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<DIV><SPAN style="FONT-FAMILY: ; COLOR: "><FONT size=4>Dear
Alberto,</FONT></SPAN></DIV>
<DIV><SPAN style="FONT-FAMILY: ; COLOR: "><FONT
size=4></FONT></SPAN> </DIV>
<DIV><SPAN style="FONT-FAMILY: ; COLOR: "><FONT size=4>Let imagine that we are
at the naturist beach, i.e. naked.</FONT></SPAN></DIV>
<DIV><SPAN style="FONT-FAMILY: ; COLOR: "><FONT size=4>OK! </FONT></SPAN></DIV>
<DIV><SPAN style="FONT-FAMILY: ; COLOR: "><FONT size=4>You will see all what I
am and I will se the same for you.</FONT></SPAN></DIV>
<DIV><SPAN style="FONT-FAMILY: ; COLOR: "><FONT
size=4></FONT></SPAN> </DIV>
<DIV><SPAN style="FONT-FAMILY: ; COLOR: "><FONT size=4>Well, will you know what
I think or shall I know the same for you?</FONT></SPAN></DIV>
<DIV><SPAN style="FONT-FAMILY: ; COLOR: "><FONT
size=4></FONT></SPAN> </DIV>
<DIV><SPAN style="FONT-FAMILY: ; COLOR: "><FONT size=4>Simple answer:
NOT!</FONT></SPAN></DIV>
<DIV><SPAN style="FONT-FAMILY: ; COLOR: "><FONT
size=4></FONT></SPAN> </DIV>
<DIV><SPAN style="FONT-FAMILY: ; COLOR: "><FONT size=4>No Data base may contain
any data about my current thoughts and feelings.</FONT></SPAN></DIV>
<DIV><SPAN style="FONT-FAMILY: ; COLOR: "><FONT size=4>Yes, the stupid part of
humanity may be controlled by big data centers.</FONT></SPAN></DIV>
<DIV><SPAN style="FONT-FAMILY: ; COLOR: "><FONT size=4>But all times it had been
controlled. Nothing new.</FONT></SPAN></DIV>
<DIV><FONT size=4></FONT> </DIV>
<DIV><FONT size=4>The pseudo scientists may analyze data and may create tons of
papers.</FONT></DIV>
<DIV><FONT size=4>For such “production” there was and will exist corresponded
more and more big cemeteries.</FONT></DIV>
<DIV><FONT size=4>I had edited more than one thousand papers.</FONT></DIV>
<DIV><FONT size=4>Only several was really very important and with great
scientific value !!!</FONT></DIV>
<DIV>
<DIV><SPAN style="FONT-FAMILY: ; COLOR: "><FONT
size=4></FONT></SPAN> </DIV><SPAN style="FONT-FAMILY: ; COLOR: "><FONT
size=4>Collection of data is important problem and it will be such for
ever.</FONT></SPAN></DIV>
<DIV><SPAN style="FONT-FAMILY: ; COLOR: "><FONT size=4>But the greater problem
for humanity is collection of money <IMG class="wlEmoticon wlEmoticon-smile"
style="BORDER-TOP-STYLE: none; BORDER-BOTTOM-STYLE: none; BORDER-RIGHT-STYLE: none; BORDER-LEFT-STYLE: none"
alt=Smile
src="cid:02627239B54B47F78D134B07BF025C07@VaioMarkov"></FONT></SPAN></DIV>
<DIV><SPAN style="FONT-FAMILY: ; COLOR: "><FONT
size=4></FONT></SPAN> </DIV>
<DIV><SPAN style="FONT-FAMILY: ; COLOR: "><FONT size=4>And the last cause the
former!</FONT></SPAN></DIV>
<DIV><SPAN style="FONT-FAMILY: ; COLOR: "><FONT size=4>And the last is many
times more dangerous than former!</FONT></SPAN></DIV>
<DIV><FONT size=4></FONT> </DIV>
<DIV><FONT size=4>Do not worry of Data-ism!</FONT></DIV>
<DIV><FONT size=4>Be worried of the Money-ism!</FONT></DIV>
<DIV><SPAN style="FONT-FAMILY: ; COLOR: "><FONT
size=4></FONT></SPAN> </DIV>
<DIV>
<DIV><SPAN style="FONT-FAMILY: ; COLOR: "><SPAN
style="FONT-FAMILY: ; COLOR: "><FONT size=4>I will continue next week because
this is my second post ( Thanks to wisdom of Pedro who had limited
Writing-letter-ism in our list! ).</FONT></SPAN></SPAN></DIV></DIV>
<DIV><SPAN style="FONT-FAMILY: ; COLOR: "><FONT
size=4></FONT></SPAN> </DIV>
<DIV><SPAN style="FONT-FAMILY: ; COLOR: "><FONT size=4>Friendly
greetings</FONT></SPAN></DIV>
<DIV><SPAN style="FONT-FAMILY: ; COLOR: "><FONT
size=4>Krassimir</FONT></SPAN></DIV>
<DIV><SPAN style="FONT-FAMILY: ; COLOR: "><FONT
size=4></FONT></SPAN> </DIV>
<DIV><SPAN style="FONT-FAMILY: ; COLOR: "><FONT
size=4></FONT></SPAN> </DIV>
<DIV><SPAN style="FONT-FAMILY: ; COLOR: "><FONT
size=4></FONT></SPAN> </DIV>
<DIV><SPAN style="FONT-FAMILY: ; COLOR: "><FONT
size=4></FONT></SPAN> </DIV>
<DIV><SPAN style="FONT-FAMILY: ; COLOR: "></SPAN> </DIV>
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<DIV><FONT size=4 face=Calibri></FONT> </DIV>
<DIV style="BACKGROUND: #f5f5f5">
<DIV style="font-color: black"><B>From:</B> <A title=ajimenez@iisaragon.es
href="mailto:ajimenez@iisaragon.es">Alberto J. Schuhmacher</A> </DIV>
<DIV><B>Sent:</B> Tuesday, March 06, 2018 10:23 PM</DIV>
<DIV><B>To:</B> <A title=fis@listas.unizar.es
href="mailto:fis@listas.unizar.es">fis</A> </DIV>
<DIV><B>Subject:</B> [Fis] Is Dataism the end of classical hypothesis-driven
research and the beginning of data-correlation-driven
research?</DIV></DIV></DIV>
<DIV> </DIV></DIV>
<DIV
style='FONT-SIZE: small; TEXT-DECORATION: none; FONT-FAMILY: "Calibri"; FONT-WEIGHT: normal; COLOR: #000000; FONT-STYLE: normal; DISPLAY: inline'>
<P>Dear FIS Colleagues,</P>
<P>I very much appreciate this opportunity to discuss with all of you.</P>
<P>My mentors and science teachers taught me that Science had a method, rules
and procedures that should be followed and pursued rigorously and with
