<html><head><meta http-equiv="Content-Type" content="text/html; charset=utf-8"></head><body><div><div style="font-family: Calibri,sans-serif; font-size: 11pt;">You'll be amused by this on Pavlov and Kornosky by Heinz Von Foerster...<br><br>https://m.youtube.com/watch?v=BomO7pbSVNA<br><br>The message is that one must be careful where one draws one's distinctions <br><br>What you call data-ism is a bit like the bell without the clapper ;-)</div></div><div dir="ltr"><hr><span style="font-family: Calibri,sans-serif; font-size: 11pt; font-weight: bold;">From: </span><span style="font-family: Calibri,sans-serif; font-size: 11pt;"><a href="mailto:karl.javorszky@gmail.com">Karl Javorszky</a></span><br><span style="font-family: Calibri,sans-serif; font-size: 11pt; font-weight: bold;">Sent: </span><span style="font-family: Calibri,sans-serif; font-size: 11pt;">07/03/2018 21:00</span><br><span style="font-family: Calibri,sans-serif; font-size: 11pt; font-weight: bold;">To: </span><span style="font-family: Calibri,sans-serif; font-size: 11pt;"><a href="mailto:markov@foibg.com">Krassimir Markov</a></span><br><span style="font-family: Calibri,sans-serif; font-size: 11pt; font-weight: bold;">Cc: </span><span style="font-family: Calibri,sans-serif; font-size: 11pt;"><a href="mailto:fis@listas.unizar.es">fis</a>; <a href="mailto:ajimenez@iisaragon.es">Alberto J. Schuhmacher</a></span><br><span style="font-family: Calibri,sans-serif; font-size: 11pt; font-weight: bold;">Subject: </span><span style="font-family: Calibri,sans-serif; font-size: 11pt;">Re: [Fis] Simple amswer: NOT!</span><br><br></div><div dir="auto">Dear Krassimir, <div dir="auto"><br></div><div dir="auto"><br></div><div dir="auto">Formalism is nice, but it can be unreasonable. </div><div dir="auto"><br></div><div dir="auto">Your example of 2 naked men on a beach can be made simpler by adding a dog, a sausage and a whistle. </div><div dir="auto"><br></div><div dir="auto">Person A (the dog's owner) sounds the whistle. The dog is apparently used to being fed and runs up, waging its tail.</div><div dir="auto"><br></div><div dir="auto">Can </div><div dir="auto">1) person A think:</div><div dir="auto">a) the dog thinks it will be fed, </div><div dir="auto">b) this other naked guy thinks I am introducing Pawlow to formal logic; </div><div dir="auto"><br></div><div dir="auto">2) person B think: </div><div dir="auto">a) the measure of intelligence is based on the number of repetitions of a stimulus until the conditioned reflex is established,</div><div dir="auto">b) this other naked guy apparently teaching his dog to learn to listen to the whistle;</div><div dir="auto"><br></div><div dir="auto">3) the dog think</div><div dir="auto">a) food coming,</div><div dir="auto">b) the connection between whistle and sausage is a secret that I have mastered, no other dog will ever figure out the mystery,</div><div dir="auto">c) we dogs live in a world in which past and future exist; these are connected by the moment, which is the natural home (in fact, so far, the only home) of formal logic;</div><div dir="auto">d) poor humans have no fur and can not therefore think.</div><div dir="auto"><br></div><div dir="auto">Do you think you can't navigate a crossing because you are not able to figure out what the drivers in the cars coming will think? Because they are not naked? </div><div dir="auto"><br></div><div dir="auto">It is time to start talking about what Pawlow said. Maybe, after that we can start discussing what Gregor Mendel said. After that, one will cry Caramba!</div><div dir="auto"><br></div><div dir="auto">Time slips by while we waste time. </div><div dir="auto"><br></div><div dir="auto">Karl </div></div><div class="gmail_extra"><br><div class="gmail_quote">Am 07.03.2018 21:10 schrieb "Krassimir Markov" <<a href="mailto:markov@foibg.com" target="_blank">markov@foibg.com</a>>:<br type="attribution"><blockquote class="gmail_quote" style="margin: 0px 0px 0px 0.8ex; padding-left: 1ex; border-left-color: rgb(204, 204, 204); border-left-width: 1px; border-left-style: solid;">
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<div><span><font size="4">Dear
Alberto,</font></span></div>
<div><span><font size="4"></font></span> </div>
<div><span><font size="4">Let imagine that we are
at the naturist beach, i.e. naked.</font></span></div>
