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<p class="MsoNormal"><a name="_MailEndCompose"><span style="font-size:11.0pt;font-family:"Calibri",sans-serif;color:#1F497D;mso-fareast-language:EN-US">Ironically, “semiotic” originally was a medical term referring to signs (symptoms) of disease. John Locke
(my favourite modern philosopher) introduced the term as we use it today, and may have derived it from the Greek
<i>seme</i>. But he also knew a lot about medicine (and just about everything else at the time, but he apparently lacked a sense of humour).<o:p></o:p></span></a></p>
<p class="MsoNormal"><span style="font-size:11.0pt;font-family:"Calibri",sans-serif;color:#1F497D;mso-fareast-language:EN-US"><o:p> </o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt;font-family:"Calibri",sans-serif;color:#1F497D;mso-fareast-language:EN-US">From an online dictionary (the other I found had the first known use in 1880. Which is clearly wrong. So beware!):<o:p></o:p></span></p>
<p class="MsoNormal"><span class="oneclick-link"><span style="font-size:11.5pt;font-family:"Verdana",sans-serif;color:#666666;background:white">1615-20;</span></span><span class="apple-converted-space"><span style="font-size:11.5pt;font-family:"Verdana",sans-serif;color:#666666;background:white"> </span></span><span class="oneclick-link"><span style="font-size:11.5pt;font-family:"Verdana",sans-serif;color:#666666;background:white">(def</span></span><span class="apple-converted-space"><span style="font-size:11.5pt;font-family:"Verdana",sans-serif;color:#666666;background:white"> </span></span><span class="oneclick-link"><span style="font-size:11.5pt;font-family:"Verdana",sans-serif;color:#666666;background:white">3)</span></span><span class="apple-converted-space"><span style="font-size:11.5pt;font-family:"Verdana",sans-serif;color:#666666;background:white"> </span></span><span style="font-size:11.5pt;font-family:"Verdana",sans-serif;color:#666666;background:white"><<span class="apple-converted-space"> </span><span class="oneclick-link">Greek</span><span class="apple-converted-space"> </span><span class="oneclick-link"><i>sēmeiōtikós</i></span><span class="apple-converted-space"><i> </i></span><span class="oneclick-link">significant,</span><span class="apple-converted-space"> </span><span class="oneclick-link">equivalent</span><span class="apple-converted-space"> </span><span class="oneclick-link">to</span><span class="apple-converted-space"> </span><span class="oneclick-link"><i>sēmeiō-,</i>verbid</span><span class="apple-converted-space"> </span><span class="oneclick-link">stem</span><span class="apple-converted-space"> </span><span class="oneclick-link">of</span><span class="apple-converted-space"> </span><span class="oneclick-link"><i>sēmeioûn</i></span><span class="apple-converted-space"><i> </i></span><span class="oneclick-link">to</span><span class="apple-converted-space"> </span><span class="oneclick-link">interpret</span><span class="apple-converted-space"> </span><span class="oneclick-link">as</span><span class="apple-converted-space"> </span><span class="oneclick-link">a</span><span class="apple-converted-space"> </span><span class="oneclick-link">sign</span><span class="apple-converted-space"> </span><span class="oneclick-link">(derivative</span><span class="apple-converted-space"> </span><span class="oneclick-link">of</span><span class="apple-converted-space"> </span><span class="oneclick-link">Greek</span><span class="apple-converted-space"> </span><span class="oneclick-link"><i>sēmeîon</i>sign)</span><span class="apple-converted-space"> </span>+<span class="apple-converted-space"> </span><span class="oneclick-link"><i>-tikos</i></span><span class="apple-converted-space"><i> </i></span></span><a href="http://www.dictionary.com/browse/-tic"><span style="font-size:11.5pt;font-family:"Verdana",sans-serif;color:#307DBC;background:white">-tic</span></a><span style="font-size:11.5pt;font-family:"Verdana",sans-serif;color:#666666;background:white">;<span class="apple-converted-space"> </span><span class="oneclick-link">(def</span><span class="apple-converted-space"> </span><span class="oneclick-link">4)</span><span class="apple-converted-space"> </span><<span