<div dir="ltr"><div><div><div><div><div><div><br></div>Dear Colleagues,<br><br></div>the link to the PDF version of my thesis has changed: <a href="https://dl.dropboxusercontent.com/u/39020576/Towards%20a%203%CF%86%20integrative%20medicine.pdf">https://dl.dropboxusercontent.com/u/39020576/Towards%20a%203%CF%86%20integrative%20medicine.pdf</a><br><br></div>For most browsers also the link to the text version at FIS should be readable with small exceptions:<br><a href="http://listas.unizar.es/pipermail/fis/2016-May/000955.html">http://listas.unizar.es/pipermail/fis/2016-May/000955.html</a>.<br><br></div>It is called "<font size="2"><span style="font-weight:normal"><i>[Fis] _ Towards a 3φ integrative medicine</i>" and began on Saturday, May 14th.<br><br></span></font></div><font size="2"><span style="font-weight:normal">Best wuishes,<br><br></span></font></div><font size="2"><span style="font-weight:normal">Plamen<br><br></span></font><div><div><div><br><div><div class="gmail_extra"><br><div class="gmail_signature"><div dir="ltr"><div><div dir="ltr"><div><div dir="ltr"><div><div dir="ltr"><div><div dir="ltr"><div dir="ltr"><div dir="ltr"><div dir="ltr"><div dir="ltr"><div><br></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div>
<br><div class="gmail_quote">On Sun, May 15, 2016 at 7:03 AM, Dr. Plamen L. Simeonov <span dir="ltr"><<a href="mailto:plamen.l.simeonov@gmail.com" target="_blank">plamen.l.simeonov@gmail.com</a>></span> wrote:<br><blockquote class="gmail_quote" style="margin:0px 0px 0px 0.8ex;border-left:1px solid rgb(204,204,204);padding-left:1ex"><div dir="ltr"><br><div class="gmail_extra">Dear Colleagues,</div><div class="gmail_extra"><br></div><div class="gmail_extra">for those whose email systems do not support special characters like Greek letters (s. first concept explained in note 1), I have placed a PDF version of my opening on the cloud: <a href="https://dl.dropboxusercontent.com/u/39020576/Plamen-Intro.pdf" target="_blank">https://dl.dropboxusercontent.com/u/39020576/Plamen-Intro.pdf</a>.</div><div class="gmail_extra">Please let me know if you register other problems in the communication.</div><div class="gmail_extra"><br></div><div class="gmail_extra">Best,</div><div class="gmail_extra"><br></div><div class="gmail_extra">Plamen</div><div class="gmail_extra"> <br clear="all"><div><div><div dir="ltr"><div><div dir="ltr"><div><div dir="ltr"><div><div dir="ltr"><div><div dir="ltr"><div dir="ltr"><div dir="ltr"><div dir="ltr"><div dir="ltr"><br></div><div dir="ltr"><div><div>____________________________________________________________</div></div><div><br></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div>
<br><div class="gmail_quote">On Sat, May 14, 2016 at 9:49 AM, Dr. Plamen L. Simeonov <span dir="ltr"><<a href="mailto:plamen.l.simeonov@gmail.com" target="_blank">plamen.l.simeonov@gmail.com</a>></span> wrote:<br><blockquote class="gmail_quote" style="margin:0px 0px 0px 0.8ex;border-left:1px solid rgb(204,204,204);padding-left:1ex"><div dir="ltr"><div><span style="font-family:Arial;font-size:10pt">Dear
Colleagues,</span><br></div>
<p class="MsoNormal"><span style="font-size:10pt;font-family:Arial" lang="EN-US"> </span></p>
<p class="MsoNormal" style="text-align:justify"><span style="font-size:10pt;font-family:Arial" lang="EN-US">My contribution will
finalize the discussion on phenomenology in the domains of biology,
mathematics, cyber/biosemiotics and physics by the previous speakers (Maxine,
Lou, Sœren and Alex) with a “challenging topic” in <u>3φ integrative medicine</u>.
