://listas.unizar.es</a><o:p></o:p></span></font></pre><pre><font
size=2 face="Courier New"><span style='font-size:10.0pt'>----------<o:p></o:p></span></font></pre></blockquote>
<p><font size=3 face="Times New Roman"><span style='font-size:12.0pt'><o:p> </o:p></span></font></p>
<pre cols=72><font size=2 face="Courier New"><span style='font-size:10.0pt'>-- <o:p></o:p></span></font></pre><pre><font
size=2 face="Courier New"><span style='font-size:10.0pt'>-------------------------------------------------<o:p></o:p></span></font></pre><pre><font
size=2 face="Courier New"><span style='font-size:10.0pt'>Pedro C. Marijuán<o:p></o:p></span></font></pre><pre><font
size=2 face="Courier New"><span style='font-size:10.0pt'>Grupo de Bioinformación / Bioinformation Group<o:p></o:p></span></font></pre><pre><font
size=2 face="Courier New"><span style='font-size:10.0pt'><o:p> </o:p></span></font></pre><pre><font
size=2 face="Courier New"><span style='font-size:10.0pt'><a
href="mailto:pcmarijuan.iacs@aragon.es">pcmarijuan.iacs@aragon.es</a><o:p></o:p></span></font></pre><pre><font
size=2 face="Courier New"><span style='font-size:10.0pt'><a
href="http://sites.google.com/site/pedrocmarijuan/">http://sites.google.com/site/pedrocmarijuan/</a><o:p></o:p></span></font></pre><pre><font
size=2 face="Courier New"><span style='font-size:10.0pt'>------------------------------------------------- <o:p></o:p></span></font></pre>
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