<html xmlns:v="urn:schemas-microsoft-com:vml" xmlns:o="urn:schemas-microsoft-com:office:office" xmlns:w="urn:schemas-microsoft-com:office:word" xmlns:m="http://schemas.microsoft.com/office/2004/12/omml" xmlns="http://www.w3.org/TR/REC-html40" xmlns:ns1="#unknown">
<head>
<meta http-equiv="Content-Type" content="text/html; charset=utf-8">
<meta name="Generator" content="Microsoft Word 15 (filtered medium)">
<!--[if !mso]><style id=signatureStyle>v\:* {behavior:url(#default#VML);}
o\:* {behavior:url(#default#VML);}
w\:* {behavior:url(#default#VML);}
.shape {behavior:url(#default#VML);}
</style><![endif]-->
<title>Re: [Fis] 10 Principles</title>
<style id="css_styles"><!--
/* Font Definitions */
@font-face
{font-family:PMingLiU;
panose-1:2 2 5 0 0 0 0 0 0 0;}
@font-face
{font-family:"Cambria Math";
panose-1:2 4 5 3 5 4 6 3 2 4;}
@font-face
{font-family:"Yu Gothic";
panose-1:2 11 4 0 0 0 0 0 0 0;}
@font-face
{font-family:Calibri;
panose-1:2 15 5 2 2 2 4 3 2 4;}
@font-face
{font-family:Consolas;
panose-1:2 11 6 9 2 2 4 3 2 4;}
@font-face
{font-family:Tahoma;
panose-1:2 11 6 4 3 5 4 4 2 4;}
@font-face
{font-family:"Segoe UI";
panose-1:2 11 6 4 2 2 2 2 2 4;}
@font-face
{font-family:"\@PMingLiU";
panose-1:2 1 6 1 0 1 1 1 1 1;}
@font-face
{font-family:"MS PGothic";
panose-1:2 11 6 0 7 2 5 8 2 4;}
@font-face
{font-family:"Lucida Sans Unicode";
panose-1:2 11 6 2 3 5 4 2 2 4;}
@font-face
{font-family:"\@MS PGothic";}
@font-face
{font-family:"\@Yu Gothic";
panose-1:2 11 4 0 0 0 0 0 0 0;}
/* Style Definitions */
p.MsoNormal, li.MsoNormal, div.MsoNormal
{margin:0cm;
margin-bottom:.0001pt;
font-size:11.0pt;
font-family:"Calibri",sans-serif;}
a:link, span.MsoHyperlink
{mso-style-priority:99;
color:blue;
text-decoration:underline;}
span.EmailStyle22
{mso-style-type:personal-reply;
font-family:"Calibri",sans-serif;
color:windowtext;}
.MsoChpDefault
{mso-style-type:export-only;
font-size:10.0pt;}
@page WordSection1
{size:612.0pt 792.0pt;
margin:72.0pt 72.0pt 72.0pt 72.0pt;}
div.WordSection1
{page:WordSection1;}
--></style><!--[if gte mso 9]><xml>
<o:shapedefaults v:ext="edit" spidmax="1026" />
</xml><![endif]--><!--[if gte mso 9]><xml>
<o:shapelayout v:ext="edit">
<o:idmap v:ext="edit" data="1" />
</o:shapelayout></xml><![endif]-->
</head>
<body lang="en-SE" link="blue" vlink="purple">
<div class="WordSection1">
<p class="MsoNormal"><span lang="SV" style="mso-fareast-language:EN-US">Dear Loet,<o:p></o:p></span></p>
<p class="MsoNormal"><span lang="EN-US" style="mso-fareast-language:EN-US">Isn’t information about something always for some agent who can act upon it?<o:p></o:p></span></p>
<p class="MsoNormal"><span lang="EN-US" style="mso-fareast-language:EN-US">In the case of libraries, they are for people, and perhaps one day for intelligent machines.<o:p></o:p></span></p>
<p class="MsoNormal"><span lang="EN-US" style="mso-fareast-language:EN-US">All the best,<o:p></o:p></span></p>
<p class="MsoNormal"><span lang="EN-US" style="mso-fareast-language:EN-US">Gordana<o:p></o:p></span></p>
<p class="MsoNormal"><span lang="EN-US" style="mso-fareast-language:EN-US"><o:p> </o:p></span></p>
<p class="MsoNormal"><span style="mso-fareast-language:EN-US"><o:p> </o:p></span></p>
<div style="border:none;border-top:solid #B5C4DF 1.0pt;padding:3.0pt 0cm 0cm 0cm">
<p class="MsoNormal"><b><span style="font-size:12.0pt;color:black">From: </span></b><span style="font-size:12.0pt;color:black">Fis <fis-bounces@listas.unizar.es> on behalf of Loet Leydesdorff <loet@leydesdorff.net><br>
<b>Reply to: </b>Loet Leydesdorff <loet@leydesdorff.net><br>
<b>Date: </b>Tuesday, 14 July 2020 at 15:50<br>
<b>To: </b>Joseph Brenner <joe.brenner@bluewin.ch>, "fis@listas.unizar.es" <fis@listas.unizar.es>, "Pedro C. Marijuan" <pcmarijuan.iacs@aragon.es><br>
<b>Subject: </b>Re: [Fis] 10 Principles<o:p></o:p></span></p>
</div>
<div>
<p class="MsoNormal"><o:p> </o:p></p>
</div>
<div>
<p class="MsoNormal">Dear colleagues, <o:p></o:p></p>
</div>
<div>
<p class="MsoNormal"><o:p> </o:p></p>
</div>
<div>
<p class="MsoNormal">Is this a coup-d'etat of the biologists? It does not follow from the role of information in processes of life that information is exclusively processed in life-processes. <o:p></o:p></p>
</div>
<div>
<p class="MsoNormal"><o:p> </o:p></p>
</div>
<div>
<p class="MsoNormal">Let me quote Luhmann who argued against Maturana as follows:<o:p></o:p></p>
</div>
<div>
<p class="MsoNormal"><o:p> </o:p></p>
</div>
<div>
<div id="x905ce3d4494642a0b89905a3928732b2">