perseverance. The scientific research needed to be preceded by one or several
hypotheses that should be subjected to validation or refutation through
experiments designed and carried out in a laboratory. The Oxford Dictionaries
Online defines the scientific method as "a method or procedure that has
characterized natural science since the 17th century, consisting in systematic
observation, measurement, and experiment, and the formulation, testing, and
modification of hypotheses". Experiments are a procedure designed to test
hypotheses. Experiments are an important tool of the scientific method.</P>
<P>In our case, molecular, personalized and precision medicine aims to
anticipate the future development of diseases in a specific individual through
molecular markers registered in the genome, variome, metagenome, metabolome or
in any of the multiple "omes" that make up the present "omics" language of
current Biology.</P>
<P>The possibilities of applying these methodologies to the prevention and
treatment of diseases have increased exponentially with the rise of a new
religion, <EM>Dataism</EM>, whose foundations are inspired by scientific
agnosticism, a way of thinking that seems classical but applied to research, it
hides a profound revolution.</P>
<P>Dataism arises from the recent human desire to collect and analyze data, data
and more data, data of everything and data for everything-from the most banal
social issues to those that decide the rhythms of life and death. “Information
flow” is one the “supreme values” of this religion. The next floods will be of
data as we can see just looking at any electronic window.</P>
<P>The recent development of gigantic clinical and biological databases, and the
concomitant progress of the computational capacity to handle and analyze these
growing tides of information represent the best substrate for the progress of
Dataism, which in turn has managed to provide a solid content material to an
always-evanescent scientific agnosticism.</P>
<P>On many occasions the establishment of correlative observations seems to be
sufficient to infer about the relevance of a certain factor in the development
of some human pathologies. It seems that we are heading towards a path in which
research, instead of being driven by hypotheses confirmed experimentally, in the
near future experimental hypotheses themselves will arise from the observation
of data of previously performed experiments. Are we facing the end of the wet
lab? Is Dataism the end of classical hypothesis-driven research (and the
beginning of data-correlation-driven research)?</P>
<P>Deep learning is based on learning data representations, as opposed to
task-specific algorithms. Learning can be supervised, semi-supervised or
unsupervised. Deep learning models are loosely related to information processing
and communication patterns in a biological nervous system, such as neural coding
that attempts to define a relationship between various stimuli and associated
neuronal responses in the brain. Deep learning architectures such as deep neural
networks, deep belief networks and recurrent neural networks have been applied
to fields including computer vision, audio recognition, speech recognition,
machine translation, natural language processing, social network filtering,
bioinformatics and drug design, where they have produced results comparable to
and in some cases superior to human experts. Will be data-correlation-driven
research the new scientific method for unsupervised deep learning machines<EM>?
</EM>Will computers became fundamentalists of <EM>Dataism</EM>?</P>
<P>Best regards,</P>
<P>AJ</P>
<P> </P>
<DIV>---<BR>
<DIV class=pre
style="FONT-FAMILY: monospace; PADDING-BOTTOM: 0px; PADDING-TOP: 0px; PADDING-LEFT: 0px; MARGIN: 0px; PADDING-RIGHT: 0px"><SPAN
style="FONT-SIZE: 10pt; FONT-FAMILY: arial,helvetica,sans-serif; COLOR: #000000">Alberto
J. Schuhmacher, PhD.</SPAN><BR><SPAN
style="FONT-SIZE: 10pt; FONT-FAMILY: arial,helvetica,sans-serif; COLOR: #000000">Head,
Molecular Oncology Group</SPAN><BR><BR><SPAN
style="FONT-SIZE: 10pt; FONT-FAMILY: arial,helvetica,sans-serif; COLOR: #000000">Aragon
Health Research Institute (IIS Aragón)</SPAN><BR><SPAN
style="FONT-SIZE: 10pt; FONT-FAMILY: arial,helvetica,sans-serif; COLOR: #000000">Biomedical
Research Center of Aragon (CIBA)</SPAN><BR><SPAN
style="FONT-SIZE: 10pt; FONT-FAMILY: arial,helvetica,sans-serif; COLOR: #000000">Avda.
Juan Bosco 13, 50009 Zaragoza (Spain)</SPAN><BR><SPAN
style="FONT-SIZE: 10pt; FONT-FAMILY: arial,helvetica,sans-serif; COLOR: #000000">email:
<A style="COLOR: #000000"
href="mailto:ajimenez@iisaragon.es">ajimenez@iisaragon.es</A></SPAN><BR><SPAN
style="FONT-SIZE: 10pt; FONT-FAMILY: arial,helvetica,sans-serif">Phone:(+34)
637939901</SPAN></DIV></DIV>
<P>
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