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    <div class="moz-cite-prefix">Dear Krassimir and FIS colleagues,</div>
    <div class="moz-cite-prefix"><br>
    </div>
    <div class="moz-cite-prefix">Most of the recent messages look in
      Sync. The consensus points, under different names, towards
      information as secondary, relative, undefinable... and
      particularly towards the need, when defining it, of including the
      context in which the definition is established. Personally I am
      more interested in the concerns about empirical information
      matters in different disciplines: we have heard snippets from
      computer science, maths, biology, neuroscience (Jose Luis--could
      you please send me that very interesting paper? It it is not an
      open access) ... My traditional position is that the
      "informational coupling" of life forms with the abduced parts of
      their environment (signals, communication, etc.) in the
      advancement of their own living cycle should be considered as the
      proto-phenomenon of information. Agents, agency, are an
      abstraction in other disciplines (computer science, economics)
      derived from the former proto-phenomenon, unfortunately depriving
      it of some of its most interesting qualities. So rich is in every
      generative aspect: Conatus principle (Spinoza), fundamental coding
      (Rosen), genetic algorithms (Holland), sel-constructing "machines"
      (von Neumann), neural topodynamics (Friston)...<br>
    </div>
    <div class="moz-cite-prefix"><br>
    </div>
    <div class="moz-cite-prefix">The above central "informational
      coupling" appears as valid along the complexity growth:
      procaryots, eukaryots, multicells, nervous systems, societies...
      in each of these realms, and in multiple ways, we can point to
      "info definitions" and contexts tailored to the particular
      phenomenology. From cellular signalling systems to the bonding
      structures of our societies, or to the adaptive role of emotions.
      For instance, I have various research papers on the intriguing
      info content of laughter and its enigmatic relationship to the
      life cycle (it is omnipresent in our lives). Why?? A neural
      network can detect with more than 90% success from just a bunch of
      your laughs whether you are falling in depression or not (Navarro
      et al. 2014). Entropy of the frequencies involved is a major key.</div>
    <div class="moz-cite-prefix"><br>
    </div>
    <div class="moz-cite-prefix">Developing consistent empirical
      research on information "caught in the act" is crucial.</div>
    <div class="moz-cite-prefix"><br>
    </div>
    <div class="moz-cite-prefix">Best--Pedro<br>
    </div>
    <div class="moz-cite-prefix"><br>
    </div>
    <div class="moz-cite-prefix">El 06/03/2020 a las 19:25, Krassimir
      Markov escribió:<br>
    </div>
    <blockquote type="cite"
      cite="mid:DDD633E0826C49169FC56DE3AC211572@VaioMarkov">
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                <p class="MsoNormal" style="MARGIN: 0cm 0cm 0pt;
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                    mso-bidi-font-size: 9.0pt; mso-bidi-font-family:
                    arial"><font size="4" face="Times New Roman">Dear
                      Pedro and Colleagues,</font></span></p>
                <p class="MsoNormal" style="MARGIN: 0cm 0cm 0pt;
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                  align="justify"><span style="LINE-HEIGHT: 14pt;
                    mso-bidi-font-size: 9.0pt; mso-bidi-font-family:
                    arial"></span> </p>
                <p class="MsoNormal" style="MARGIN: 0cm 0cm 0pt;
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                  align="justify"><font face="Times New Roman"><font
                      size="4"><span style="LINE-HEIGHT: 14pt;
                        mso-bidi-font-size: 9.0pt; mso-bidi-font-family:
                        arial">First of all, I apologize again to </span>Yixin
                      for asking postponing this discussion and to
                      Joseph for my silence in January. </font></font></p>
                <p class="MsoNormal" style="MARGIN: 0cm 0cm 0pt;
                  LINE-HEIGHT: 14pt; TEXT-INDENT: 42.55pt"
                  align="justify"><font face="Times New Roman"><font
                      size="4">As you all see now, this one is very
                      intensive and it was possible to interrupt the New
                      Year Lecture of Joseph. </font></font></p>
                <p class="MsoNormal" style="MARGIN: 0cm 0cm 0pt;