<b>You may wish to skip the small font text
notes following each underscored phrase like the one below.</b></span></p>
<p class="MsoNormal" style="text-align:justify"><span style="font-size:10pt;font-family:Arial" lang="EN-US"> </span></p>
<p class="MsoNormal" style="text-align:justify"><u><span style="font-size:8pt;font-family:Arial" lang="EN-US">Note 1:</span></u><span style="font-size:8pt;font-family:Arial" lang="EN-US"> Although this term is often
used as synonym for holistic healing (s. ref. list A), its meaning in this
context with the prefix 3φ goes much “deeper” into the disciplines’ integration
leaving no room for speculations by mainstream scientists. The concept is a
linguistic choice of mine for the intended merge of the complexity sciences <u>ph</u>ysics
and <u>ph</u>ysiology with <u>ph</u>enomenology for application in modern medicine
along the line of integral biomathics (s. ref. list B). </span></p>
<p class="MsoNormal" style="text-align:justify"><span style="font-size:10pt;font-family:Arial" lang="EN-US"> </span></p>
<p class="MsoNormal" style="text-align:justify"><span style="font-size:10pt;font-family:Arial" lang="EN-US">It is rooted in the last presentation
of Alex Hankey, since it naturally provides the link from physics to physiology
and medicine, and thus to an anthropocentric domain implying a leading part of
phenomenological studies. To begin, I compiled a précis of Alex’ thesis about
self-organized criticality (s. ref. list C) from his paper “A New Approach to
Biology and Medicine” -- the download link to it was distributed in a previous
email of him -- and extended it with my reflections including some questions I
hope you will resonate on. </span></p>
<p class="MsoNormal" style="text-align:justify"><br></p>
<p class="MsoNormal" style="text-align:justify"><span style="font-size:10pt;font-family:Arial" lang="EN-US">I am curious of your
opinion about how to apply the scientific method, and in particular mathematics
and information science, to study illness and recovery as complex phenomena. </span></p>
<p class="MsoNormal" style="text-align:justify"><span style="font-size:10pt;font-family:Arial" lang="EN-US"> </span></p>
<p class="MsoNormal" style="text-align:justify"><b><span style="font-size:10pt;font-family:Arial" lang="EN-US">Alex Hankey: self-organized criticality and regulation in
living systems</span></b></p>
<p class="MsoNormal" style="text-align:justify"><span style="font-size:10pt;font-family:Arial" lang="EN-US"> </span></p>
<p class="MsoNormal" style="margin-left:36pt;text-align:justify"><b><span style="font-size:10pt;font-family:Arial" lang="EN-US">There is a continuous growth and change
at the end of a phase transition in an organism, i.e. at its critical point,
which is the end point of phase equilibrium.</span></b></p>
<p class="MsoNormal" style="margin-left:36pt;text-align:justify"><b><span style="font-size:10pt;font-family:Arial" lang="EN-US"> </span></b></p>
<p class="MsoNormal" style="margin-left:36pt;text-align:justify"><b><span style="font-size:10pt;font-family:Arial" lang="EN-US">Both endo and exo, genetics and
epigenetics are important for life.</span></b></p>
<p class="MsoNormal" style="margin-left:36pt;text-align:justify"><b><span style="font-size:10pt;font-family:Arial" lang="EN-US"> </span></b></p>
<p class="MsoNormal" style="margin-left:36pt;text-align:justify"><b><span style="font-size:10pt;font-family:Arial" lang="EN-US">Self-organized criticality</span></b><span style="font-size:10pt;font-family:Arial" lang="EN-US"> is a characteristic
state of a system at its critical point generated by self-organization during a
long transient period at the complexity edge between order/stability/predictability
and disorder/chaos/unpredictability.</span></p>
<p class="MsoNormal" style="text-align:justify"><span style="font-size:10pt;font-family:Arial" lang="EN-US"> </span></p>
<p class="MsoNormal" style="margin-left:36pt;text-align:justify"><b><i><span style="font-size:10pt;font-family:Arial" lang="EN-US">Regulation of growth, form and function as a balance between
health and illness.</span></i></b><span style="font-size:10pt;font-family:Arial" lang="EN-US"> The role of regulation and homeostasis in maintaining the structure
and function of living systems is critical. Every deviation from a regulated
state of being leads to imbalances, failures and subsystem dysfunction that is
usually transitory, but could also become life-threatening, if the organism
cannot find a way to restore quickly to a balanced, healthy state. Living
beings are robust and fault-tolerant with respect to hazards; they possess multiple
alternative pathways for supplying and maintaining their existential functions.
However, some state transitions in response to severe harms can become practically
irreversible, because of the deep evolutionary interlocking between the
participating entities and processes. Sometimes the normal functioning of the organism
cannot be easily restored by its natural repair processes, especially when adversities
reoccur frequently, and the organism fails ill.</span></p>
<p class="MsoNormal" style="text-align:justify"><span style="font-size:10pt;font-family:Arial" lang="EN-US"> </span></p>
<p class="MsoNormal" style="margin-left:36pt;text-align:justify"><b><span style="font-size:10pt;font-family:Arial" lang="EN-US">Synchronicity of action and
information between the building blocks of a living system.</span></b><span style="font-size:10pt;font-family:Arial" lang="EN-US"> There is a need for
every physiological function to be correctly coordinated with all other “peer” functions.
