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<p style="margin-top:0; margin-bottom:0">Hi John, Pedro, and FISers</p>
<p style="margin-top:0; margin-bottom:0"><br>
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<p style="margin-top:0; margin-bottom:0">(<b>1</b>) I agree with John that there must exist a set of the principles, laws or concepts that apply universally, from molecules to cells to human brains to the cosmos. But the millions dollar question is what are
these principles, laws and concepts? <br>
<br>
</p>
<p style="margin-top:0; margin-bottom:0">(<b>2</b>) I disagree that "chemiosmosis" of P. Mitchell is one of the principles underlying life's physiology. I will delineate the reasons for my objecting the concept of chemiosmosis being a fundamental mechanism
of energy transduction in living cells in a later post. I recently discussed this topic in Section 3.3.3 in [1] entitled "Deconstructing the Chemiosmotic Model" </p>
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</p>
<p style="margin-top:0; margin-bottom:0">(<b>3</b>) I disagree that "negentropy", also called "negative entropy", is a fundamental concept in biology or physics. I critiqued this concept in Section 3.3.3 in [2]. To make a long story sort, there are two meanings
to the term "negentropy", one violating the Third Law of thermodynamics and the other not (see
<b>Table 1</b> below).</p>
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<b><span style="font-size:12.0pt;
font-family:"Times New Roman",serif">Table 1.</span></b><span style="font-size:12.0pt;font-family:"Times New Roman",serif"> The dual meanings of the term ¡°negentropy¡±<o:p></o:p></span></p>
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<span style="font-size:12.0pt;font-family:"Times New Roman",serif"><o:p> </o:p></span></p>
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<td width="474" colspan="2" valign="top" style="width:355.25pt;border-top:none;
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<span style="font-size:12.0pt;font-family:"Times New Roman",serif"> Negentropy
<o:p></o:p></span></p>
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<span style="font-size:12.0pt;font-family:"Times New Roman",serif"> Negative Entropy
<o:p></o:p></span></p>
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<span style="font-size:12.0pt;font-family:"Times New Roman",serif"> (<b>-S</b>)<o:p></o:p></span></p>
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<span style="font-size:12.0pt;font-family:"Times New Roman",serif"> Negative Entropy Change
<o:p></o:p></span></p>
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<span style="font-size:12.0pt;font-family:"Times New Roman",serif"> (<b>-
<span style="background: white;">¦¤</span>S</b></span><span style="background: white;">)</span><o:p></o:p></p>
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<span style="font-size:12.0pt;font-family:"Times New Roman",serif">Third Law of thermodynamics<o:p></o:p></span></p>
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<span style="font-size:12.0pt;font-family:"Times New Roman",serif"> is violated<o:p></o:p></span></p>
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<span style="font-size:12.0pt;font-family:"Times New Roman",serif"> is not violated<o:p></o:p></span></p>
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<p style="margin-top:0; margin-bottom:0">(<b>4</b>) The Second Law of thermodynamics when applied to an isolated system (i.e., a system that does not exchange energy nor matter with its environment) states that the entropy of the system increases with time
or that the thermodynamic driving force of an isolated system is the increase in entropy: </p>
<p style="margin-top:0; margin-bottom:0"><span style="font-family: Calibri, Helvetica, sans-serif, EmojiFont, "Apple Color Emoji", "Segoe UI Emoji", NotoColorEmoji, "Segoe UI Symbol", "Android Emoji", EmojiSymbols; font-size: 16px;"><br>
</span></p>
<p style="margin-top:0; margin-bottom:0"><span style="font-family: Calibri, Helvetica, sans-serif, EmojiFont, "Apple Color Emoji", "Segoe UI Emoji", NotoColorEmoji, "Segoe UI Symbol", "Android Emoji", EmojiSymbols; font-size: 16px;"><br>