                  LINE-HEIGHT: 14pt; TEXT-INDENT: 42.55pt"
                  align="justify"><font face="Times New Roman"><font
                      size="4">In addition, Joseph had moderated it very
                      nice and we receive very good collection of
                      examples of disinformation, misinformation and
                      etc. </font></font></p>
                <p class="MsoNormal" style="MARGIN: 0cm 0cm 0pt;
                  LINE-HEIGHT: 14pt; TEXT-INDENT: 42.55pt"
                  align="justify"><font face="Times New Roman"><font
                      size="4">From my point of view, it is just what we
                      need now.</font></font></p>
                <p class="MsoNormal" style="MARGIN: 0cm 0cm 0pt;
                  LINE-HEIGHT: 14pt; TEXT-INDENT: 42.55pt"
                  align="justify"> </p>
                <p class="MsoNormal" style="MARGIN: 0cm 0cm 0pt;
                  LINE-HEIGHT: 14pt; TEXT-INDENT: 42.55pt"
                  align="justify"><font size="4" face="Times New Roman">Well,
                    let’s go further.</font></p>
                <p class="MsoNormal" style="MARGIN: 0cm 0cm 0pt;
                  LINE-HEIGHT: 14pt; TEXT-INDENT: 42.55pt"
                  align="justify"> </p>
                <p class="MsoNormal" style="MARGIN: 0cm 0cm 0pt;
                  LINE-HEIGHT: 14pt; TEXT-INDENT: 42.55pt"
                  align="justify"><font face="Times New Roman"><font
                      size="4"><b>1. What is our goal</b> - to give one
                      or more definitions of concept “information” or to
                      establish useful information theories to be
                      applied to practical domains to understand and
                      solve real problems? </font></font></p>
                <p class="MsoNormal" style="MARGIN: 0cm 0cm 0pt;
                  LINE-HEIGHT: 14pt; TEXT-INDENT: 42.55pt"
                  align="justify"><font size="4" face="Times New Roman">From
                    my point of view - the last is our goal. </font></p>
                <p class="MsoNormal" style="MARGIN: 0cm 0cm 0pt;
                  LINE-HEIGHT: 14pt; TEXT-INDENT: 42.55pt"
                  align="justify"><font size="4" face="Times New Roman">Because
                    of this it doesn’t matter how much definitions we
                    will have. </font></p>
                <p class="MsoNormal" style="MARGIN: 0cm 0cm 0pt;
                  LINE-HEIGHT: 14pt; TEXT-INDENT: 42.55pt"
                  align="justify"><font size="4" face="Times New Roman">It
                    is important to see that the concrete definition may
                    be applied to a concrete domain to explain a
                    concrete phenomenon.</font></p>
                <p class="MsoNormal" style="MARGIN: 0cm 0cm 0pt;
                  LINE-HEIGHT: 14pt; TEXT-INDENT: 42.55pt"
                  align="justify"><font size="4" face="Times New Roman">In
                    other words, I expect to see examples as more as
                    possible.</font></p>
                <p class="MsoNormal" style="MARGIN: 0cm 0cm 0pt;
                  LINE-HEIGHT: 14pt; TEXT-INDENT: 42.55pt"
                  align="justify"><span style="LINE-HEIGHT: 14pt;
                    mso-bidi-font-size: 9.0pt; mso-bidi-font-family:
                    arial"></span> </p>
                <p class="MsoNormal" style="MARGIN: 0cm 0cm 0pt;
                  LINE-HEIGHT: 14pt; TEXT-INDENT: 42.55pt"
                  align="justify"><font face="Times New Roman"><font
                      size="4"><b><span style="LINE-HEIGHT: 14pt;
                          mso-bidi-font-size: 9.0pt;
                          mso-bidi-font-family: arial">2. We need
                          methodological</span></b><span
                        style="LINE-HEIGHT: 14pt; mso-bidi-font-size:
                        9.0pt; mso-bidi-font-family: arial"> <b>knowledge</b>
                        to establish new concepts and theories. </span></font></font></p>
                <p class="MsoNormal" style="MARGIN: 0cm 0cm 0pt;
                  LINE-HEIGHT: 14pt; TEXT-INDENT: 42.55pt"
                  align="justify"><span style="LINE-HEIGHT: 14pt;
                    mso-bidi-font-size: 9.0pt; mso-bidi-font-family:
                    arial"><font size="4" face="Times New Roman">First
                      of all, we need to clear what kind is our new
                      concept - primary or secondary. </font></span></p>
                <p class="MsoNormal" style="MARGIN: 0cm 0cm 0pt;
                  LINE-HEIGHT: 14pt; TEXT-INDENT: 42.55pt"