Information flows within a living system interconnect all physiological functions
and organs at multiple levels into a single mesh of regulatory
interconnections. Multiple feedback-control loops enable the cross-functional
interlocking of both healthy and ill state changes of the organism. Adjacent/peripheral/secondary
homeostasis processes act as fine-tuning catalyzers of substrate ratios and
process rates exchanged within the living system. Imbalances of these
quantities lead to excess/blockage or scarcity/draining of essential
nourishment and information exchange pathways.</span></p>
<p class="MsoNormal" style="text-align:justify"><b><span style="font-size:10pt;font-family:Arial" lang="EN-US"> </span></b></p>
<p class="MsoNormal" style="margin-left:36pt;text-align:justify"><b><span style="font-size:10pt;font-family:Arial" lang="EN-US">Regulation at criticality</span></b><span style="font-size:10pt;font-family:Arial" lang="EN-US"> not only fine-tunes a
process, it <i>optimizes</i> it for
survival: with respect to a given generation’s available possibilities in the
light of the past generations’ possibilities. To survive an organism or a
species needs to develop optimal <i>response-ability</i>
to environmental distress.<b></b></span></p>
<p class="MsoNormal" style="text-align:justify"><b><span style="font-size:10pt;font-family:Arial" lang="EN-US"><br></span></b></p><p class="MsoNormal" style="text-align:justify"><b><span style="font-size:10pt;font-family:Arial" lang="EN-US">New ecological definition of life according to Hankey: self-regulating,
self-reproducing systems that maximize efficiency of function to maximize competitiveness
in their chosen environment. </span></b></p>
<p class="MsoNormal" style="text-align:justify"><b><span style="font-size:10pt;font-family:Arial" lang="EN-US"> </span></b></p>
<p class="MsoNormal" style="text-align:justify"><b><span style="font-size:10pt;font-family:Arial" lang="EN-US">Summary: Elements of self-organized criticality</span></b></p>
<p class="MsoNormal" style="text-align:justify"><b><span style="font-size:10pt;font-family:Arial" lang="EN-US"> </span></b></p>
<ol style="margin-top:0cm" start="1" type="1">
<li class="MsoNormal" style="text-align:justify"><span style="font-size:10pt;font-family:Arial" lang="EN-US">Criticality</span></li>
<li class="MsoNormal" style="text-align:justify"><span style="font-size:10pt;font-family:Arial" lang="EN-US">Edge of the chaos</span></li>
<li class="MsoNormal" style="text-align:justify"><span style="font-size:10pt;font-family:Arial" lang="EN-US">Self-organized criticality</span></li>
<li class="MsoNormal" style="text-align:justify"><span style="font-size:10pt;font-family:Arial" lang="EN-US">1/f fractal patterns of response </span></li>
</ol>
<p class="MsoNormal" style="text-align:justify"><span style="font-size:10pt;font-family:Arial" lang="EN-US"> </span></p>
<p class="MsoNormal" style="text-align:justify"><b><span style="font-size:10pt;font-family:Arial" lang="EN-US">… and beyond</span></b><span style="font-size:10pt;font-family:Arial" lang="EN-US"></span></p>
<p class="MsoNormal" style="text-align:justify"><span style="font-size:10pt;font-family:Arial" lang="EN-US"> </span></p>
<p class="MsoNormal" style="text-align:justify"><span style="font-size:10pt;font-family:Arial" lang="EN-US">I wish to add a 5<sup>th</sup>
aspect to this definition from the perspective of integral biomathics:</span></p>
<p class="MsoNormal" style="text-align:justify"><span style="font-size:10pt;font-family:Arial" lang="EN-US"> </span></p>
<ol style="margin-top:0cm" start="5" type="1">
<li class="MsoNormal" style="text-align:justify"><i><span style="font-size:10pt;font-family:Arial" lang="EN-US">Phenomenology</span></i></li>
</ol>
<p class="MsoNormal" style="text-align:justify"><span style="font-size:10pt;font-family:Arial;color:red" lang="EN-US"> </span></p>
<p class="MsoNormal" style="text-align:justify"><span style="font-size:10pt;font-family:Arial" lang="EN-US">The latter is a largely
studied matter in contemporary medicine (s. ref. list D), at least at the
macro, interpersonal <u>level</u>. </span></p>
<p class="MsoNormal" style="text-align:justify"><span style="font-size:10pt;font-family:Arial" lang="EN-US"> </span></p>
<p class="MsoNormal"><u><span style="font-size:8pt;font-family:Arial" lang="EN-US">Note 2</span></u><span style="font-size:8pt;font-family:Arial" lang="EN-US">: </span><span style="font-size:8pt;font-family:Arial;color:black" lang="EN-US">A level refers to the compositional
hierarchy defining levels by scale.</span><span style="font-size:8pt;font-family:Arial" lang="EN-US"></span></p>
<p class="MsoNormal" style="text-align:justify"><span style="font-size:10pt;font-family:Arial" lang="EN-US"> </span></p>
<p class="MsoNormal" style="text-align:justify"><b><span style="font-size:10pt;font-family:Arial" lang="EN-US">The key question in such a “deep holistic” physically-phenomenological