<div><span><font size="4">OK! </font></span></div>
<div><span><font size="4">You will see all what I
am and I will se the same for you.</font></span></div>
<div><span><font size="4"></font></span> </div>
<div><span><font size="4">Well, will you know what
I think or shall I know the same for you?</font></span></div>
<div><span><font size="4"></font></span> </div>
<div><span><font size="4">Simple answer:
NOT!</font></span></div>
<div><span><font size="4"></font></span> </div>
<div><span><font size="4">No Data base may contain
any data about my current thoughts and feelings.</font></span></div>
<div><span><font size="4">Yes, the stupid part of
humanity may be controlled by big data centers.</font></span></div>
<div><span><font size="4">But all times it had been
controlled. Nothing new.</font></span></div>
<div><font size="4"></font> </div>
<div><font size="4">The pseudo scientists may analyze data and may create tons of
papers.</font></div>
<div><font size="4">For such “production” there was and will exist corresponded
more and more big cemeteries.</font></div>
<div><font size="4">I had edited more than one thousand papers.</font></div>
<div><font size="4">Only several was really very important and with great
scientific value !!!</font></div>
<div>
<div><span><font size="4"></font></span> </div><span><font size="4">Collection of data is important problem and it will be such for
ever.</font></span></div>
<div><span><font size="4">But the greater problem
for humanity is collection of money <img class="m_-93222048804612654wlEmoticon m_-93222048804612654wlEmoticon-smile" alt="Smile" src="cid:02627239B54B47F78D134B07BF025C07@VaioMarkov"></font></span></div>
<div><span><font size="4"></font></span> </div>
<div><span><font size="4">And the last cause the
former!</font></span></div>
<div><span><font size="4">And the last is many
times more dangerous than former!</font></span></div>
<div><font size="4"></font> </div>
<div><font size="4">Do not worry of Data-ism!</font></div>
<div><font size="4">Be worried of the Money-ism!</font></div>
<div><span><font size="4"></font></span> </div>
<div>
<div><span><span><font size="4">I will continue next week because
this is my second post ( Thanks to wisdom of Pedro who had limited
Writing-letter-ism in our list! ).</font></span></span></div></div>
<div><span><font size="4"></font></span> </div>
<div><span><font size="4">Friendly
greetings</font></span></div>
<div><span><font size="4">Krassimir</font></span></div>
<div><span><font size="4"></font></span> </div>
<div><span><font size="4"></font></span> </div>
<div><span><font size="4"></font></span> </div>
<div><span><font size="4"></font></span> </div>
<div><span></span> </div>
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<div><font face="Calibri" size="4"></font> </div>
<div style="background: rgb(245, 245, 245);">
<div><b>From:</b> <a title="ajimenez@iisaragon.es" href="mailto:ajimenez@iisaragon.es" target="_blank">Alberto J. Schuhmacher</a> </div>
<div><b>Sent:</b> Tuesday, March 06, 2018 10:23 PM</div>
<div><b>To:</b> <a title="fis@listas.unizar.es" href="mailto:fis@listas.unizar.es" target="_blank">fis</a> </div>
<div><b>Subject:</b> [Fis] Is Dataism the end of classical hypothesis-driven
research and the beginning of data-correlation-driven
research?</div></div></div>
<div> </div></div>
<div style='color: rgb(0, 0, 0); font-family: "Calibri"; font-size: small; font-style: normal; font-weight: normal; text-decoration: none; display: inline;'>
<p>Dear FIS Colleagues,</p>
<p>I very much appreciate this opportunity to discuss with all of you.</p>
<p>My mentors and science teachers taught me that Science had a method, rules
and procedures that should be followed and pursued rigorously and with
perseverance. The scientific research needed to be preceded by one or several
hypotheses that should be subjected to validation or refutation through
experiments designed and carried out in a laboratory. The Oxford Dictionaries
Online defines the scientific method as "a method or procedure that has
characterized natural science since the 17th century, consisting in systematic
observation, measurement, and experiment, and the formulation, testing, and
modification of hypotheses". Experiments are a procedure designed to test