</span></p>
<p style="margin-top:0; margin-bottom:0"><span style="font-family: Calibri, Helvetica, sans-serif, EmojiFont, "Apple Color Emoji", "Segoe UI Emoji", NotoColorEmoji, "Segoe UI Symbol", "Android Emoji", EmojiSymbols; font-size: 16px;">
¦¤S = S_final - S_initial > 0. (I)</span></p>
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</p>
<p style="margin-top:0; margin-bottom:0"><br>
</p>
<p style="margin-top:0; margin-bottom:0">But many scientists do not realize that Inequality (I) holds only for isolated systems and not for non-isolated systems such as living organisms (which are open systems, i.e., systems that exchange both energy and matter
with their environment) or physical systems, e.g., refrigerators that are closed (i.e., exchange energy but not matter with their environment). </p>
<p style="margin-top:0; margin-bottom:0"><br>
</p>
<p style="margin-top:0; margin-bottom:0">(<b>5</b>) For biological systems under constant pressure (P) and temperature (T), the driving force behind all spontaneous physicochemical changes occurring in them (e.g., respiration, morphogenesis) is a decrease in
Gibbs free energy (<span style="font-family: Calibri, Helvetica, sans-serif, EmojiFont, "Apple Color Emoji", "Segoe UI Emoji", NotoColorEmoji, "Segoe UI Symbol", "Android Emoji", EmojiSymbols; font-size: 16px;">¦¤G)</span> , which is a function of both energy
and entropy:<br>
<br>
<span style="font-family: Calibri, Helvetica, sans-serif, EmojiFont, "Apple Color Emoji", "Segoe UI Emoji", NotoColorEmoji, "Segoe UI Symbol", "Android Emoji", EmojiSymbols; font-size: 16px;">¦¤G = </span><span style="font-family: Calibri, Helvetica, sans-serif, EmojiFont, "Apple Color Emoji", "Segoe UI Emoji", NotoColorEmoji, "Segoe UI Symbol", "Android Emoji", EmojiSymbols; font-size: 16px;">¦¤E
+ P</span><span style="font-family: Calibri, Helvetica, sans-serif, EmojiFont, "Apple Color Emoji", "Segoe UI Emoji", NotoColorEmoji, "Segoe UI Symbol", "Android Emoji", EmojiSymbols; font-size: 16px;">¦¤V - T</span><span style="font-family: Calibri, Helvetica, sans-serif, EmojiFont, "Apple Color Emoji", "Segoe UI Emoji", NotoColorEmoji, "Segoe UI Symbol", "Android Emoji", EmojiSymbols; font-size: 16px;">¦¤S
(II)</span></p>
<p style="margin-top:0; margin-bottom:0"><br>
</p>
<p style="margin-top:0; margin-bottom:0">As you can see here, <span style="font-family: Calibri, Helvetica, sans-serif, EmojiFont, "Apple Color Emoji", "Segoe UI Emoji", NotoColorEmoji, "Segoe UI Symbol", "Android Emoji", EmojiSymbols; font-size: 16px;">¦¤G
can be negative (thus driving all spontaneous living processes) without any negative entropy change (or negentropy), since <span style="font-family: Calibri, Helvetica, sans-serif, EmojiFont, "Apple Color Emoji", "Segoe UI Emoji", NotoColorEmoji, "Segoe UI Symbol", "Android Emoji", EmojiSymbols; font-size: 16px;">¦¤G
<0 as long as (<span style="font-family: Calibri, Helvetica, sans-serif, EmojiFont, "Apple Color Emoji", "Segoe UI Emoji", NotoColorEmoji, "Segoe UI Symbol", "Android Emoji", EmojiSymbols; font-size: 16px;">¦¤E + P</span><span style="font-family: Calibri, Helvetica, sans-serif, EmojiFont, "Apple Color Emoji", "Segoe UI Emoji", NotoColorEmoji, "Segoe UI Symbol", "Android Emoji", EmojiSymbols; font-size: 16px;">¦¤V)
< - T</span><span style="font-family: Calibri, Helvetica, sans-serif, EmojiFont, "Apple Color Emoji", "Segoe UI Emoji", NotoColorEmoji, "Segoe UI Symbol", "Android Emoji", EmojiSymbols; font-size: 16px;">¦¤S, regardless of whether <span style="font-family: Calibri, Helvetica, sans-serif, EmojiFont, "Apple Color Emoji", "Segoe UI Emoji", NotoColorEmoji, "Segoe UI Symbol", "Android Emoji", EmojiSymbols; font-size: 16px;">¦¤S
is negative or positive. This demonstrates that negentropy cannot serve as a fundamental focces for life's physiology.</span> </span></span></span></p>