physiology (</span></b><span style="font-size:10pt;font-family:Arial" lang="EN-US">3φ<u>)</u><b> is how to define or
comprehend (self-organized) criticality operationally within the unifying framework
of biomathematics and biocomputation</b>. Indeed, a single temporary imbalance within
a living system regarded as disease involves multiple agents, perspectives and
interpretations at all levels altogether, moreover <u>simultaneously</u>. </span></p>
<p class="MsoNormal" style="text-align:justify"><span style="font-size:10pt;font-family:Arial" lang="EN-US"> </span></p>
<p class="MsoNormal" style="text-align:justify"><u><span style="font-size:8pt;font-family:Arial" lang="EN-US">Note 3</span></u><span style="font-size:8pt;font-family:Arial" lang="EN-US">: </span><span style="font-size:8pt;font-family:Arial;color:black" lang="EN-US">Simultaneously at different levels
involves very different sized 'moments' at the different scales.</span><span style="font-size:8pt;font-family:Arial" lang="EN-US"></span></p>
<p class="MsoNormal" style="text-align:justify"><span style="font-size:10pt;font-family:Arial" lang="EN-US"> </span></p>
<p class="MsoNormal" style="text-align:justify"><span style="font-size:10pt;font-family:Arial" lang="EN-US">So, how should we
approach and take into account the other levels/scales in order to derive a
reliable diagnosis and <u>therapy</u>? </span></p>
<p class="MsoNormal" style="text-align:justify"><span style="font-size:10pt;font-family:Arial" lang="EN-US"> </span></p>
<p class="MsoNormal" style="text-align:justify"><u><span style="font-size:8pt;font-family:Arial" lang="EN-US">Note 4</span></u><span style="font-size:8pt;font-family:Arial" lang="EN-US">: </span><span style="font-size:8pt;font-family:Arial" lang="EN-US">The notion of
“subject” becomes plural (“subjects”) as superposition of quantum states to survive
the integration of the multiple first-person subjective descriptions and the
standard third-person objective one. </span></p>
<p class="MsoNormal" style="text-align:justify"><span style="font-size:10pt;font-family:Arial" lang="EN-US"> </span></p>
<p class="MsoNormal" style="text-align:justify"><span style="font-size:10pt;font-family:Arial" lang="EN-US">Until now criticality has
been <u>non-phenomenological</u>. </span></p>
<p class="MsoNormal" style="text-align:justify"><br></p>
<p style="text-align:justify"><u><span style="font-size:8pt;font-family:Arial" lang="EN-US">Note 5:</span></u><span style="font-size:8pt;font-family:Arial" lang="EN-US"> In their 2012 paper “No
entailing laws, but enablement in the evolution of the biosphere” Longo,
Montévil and Kauffman claim that biological evolution “marks the end of a
physics world view of law entailed dynamics” (<a href="http://arxiv.org/abs/1201.2069" target="_blank">http://arxiv.org/abs/1201.2069</a>). They
argue that the evolutionary phase space or space of possibilities constituted
of interactions between organisms, biological niches and ecosystems is “ever
changing, intrinsically indeterminate and even (mathematically)
unprestatable”.Hence, the authors' claim that it is impossible to know “ahead
of time the 'niches' which constitute the boundary conditions on selection” in
order to formulate laws of motion for evolution. They call this effect “radical
emergence”, from life to life. Yet this applies to abiotic dissipative
structures like tornadoes as well. Living beings are not radically different in
this respect. In their study of biological evolution, Longo and colleagues
carried close comparisons with physics. They investigated the mathematical
constructions of phase spaces and the role of symmetries as invariant
preserving transformations, and introduced the notion of “enablement” to
restrict causal analyses to Batesonian differential cases (1972: “the
difference that makes a difference”). The authors have shown that mutations or
other “causal differences” at the core of evolution enable the establishment of
non-conservation principles, in contrast to physical dynamics, which is largely
based on conservation principles as symmetries. Their new notion of “extended
criticality” also helps to understand the distinctiveness of the living state
of matter when compared to the non-animal one. However, their approach to both
physics and biology is also <i>non-phenomenological</i>.
The possibility for endo states that can trigger the “(genetic/epigenetic)
switches of mutation” has not been examined in their model. This is intended to
be different in 3φ<i> integrative medicine</i>. </span></p>
<p class="MsoNormal" style="text-align:justify"><span style="font-size:10pt;font-family:Arial" lang="EN-US">If we split a human body
into macro (patient), mezzo (systems) and micro levels (cells) three distinct
questions regarding phenomenology arise: i) <i>how</i>
these levels pervade into each other with </span><span style="font-size:10pt;font-family:Arial;color:black" lang="EN-US">larger scale providing context (boundary