<p class="MsoNormal" style="margin-top:.15pt;vertical-align:baseline"><span style="font-family:"Times New Roman",serif">"Moreover, because it is tied to life as a mode of self-reproduction of autopoietic systems, the 'theory of autopoiesis does not really attain
the level of general systems theory which includes brains and machines, psychic systems and social systems, societies and short-term interactions. From this point of view, living systems are a special type of systems. However, if we abstract from life and
define autopoiesis as a general form of system-building using self-referential closure, we would have to admit that there are non-living autopoietic systems, different modes of autopoietic reproduction, and general principles of autopoietic organization which
materialize as life, but also in other modes of circularity and self-reproduction. In other words, if we find non-living autopoietic systems in our world, then and only then will we need a truly general theory of autopoiesis which carefully avoids references
which hold true only for living systems. But which attributes of autopoiesis will remain valid on this highest level, and which will have to be dropped on behalf of their connection with life?"</span><span style="font-size:9.5pt;font-family:"Times New Roman",serif;letter-spacing:-.1pt"><o:p></o:p></span></p>
</div>
</div>
<div>
<p class="MsoNormal"><o:p> </o:p></p>
</div>
<div>
<p class="MsoNormal">It seems to me that one can define information more abstractly than its manifestation in processes of living. For example, information and its meaning can be archived in libraries. A librarian may hope that there are no insects in the books
who like eating them. <o:p></o:p></p>
</div>
<div>
<p class="MsoNormal"><o:p> </o:p></p>
</div>
<div>
<p class="MsoNormal">Best, <o:p></o:p></p>
</div>
<div>
<p class="MsoNormal">Loet<o:p></o:p></p>
</div>
<div>
<p class="MsoNormal"><o:p> </o:p></p>
</div>
<div id="signature_old">
<div id="xc10918b797d7451">
<div id="x78c9f4c0540648e7b564d127ae9a7d74">
<div>
<div id="signature_old">
<div id="x068ffe68e305459">
<div style="margin-right:6.0pt" id="xd031ae4a00354d21ab008b16080cd048">
<div>
<p class="MsoNormal" style="background:white"><span style="font-size:12.0pt;font-family:"Segoe UI",serif;color:black"><o:p> </o:p></span></p>
</div>
<div id="signature_old">
<div id="x4f407acb80d4411">
<div style="margin-right:6.0pt" id="x775eaf3ae7f6460082dcdda3faf877c6">
<div id="signature_old">
<div id="x920d19d74fc84b0">
<div id="x337b22579712426abf55c20f258d0a74">
<div class="MsoNormal" align="center" style="text-align:center;background:white">
<span style="font-size:10.0pt;color:#1F497D">
<hr size="0" width="100%" align="center">
</span></div>
<p class="MsoNormal" style="background:white"><span style="font-size:10.0pt;color:#1F497D">Loet Leydesdorff
<o:p></o:p></span></p>
<p class="MsoNormal" style="background:white"><span style="font-size:10.0pt;color:#1F497D">Professor emeritus, University of Amsterdam<br>
Amsterdam School of Communication Research (ASCoR)<o:p></o:p></span></p>
<p class="MsoNormal" style="background:white"><span style="color:#44546A"><a href="mailto:loet@leydesdorff.net" title="mailto:loet@leydesdorff.net"><span style="font-size:10.0pt">loet@leydesdorff.net
</span></a></span><span style="font-size:10.0pt;color:#1F497D">; </span><span style="color:#44546A"><a href="https://eur01.safelinks.protection.outlook.com/?url=http%3A%2F%2Fwww.leydesdorff.net%2F&data=02%7C01%7Cgordana.dodig-crnkovic%40mdh.se%7Ce7a0ea0f8d5f438691ef08d827fce7dc%7Ca1795b64dabd4758b988b309292316cf%7C0%7C0%7C637303314463497075&sdata=t2ibSpXrcf1Z4pLrJA8rU%2Bsxzx2RyHte12OA3eRj0t0%3D&reserved=0" title="http://www.leydesdorff.net/"><span style="font-size:10.0pt">http://www.leydesdorff.net/</span></a></span><span style="font-size:10.0pt;color:#1F497D">
<br>
</span><span style="font-size:9.0pt;color:black">Associate Faculty, </span><span style="color:#44546A"><a href="https://eur01.safelinks.protection.outlook.com/?url=http%3A%2F%2Fwww.sussex.ac.uk%2Fspru%2F&data=02%7C01%7Cgordana.dodig-crnkovic%40mdh.se%7Ce7a0ea0f8d5f438691ef08d827fce7dc%7Ca1795b64dabd4758b988b309292316cf%7C0%7C0%7C637303314463502065&sdata=k4tY8Gwvx5OFnMuOeyuvBcIbya9t0847OVt1KYMNL0w%3D&reserved=0"><span style="font-size:9.0pt">SPRU,
</span></a></span><span style="font-size:9.0pt;color:black">University of Sussex;
<o:p></o:p></span></p>
<p class="MsoNormal" style="background:white"><span style="font-size:9.0pt;color:black">Guest Professor