<p style="margin-top:0; margin-bottom:0"><span style="font-family: Calibri, Helvetica, sans-serif, EmojiFont, "Apple Color Emoji", "Segoe UI Emoji", NotoColorEmoji, "Segoe UI Symbol", "Android Emoji", EmojiSymbols; font-size: 16px;"><span style="font-family: Calibri, Helvetica, sans-serif, EmojiFont, "Apple Color Emoji", "Segoe UI Emoji", NotoColorEmoji, "Segoe UI Symbol", "Android Emoji", EmojiSymbols; font-size: 16px;"><span style="font-family: Calibri, Helvetica, sans-serif, EmojiFont, "Apple Color Emoji", "Segoe UI Emoji", NotoColorEmoji, "Segoe UI Symbol", "Android Emoji", EmojiSymbols; font-size: 16px;"><br>
</span></span></span></p>
<p style="margin-top:0; margin-bottom:0"><span style="font-family: Calibri, Helvetica, sans-serif, EmojiFont, "Apple Color Emoji", "Segoe UI Emoji", NotoColorEmoji, "Segoe UI Symbol", "Android Emoji", EmojiSymbols; font-size: 16px;"><span style="font-family: Calibri, Helvetica, sans-serif, EmojiFont, "Apple Color Emoji", "Segoe UI Emoji", NotoColorEmoji, "Segoe UI Symbol", "Android Emoji", EmojiSymbols; font-size: 16px;"><span style="font-family: Calibri, Helvetica, sans-serif, EmojiFont, "Apple Color Emoji", "Segoe UI Emoji", NotoColorEmoji, "Segoe UI Symbol", "Android Emoji", EmojiSymbols; font-size: 16px;">(6) </span></span></span></p>
<p style="margin-top:0; margin-bottom:0"><br>
</p>
<p style="margin-top:0; margin-bottom:0"><br>
</p>
<p style="margin-top:0; margin-bottom:0"><br>
<br>
</p>
<p style="margin-top:0; margin-bottom:0"><br>
</p>
<p style="margin-top:0; margin-bottom:0"><br>
</p>
<p style="margin-top:0; margin-bottom:0"><br>
</p>
<p style="margin-top:0; margin-bottom:0">References:</p>
<p style="margin-top:0; margin-bottom:0"> [1] Ji, S. (2018). <span style="font-family:Calibri,Helvetica,sans-serif,EmojiFont,"Apple Color Emoji","Segoe UI Emoji",NotoColorEmoji,"Segoe UI Symbol","Android Emoji",EmojiSymbols; font-size:16px">"The Cell Language
Theory: Connecting Mind and Matter", World Scientific Publishing, New Jersey.</span></p>
<p style="margin-top:0; margin-bottom:0"><span style="font-family:Calibri,Helvetica,sans-serif,EmojiFont,"Apple Color Emoji","Segoe UI Emoji",NotoColorEmoji,"Segoe UI Symbol","Android Emoji",EmojiSymbols; font-size:16px"> [2] <span style="color:rgb(51,51,51); font-family:Lato,sans-serif; font-size:16px">Ji,
S. (2012). The Third Law of Thermodynamics and </span><a title="Schroedinger's paradox" href="http://www.conformon.net/?attachment_id=1033" target="_blank" style="background-image:initial">¡°Schroedinger¡¯s Paradox¡±</a><span style="color:rgb(51,51,51); font-family:Lato,sans-serif; font-size:16px">.
In:</span><em style="color:rgb(51,51,51); font-family:Lato,sans-serif; font-size:16px">Molecular Theory of the Living Cell: Concepts, Molecular Mechanisms, and Biomedical Applications.</em><span style="color:rgb(51,51,51); font-family:Lato,sans-serif; font-size:16px"> Springer,
New York. pp. 12-15. PDF at <a href="http://www.conformon.net/wp-content/uploads/2014/03/Schroedinger_paradox.pdf" class="OWAAutoLink" id="LPlnk330629" title="http://www.conformon.net/wp-content/uploads/2014/03/Schroedinger_paradox.pdf
Ctrl+Click or tap to follow the link" previewremoved="true">http://www.conformon.net/wp-content/uploads/2014/03/Schroedinger_paradox.pdf</a></span></span></p>
<p style="margin-top:0; margin-bottom:0"></p>
<div style="color:rgb(0,0,0)">
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<div id="divRplyFwdMsg" dir="ltr"><font face="Calibri, sans-serif" color="#000000" style="font-size:11pt"><b>From:</b> Fis <fis-bounces@listas.unizar.es> on behalf of JOHN TORDAY <jtorday@ucla.edu><br>
<b>Sent:</b> Wednesday, January 24, 2018 9:33 AM<br>
<b>To:</b> fis@listas.unizar.es<br>
<b>Subject:</b> Re: [Fis] Summing up: New Year Lecture</font>
<div> </div>
</div>
<div>
<div dir="ltr">Dear FIS colleagues, Pedro has pointed out some rookie errors in my post. You can find my paper "From cholesterol to consciousness" at <a href="https://na01.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F28830682&data=02%7C01%7Csji%40pharmacy.rutgers.edu%7C9f589c1cbb2849cc703708d563379424%7Cb92d2b234d35447093ff69aca6632ffe%7C1%7C0%7C636524012734836141&sdata=UqJTwNJJ3%2B7mLi8d1co0TQ7V%2FyWFlrk7eRX3w217tSQ%3D&reserved=0" tabindex="-1">https://www.ncbi.nlm.nih.gov/pubmed/28830682</a>.