conditions) and lowest scale providing raw materials for middle scale to
function,</span><span style="font-size:10pt;font-family:Arial" lang="EN-US"> monitor
and control vital processes, ii) <i>who/which</i>
are the agents taking care for this to happen spontaneously, and iii) <i>what kind and role</i> plays information in
the context of i) and ii). After all w<span style="color:rgb(26,26,26)">hat we are concerned
about is modeling the agency of the systems in the mezzo level.</span> </span></p>
<p class="MsoNormal" style="text-align:justify"><span style="font-size:10pt;font-family:Arial;color:red" lang="EN-US"> </span></p>
<p class="MsoNormal" style="text-align:justify"><span style="font-size:10pt;font-family:Arial" lang="EN-US">Where should we go from
here?</span></p><p class="MsoNormal" style="text-align:justify"><span style="font-size:10pt;font-family:Arial" lang="EN-US"><br></span></p>
<p class="MsoNormal" style="text-align:justify"><span style="font-size:10pt;font-family:Arial" lang="EN-US">In particular, I am
interested to know <b>what kind of <i>scientific-phenomenological methodology</i>
can be developed and applied for investigating </b>the following three major groups
of ailments:</span></p>
<p class="MsoNormal" style="text-align:justify"><span style="font-size:10pt;font-family:Arial" lang="EN-US"> </span></p>
<ol style="margin-top:0cm" start="1" type="1">
<li class="MsoNormal"><b><span style="font-size:10pt;font-family:Arial" lang="EN-US">oncological
diseases</span></b><span style="font-size:10pt;font-family:Arial" lang="EN-US"> with a particular focus on spatial and temporal heterogeneity both
in terms of flawed histological structures and biochemical reactions;</span></li></ol>
<ol style="margin-top:0cm" start="2" type="1">
<li class="MsoNormal"><b><span style="font-size:10pt;font-family:Arial" lang="EN-US">neuro-degenerative
disorders</span></b><span style="font-size:10pt;font-family:Arial" lang="EN-US"> such as vascular dementia, Parkinson and Alzheimer diseases:</span></li></ol>
<ol style="margin-top:0cm" start="3" type="1">
<li class="MsoNormal"><b><span style="font-size:10pt;font-family:Arial" lang="EN-US">altered
organ and physiological system failures</span></b><span style="font-size:10pt;font-family:Arial" lang="EN-US"> such as the Multiple Organ
Dysfunction Syndrome (MODS), cardiovascular and autoimmune diseases.</span></li>
</ol>
<p class="MsoNormal"><span style="font-size:10pt;font-family:Arial;color:red" lang="EN-US"> </span></p>
<p class="MsoNormal" style="text-align:justify"><span style="font-size:10pt;font-family:Arial;color:rgb(26,26,26)" lang="EN-US">In the first
group, the <b>extreme diversity of cancer
tissue structures and circulating tumor cells (CTC) concentrations over both
spatial and temporal scales</b> makes the reliable classification, diagnosis,
model/hypothesis generation, forecast and treatment of individual patients very
difficult. This is a real challenge for modern pathology. Another problem is
that pathologists are actually dealing with random tissue and blood samples
over irregular periods, which hinder the exact 3D histological reconstruction
of the tumor formations and tracing their development over time and space.
Using additional means such as diagnostic sonography, CT, MRT and PET images do
not improve sufficiently the hypotheses about the individual cancer morphology
and development. All this makes tumor classification and diagnosis, even when
analyzing high-resolution digital images from biopsy slices by means of virtual
microscopy, very difficult and often a guesswork also for experts. The recent
advances in high-performance medical scanning and automation systems,
computerized visualization and graphical modeling tools, as well the collection
of huge amounts of anonymous patient data in specialized medical databases make
the impression that the solution of these problems is only a question of more
automation, performance, investment and time. However, many pathologists begin
to realize a third problem, namely that <b>tumors
appear to be <i>unique</i> in their
histological structure and development</b>, related to the personal history and
the overall state of health of the individual patients. This argument reveals
the need for developing a more personalized and differentiated medicine that
goes over scales without becoming purely symptomatic, causality-driven and
reductionistic.</span></p>
<p class="MsoNormal" style="text-align:justify"><span style="font-size:10pt;font-family:Arial" lang="EN-US"> </span></p>
<p class="MsoNormal" style="text-align:justify"><span style="font-size:10pt;font-family:Arial" lang="EN-US">Recent research in the other
two fields leads to the same conclusion. Therefore, I think that we may be able
to develop and test hypotheses about emergence and development of deficiency