                  align="justify"><span style="LINE-HEIGHT: 14pt;
                    mso-bidi-font-size: 9.0pt; mso-bidi-font-family:
                    arial"><font size="4" face="Times New Roman">Concerning
                      the concept “information”, it may be introduced as
                      a primary, as well as, as a secondary concept.</font></span></p>
                <p class="MsoNormal" style="MARGIN: 0cm 0cm 0pt;
                  LINE-HEIGHT: 14pt; TEXT-INDENT: 42.55pt"
                  align="justify"><span style="LINE-HEIGHT: 14pt;
                    mso-bidi-font-size: 9.0pt; mso-bidi-font-family:
                    arial"><font size="4" face="Times New Roman">If it
                      is a primary concept, it has to be introduces by
                      series of well known examples.</font></span></p>
                <p class="MsoNormal" style="MARGIN: 0cm 0cm 0pt;
                  LINE-HEIGHT: 14pt; TEXT-INDENT: 42.55pt"
                  align="justify"><span style="LINE-HEIGHT: 14pt;
                    mso-bidi-font-size: 9.0pt; mso-bidi-font-family:
                    arial"><font size="4" face="Times New Roman">If it
                      is a secondary concept, the primary concepts,
                      which will define it, need to be chosen precisely
                      and again to be introduced by corresponded series
                      of examples.</font></span></p>
                <p class="MsoNormal" style="MARGIN: 0cm 0cm 0pt;
                  LINE-HEIGHT: 14pt; TEXT-INDENT: 42.55pt"
                  align="justify"><span style="LINE-HEIGHT: 14pt;
                    mso-bidi-font-size: 9.0pt; mso-bidi-font-family:
                    arial"></span> </p>
                <p class="MsoNormal" style="MARGIN: 0cm 0cm 0pt;
                  LINE-HEIGHT: 14pt; TEXT-INDENT: 42.55pt"
                  align="justify"><span style="LINE-HEIGHT: 14pt;
                    mso-bidi-font-size: 9.0pt; mso-bidi-font-family:
                    arial"><font size="4" face="Times New Roman">For me,
                      the “information” is a secondary concept! </font></span></p>
                <p class="MsoNormal" style="MARGIN: 0cm 0cm 0pt;
                  LINE-HEIGHT: 14pt; TEXT-INDENT: 42.55pt"
                  align="justify"><span style="LINE-HEIGHT: 14pt;
                    mso-bidi-font-size: 9.0pt; mso-bidi-font-family:
                    arial"></span> </p>
                <p class="MsoNormal" style="MARGIN: 0cm 0cm 0pt;
                  LINE-HEIGHT: 14pt; TEXT-INDENT: 42.55pt"
                  align="justify"><span style="LINE-HEIGHT: 14pt;
                    mso-bidi-font-size: 9.0pt; mso-bidi-font-family:
                    arial"><font size="4" face="Times New Roman">If we
                      assume it as a primary concept, it will be direct
                      way to well known concepts of “Got” and modern
                      variants, such as “Information-space-time
                      continuum”. </font></span></p>
                <p class="MsoNormal" style="MARGIN: 0cm 0cm 0pt;
                  LINE-HEIGHT: 14pt; TEXT-INDENT: 42.55pt"
                  align="justify"><span style="LINE-HEIGHT: 14pt;
                    mso-bidi-font-size: 9.0pt; mso-bidi-font-family:
                    arial"><font size="4" face="Times New Roman">If one
                      believes in “Information”, he/she may explain many
                      of real phenomena. </font></span></p>
                <p class="MsoNormal" style="MARGIN: 0cm 0cm 0pt;
                  LINE-HEIGHT: 14pt; TEXT-INDENT: 42.55pt"
                  align="justify"><span style="LINE-HEIGHT: 14pt;
                    mso-bidi-font-size: 9.0pt; mso-bidi-font-family:
                    arial"><font size="4" face="Times New Roman">But in
                      the same time, he/she will fall down in some kind
                      of dogma. (Dear Gordana, elections are the same
                      case!).</font></span></p>
                <p class="MsoNormal" style="MARGIN: 0cm 0cm 0pt;
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                  align="justify"><span style="LINE-HEIGHT: 14pt;
                    mso-bidi-font-size: 9.0pt; mso-bidi-font-family:
                    arial"></span> </p>
                <p class="MsoNormal" style="MARGIN: 0cm 0cm 0pt;
                  LINE-HEIGHT: 14pt; TEXT-INDENT: 42.55pt"
                  align="justify"><span style="LINE-HEIGHT: 14pt;
                    mso-bidi-font-size: 9.0pt; mso-bidi-font-family:
                    arial"><font size="4" face="Times New Roman"><strong>3.