Hopefully you have access to the paper without having to buy it. If you don't please
<nobr><a class="in-text-unit" href="http://7769domain.com/Ad/GoIEx2/?token=eUdrQTFmaHMwNEgweUZVY0UvNnNXOUozTEpmWlNNcnh1czlxT0xGS2xReW93SkpzNXNvNVZ1UCtsYVZEZy8xNDZsdkJMYWlVN1JlR1hEL29DYzB2blVYVmJITG1jUkRaNjR0N0xMbnd0SDNFQXF1OTlSNFhJQldrVnZGVDRldlY0V0pjRk5CaUc4MjRSWDRGcll5aHFZYm5nWXpxL0NJRlpDbmtvVk9Bb05FPQ2" target="_blank">email</a></nobr>
me at <a href="mailto:jtorday@ucla.edu" tabindex="-1">jtorday@ucla.edu</a> and i will send you a copy. As for addressing consciousness at the cellular/molecular level, I understand that the
<nobr><a class="in-text-unit" href="http://7769domain.com/Ad/GoIEx2/?token=RURoMlVLRFhYRytKQUovU21uTjVyMlExUVA0eEoyK29icGtYMENQa1BIazUxMlJZR2hTY05iVXN6UnB4TEsyZEFweC80T2lLRmxYQThOMGlCVkI1S21RaVdOMUlnMmFVOVZRMGVBTVVoYlRPTXBTVEFxa0RGTGhFcDZCZlZxU2JhcnJaaWJtMFJESWRZYlRWUUFqZGZKc2ZFTWhuZVBKc05BQ1BIbEgxL25LK3Z0M2ZwaFNreTk1clN4aEZveXd20" target="_blank">mental
health</a></nobr> professionals have a problem with consciousness beyond the brain/mind. But I consider that anthropocentric. Just like every other aspect of our physiology, consciousness is the endogenization of environmental factors. In the case of consciousness
it is the vertical integration of calcium fluxes for all of the cells of the organism. All organisms are conscious of their surroundings to one degree or another. And self-reference is, in my opinion, a result of the Singularity/Big Bang, so it would apply
to all organisms, unicellular and multicellular alike. I refer to the experiments of Helmut Plattner, exposing paramecia to
<nobr><a class="in-text-unit" href="http://7769domain.com/Ad/GoIEx2/?token=aFZnQXVjUnYvS3RpaEU5cmFGOTFnSUEwWVZ0TlM2YWZBWlY4eC9raDM5VUlDRmc2VlUwKzExVWJLNXZSbm5SSER4UEh1SWhuUWdVcnJNSGJvbGQ0ejY2RG54RXVxalBacEZGNUFHQXg5M3ZNMWtuSm4xY29iV09nOFhaZWdHQ3AzUXJvc0hSZWoyclFVL0xPbXVNZ2hjVUxnajZSN1lRdTlDeUtYRHRBRnNRPQ2" target="_blank">glucose</a></nobr>.
