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</head><body><p>Dear FiSers, </p><p>gamechanging? Look at here: </p><p><a href="https://www.ncbi.nlm.nih.gov/pubmed/29310692">https://www.ncbi.nlm.nih.gov/pubmed/29310692</a></p><p><br></p><p>Ciao!</p><blockquote type="cite">Il 22 gennaio 2018 alle 13.01 "Pedro C. Marijuan" <pcmarijuan.iacs@aragon.es> ha scritto:<br><br><div class="ox-9f386018b6-moz-cite-prefix">Dear FISers,<br> <br> Going to the extreme, I think this year opening lecture can be summarized in three contentious points. <br> <br> 1. That life's physiology is based on the conjunction of a few principles: neguentropy, chemiosmosis, and homeostasis-homeorhesis.<br> <br> 2. That communication (cell signaling) is an essential factor in the multicellular evolution towards complexity.<br> <br> 3. That epigenetic inheritance and the obligate recursion to the unicellular state become the basis of a new evolutionary theory.<br> <br> I disagree with point 1, as I think some nonliving states could also be characterized by those principles (eg, chemical cycles/hypercycles in marine vents, and other outcomes derived from "energy flows"); besides, some previous "info stuff" has to be in place. Then I completely agree with point 2, for signaling is not just another characteristic of the cell, it is "the" eukaryotic trait par excellence. And I am curious on how point 3 could be further substantiated... In this respect I recommend the two papers that Bill sent to the list a few weeks ago. Do we need to postulate the emergence of a form of "self-referential cognition" right at the beginning?<br> Perhaps!<br> <br> All the best--Pedro<br> <br> <br> <br> El 09/01/2018 a las 19:05, Bill escribió:<br></div><blockquote type="cite"><div class="ox-9f386018b6-moz-cite-prefix">Dear Pedro and Colleagues, <br> <br> I have been following the thread of comments with great interest, all of which have all been occasioned by John Torday's profound insights about the nature of evolutionary development in light of the importance of cell-cell signaling and molecular biology. From the comments, it is clear that there is a strong impulse to seek a means of integrating the role of symbiogenesis, viruses and mobile elements, multilevel selection, niche construction, genomic plasticity into a common narrative with an informational perspective at its foundation. <br> In the spirit of that line of discussion, I am offering two links that discuss evolution as an biologic information management system. Some of this work shares direct commonality with John's, since he and I are frequent collaborators. <br> <br> <a href="http://www.mdpi.com/2079-7737/5/2/21/htm">http://www.mdpi.com/2079-7737/5/2/21/htm</a><br> <br> <a href="https://www.sciencedirect.com/science/article/pii/S007961071730233X">https://www.sciencedirect.com/science/article/pii/S007961071730233X</a><br> <br> Both of these articles can be considered as complementary to Pedro's very fine article, 'How prokaryotes ‘encode’ their environment: Systemic tools for organizing the information flow', which is in BioSystems. <br> <br> I am grateful to John for inviting me to participate in the forum and to Pedro for encouraging me to share these manuscripts. <br> <br> Best regards, <br> Bill<br> <br> William B. Miller, Jr., M.D.<br> 602-463-5236<br> <a class="ox-9f386018b6-moz-txt-link-abbreviated" href="mailto:wbmiller1@cox.net">wbmiller1@cox.net</a><br></div></blockquote><br><pre class="ox-9f386018b6-moz-signature">--
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Pedro C. Marijuán
Grupo de Bioinformación / Bioinformation Group
Instituto Aragonés de Ciencias de la Salud
Centro de Investigación Biomédica de Aragón (CIBA)
Avda. San Juan Bosco, 13, planta 0
50009 Zaragoza, Spain
Tfno. +34 976 71 3526 (& 6818)
<a class="ox-9f386018b6-moz-txt-link-abbreviated" href="mailto:pcmarijuan.iacs@aragon.es">pcmarijuan.iacs@aragon.es</a>
<a class="ox-9f386018b6-moz-txt-link-freetext" href="http://sites.google.com/site/pedrocmarijuan/">http://sites.google.com/site/pedrocmarijuan/</a>
------------------------------------------------- </pre></blockquote><p><br> </p><blockquote type="cite">_______________________________________________<br>Fis mailing list<br>Fis@listas.unizar.es<br>http://listas.unizar.es/cgi-bin/mailman/listinfo/fis<br></blockquote><p><br></p><div class="io-ox-signature"><p class="MsoNormalCxSpFirst" style="text-align: justify; line-height: 115%; margin: 12.0pt 0cm 12.0pt 0cm;"><span style="font-size: 14px;"><span style="font-family: 'courier new', monospace;"><strong>Arturo Tozzi</strong></span></span></p><p class="MsoNormalCxSpFirst" style="text-align: justify; line-height: 115%; margin: 12.0pt 0cm 12.0pt 0cm;"><span style="line-height: 115%;"><span style="font-family: 'courier new', monospace;">AA Professor Physics, University North Texas</span></span></p><p class="MsoNormalCxSpFirst" style="text-align: justify; line-height: 115%; margin: 12.0pt 0cm 12.0pt 0cm;"><span style="font-size: 14px;"><span style="font-family: 'courier new', monospace;">Pediatrician ASL Na2Nord, Italy</span></span></p><p class="MsoNormalCxSpFirst" style="text-align: justify; line-height: 115%; margin: 12.0pt 0cm 12.0pt 0cm;"><span style="font-size: 14px;"><span style="font-family: 'courier new', monospace;">Comput Intell Lab, University Manitoba</span></span></p><p class="MsoNormalCxSpFirst" style="text-align: justify; line-height: 115%; margin: 12.0pt 0cm 12.0pt 0cm;"><span style="font-family: 'courier new', monospace;"><a href="http://arturotozzi.webnode.it/" style="font-size: 14px; color: #05447e;">http://arturotozzi.webnode.it/</a><span style="font-size: 14px;"> </span></span><br></p></div></body></html>