                        I propose to follow the next steps</strong> when
                      we propose definitions of “information”:</font></span></p>
                <p class="MsoNormal" style="MARGIN: 0cm 0cm 0pt;
                  LINE-HEIGHT: 14pt; TEXT-INDENT: 42.55pt"
                  align="justify"><span style="LINE-HEIGHT: 14pt;
                    mso-bidi-font-size: 9.0pt; mso-bidi-font-family:
                    arial"><font size="4" face="Times New Roman">1) to
                      point clearly if it is a primary or a secondary
                      concept;</font></span></p>
                <p class="MsoNormal" style="MARGIN: 0cm 0cm 0pt;
                  LINE-HEIGHT: 14pt; TEXT-INDENT: 42.55pt"
                  align="justify"><span style="LINE-HEIGHT: 14pt;
                    mso-bidi-font-size: 9.0pt; mso-bidi-font-family:
                    arial"><font size="4" face="Times New Roman">2) if
                      it is a primary concept, to stop further
                      discussion and to try to understand the examples
                      given by the author(s);</font></span></p>
                <p class="MsoNormal" style="MARGIN: 0cm 0cm 0pt;
                  LINE-HEIGHT: 14pt; TEXT-INDENT: 42.55pt"
                  align="justify"><span style="LINE-HEIGHT: 14pt;
                    mso-bidi-font-size: 9.0pt; mso-bidi-font-family:
                    arial"><font size="4" face="Times New Roman">3) in
                      the second case, to introduce clearly the primary
                      concepts and step by step to present the theory.</font></span></p>
                <p class="MsoNormal" style="MARGIN: 0cm 0cm 0pt;
                  LINE-HEIGHT: 14pt; TEXT-INDENT: 42.55pt"
                  align="justify"><span style="LINE-HEIGHT: 14pt;
                    mso-bidi-font-size: 9.0pt; mso-bidi-font-family:
                    arial"></span> </p>
                <p class="MsoNormal" style="MARGIN: 0cm 0cm 0pt;
                  LINE-HEIGHT: 14pt; TEXT-INDENT: 42.55pt"
                  align="justify"><span style="LINE-HEIGHT: 14pt;
                    mso-bidi-font-size: 9.0pt; mso-bidi-font-family:
                    arial"><font size="4" face="Times New Roman"><strong>4.
                        No problems if we will have many theories</strong>
                      for the same phenomenon. </font></span></p>
                <p class="MsoNormal" style="MARGIN: 0cm 0cm 0pt;
                  LINE-HEIGHT: 14pt; TEXT-INDENT: 42.55pt"
                  align="justify"><span style="LINE-HEIGHT: 14pt;
                    mso-bidi-font-size: 9.0pt; mso-bidi-font-family:
                    arial"><font size="4" face="Times New Roman">It is
                      well known that, for instance, the Geometry is not
                      a single theory. </font></span></p>
                <p class="MsoNormal" style="MARGIN: 0cm 0cm 0pt;
                  LINE-HEIGHT: 14pt; TEXT-INDENT: 42.55pt"
                  align="justify"><span style="LINE-HEIGHT: 14pt;
                    mso-bidi-font-size: 9.0pt; mso-bidi-font-family:
                    arial"><font size="4" face="Times New Roman">You may
                      know at least several geometries:</font></span></p>
                <p class="MsoNormal" style="MARGIN: 0cm 0cm 0pt;
                  LINE-HEIGHT: 14pt; TEXT-INDENT: 42.55pt"
                  align="justify"><span style="LINE-HEIGHT: 14pt;
                    mso-bidi-font-size: 9.0pt; mso-bidi-font-family:
                    arial"><font face="Times New Roman"><font size="4">-
                        Euclidean (</font></font><a style="href:
                      "https://en.wikipedia.org/wiki/Euclidean_geometry""
                      moz-do-not-send="true"><font color="#0000ff"><font
                          style="TEXT-DECORATION: none" size="4"
                          face="Times New Roman">https://en.wikipedia.org/wiki/Euclidean_geometry</font></font></a><font
                      size="4" face="Times New Roman">);</font></span></p>
                <p class="MsoNormal" style="MARGIN: 0cm 0cm 0pt;
                  LINE-HEIGHT: 14pt; TEXT-INDENT: 42.55pt"
                  align="justify"><span style="LINE-HEIGHT: 14pt;
                    mso-bidi-font-size: 9.0pt; mso-bidi-font-family:
                    arial"><font size="4" face="Times New Roman">-
                      Non-Euclidean: hyperbolic or elliptic (</font><a
                      style="href:
                      "https://en.wikipedia.org/wiki/Non-Euclidean_geometry""