When the paramecium <nobr><a class="in-text-unit" href="http://7769domain.com/Ad/GoIEx2/?token=SVpHR1pPRjQ5cjMwK1E1b3NhUVdYZWNCcGxiZlJjUGhlbEFPemROVE1xWnNEaHBOZ2xoRURacHc2eitWaEJPOE9XVVNyMlJkN0hRRHJFUEVBM2syeFQvTmdBRmNDWlFzRUlkbkxRajR5Z3ppS0dBR0piZnlYYVpTc2JnZXVseDFVdC9pb2M0dFMxV3BMZWtGcWg5bG9rYXJOWlc3NzBRbGxVRzJ4N25iQW1NPQ2" target="_blank">homes</a></nobr>
in on the <nobr><a class="in-text-unit" href="http://7769domain.com/Ad/GoIEx2/?token=bnR5SFZXc3JvZmh1NkQzQ2tqaFpZa0xpcWh4eTBPUEx2NjRGMzRWNHR2ZkFYU2N2YnRPMzlXc2g1eHFyUWt4TjFZcmFFYkVhaG4yTDFyOGUyNk5PMkFvNGdxYWF4Y1VQa0gwMzFHd25yTm1jV21iemNEejNBVk9RcndQbFZQbUc3OHlCSk9mYmRsZE9DVUhSNkNKZ2lmSWVMSElrWUQxRm9tVUpIcm5GU3YwPQ2" target="_blank">sugar</a></nobr>
its 'nervous system' of calcium flux lights up just like the neurons in our brains. And as to the extrapolation from individual consciousness to cosmology based on the homologies between Quantum Mechanics and Evolutionary Biology, I see that as a means of
fully understanding the significance of consciousness as the connection between the animate and inanimate as one continuous Singularity. It is only in that way that the true nature of Nature can be fully understood. As for smaller increments, the work of Daniel
Fels on electromagnetic communication between cells may hold the answer (<a href="https://na01.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC4793142%2F&data=02%7C01%7Csji%40pharmacy.rutgers.edu%7C9f589c1cbb2849cc703708d563379424%7Cb92d2b234d35447093ff69aca6632ffe%7C1%7C0%7C636524012734836141&sdata=C%2B%2BUtVTSGMTYaJ8WeoWBrei1WZWZMwYFHd2AaqZs918%3D&reserved=0" tabindex="-1">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4793142/</a>).
<div><br>
</div>
<div>Best, John</div>
</div>
<div class="x_gmail_extra"><br>
<div class="x_gmail_quote">On Wed, Jan 24, 2018 at 5:41 AM, Pedro C. Marijuan <span dir="ltr">
<<a href="mailto:pcmarijuan.iacs@aragon.es" target="_blank" tabindex="-1">pcmarijuan.iacs@aragon.es</a>></span> wrote:<br>
<blockquote class="x_gmail_quote" style="margin:0 0 0 .8ex; border-left:1px #ccc solid; padding-left:1ex">
<div bgcolor="#FFFFFF">
<div class="x_m_-3460398545966745048moz-cite-prefix">Dear John and FIS colleagues,<br>
<br>
It was nice <nobr><a class="in-text-unit" href="http://7769domain.com/Ad/GoIEx2/?token=eGhyRTVLT2duUDUzNm9PK1JmbkRFSUpMbk02dURYRUp3OUpIZ2lwcE5id0ZMSXdKbVdScEh6dG5CbEpvb2JoNzdxeExNRDN1RnJKbVBMTXJNQVZhVVBLeHU3QUhmbXNkZ0JWZzQ3eDRaU0pvcnE4b2IxNXZWSmcxVmQveXVUTnRTTFRCOEpNa2dkS2pDb1gxNENCMi9CL2FnUS9nVmk2RFAyY2YyMGl5WTFFPQ2" target="_blank">hearing</a></nobr>
your response. For technical reasons of the server, <u>attachments are unwelcome</u> (and often directly rejected). Send please a web address where interested people can download your document. Also, it is better if you send directly your response to FIS list
(<u><b><a class="x_m_-3460398545966745048moz-txt-link-abbreviated" href="mailto:fis@listas.unizar.es" target="_blank" tabindex="-1">fis@listas.unizar.es</a></b></u>). About your content, I see a couple of problems introducing "consciousness" at the cellular/molecular
level. For this term has a very definite meaning in the <i>ad hoc</i> research that is taken place during last decades. Conflating it with basic cellular processes may not be necessary, given that other terms (more realistic ones?) are available. For instance,
I referred to self-referential cognition. In any case, I agree that classical autopoiesis falls too short of what is needed... Besides, about the cosmological relationship with fundamental physics, is it a convenient step? Does it introduce a premature closure
in the bio-informational thinking process? <br>
<br>
Best--Pedro
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El 22/01/2018 a las 16:02, JOHN TORDAY escribi¨®:<br>
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<div dir="ltr">Dear FISers, I greatly appreciate Pedro's comments regarding my New Year Lecture. I fully agree with his comment "<span style="font-size:12.800000190734863px"> That life's physiology is based on the conjunction of a few principles: neguentropy,
chemiosmosis, and homeostasis-homeorhesis" applies to non-living states too. I did not intend to make that statement exclusive, and if it sounded like that Pedro's clarification is important. In fact have just published a paper entitled "Quantum Mechanics