and illness that will lead to individual therapies in <i>3φ</i> integrative medicine. Your ideas regarding this assumption are
very welcome. </span></p>
<p class="MsoNormal"><span style="font-size:10pt;font-family:Arial" lang="EN-US"> </span></p>
<p class="MsoNormal" style="text-align:justify"><span style="font-size:10pt;font-family:Arial" lang="EN-US">Some interesting
questions bridging the previous discussion sessions to this one are: </span></p>
<p class="MsoNormal"><span style="font-size:10pt;font-family:Arial" lang="EN-US"> </span></p>
<p class="MsoNormal" style="margin-left:36pt"><span style="font-size:10pt;font-family:Arial" lang="EN-US">-<span style="font-size:7pt;line-height:normal;font-family:"Times New Roman"">
</span></span><span style="font-size:10pt;font-family:Arial" lang="EN-US">Why does a human embryo repeat the evolutionary history of
its species when going through its development stages? Is it because it is more
secure to project and set up the execution of a future life plan by tracing and
bodily memorizing a series of evolutionary encoded (successful) “locks” through
equilibrium states at the edge of criticality? </span></p>
<p class="MsoNormal"><span style="font-size:10pt;font-family:Arial" lang="EN-US"> </span></p>
<p class="MsoNormal" style="margin-left:36pt"><span style="font-size:10pt;font-family:Arial" lang="EN-US">-<span style="font-size:7pt;line-height:normal;font-family:"Times New Roman"">
</span></span><span style="font-size:10pt;font-family:Arial" lang="EN-US">Which is the <i>vital </i>role
of recursion and repetition of life processes including their material and
information exchange flows in the criticality driven self-regulation for
recovery from imbalances and the reversibility and healing of diseases? How can
we effectively model such processes?</span></p>
<p style="margin-left:36pt"><span style="font-size:10pt;font-family:Arial" lang="EN-US">-<span style="font-size:7pt;line-height:normal;font-family:"Times New Roman"">
</span></span><span style="font-size:10pt;font-family:Arial" lang="EN-US">Do we make difference between a
physicist’s time and a biologist’s time in complex living systems?</span></p>
<p class="MsoNormal"><span style="font-size:10pt;font-family:Arial" lang="EN-US"> </span></p>
<p class="MsoNormal"><b><span style="font-size:10pt;font-family:Arial" lang="EN-US"> I look forward to your feedback and notes on the subject.</span></b></p>
<p class="MsoNormal"><b><span style="font-size:10pt;font-family:Arial" lang="EN-US"> </span></b></p>
<p class="MsoNormal"><b><span style="font-size:10pt;font-family:Arial" lang="EN-US">References:</span></b></p>
<p style="margin-left:36pt"><b><span style="font-size:9pt;font-family:Arial" lang="EN-US">A.<span style="font-weight:normal;font-size:7pt;line-height:normal;font-family:"Times New Roman""> </span></span></b><b><u><span style="font-size:9pt;font-family:Arial" lang="EN-US">Integrative Medicine</span></u></b></p>
<p style="margin-left:36pt"><span style="font-size:9pt;font-family:Arial" lang="EN-US">Integrative Medicine: </span><a href="http://www.wikiwand.com/en/Integrative_medicine" style="font-family:Arial;font-size:9pt" target="_blank">https://en.wikipedia.org/wiki/Integrative_medicine</a></p>
<p class="MsoNormal" style="margin-left:36pt"><span style="font-size:9pt;font-family:Arial" lang="EN-US">What Is
Integrative Medicine?:</span></p>
<p class="MsoNormal" style="margin-left:36pt"><span style="font-size:9pt;font-family:Arial" lang="DE"><a href="http://www.webmd.com/a-to-z-guides/features/alternative-medicine-integrative-medicine" target="_blank"><span lang="EN-US">http://www.webmd.com/a-to-z-guides/features/alternative-medicine-integrative-medicine</span></a></span><span style="font-size:9pt;font-family:Arial" lang="EN-US"></span></p>
<p class="MsoNormal" style="margin-left:36pt"><span style="font-size:9pt;font-family:Arial" lang="EN-US"> </span></p>
<p class="MsoNormal" style="margin-left:36pt"><span style="font-size:9pt;font-family:Arial" lang="EN-US">Integrative
Medicine Research:</span></p>
<p class="MsoNormal" style="margin-left:36pt"><cite><span style="font-size:9pt;font-family:Arial;font-style:normal" lang="EN-US"><a href="http://www.journals.elsevier.com/integrative-medicine-research/" target="_blank">http://www.journals.elsevier.com/integrative-medicine-research/</a></span></cite></p>
<p class="MsoNormal" style="margin-left:36pt"><cite><span style="font-size:9pt;font-family:Arial;font-style:normal" lang="EN-US"> </span></cite></p>
<p class="MsoNormal" style="margin-left:36pt"><span style="font-size:9pt;font-family:Arial" lang="EN-US">Advances in Integrative Medicine</span><span style="font-size:9pt;font-family:Arial" lang="EN-US"></span></p>
<p class="MsoNormal" style="margin-left:36pt"><cite><span style="font-size:9pt;font-family:Arial;font-style:normal" lang="EN-US"><a href="http://www.journals.elsevier.com/advances-in-integrative-medicine" target="_blank">http://www.journals.elsevier.com/advances-in-integrative-medicine</a></span></cite></p>
