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<div class="moz-cite-prefix">Dear FISers,<br>
<br>
Going to the extreme, I think this year opening lecture can be
summarized in three contentious points. <br>
<br>
1. That life's physiology is based on the conjunction of a few
principles: neguentropy, chemiosmosis, and
homeostasis-homeorhesis.<br>
<br>
2. That communication (cell signaling) is an essential factor in
the multicellular evolution towards complexity.<br>
<br>
3. That epigenetic inheritance and the obligate recursion to the
unicellular state become the basis of a new evolutionary theory.<br>
<br>
I disagree with point 1, as I think some nonliving states could
also be characterized by those principles (eg, chemical
cycles/hypercycles in marine vents, and other outcomes derived
from "energy flows"); besides, some previous "info stuff" has to
be in place. Then I completely agree with point 2, for signaling
is not just another characteristic of the cell, it is "the"
eukaryotic trait par excellence. And I am curious on how point 3
could be further substantiated... In this respect I recommend the
two papers that Bill sent to the list a few weeks ago. Do we need
to postulate the emergence of a form of "self-referential
cognition" right at the beginning?<br>
Perhaps!<br>
<br>
All the best--Pedro<br>
<br>
<br>
<br>
El 09/01/2018 a las 19:05, Bill escribió:<br>
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<div class="moz-cite-prefix">Dear Pedro and Colleagues, <br>
<br>
I have been following the thread of comments with great
interest, all of which have all been occasioned by John
Torday's profound insights about the nature of evolutionary
development in light of the importance of cell-cell signaling
and molecular biology. From the comments, it is clear that
there is a strong impulse to seek a means of integrating the
role of symbiogenesis, viruses and mobile elements, multilevel
selection, niche construction, genomic plasticity into a common
narrative with an informational perspective at its foundation. <br>
In the spirit of that line of discussion, I am offering two
links that discuss evolution as an biologic information
management system. Some of this work shares direct commonality
with John's, since he and I are frequent collaborators. <br>
<br>
<a moz-do-not-send="true"
href="http://www.mdpi.com/2079-7737/5/2/21/htm">http://www.mdpi.com/2079-7737/5/2/21/htm</a><br>
<br>
<a moz-do-not-send="true"
href="https://www.sciencedirect.com/science/article/pii/S007961071730233X">https://www.sciencedirect.com/science/article/pii/S007961071730233X</a><br>
<br>
Both of these articles can be considered as complementary to
Pedro's very fine article, 'How prokaryotes ‘encode’ their
environment: Systemic tools for organizing the information
flow', which is in BioSystems. <br>
<br>
I am grateful to John for inviting me to participate in the
forum and to Pedro for encouraging me to share these
manuscripts. <br>
<br>
Best regards, <br>
Bill<br>
<br>
William B. Miller, Jr., M.D.<br>
602-463-5236<br>
<a moz-do-not-send="true" class="moz-txt-link-abbreviated"
href="mailto:wbmiller1@cox.net">wbmiller1@cox.net</a><br>
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<br>
<pre class="moz-signature" cols="72">--
-------------------------------------------------
Pedro C. Marijuán
Grupo de Bioinformación / Bioinformation Group
Instituto Aragonés de Ciencias de la Salud
Centro de Investigación Biomédica de Aragón (CIBA)
Avda. San Juan Bosco, 13, planta 0
50009 Zaragoza, Spain
Tfno. +34 976 71 3526 (& 6818)
<a class="moz-txt-link-abbreviated" href="mailto:pcmarijuan.iacs@aragon.es">pcmarijuan.iacs@aragon.es</a>
<a class="moz-txt-link-freetext" href="http://sites.google.com/site/pedrocmarijuan/">http://sites.google.com/site/pedrocmarijuan/</a>
------------------------------------------------- </pre>
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