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<p>-------- Mensaje reenviado --------</p>
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<th align="RIGHT" nowrap="nowrap" valign="BASELINE">Asunto:
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<td>Re: [Fis] Summing up: New Year Lecture</td>
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<th align="RIGHT" nowrap="nowrap" valign="BASELINE">Fecha: </th>
<td>Mon, 22 Jan 2018 07:02:42 -0800</td>
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<th align="RIGHT" nowrap="nowrap" valign="BASELINE">De: </th>
<td>JOHN TORDAY <a class="moz-txt-link-rfc2396E" href="mailto:jtorday@ucla.edu"><jtorday@ucla.edu></a></td>
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<th align="RIGHT" nowrap="nowrap" valign="BASELINE">Para: </th>
<td>Pedro C. Marijuan <a class="moz-txt-link-rfc2396E" href="mailto:pcmarijuan.iacs@aragon.es"><pcmarijuan.iacs@aragon.es></a></td>
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<div dir="ltr">Dear FISers, I greatly appreciate Pedro's comments
regarding my New Year Lecture. I fully agree with his comment " That
life's physiology is based on the conjunction of a few
principles: neguentropy, chemiosmosis, and
homeostasis-homeorhesis" applies to non-living states too. I did
not intend to make that statement exclusive, and if it sounded
like that Pedro's clarification is important. In fact have just
published a paper entitled "Quantum Mechanics Predicts
Evolutionary Biology" which is predicated on the hypothesis that
self-referential self-organization is the result of
the Singularity/Big Bang, Newton's Third Law of Thermodynamics
that every action has an equal and opposite reaction. That idea
would apply to both evolutionary biology and to balanced
chemical reactions alike. As for the question of the emergence
of self-referential consciousness 'right at the beginning', I am
in favor of that concept, as I have expressed it in a recent
paper, entitled "From Cholesterol to Consciousness" (see
attached) so I look forward to reading your comments about that
idea as well, since it has the potential to fully integrate
physics and biology in my humble opinion. <br>
<br>
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<div class="gmail_extra"><br>
<div class="gmail_quote">On Mon, Jan 22, 2018 at 4:01 AM, Pedro
C. Marijuan <span dir="ltr"><<a moz-do-not-send="true"
href="mailto:pcmarijuan.iacs@aragon.es" target="_blank">pcmarijuan.iacs@aragon.es</a>></span>
wrote:<br>
<blockquote class="gmail_quote" style="margin:0 0 0
.8ex;border-left:1px #ccc solid;padding-left:1ex">
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<div class="m_-3976825554907599061moz-cite-prefix">Dear
FISers,<br>
<br>
Going to the extreme, I think this year opening lecture
can be summarized in three contentious points. <br>
<br>
1. That life's physiology is based on the conjunction of
a few principles: neguentropy, chemiosmosis, and
homeostasis-homeorhesis.<br>
<br>
2. That communication (cell signaling) is an essential
factor in the multicellular evolution towards
complexity.<br>
<br>
3. That epigenetic inheritance and the obligate
recursion to the unicellular state become the basis of a
new evolutionary theory.<br>
<br>
I disagree with point 1, as I think some nonliving
states could also be characterized by those principles
(eg, chemical cycles/hypercycles in marine vents, and
other outcomes derived from "energy flows"); besides,
some previous "info stuff" has to be in place. Then I
completely agree with point 2, for signaling is not just
another characteristic of the cell, it is "the"
eukaryotic trait par excellence. And I am curious on
how point 3 could be further substantiated... In this
respect I recommend the two papers that Bill sent to the
list a few weeks ago. Do we need to postulate the
emergence of a form of "self-referential cognition"
right at the beginning?<br>
Perhaps!<br>
<br>
All the best--Pedro<br>
<br>
<br>
<br>
El 09/01/2018 a las 19:05, Bill escribió:<br>
</div>
<blockquote type="cite">
<div class="m_-3976825554907599061moz-cite-prefix">Dear
Pedro and Colleagues, <br>
<br>
I have been following the thread of comments with
great interest, all of which have all been occasioned
by John Torday's profound insights about the nature of
evolutionary development in light of the importance of
cell-cell signaling and molecular biology. From the
comments, it is clear that there is a strong impulse
to seek a means of integrating the role of
symbiogenesis, viruses and mobile elements, multilevel
selection, niche construction, genomic plasticity into
a common narrative with an informational perspective
at its foundation. <br>
In the spirit of that line of discussion, I am
offering two links that discuss evolution as an
biologic information management system. Some of this
work shares direct commonality with John's, since he
and I are frequent collaborators. <br>
<br>
<a moz-do-not-send="true"
href="http://www.mdpi.com/2079-7737/5/2/21/htm"
target="_blank">http://www.mdpi.com/2079-7737/<wbr>5/2/21/htm</a><br>
<br>
<a moz-do-not-send="true"
href="https://www.sciencedirect.com/science/article/pii/S007961071730233X"
target="_blank">https://www.sciencedirect.com/<wbr>science/article/pii/<wbr>S007961071730233X</a><br>
<br>
Both of these articles can be considered as
complementary to Pedro's very fine article, 'How
prokaryotes ‘encode’ their environment: Systemic tools
for organizing the information flow', which is in
BioSystems. <br>
<br>
I am grateful to John for inviting me to participate
in the forum and to Pedro for encouraging me to share
these manuscripts. <br>
<br>
Best regards, <br>
Bill<br>
<br>
William B. Miller, Jr., M.D.<br>
<a moz-do-not-send="true"
href="tel:%28602%29%20463-5236" value="+16024635236"
target="_blank">602-463-5236</a><br>
<a moz-do-not-send="true"
class="m_-3976825554907599061moz-txt-link-abbreviated"
href="mailto:wbmiller1@cox.net" target="_blank">wbmiller1@cox.net</a><span
class="HOEnZb"><font color="#888888"><br>
</font></span></div>
<span class="HOEnZb"><font color="#888888"> </font></span></blockquote>
<span class="HOEnZb"><font color="#888888"> <br>
<pre class="m_-3976825554907599061moz-signature" cols="72">--
------------------------------<wbr>-------------------
Pedro C. Marijuán
Grupo de Bioinformación / Bioinformation Group
Instituto Aragonés de Ciencias de la Salud
Centro de Investigación Biomédica de Aragón (CIBA)
Avda. San Juan Bosco, 13, planta 0
50009 Zaragoza, Spain
Tfno. <a moz-do-not-send="true" href="tel:+34%20976%2071%2035%2026" value="+34976713526" target="_blank">+34 976 71 3526</a> (& 6818)
<a moz-do-not-send="true" class="m_-3976825554907599061moz-txt-link-abbreviated" href="mailto:pcmarijuan.iacs@aragon.es" target="_blank">pcmarijuan.iacs@aragon.es</a>
<a moz-do-not-send="true" class="m_-3976825554907599061moz-txt-link-freetext" href="http://sites.google.com/site/pedrocmarijuan/" target="_blank">http://sites.google.com/site/<wbr>pedrocmarijuan/</a>
------------------------------<wbr>------------------- </pre>
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