                      moz-do-not-send="true"><font color="#0000ff"><font
                          style="TEXT-DECORATION: none" size="4"
                          face="Times New Roman">https://en.wikipedia.org/wiki/Non-Euclidean_geometry</font></font></a><font
                      size="4" face="Times New Roman">);</font></span></p>
                <p class="MsoNormal" style="MARGIN: 0cm 0cm 0pt;
                  LINE-HEIGHT: 14pt; TEXT-INDENT: 42.55pt"
                  align="justify"><span style="LINE-HEIGHT: 14pt;
                    mso-bidi-font-size: 9.0pt; mso-bidi-font-family:
                    arial"><font size="4" face="Times New Roman">-
                      Spherical geometry (</font><a style="href:
                      "https://en.wikipedia.org/wiki/Spherical_geometry""
                      moz-do-not-send="true"><font color="#0000ff"><font
                          style="TEXT-DECORATION: none" size="4"
                          face="Times New Roman">https://en.wikipedia.org/wiki/Spherical_geometry</font></font></a><font
                      size="4" face="Times New Roman">),</font></span></p>
                <p class="MsoNormal" style="MARGIN: 0cm 0cm 0pt;
                  LINE-HEIGHT: 14pt; TEXT-INDENT: 42.55pt"
                  align="justify"><span style="LINE-HEIGHT: 14pt;
                    mso-bidi-font-size: 9.0pt; mso-bidi-font-family:
                    arial"><font size="4" face="Times New Roman">etc.</font></span></p>
                <p class="MsoNormal" style="MARGIN: 0cm 0cm 0pt;
                  LINE-HEIGHT: 14pt; TEXT-INDENT: 42.55pt"
                  align="justify"><font face="Times New Roman"><font
                      size="4"><span style="LINE-HEIGHT: 14pt;
                        mso-bidi-font-size: 9.0pt; mso-bidi-font-family:
                        arial">This point of view, in 1993, I had
                        included in the name of the first ITHEA</span><sup><span
                          style="LINE-HEIGHT: 12pt; mso-bidi-font-size:
                          9.0pt">®</span></sup><span style="LINE-HEIGHT:
                        14pt; mso-bidi-font-size: 9.0pt;
                        mso-bidi-font-family: arial"> International
                        Journal calling it “Information Theories and
                        Applications” .</span></font></font></p>
                <p class="MsoNormal" style="MARGIN: 0cm 0cm 0pt;
                  LINE-HEIGHT: 14pt; TEXT-INDENT: 42.55pt"
                  align="justify"><span style="LINE-HEIGHT: 14pt;
                    mso-bidi-font-size: 9.0pt; mso-bidi-font-family:
                    arial"></span> </p>
                <p class="MsoNormal" style="MARGIN: 0cm 0cm 0pt;
                  LINE-HEIGHT: 14pt; TEXT-INDENT: 42.55pt"
                  align="justify"><span style="LINE-HEIGHT: 14pt;
                    mso-bidi-font-size: 9.0pt; mso-bidi-font-family:
                    arial"><font size="4" face="Times New Roman">Friendly
                      greetings</font></span></p>
                <p class="MsoNormal" style="MARGIN: 0cm 0cm 0pt;
                  LINE-HEIGHT: 14pt; TEXT-INDENT: 42.55pt"
                  align="justify"><span style="LINE-HEIGHT: 14pt;
                    mso-bidi-font-size: 9.0pt; mso-bidi-font-family:
                    arial"><font size="4" face="Times New Roman">Krassimir</font></span></p>
                <p class="MsoNormal" style="MARGIN: 0cm 0cm 0pt;
                  LINE-HEIGHT: 14pt; TEXT-INDENT: 42.55pt"
                  align="justify"><span style="LINE-HEIGHT: 14pt;
                    mso-bidi-font-size: 9.0pt; mso-bidi-font-family:
                    arial"></span> </p>
                <p class="MsoNormal" style="MARGIN: 0cm 0cm 0pt;
                  LINE-HEIGHT: 14pt; TEXT-INDENT: 42.55pt"
                  align="justify"><span style="LINE-HEIGHT: 14pt;
                    mso-bidi-font-size: 9.0pt; mso-bidi-font-family:
                    arial"></span> <br>
                </p>
              </div>
            </div>
          </div>
        </div>
      </div>
    </blockquote>
    <p><br>
    </p>
    <pre class="moz-signature" cols="72">-- 
-------------------------------------------------
Pedro C. Marijuán
Grupo de Bioinformación / Bioinformation Group

<a class="moz-txt-link-abbreviated" href="mailto:pcmarijuan.iacs@aragon.es">pcmarijuan.iacs@aragon.es</a>
<a class="moz-txt-link-freetext" href="http://sites.google.com/site/pedrocmarijuan/">http://sites.google.com/site/pedrocmarijuan/</a>
------------------------------------------------- </pre>
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