</span><span style="color:#44546A"><a href="https://eur01.safelinks.protection.outlook.com/?url=http%3A%2F%2Fwww.zju.edu.cn%2Fenglish%2F&data=02%7C01%7Cgordana.dodig-crnkovic%40mdh.se%7Ce7a0ea0f8d5f438691ef08d827fce7dc%7Ca1795b64dabd4758b988b309292316cf%7C0%7C0%7C637303314463507041&sdata=hkVH8gohKYoXRrLAdj6XiG8k8HK07nXF8AMGYOpJidY%3D&reserved=0"><span style="font-size:9.0pt">Zhejiang
Univ.</span></a></span><span style="font-size:9.0pt;color:black">, Hangzhou; Visiting Professor,
</span><span style="color:#44546A"><a href="https://eur01.safelinks.protection.outlook.com/?url=http%3A%2F%2Fwww.istic.ac.cn%2FEng%2Fbrief_en.html&data=02%7C01%7Cgordana.dodig-crnkovic%40mdh.se%7Ce7a0ea0f8d5f438691ef08d827fce7dc%7Ca1795b64dabd4758b988b309292316cf%7C0%7C0%7C637303314463507041&sdata=KkuJXa9%2FA5Iqsr2QwsLYXHWwzrdMCXahkUwoTzZj%2Fh4%3D&reserved=0"><span style="font-size:9.0pt">ISTIC,
</span></a></span><span style="font-size:9.0pt;color:black">Beijing;<o:p></o:p></span></p>
<p class="MsoNormal" style="background:white"><span style="font-size:9.0pt;color:black">Visiting Fellow,
</span><span style="color:#44546A"><a href="https://eur01.safelinks.protection.outlook.com/?url=http%3A%2F%2Fwww.bbk.ac.uk%2F&data=02%7C01%7Cgordana.dodig-crnkovic%40mdh.se%7Ce7a0ea0f8d5f438691ef08d827fce7dc%7Ca1795b64dabd4758b988b309292316cf%7C0%7C0%7C637303314463512016&sdata=VvbIx6HGPnKsnxu90%2B3ivHM0bJzgksF0wTgq1OKYPtU%3D&reserved=0"><span style="font-size:9.0pt">Birkbeck</span></a></span><span style="font-size:9.0pt;color:black">,
University of London; <o:p></o:p></span></p>
<p class="MsoNormal" style="background:white"><span lang="EN-US" style="font-size:9.0pt;color:#44546A;mso-fareast-language:EN-US"><a href="https://eur01.safelinks.protection.outlook.com/?url=http%3A%2F%2Fscholar.google.com%2Fcitations%3Fuser%3Dych9gNYAAAAJ%26hl%3Den&data=02%7C01%7Cgordana.dodig-crnkovic%40mdh.se%7Ce7a0ea0f8d5f438691ef08d827fce7dc%7Ca1795b64dabd4758b988b309292316cf%7C0%7C0%7C637303314463516994&sdata=cWyeY5Jq2GCpitVWJ3LGyFQ%2BOuMt9i5B9cUjziAg9Sw%3D&reserved=0">http://scholar.google.com/citations?user=ych9gNYAAAAJ&hl=en</a></span><span style="font-family:"Tahoma",sans-serif;color:black"><o:p></o:p></span></p>
</div>
<div id="x337b22579712426abf55c20f258d0a74">
<div style="margin-right:6.0pt" id="x6d48cd6784e049409ff4972e00ee71a6">
<div>
<div>
<p class="MsoNormal" style="background:white"><span style="font-size:9.0pt;color:black">ORCID:
<a href="https://eur01.safelinks.protection.outlook.com/?url=http%3A%2F%2Forcid.org%2F0000-0002-7835-3098&data=02%7C01%7Cgordana.dodig-crnkovic%40mdh.se%7Ce7a0ea0f8d5f438691ef08d827fce7dc%7Ca1795b64dabd4758b988b309292316cf%7C0%7C0%7C637303314463521961&sdata=pI3ItOLXHbL%2FzJhKPE62yHNRLSgzcbBZgWPlCFbFAVE%3D&reserved=0">
http://orcid.org/0000-0002-7835-3098</a>;</span><span style="color:black"> </span><span style="font-size:12.0pt;font-family:"Segoe UI",serif;color:black"><o:p></o:p></span></p>
</div>
</div>
</div>
</div>
</div>
</div>
</div>
</div>
</div>
</div>
</div>
</div>
</div>
</div>
</div>
</div>
<div>
<p class="MsoNormal"><o:p> </o:p></p>
</div>
<div>
<p class="MsoNormal">------ Original Message ------<o:p></o:p></p>
</div>
<div>
<p class="MsoNormal">From: "Joseph Brenner" <<a href="mailto:joe.brenner@bluewin.ch">joe.brenner@bluewin.ch</a>><o:p></o:p></p>
</div>
<div>
<p class="MsoNormal">To: "Pedro C. Marijuan" <<a href="mailto:pcmarijuan.iacs@aragon.es">pcmarijuan.iacs@aragon.es</a>>; "fis" <<a href="mailto:fis@listas.unizar.es">fis@listas.unizar.es</a>><o:p></o:p></p>
</div>
<div>
<p class="MsoNormal">Sent: 7/14/2020 3:38:26 PM<o:p></o:p></p>
</div>
<div>
<p class="MsoNormal">Subject: Re: [Fis] 10 Principles<o:p></o:p></p>
</div>
<div>
<p class="MsoNormal"><o:p> </o:p></p>
</div>
<div id="xa4d07a498641477">
<blockquote style="border:none;border-left:solid #CCCCCC 1.0pt;padding:0cm 0cm 0cm 8.0pt;margin-left:3.75pt;margin-top:2.25pt;margin-right:0cm;margin-bottom:5.0pt">
<p class="MsoNormal"><span lang="EN-GB" style="font-size:12.0pt;font-family:"Lucida Sans Unicode",sans-serif">Dear Pedro and FIS Colleagues,</span><span style="font-size:12.0pt;font-family:"MS PGothic",sans-serif"><o:p></o:p></span></p>
<p class="MsoNormal"><span lang="EN-GB" style="font-size:12.0pt;font-family:"Lucida Sans Unicode",sans-serif">I endorse this latest statement of principles. I suggest only that in 4, the phrase “among adaptive life-cycles” be deleted or replaced by “organisms”.