hypotheses. Experiments are an important tool of the scientific method.</p>
<p>In our case, molecular, personalized and precision medicine aims to
anticipate the future development of diseases in a specific individual through
molecular markers registered in the genome, variome, metagenome, metabolome or
in any of the multiple "omes" that make up the present "omics" language of
current Biology.</p>
<p>The possibilities of applying these methodologies to the prevention and
treatment of diseases have increased exponentially with the rise of a new
religion, <em>Dataism</em>, whose foundations are inspired by scientific
agnosticism, a way of thinking that seems classical but applied to research, it
hides a profound revolution.</p>
<p>Dataism arises from the recent human desire to collect and analyze data, data
and more data, data of everything and data for everything-from the most banal
social issues to those that decide the rhythms of life and death. “Information
flow” is one the “supreme values” of this religion. The next floods will be of
data as we can see just looking at any electronic window.</p>
<p>The recent development of gigantic clinical and biological databases, and the
concomitant progress of the computational capacity to handle and analyze these
growing tides of information represent the best substrate for the progress of
Dataism, which in turn has managed to provide a solid content material to an
always-evanescent scientific agnosticism.</p>
<p>On many occasions the establishment of correlative observations seems to be
sufficient to infer about the relevance of a certain factor in the development
of some human pathologies. It seems that we are heading towards a path in which
research, instead of being driven by hypotheses confirmed experimentally, in the
near future experimental hypotheses themselves will arise from the observation
of data of previously performed experiments. Are we facing the end of the wet
lab? Is Dataism the end of classical hypothesis-driven research (and the
beginning of data-correlation-driven research)?</p>
<p>Deep learning is based on learning data representations, as opposed to
task-specific algorithms. Learning can be supervised, semi-supervised or
unsupervised. Deep learning models are loosely related to information processing
and communication patterns in a biological nervous system, such as neural coding
that attempts to define a relationship between various stimuli and associated
neuronal responses in the brain. Deep learning architectures such as deep neural
networks, deep belief networks and recurrent neural networks have been applied
to fields including computer vision, audio recognition, speech recognition,
machine translation, natural language processing, social network filtering,
bioinformatics and drug design, where they have produced results comparable to
and in some cases superior to human experts. Will be data-correlation-driven
research the new scientific method for unsupervised deep learning machines<em>?
</em>Will computers became fundamentalists of <em>Dataism</em>?</p>
<p>Best regards,</p>
<p>AJ</p>
<p> </p>
<div>---<br>
<div class="m_-93222048804612654pre" style="margin: 0px; padding: 0px; font-family: monospace;"><span style="color: rgb(0, 0, 0); font-family: arial,helvetica,sans-serif; font-size: 10pt;">Alberto
J. Schuhmacher, PhD.</span><br><span style="color: rgb(0, 0, 0); font-family: arial,helvetica,sans-serif; font-size: 10pt;">Head,
Molecular Oncology Group</span><br><br><span style="color: rgb(0, 0, 0); font-family: arial,helvetica,sans-serif; font-size: 10pt;">Aragon
Health Research Institute (IIS Aragón)</span><br><span style="color: rgb(0, 0, 0); font-family: arial,helvetica,sans-serif; font-size: 10pt;">Biomedical
Research Center of Aragon (CIBA)</span><br><span style="color: rgb(0, 0, 0); font-family: arial,helvetica,sans-serif; font-size: 10pt;">Avda.
Juan Bosco 13, 50009 Zaragoza (Spain)</span><br><span style="color: rgb(0, 0, 0); font-family: arial,helvetica,sans-serif; font-size: 10pt;">email:
<a style="color: rgb(0, 0, 0);" href="mailto:ajimenez@iisaragon.es" target="_blank">ajimenez@iisaragon.es</a></span><br><span style="font-family: arial,helvetica,sans-serif; font-size: 10pt;">Phone:(+34)
637939901</span></div></div>
<p>
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