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<div class="moz-cite-prefix">Dear Plamen, Bob, and FIS Colleagues, <br>
<br>
I respond to ideas previously expressed on the connection of
living cells with physics. SOC may be one of the ways, but there
are other instances, eg "constructal law", catastrophe theory,
tensegrity (at least, all of these are well related to
development), and many others... My own bet regarding the
centrality and potential extension of the construct is "molecular
recognition". Elevating beyond heterogeneity, its conflation with
symmetry makes sense on the polymerization and supramolecular
strategies of life. <br>
<br>
Molecular recognition appears as the key element from which the
whole biochemical and evolutionary universe is constructed. Like
any other chemical reaction, recognition between molecules is
based on the “making and breaking of bonds”. This ––and only
this–– is what makes possible the mutual recognition and the
formation of complexes between biomolecular partners. The big
problem with biomolecular recognition instances is that they
involve an amazing variety and combinatorics of almost any type of
chemical interaction: hydrogen bonds, hydrophobic / hydrophilic
forces, dipole forces, van der Waals forces, ionic Coulombian
forces, etc. Dozens or even hundreds of weak bonds participate,
for instance, in the formation of a protein-protein specific
complex. Quite probably, measuring molecular recognition and
establishing its crucial parameters and variables can only be
realized biologically on a case-by-case basis. At least this is
the current trend in most molecular biological and molecular
dynamic approaches. But a few "classic" references have provided
some interesting insights about molecular-recognition
generalities. First, <b>W. Meggs</b> about “biological homing”,
mainly from a Coulombian “lock and key” combinatory point of view;
then <b>Shu-Kun Lin</b> about the changes in thermodynamic
entropy of mixing derived from molecular similarity changes; and
finally <b>M. Carlton</b>, with original proposals for measuring
the information content of any complex molecular system.<br>
<br>
Anyhow, the result of the whole organization of molecular
recognition instances would remind our artificial computers--is it
interesting to connect them "meaningfully" with physics? Yes, the
physics is all around, but it is submerged very deep into the
architectural and functional constraints of the living system. No
royal road, no "camino real" to explain the entirety, a pleiad of
disciplines has to be involved. For cancer, or for biomaterial
engineering, recombination of multiple disciplines becomes the
basic research enterprise of our times. We have to combine the
surfing of many disciplines with the occasional fundamental
insights (from physics, maths, symmetry, information science,
etc.). But neither reductionism, nor wholism, nor phenomenology,
nor perspectivism, nor... are going very far making sense of the
whole social intelligence caught into action (blind spots
included). We made the "artistic" drawing below. <br>
<br>
Enough for today. Greetings to all, and congratulations to Xueshan
for his
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<![endif]--> Magnus Opus! --Pedro
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--.
--Pedro</style><font size="+2"><br>
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align="center"><b><span style="mso-ansi-language:EN-US"
lang="EN-US">Disciplines involved in modern
biomaterial research. The representation is based on the
description made by
bioengineer </span></b><b><span
style="mso-ansi-language:EN-GB" lang="EN-GB">James
Kirkpatrick (2009) and also del Moral et al., (2011).</span></b><span
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<br>
El 02/06/2016 a las 13:20, Pedro C. Marijuan escribió:<br>
</div>
<blockquote
cite="mid:62b05094-2fae-433e-e0dc-cb3ab02a3a84@aragon.es"
type="cite">
<div>
<div><br>
</div>
</div>
<div>
<div class="gmail_extra"><br clear="all">
<div><br>
</div>
<br>
<div class="gmail_quote">On Tue, May 31, 2016 at 6:54 PM,
Robert E. Ulanowicz <span dir="ltr"><<a
moz-do-not-send="true" class="moz-txt-link-abbreviated"
href="mailto:ulan@umces.edu"><a class="moz-txt-link-abbreviated" href="mailto:ulan@umces.edu">ulan@umces.edu</a></a>></span>
wrote:<br>
<blockquote class="gmail_quote" style="margin:0 0 0
.8ex;border-left:1px #ccc solid;padding-left:1ex"><span
class="">> Dear Bob,<br>
><br>
> thank you for your response. What you said in the
core - heterogeneity -<br>
> resonated with the first suggested example I began
this session with: the<br>
> puzzle of registering the heterogeneity of cancer,
both in the<br>
> molecular-biological and histological level, both
in space and time. It<br>
> appears that exactly this elusive property of
matter, liveness, from the<br>
> single cell to entire eco-systems, which implies
intelligence throughout<br>
> all scales (as Brian Ford states) is what we still
cannot in system(s)<br>
> biology put on the feet of statistical mechanics
and classical<br>
> physics.Aren't tumors such intelligent clusters of
heterogeneous cell<br>
> computers interacting within internaly secured
invasive networks that<br>
> escape our medical enigma code breakers placed in
our synthetic drugs and<br>
> radiation devices? Also such undesired life is not
easy to kill. And yet<br>
> cancer cannot win the battle unless our own
internal systems surrender and<br>
> become allies of the invador.</span></blockquote>
</div>
</div>
</div>
</blockquote>
<br>
<pre class="moz-signature" cols="72">--
-------------------------------------------------
Pedro C. Marijuán
Grupo de Bioinformación / Bioinformation Group
Instituto Aragonés de Ciencias de la Salud
Centro de Investigación Biomédica de Aragón (CIBA)
Avda. San Juan Bosco, 13, planta X
50009 Zaragoza, Spain
Tfno. +34 976 71 3526 (& 6818)
<a class="moz-txt-link-abbreviated" href="mailto:pcmarijuan.iacs@aragon.es">pcmarijuan.iacs@aragon.es</a>
<a class="moz-txt-link-freetext" href="http://sites.google.com/site/pedrocmarijuan/">http://sites.google.com/site/pedrocmarijuan/</a>
-------------------------------------------------
</pre>
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