A ‘life-cycle’ is an abstraction that cannot and does not in and of itself exchange information.</span><span style="font-size:12.0pt;font-family:"MS PGothic",sans-serif"><o:p></o:p></span></p>
<p class="MsoNormal"><span lang="EN-GB" style="font-size:12.0pt;font-family:"Lucida Sans Unicode",sans-serif"> </span><span style="font-size:12.0pt;font-family:"MS PGothic",sans-serif"><o:p></o:p></span></p>
<p class="MsoNormal"><span lang="EN-GB" style="font-size:12.0pt;font-family:"Lucida Sans Unicode",sans-serif">As to Koichiro’s comment, I propose restating it positively as follows:
</span><span lang="EN-US" style="font-family:"Yu Gothic",sans-serif">This observation can never stand alone since
</span><span lang="EN-GB" style="font-family:"Yu Gothic",sans-serif">“</span><span lang="EN-US" style="font-family:"Yu Gothic",sans-serif">all colleagues</span><span lang="EN-GB" style="font-family:"Yu Gothic",sans-serif">”</span><span lang="EN-US" style="font-family:"Yu Gothic",sans-serif">
ARE inhabitants INSIDE the LIFE sphere.</span><span style="font-size:12.0pt;font-family:"MS PGothic",sans-serif"><o:p></o:p></span></p>
<p class="MsoNormal"><span lang="EN-US" style="font-size:12.0pt;font-family:"MS PGothic",sans-serif"> </span><span style="font-size:12.0pt;font-family:"MS PGothic",sans-serif"><o:p></o:p></span></p>
<p class="MsoNormal"><span lang="EN-US" style="font-size:12.0pt;font-family:"Lucida Sans Unicode",sans-serif">Thank you and kind regards,</span><span style="font-size:12.0pt;font-family:"MS PGothic",sans-serif"><o:p></o:p></span></p>
<p class="MsoNormal"><span lang="EN-US" style="font-size:12.0pt;font-family:"Lucida Sans Unicode",sans-serif"> </span><span style="font-size:12.0pt;font-family:"MS PGothic",sans-serif"><o:p></o:p></span></p>
<p class="MsoNormal"><span lang="EN-US" style="font-size:12.0pt;font-family:"Lucida Sans Unicode",sans-serif">Joseph</span><span style="font-size:12.0pt;font-family:"MS PGothic",sans-serif"><o:p></o:p></span></p>
<p class="MsoNormal"><span lang="EN-US" style="font-size:12.0pt;font-family:"Lucida Sans Unicode",sans-serif;color:#3366FF"> </span><span style="font-size:12.0pt;font-family:"MS PGothic",sans-serif"><o:p></o:p></span></p>
<p class="MsoNormal"><span lang="EN-GB" style="font-size:12.0pt;font-family:"Lucida Sans Unicode",sans-serif;color:navy"> </span><span style="font-size:12.0pt;font-family:"MS PGothic",sans-serif"><o:p></o:p></span></p>
<p class="MsoNormal"><span lang="EN-GB" style="font-size:10.0pt;font-family:"Arial",sans-serif;color:navy"> </span><span style="font-size:12.0pt;font-family:"MS PGothic",sans-serif"><o:p></o:p></span></p>
<div>
<div class="MsoNormal" align="center" style="text-align:center"><span lang="EN-US" style="font-size:12.0pt;font-family:"Times New Roman",serif">
<hr size="0" width="100%" align="center">
</span></div>
<p class="MsoNormal"><b><span lang="EN-US" style="font-size:10.0pt;font-family:"Tahoma",sans-serif">From:</span></b><span lang="EN-US" style="font-size:10.0pt;font-family:"Tahoma",sans-serif"> Fis [mailto:<a href="mailto:fis-bounces@listas.unizar.es">fis-bounces@listas.unizar.es</a>]
<b>On Behalf Of </b>Pedro C. Marijuan<br>
<b>Sent:</b> mardi, 14 juillet 2020 14:30<br>
<b>To:</b> 'fis'<br>
<b>Subject:</b> Re: [Fis] 10 Principles</span><span style="font-size:12.0pt;font-family:"MS PGothic",sans-serif"><o:p></o:p></span></p>
</div>
<p class="MsoNormal"><span style="font-size:12.0pt;font-family:"MS PGothic",sans-serif"> <o:p></o:p></span></p>
<div>
<p class="MsoNormal"><span style="font-size:12.0pt;font-family:"MS PGothic",sans-serif">Dear List,
<o:p></o:p></span></p>
</div>
<div>
<p class="MsoNormal"><span style="font-size:12.0pt;font-family:"MS PGothic",sans-serif"> <o:p></o:p></span></p>
</div>
<div>
<p class="MsoNormal"><span style="font-size:12.0pt;font-family:"MS PGothic",sans-serif">Thanks for the comments. I have tried to be more inclusive in the new point 2.