Predicts Evolutionary Biology" which is predicated on the hypothesis that self-referential self-organization is the result of the Singularity/Big Bang, Newton's Third Law of Thermodynamics that every action has an equal and opposite reaction. That idea would
apply to both evolutionary biology and to balanced chemical reactions alike. As for the question of the emergence of self-referential consciousness 'right at the beginning', I am in favor of that concept, as I have expressed it in a recent paper, entitled
"From Cholesterol to Consciousness" (see attached) so I look forward to reading your comments about that idea as well, since it has the potential to fully integrate physics and biology in my humble opinion. </span></div>
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<div class="x_gmail_quote">On Mon, Jan 22, 2018 at 4:01 AM, Pedro C. Marijuan <span dir="ltr">
<<a href="mailto:pcmarijuan.iacs@aragon.es" target="_blank" tabindex="-1">pcmarijuan.iacs@aragon.es</a>></span> wrote:<br>
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<div class="x_m_-3460398545966745048m_-3976825554907599061moz-cite-prefix">Dear FISers,<br>
<br>
Going to the extreme, I think this year opening lecture can be summarized in three contentious points.
<br>
<br>
1. That life's physiology is based on the conjunction of a few principles: neguentropy, chemiosmosis, and homeostasis-homeorhesis.<br>
<br>
2. That communication (cell signaling) is an essential factor in the multicellular evolution towards complexity.<br>
<br>
3. That epigenetic inheritance and the obligate recursion to the unicellular state become the basis of a new evolutionary theory.<br>
<br>
I disagree with point 1, as I think some nonliving states could also be characterized by those principles (eg, chemical cycles/hypercycles in marine vents, and other outcomes derived from "energy flows"); besides, some previous "info stuff" has to be in place.
Then I completely agree with point 2, for signaling is not just another characteristic of the cell, it is "the" eukaryotic trait par excellence. And I am curious on how point 3 could be further substantiated... In this respect I recommend the two papers that
Bill sent to the list a few weeks ago. Do we need to postulate the emergence of a form of "self-referential cognition" right at the beginning?<br>
Perhaps!<br>
<br>
All the best--Pedro<br>
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El 09/01/2018 a las 19:05, Bill escribi¨®:<br>
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<div class="x_m_-3460398545966745048m_-3976825554907599061moz-cite-prefix">Dear Pedro and Colleagues,
<br>
<br>
I have been following the thread of comments with great interest, all of which have all been occasioned by John Torday's profound insights about the nature of evolutionary development in light of the importance of cell-cell signaling and molecular biology.
From the comments, it is clear that there is a strong impulse to seek a means of integrating the role of symbiogenesis, viruses and mobile elements, multilevel selection, niche construction, genomic plasticity into a common narrative with an informational
perspective at its foundation. <br>
In the spirit of that line of discussion, I am offering two links that discuss evolution as an biologic information management system. Some of this work shares direct commonality with John's, since he and I are frequent collaborators.
<br>
<br>
<a href="https://na01.safelinks.protection.outlook.com/?url=http%3A%2F%2Fwww.mdpi.com%2F2079-7737%2F5%2F2%2F21%2Fhtm&data=02%7C01%7Csji%40pharmacy.rutgers.edu%7C9f589c1cbb2849cc703708d563379424%7Cb92d2b234d35447093ff69aca6632ffe%7C1%7C0%7C636524012734836141&sdata=4XaEIa6E93qyfM0C482FgdhyEXmFmibmGdgNRZQijZU%3D&reserved=0" target="_blank" tabindex="-1">http://www.mdpi.com/2079-7737/<wbr>5/2/21/htm</a><br>
<br>
<a href="https://na01.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.sciencedirect.com%2Fscience%2Farticle%2Fpii%2FS007961071730233X&data=02%7C01%7Csji%40pharmacy.rutgers.edu%7C9f589c1cbb2849cc703708d563379424%7Cb92d2b234d35447093ff69aca6632ffe%7C1%7C0%7C636524012734836141&sdata=jOUTX2%2FY%2BSSBwCmaszbL16mevcaQiKWHQ8f37pvhoto%3D&reserved=0" target="_blank" tabindex="-1">https://www.sciencedirect.com/<wbr>science/article/pii/S007961071<wbr>730233X</a><br>
<br>
Both of these articles can be considered as complementary to Pedro's very fine article, 'How prokaryotes ¡®encode¡¯ their environment: Systemic tools for organizing the information flow', which is in BioSystems.