<p class="MsoNormal" style="margin-left:36pt"><cite><span style="font-size:9pt;font-family:Arial;font-style:normal" lang="EN-US"> </span></cite></p>
<p style="margin-left:36pt"><cite><b><span style="font-size:9pt;font-family:Arial;font-style:normal" lang="EN-US">B.<span style="font-weight:normal;font-size:7pt;line-height:normal;font-family:"Times New Roman"">
</span></span></b></cite><cite><b><u><span style="font-size:9pt;font-family:Arial;font-style:normal" lang="EN-US">Integral Biomathics</span></u></b></cite></p>
<p style="margin-left:36pt"><cite><span style="font-size:9pt;font-family:Arial;font-style:normal" lang="EN-US">Integral Biomathics:</span></cite></p>
<p style="margin-left:36pt"><span style="font-size:9pt;font-family:Arial" lang="EN-US"><a href="http://www.wikiwand.com/en/Integral_Biomathics" target="_blank">https://en.wikipedia.org/wiki/Integral_Biomathics</a></span><b><i><span style="font-size:9pt;font-family:Arial" lang="EN-US"> </span></i></b></p>
<p class="MsoNormal" style="margin-left:36pt"><span style="font-size:9pt;font-family:Arial" lang="EN-US">Integral Biomathics: A Post-Newtonian View into the
Logos of Bios </span></p>
<p style="margin-left:36pt"><span style="font-size:9pt;font-family:Arial" lang="EN-US"><a href="https://arxiv.org/ftp/cs/papers/0703/0703002.pdf" target="_blank">https://arxiv.org/ftp/cs/papers/0703/0703002.pdf</a></span></p>
<p style="margin-left:36pt"><span style="font-size:9pt;font-family:Arial" lang="EN-US">On Some Recent Insights in Integral Biomathics:</span></p>
<p style="margin-left:36pt"><span style="font-size:9pt;font-family:Arial" lang="EN-US"><a href="https://arxiv.org/ftp/arxiv/papers/1306/1306.2843.pdf" target="_blank">https://arxiv.org/ftp/arxiv/papers/1306/1306.2843.pdf</a>.</span></p>
<p style="margin-left:36pt"><span style="font-size:9pt;font-family:Arial" lang="EN-US">Integral Biomathics Reloaded: 2015 (free access until
July 19<sup>th</sup> 2016):</span></p>
<p style="margin-left:36pt"><span style="font-size:9pt;font-family:Arial" lang="EN-US"><a href="http://www.sciencedirect.com/science/article/pii/S0079610715001509" target="_blank">http://www.sciencedirect.com/science/article/pii/S0079610715001509</a></span></p>
<p class="MsoNormal" style="text-indent:36pt"><span style="font-size:9pt;font-family:Arial" lang="EN-US"> </span></p>
<p class="MsoNormal" style="margin-left:36pt"><b><span style="font-size:9pt;font-family:Arial" lang="EN-US">C.<span style="font-weight:normal;font-size:7pt;line-height:normal;font-family:"Times New Roman""> </span></span></b><b><u><span style="font-size:9pt;font-family:Arial" lang="EN-US">Self-organized criticality</span></u></b><u><span style="font-size:9pt;font-family:Arial" lang="EN-US">:</span></u></p>
<p class="MsoNormal"><span style="font-size:9pt;font-family:Arial" lang="EN-US"> </span></p>
<p class="MsoNormal" style="margin-left:36pt"><span style="font-size:9pt;font-family:Arial" lang="EN-US">Self-organized criticality:</span></p>
<p class="MsoNormal" style="margin-left:36pt"><span style="font-size:9pt;font-family:Arial" lang="EN-US"><a href="http://www.wikiwand.com/en/Self-organized_criticality" target="_blank">https://en.wikipedia.org/wiki/Self-organized_criticality</a></span></p>
<p class="MsoNormal" style="margin-left:36pt"><span style="font-size:9pt;font-family:Arial" lang="EN-US"> </span></p>
<p class="MsoNormal" style="margin-left:36pt"><span style="font-size:9pt;font-family:Arial" lang="EN-US">Self-organized criticality (SOC):</span></p>
<p class="MsoNormal" style="margin-left:36pt"><span style="font-size:9pt;font-family:Arial" lang="EN-US"><a href="http://www.johnboccio.com/courses/SOC26/15-SOC.pdf" target="_blank">http://www.johnboccio.com/courses/SOC26/15-SOC.pdf</a></span></p>
<p class="MsoNormal" style="margin-left:36pt"><span style="font-size:9pt;font-family:Arial" lang="EN-US"> </span></p>
<p class="MsoNormal" style="margin-left:36pt"><span style="font-size:9pt;font-family:Arial" lang="EN-US">Self-organized criticality:</span></p>
<p class="MsoNormal" style="margin-left:36pt"><span style="font-size:9pt;font-family:Arial" lang="EN-US"><a href="http://web.mit.edu/8.334/www/grades/projects/projects12/V.%20A.%20Golyk.pdf" target="_blank">http://web.mit.edu/8.334/www/grades/projects/projects12/V.%20A.%20Golyk.pdf</a></span></p>
<p class="MsoNormal" style="margin-left:36pt"><span style="font-size:9pt;font-family:Arial" lang="EN-US"> </span></p>
<p class="MsoNormal" style="margin-left:36pt"><span style="font-size:9pt;font-family:Arial" lang="EN-US">Self-organized criticality – what it
is and what it isn’t</span></p>
<p class="MsoNormal" style="margin-left:36pt"><span style="font-size:9pt;font-family:Arial" lang="EN-US"><a href="http://citeseerx.ist.psu.edu/viewdoc/download?doi=10.1.1.96.8017&rep=rep1&type=pdf" target="_blank">http://citeseerx.ist.psu.edu/viewdoc/download?doi=10.1.1.96.8017&rep=rep1&type=pdf</a>.