<o:p></o:p></span></p>
</div>
<div>
<p class="MsoNormal"><span style="font-size:12.0pt;font-family:"MS PGothic",sans-serif">Also, Point 1 has been slightly modified reminding an old comment from Lars (that info always goes "by contact")<o:p></o:p></span></p>
</div>
<p class="MsoNormal"><span style="font-size:12.0pt;font-family:"MS PGothic",sans-serif">Other changes, in point 3 now, can be justified as follows:
<o:p></o:p></span></p>
<div>
<p class="MsoNormal"><span style="font-size:12.0pt;font-family:"MS PGothic",sans-serif">The fact that biological self-production either in bacteria or in organisms is accompanied respectively by a "bacterial signaling system" or by a "central nervous system"
tells us that the way of life, the adaptation to the niche, always needs the development of ad hoc informational detectors. Otherwise the life cycle becomes "blind", truncated and unable to advance towards completion. At the same time, inside every cell, inside
every organism, there is an internal information flow related to its own self-production. For instance in a living cell, the self-production may imply: expression, copying, translation, genetic code, modification codes, degradation... While the signaling flow
may imply: signal generation, emission, transmission channel, reception, decoding/processing, meaning elaboration, response... Both information flows, the external and the internal, become intertwined, densely mixed, at all scales of biological organization.
Let us further emphasize point 1, for all these information processes imply a physical contact, as they always have to impinge on the system receptors or sensory surfaces.
<o:p></o:p></span></p>
</div>
<div>
<p class="MsoNormal"><span style="font-size:12.0pt;font-family:"MS PGothic",sans-serif"> <o:p></o:p></span></p>
</div>
<div>
<p class="MsoNormal"><span style="font-size:12.0pt;font-family:"MS PGothic",sans-serif">So, points 1 to 5 could read as follows:<o:p></o:p></span></p>
</div>
<div>
<p class="MsoNormal"><span style="font-size:12.0pt;font-family:"MS PGothic",sans-serif"> <o:p></o:p></span></p>
</div>
<div>
<div>
<p class="MsoNormal"><span style="font-size:12.0pt;font-family:"MS PGothic",sans-serif">1. Information as such: distinction of an "adjacent" difference.<o:p></o:p></span></p>
</div>
<div>
<p class="MsoNormal"><span style="font-size:12.0pt;font-family:"MS PGothic",sans-serif"> <o:p></o:p></span></p>
</div>
<div>
<p class="MsoNormal"><span lang="EN-US" style="font-size:12.0pt;font-family:"MS PGothic",sans-serif">2. Information processes: organized action upon distinctions collected into structures, patterns, sequences, messages, or flows.</span><span style="font-size:12.0pt;font-family:"MS PGothic",sans-serif"><o:p></o:p></span></p>
</div>
<div>
<p class="MsoNormal"><span style="font-size:12.0pt;font-family:"MS PGothic",sans-serif"> <o:p></o:p></span></p>
</div>
<div>
<p class="MsoNormal"><span style="font-size:12.0pt;font-family:"MS PGothic",sans-serif">3. Integrated information processes of life:
</span><span lang="EN-US" style="font-size:12.0pt;font-family:"MS PGothic",sans-serif">information flows, both from the external signaling environment and from the internal productive environment, are tightly integrated along the advancement of the adaptive
life cycle --they regularly anticipate, shape, and mix up with the accompanying energy flows.
</span><span style="font-size:12.0pt;font-family:"MS PGothic",sans-serif"><o:p></o:p></span></p>
</div>
<div>
<p class="MsoNormal"><span style="font-size:12.0pt;font-family:"MS PGothic",sans-serif"> <o:p></o:p></span></p>
</div>
</div>
<div>
<p class="MsoNormal"><span lang="EN-US" style="font-size:12.0pt;font-family:"MS PGothic",sans-serif">4. Biological complexity: communication/information exchanges among adaptive life-cycles underlie the complexity of biological organization at all scales.</span><span style="font-size:12.0pt;font-family:"MS PGothic",sans-serif"><o:p></o:p></span></p>
</div>
<div>
<p class="MsoNormal"><span style="font-size:12.0pt;font-family:"MS PGothic",sans-serif"> <o:p></o:p></span></p>
</div>
<div>
<p class="MsoNormal"><span lang="EN-US" style="font-size:12.0pt;font-family:"MS PGothic",sans-serif">5. Biological cognition: cognition, meaning and knowledge can be identified within the integrated signaling/productive molecular mechanisms that adaptively
transform the cell-cycle trajectory as well as in the action/perception cycle of central nervous systems.