<br>
<br>
I am grateful to John for inviting me to participate in the forum and to Pedro for encouraging me to share these manuscripts.
<br>
<br>
Best regards, <br>
Bill<br>
<br>
William B. Miller, Jr., M.D.<br>
<a href="tel:%28602%29%20463-5236" value="+16024635236" target="_blank" tabindex="-1">602-463-5236</a><br>
<a class="x_m_-3460398545966745048m_-3976825554907599061moz-txt-link-abbreviated" href="mailto:wbmiller1@cox.net" target="_blank" tabindex="-1">wbmiller1@cox.net</a><span class="x_m_-3460398545966745048HOEnZb"><font color="#888888"><br>
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<pre class="x_m_-3460398545966745048m_-3976825554907599061moz-signature" cols="72">--
------------------------------<wbr>-------------------
Pedro C. Mariju¨¢n
Grupo de Bioinformaci¨®n / Bioinformation Group
Instituto Aragon¨¦s de Ciencias de la Salud
Centro de Investigaci¨®n Biom¨¦dica de Arag¨®n (CIBA)
Avda. San Juan Bosco, 13, planta 0
50009 Zaragoza, Spain
Tfno. <a href="tel:+34%20976%2071%2035%2026" value="+34976713526" target="_blank" tabindex="-1">+34 976 71 3526</a> (& 6818)
<a class="x_m_-3460398545966745048m_-3976825554907599061moz-txt-link-abbreviated" href="mailto:pcmarijuan.iacs@aragon.es" target="_blank" tabindex="-1">pcmarijuan.iacs@aragon.es</a>
<a class="x_m_-3460398545966745048m_-3976825554907599061moz-txt-link-freetext" href="https://na01.safelinks.protection.outlook.com/?url=http%3A%2F%2Fsites.google.com%2Fsite%2Fpedrocmarijuan%2F&data=02%7C01%7Csji%40pharmacy.rutgers.edu%7C9f589c1cbb2849cc703708d563379424%7Cb92d2b234d35447093ff69aca6632ffe%7C1%7C0%7C636524012734836141&sdata=gQVoyK8tvq6K74fp37Tto%2BL665jOWFyHQ2di%2FCndZmk%3D&reserved=0" target="_blank" tabindex="-1">http://sites.google.com/site/p<wbr>edrocmarijuan/</a>
------------------------------<wbr>------------------- </pre>
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______________________________<wbr>_________________ Fis mailing list <a href="mailto:Fis@listas.unizar.es" target="_blank" tabindex="-1">
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<pre class="x_m_-3460398545966745048moz-signature" cols="72">--
------------------------------<wbr>-------------------
Pedro C. Mariju¨¢n
Grupo de Bioinformaci¨®n / Bioinformation Group
Instituto Aragon¨¦s de Ciencias de la Salud
Centro de Investigaci¨®n Biom¨¦dica de Arag¨®n (CIBA)
Avda. San Juan Bosco, 13, planta 0
50009 Zaragoza, Spain
Tfno. <a href="tel:+34%20976%2071%2035%2026" value="+34976713526" target="_blank" tabindex="-1">+34 976 71 3526</a> (& 6818)
<a class="x_m_-3460398545966745048moz-txt-link-abbreviated" href="mailto:pcmarijuan.iacs@aragon.es" target="_blank" tabindex="-1">pcmarijuan.iacs@aragon.es</a>
<a class="x_m_-3460398545966745048moz-txt-link-freetext" href="https://na01.safelinks.protection.outlook.com/?url=http%3A%2F%2Fsites.google.com%2Fsite%2Fpedrocmarijuan%2F&data=02%7C01%7Csji%40pharmacy.rutgers.edu%7C9f589c1cbb2849cc703708d563379424%7Cb92d2b234d35447093ff69aca6632ffe%7C1%7C0%7C636524012734836141&sdata=gQVoyK8tvq6K74fp37Tto%2BL665jOWFyHQ2di%2FCndZmk%3D&reserved=0" target="_blank" tabindex="-1">http://sites.google.com/site/<wbr>pedrocmarijuan/</a>
------------------------------<wbr>------------------- </pre>
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