</span></p>
<p class="MsoNormal"><span style="font-size:9pt;font-family:Arial" lang="EN-US"> </span></p>
<p class="MsoNormal" style="margin-left:36pt"><b><span style="font-size:9pt;font-family:Arial" lang="EN-US">D.<span style="font-weight:normal;font-size:7pt;line-height:normal;font-family:"Times New Roman""> </span></span></b><b><u><span style="font-size:9pt;font-family:Arial" lang="EN-US">Phenomenology in Medicine</span></u></b></p>
<p class="MsoNormal"><span style="font-size:9pt;font-family:Arial" lang="EN-US"> </span></p>
<p class="MsoNormal" style="margin-left:36pt"><span style="font-size:9pt;font-family:Arial;color:rgb(3,37,17)" lang="EN-US">The meaning of illness:
a phenomenological approach to the physician/patient relationship: <a href="https://baylor-ir.tdl.org/baylor-ir/handle/2104/8286" target="_blank">https://baylor-ir.tdl.org/baylor-ir/handle/2104/8286</a>
; </span><span style="font-size:9pt;font-family:Arial;color:rgb(38,38,38)" lang="EN-US"><a href="http://hdl.handle.net/2104/8286" target="_blank">http://hdl.handle.net/2104/8286</a>. </span><span style="font-size:9pt;font-family:Arial;color:rgb(3,37,17)" lang="EN-US"></span></p>
<p class="MsoNormal"><span style="font-size:9pt;font-family:Arial" lang="EN-US"> </span></p>
<p class="MsoNormal" style="margin-left:36pt"><span style="font-size:9pt;font-family:Arial" lang="EN-US">Body Matters: A Phenomenology of
Sickness, Disease, and Illness:</span></p>
<p class="MsoNormal" style="margin-left:36pt"><span style="font-size:9pt;font-family:Arial" lang="EN-US"><a href="http://philpapers.org/rec/AHOBMA" target="_blank">http://philpapers.org/rec/AHOBMA</a>. </span></p>
<p class="MsoNormal" style="margin-left:36pt"><span style="font-size:9pt;font-family:Arial" lang="EN-US"> </span></p>
<p class="MsoNormal" style="margin-left:36pt"><span style="font-size:9pt;font-family:Arial" lang="EN-US">Suffering Transfigured: Phenomenological Personalism In the
Doctor-Patient Relationship: <a href="http://elischolar.library.yale.edu/cgi/viewcontent.cgi?article=1658&context=ymtdl" target="_blank">http://elischolar.library.yale.edu/cgi/viewcontent.cgi?article=1658&context=ymtdl</a>.</span></p>
<p style="margin-left:36pt"><span style="font-size:9pt;font-family:Arial" lang="EN-US">The challenge of
neuroscience: Psychiatry and phenomenology today: </span><span style="font-size:9pt;font-family:Arial" lang="EN-US"><a href="https://www.klinikum.uni-heidelberg.de/fileadmin/zpm/psychatrie/fuchs/Challenge_of_Neuroscience.pdf" target="_blank">https://www.klinikum.uni-heidelberg.de/fileadmin/zpm/psychatrie/fuchs/Challenge_of_Neuroscience.pdf</a>.</span><span style="font-size:9pt;font-family:Arial" lang="EN-US">
</span></p>
<p class="MsoNormal" style="margin-left:36pt"><span style="font-size:9pt;font-family:Arial" lang="EN-US"> </span></p>
<p class="MsoNormal" style="margin-left:36pt"><span style="font-size:9pt;font-family:Arial" lang="EN-US">Rediscovering Psychopathology: The Epistemology and Phenomenology </span><span style="font-family:Arial;font-size:9pt">of the Psychiatric Object:
</span><a href="http://cfs.ku.dk/staff/zahavi-publications/Rediscovering_Psychopathology.pdf" style="font-family:Arial;font-size:9pt" target="_blank">http://cfs.ku.dk/staff/zahavi-publications/Rediscovering_Psychopathology.pdf</a><span style="font-family:Arial;font-size:9pt">.</span></p>
<p style="margin-left:36pt"><span style="font-size:9pt;font-family:Arial" lang="EN-US">PHENOMENOLOGY IN PSYCHIATRY:
<a href="http://www.wpanet.org/uploads/Sections/Philosopy_and_Humanities/Phenomenology-in-Psychiatry.pdf" target="_blank">http://www.wpanet.org/uploads/Sections/Philosopy_and_Humanities/Phenomenology-in-Psychiatry.pdf</a>.
</span></p>
<div><div><div dir="ltr"><div dir="ltr"><div dir="ltr"><div dir="ltr"><div dir="ltr"><div dir="ltr"><div dir="ltr"><div dir="ltr"><div dir="ltr"><b><span style="font-size:10pt;font-family:Arial" lang="EN-US"> </span></b></div><div><font face="Arial"><b>Plamen</b></font></div><div dir="ltr"><div>____________________________________________________________</div><div><span style="font-family:georgia,serif"><a href="http://www.sciencedirect.com/science/journal/00796107/119/3" target="_blank">2015 JPBMB Special Issue on Integral Biomathics: Life Sciences, Mathematics and Phenomenological Philosophy</a> </span></div><div><span style="font-family:georgia,serif">(note: free access to all articles until July 19th, 2016)</span></div><div><span style="font-family:georgia,serif"><br></span></div><div><font face="georgia, serif"><a href="http://www.sciencedirect.com/science/journal/00796107/113/1" target="_blank">2013 JPBMB Special Issue on Integral Biomathics: Can Biology Create a Profoundly New Mathematics and Computation?</a></font></div><div><br></div><div><font face="georgia, serif"><a href="http://www.springer.com/engineering/computational+intelligence+and+complexity/book/978-3-642-28110-5" target="_blank">2012 Integral Biomathics: Tracing the Road to Reality</a></font></div><div><br></div><div><a href="http://www.inbiosa.eu" style="font-family:georgia,serif" target="_blank">2011 INtegral BIOmathics Support Action (INBIOSA)</a> </div><div><div>____________________________________________________________</div></div><div><br></div></div></div></div></div></div></div></div></div></div></div></div>
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