</span><span style="font-size:12.0pt;font-family:"MS PGothic",sans-serif"><o:p></o:p></span></p>
</div>
<div>
<p class="MsoNormal"><span style="font-size:12.0pt;font-family:"MS PGothic",sans-serif"> <o:p></o:p></span></p>
</div>
<div>
<p class="MsoNormal"><span lang="EN-US" style="font-size:12.0pt;font-family:"MS PGothic",sans-serif">The other 5 points regarding human & social aspects may be discussed later on.
</span><span style="font-size:12.0pt;font-family:"MS PGothic",sans-serif"><o:p></o:p></span></p>
</div>
<div>
<p class="MsoNormal"><span style="font-size:12.0pt;font-family:"MS PGothic",sans-serif"> <o:p></o:p></span></p>
</div>
<div>
<p class="MsoNormal"><span lang="EN-US" style="font-size:12.0pt;font-family:"MS PGothic",sans-serif">All the best</span><span style="font-size:12.0pt;font-family:"MS PGothic",sans-serif"><o:p></o:p></span></p>
</div>
<div>
<p class="MsoNormal"><span lang="EN-US" style="font-size:12.0pt;font-family:"MS PGothic",sans-serif">--Pedro</span><span style="font-size:12.0pt;font-family:"MS PGothic",sans-serif"><o:p></o:p></span></p>
<p class="MsoNormal" style="margin-left:2.0cm;text-align:justify;line-height:14.0pt">
<span lang="EN-US" style="font-size:12.0pt;font-family:"MS PGothic",sans-serif"> </span><span style="font-size:12.0pt;font-family:"MS PGothic",sans-serif"><o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:12.0pt;font-family:"MS PGothic",sans-serif"> <o:p></o:p></span></p>
</div>
<div>
<p class="MsoNormal"><span style="font-size:12.0pt;font-family:"MS PGothic",sans-serif">El 13/07/2020 a las 2:01, Koichiro Matsuno escribió:<o:p></o:p></span></p>
</div>
<blockquote style="border:none;border-left:solid #CCCCCC 1.0pt;padding:0cm 0cm 0cm 8.0pt;margin-left:3.75pt;margin-top:5.0pt;margin-right:0cm;margin-bottom:5.0pt">
<p class="MsoNormal"><span lang="EN-US" style="font-family:"Yu Gothic",sans-serif;color:#1F497D">On Monday, July 13, 2020 5:14 AM, Krassimir Markov wrote: </span><span lang="EN-US" style="font-size:13.5pt;color:black">I am not sure that all colleagues agree
that information does not exist out of the LIFE sphere.</span><span style="font-size:12.0pt;font-family:"MS PGothic",sans-serif"><o:p></o:p></span></p>
<p class="MsoNormal"><span lang="EN-US" style="font-size:13.5pt;color:black"> </span><span style="font-size:12.0pt;font-family:"MS PGothic",sans-serif"><o:p></o:p></span></p>
<p class="MsoNormal" style="text-indent:16.5pt"><span lang="EN-US" style="font-family:"Yu Gothic",sans-serif;color:#1F497D">This observation should stand alone only when
</span><span lang="EN-GB" style="font-family:"Yu Gothic",sans-serif;color:#1F497D">“</span><span lang="EN-US" style="font-family:"Yu Gothic",sans-serif;color:#1F497D">all colleagues</span><span lang="EN-GB" style="font-family:"Yu Gothic",sans-serif;color:#1F497D">”</span><span lang="EN-US" style="font-family:"Yu Gothic",sans-serif;color:#1F497D">
are the inhabitants outside the LIFE sphere.</span><span style="font-size:12.0pt;font-family:"MS PGothic",sans-serif"><o:p></o:p></span></p>
<p class="MsoNormal" style="text-indent:16.5pt"><span lang="EN-US" style="font-family:"Yu Gothic",sans-serif;color:#1F497D"> </span><span style="font-size:12.0pt;font-family:"MS PGothic",sans-serif"><o:p></o:p></span></p>
<p class="MsoNormal" style="text-indent:16.5pt"><span lang="EN-US" style="font-family:"Yu Gothic",sans-serif;color:#1F497D">Best regards,</span><span style="font-size:12.0pt;font-family:"MS PGothic",sans-serif"><o:p></o:p></span></p>
<p class="MsoNormal" style="text-indent:16.5pt"><span lang="EN-US" style="font-family:"Yu Gothic",sans-serif;color:#1F497D">Koichiro Matsuno</span><span style="font-size:12.0pt;font-family:"MS PGothic",sans-serif"><o:p></o:p></span></p>
<p class="MsoNormal"><span lang="EN-US" style="font-family:"Yu Gothic",sans-serif;color:#1F497D"> </span><span style="font-size:12.0pt;font-family:"MS PGothic",sans-serif"><o:p></o:p></span></p>
<p class="MsoNormal"><span lang="EN-US" style="font-family:"Yu Gothic",sans-serif;color:#1F497D"> </span><span style="font-size:12.0pt;font-family:"MS PGothic",sans-serif"><o:p></o:p></span></p>
<div>
<div style="border:none;border-top:solid #E1E1E1 1.0pt;padding:3.0pt 0cm 0cm 0cm">
<p class="MsoNormal"><b><span lang="EN-US">From:</span></b><span lang="EN-US"> Fis
<a href="mailto:fis-bounces@listas.unizar.es"><fis-bounces@listas.unizar.es></a> <b>
On Behalf Of </b>Krassimir Markov<br>
<b>Sent:</b> Monday, July 13, 2020 5:14 AM<br>
<b>To:</b> 'fis' <a href="mailto:fis@listas.unizar.es"><fis@listas.unizar.es></a><br>
<b>Subject:</b> Re: [Fis] 10 Principles</span><span style="font-size:12.0pt;font-family:"MS PGothic",sans-serif"><o:p></o:p></span></p>
</div>
</div>
<p class="MsoNormal"><span lang="EN-US" style="font-size:12.0pt;font-family:"MS PGothic",sans-serif"> </span><span style="font-size:12.0pt;font-family:"MS PGothic",sans-serif"><o:p></o:p></span></p>
<div>
<div>
<div>
<p class="MsoNormal"><span lang="EN-US" style="font-size:13.5pt;color:black">Dear Pedro and FIS Colleagues,</span><span style="font-size:12.0pt;font-family:"MS PGothic",sans-serif"><o:p></o:p></span></p>
</div>
<div>
<p class="MsoNormal"><span lang="EN-US" style="font-size:13.5pt;color:black">I see that maybe INFORMATION and LIFE are interconnected.</span><span style="font-size:12.0pt;font-family:"MS PGothic",sans-serif"><o:p></o:p></span></p>
</div>
<div>
<p class="MsoNormal"><span lang="EN-US" style="font-size:13.5pt;color:black">Unfortunately, I am not sure that all colleagues agree that information does not exist out of the LIFE sphere.</span><span style="font-size:12.0pt;font-family:"MS PGothic",sans-serif"><o:p></o:p></span></p>
</div>
<div>
<p class="MsoNormal"><span lang="EN-US" style="font-size:13.5pt;color:black">Because of this, the first point I expect to reflect the correspondence between information and life.</span><span style="font-size:12.0pt;font-family:"MS PGothic",sans-serif"><o:p></o:p></span></p>
</div>
<div>
<p class="MsoNormal"><span lang="EN-US" style="font-size:13.5pt;color:black">Friendly greetings</span><span style="font-size:12.0pt;font-family:"MS PGothic",sans-serif"><o:p></o:p></span></p>
</div>
<div>
<p class="MsoNormal"><span lang="EN-US" style="font-size:13.5pt;color:black">Krassimir</span><span style="font-size:12.0pt;font-family:"MS PGothic",sans-serif"><o:p></o:p></span></p>
</div>
<div>
<p class="MsoNormal"><span lang="EN-US" style="font-size:14.0pt;color:black"> </span><span style="font-size:12.0pt;font-family:"MS PGothic",sans-serif"><o:p></o:p></span></p>
</div>
<div>
<p class="MsoNormal"><span lang="EN-US" style="font-size:14.0pt;color:black"> </span><span style="font-size:12.0pt;font-family:"MS PGothic",sans-serif"><o:p></o:p></span></p>
</div>
<div>
<div>
<div>
<p class="MsoNormal"><span lang="EN-US" style="font-size:10.0pt;font-family:"Tahoma",sans-serif;color:black"> </span><span style="font-size:12.0pt;font-family:"MS PGothic",sans-serif"><o:p></o:p></span></p>
</div>
</div>
</div>
</div>
</div>
<p class="MsoNormal" style="margin-bottom:12.0pt"><span style="font-size:12.0pt;font-family:"MS PGothic",sans-serif"><o:p> </o:p></span></p>
<p class="MsoNormal"><span style="font-size:10.0pt;font-family:"Courier New"">_______________________________________________<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:10.0pt;font-family:"Courier New"">Fis mailing list<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:10.0pt;font-family:"Courier New""><a href="mailto:Fis@listas.unizar.es">Fis@listas.unizar.es</a><o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:10.0pt;font-family:"Courier New""><a href="https://eur01.safelinks.protection.outlook.com/?url=http%3A%2F%2Flistas.unizar.es%2Fcgi-bin%2Fmailman%2Flistinfo%2Ffis&data=02%7C01%7Cgordana.dodig-crnkovic%40mdh.se%7Ce7a0ea0f8d5f438691ef08d827fce7dc%7Ca1795b64dabd4758b988b309292316cf%7C0%7C0%7C637303314463521961&sdata=8tvsbDCnwxC1QHJL%2FGYndKmnLy9Lf9tzdknmP7PS27g%3D&reserved=0">http://listas.unizar.es/cgi-bin/mailman/listinfo/fis</a><o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:10.0pt;font-family:"Courier New"">----------<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:10.0pt;font-family:"Courier New"">INFORMACIÓN SOBRE PROTECCIÓN DE DATOS DE CARÁCTER PERSONAL<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:10.0pt;font-family:"Courier New""> <o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:10.0pt;font-family:"Courier New"">Ud. recibe este correo por pertenecer a una lista de correo gestionada por la Universidad de Zaragoza.<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:10.0pt;font-family:"Courier New"">Puede encontrar toda la información sobre como tratamos sus datos en el siguiente enlace:
<a href="https://eur01.safelinks.protection.outlook.com/?url=https%3A%2F%2Fsicuz.unizar.es%2Finformacion-sobre-proteccion-de-datos-de-caracter-personal-en-listas&data=02%7C01%7Cgordana.dodig-crnkovic%40mdh.se%7Ce7a0ea0f8d5f438691ef08d827fce7dc%7Ca1795b64dabd4758b988b309292316cf%7C0%7C0%7C637303314463526951&sdata=nXQv062xWWHRMT405p6Ccb3cmLmH0H8M8p3VGehowL8%3D&reserved=0">
https://sicuz.unizar.es/informacion-sobre-proteccion-de-datos-de-caracter-personal-en-listas</a><o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:10.0pt;font-family:"Courier New"">Recuerde que si está suscrito a una lista voluntaria Ud. puede darse de baja desde la propia aplicación en el momento en que lo desee.<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:10.0pt;font-family:"Courier New""><a href="https://eur01.safelinks.protection.outlook.com/?url=http%3A%2F%2Flistas.unizar.es%2F&data=02%7C01%7Cgordana.dodig-crnkovic%40mdh.se%7Ce7a0ea0f8d5f438691ef08d827fce7dc%7Ca1795b64dabd4758b988b309292316cf%7C0%7C0%7C637303314463531921&sdata=zFEdkQLFg3is884tAUWdDDfjH9aq3q7LAKfJSXJBeeU%3D&reserved=0">http://listas.unizar.es</a><o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:10.0pt;font-family:"Courier New"">----------<o:p></o:p></span></p>
</blockquote>
<p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto"><span style="font-size:12.0pt;font-family:"Times New Roman",serif"> <o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:10.0pt;font-family:"Courier New"">-- <o:p>
</o:p></span></p>
<p class="MsoNormal"><span style="font-size:10.0pt;font-family:"Courier New"">-------------------------------------------------<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:10.0pt;font-family:"Courier New"">Pedro C. Marijuán<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:10.0pt;font-family:"Courier New"">Grupo de Bioinformación / Bioinformation Group<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:10.0pt;font-family:"Courier New""> <o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:10.0pt;font-family:"Courier New""><a href="mailto:pcmarijuan.iacs@aragon.es">pcmarijuan.iacs@aragon.es</a><o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:10.0pt;font-family:"Courier New""><a href="https://eur01.safelinks.protection.outlook.com/?url=http%3A%2F%2Fsites.google.com%2Fsite%2Fpedrocmarijuan%2F&data=02%7C01%7Cgordana.dodig-crnkovic%40mdh.se%7Ce7a0ea0f8d5f438691ef08d827fce7dc%7Ca1795b64dabd4758b988b309292316cf%7C0%7C0%7C637303314463536909&sdata=%2FVQQjMUgOBTIFJdue0HFDwdcYTq7EfW%2Buavo9Xn38%2BM%3D&reserved=0">http://sites.google.com/site/pedrocmarijuan/</a><o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:10.0pt;font-family:"Courier New"">-------------------------------------------------
<o:p></o:p></span></p>
<div id="DAB4FAD8-2DD7-40BB-A1B8-4E2AA1F9FDF2">
<p class="MsoNormal"><span style="font-size:12.0pt;font-family:"Times New Roman",serif"> </span><span style="font-size:12.0pt;font-family:"MS PGothic",sans-serif"><o:p></o:p></span></p>
<table class="MsoNormalTable" border="1" cellpadding="0" style="border:none;border-top:solid #D3D4DE 1.0pt">
<tbody>
<tr>
<td width="46" style="width:34.45pt;border:none;padding:11.25pt .75pt .75pt .75pt">
<p class="MsoNormal"><span style="font-size:12.0pt;font-family:"Times New Roman",serif"><a href="https://eur01.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.avast.com%2Fsig-email%3Futm_medium%3Demail%26utm_source%3Dlink%26utm_campaign%3Dsig-email%26utm_content%3Demailclient&data=02%7C01%7Cgordana.dodig-crnkovic%40mdh.se%7Ce7a0ea0f8d5f438691ef08d827fce7dc%7Ca1795b64dabd4758b988b309292316cf%7C0%7C0%7C637303314463536909&sdata=6Hp2k9%2BlbAP7OG6y6Q%2F%2BAAQWWXz52klwXPo85rDM%2BYM%3D&reserved=0"><span style="color:windowtext;text-decoration:none"><span style="color:blue;border:solid windowtext 1.0pt;padding:0cm"><img border="0" width="46" height="29" style="width:.4791in;height:.302in" id="_x0000_i1025" src="cid:~WRD0001.jpg" alt="Image removed by sender."></span></span></a></span><span style="font-size:12.0pt;font-family:"MS PGothic",sans-serif"><o:p></o:p></span></p>
</td>
<td width="392" style="width:294.25pt;border:none;padding:10.65pt .75pt .75pt .75pt">
<p class="MsoNormal" style="line-height:11.25pt"><span style="font-size:8.0pt;font-family:"Arial",sans-serif;color:#41424E">Libre de virus.
<a href="https://eur01.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.avast.com%2Fsig-email%3Futm_medium%3Demail%26utm_source%3Dlink%26utm_campaign%3Dsig-email%26utm_content%3Demailclient&data=02%7C01%7Cgordana.dodig-crnkovic%40mdh.se%7Ce7a0ea0f8d5f438691ef08d827fce7dc%7Ca1795b64dabd4758b988b309292316cf%7C0%7C0%7C637303314463541883&sdata=rGOpVsNk0%2FUd0NQLIttGzSCE7SgGsXoYWqgttn8K3%2BE%3D&reserved=0">
<span style="color:#4453EA">www.avast.com</span></a> </span><span style="font-size:12.0pt;font-family:"MS PGothic",sans-serif"><o:p></o:p></span></p>
</td>
</tr>
</tbody>
</table>
<p class="MsoNormal"><o:p> </o:p></p>
</div>
</blockquote>
</div>
</div>
</body>
</html>