class="apple-converted-space"> </span></span><span class="oneclick-link"><span style="font-size:11.5pt;font-family:"Verdana",sans-serif;color:#3D7BBF;background:white">Greek</span></span><span class="apple-converted-space"><span style="font-size:11.5pt;font-family:"Verdana",sans-serif;color:#666666;background:white"> </span></span><span class="oneclick-link"><i><span style="font-size:11.5pt;font-family:"Verdana",sans-serif;color:#666666;background:white">sēmeiōtik</span></i></span><span class="oneclick-link"><i><span style="font-size:11.5pt;font-family:"Calibri",sans-serif;color:#666666;background:white">ḗ</span></i></span><span class="oneclick-link"><i><span style="font-size:11.5pt;font-family:"Verdana",sans-serif;color:#666666;background:white">,</span></i></span><span class="apple-converted-space"><i><span style="font-size:11.5pt;font-family:"Verdana",sans-serif;color:#666666;background:white"> </span></i></span><span class="oneclick-link"><span style="font-size:11.5pt;font-family:"Verdana",sans-serif;color:#666666;background:white">noun</span></span><span class="apple-converted-space"><span style="font-size:11.5pt;font-family:"Verdana",sans-serif;color:#666666;background:white"> </span></span><span class="oneclick-link"><span style="font-size:11.5pt;font-family:"Verdana",sans-serif;color:#666666;background:white">use</span></span><span class="apple-converted-space"><span style="font-size:11.5pt;font-family:"Verdana",sans-serif;color:#666666;background:white"> </span></span><span class="oneclick-link"><span style="font-size:11.5pt;font-family:"Verdana",sans-serif;color:#666666;background:white">of</span></span><span class="apple-converted-space"><span style="font-size:11.5pt;font-family:"Verdana",sans-serif;color:#666666;background:white"> </span></span><span class="oneclick-link"><span style="font-size:11.5pt;font-family:"Verdana",sans-serif;color:#666666;background:white">feminine</span></span><span class="apple-converted-space"><span style="font-size:11.5pt;font-family:"Verdana",sans-serif;color:#666666;background:white"> </span></span><span class="oneclick-link"><span style="font-size:11.5pt;font-family:"Verdana",sans-serif;color:#666666;background:white">of<i>sēmeiōtikós,</i></span></span><span class="apple-converted-space"><i><span style="font-size:11.5pt;font-family:"Verdana",sans-serif;color:#666666;background:white"> </span></i></span><span class="oneclick-link"><span style="font-size:11.5pt;font-family:"Verdana",sans-serif;color:#666666;background:white">adapted</span></span><span class="apple-converted-space"><span style="font-size:11.5pt;font-family:"Verdana",sans-serif;color:#666666;background:white"> </span></span><span class="oneclick-link"><span style="font-size:11.5pt;font-family:"Verdana",sans-serif;color:#666666;background:white">by</span></span><span class="apple-converted-space"><span style="font-size:11.5pt;font-family:"Verdana",sans-serif;color:#666666;background:white"> </span></span><span class="oneclick-link"><span style="font-size:11.5pt;font-family:"Verdana",sans-serif;color:#666666;background:white">John</span></span><span class="apple-converted-space"><span style="font-size:11.5pt;font-family:"Verdana",sans-serif;color:#666666;background:white"> </span></span><span class="oneclick-link"><span style="font-size:11.5pt;font-family:"Verdana",sans-serif;color:#666666;background:white">Locke</span></span><span class="apple-converted-space"><span style="font-size:11.5pt;font-family:"Verdana",sans-serif;color:#666666;background:white"> </span></span><span class="oneclick-link"><span style="font-size:11.5pt;font-family:"Verdana",sans-serif;color:#666666;background:white">(on</span></span><span class="apple-converted-space"><span style="font-size:11.5pt;font-family:"Verdana",sans-serif;color:#666666;background:white"> </span></span><span class="oneclick-link"><span style="font-size:11.5pt;font-family:"Verdana",sans-serif;color:#666666;background:white">the</span></span><span class="apple-converted-space"><span style="font-size:11.5pt;font-family:"Verdana",sans-serif;color:#666666;background:white"> </span></span><span class="oneclick-link"><span style="font-size:11.5pt;font-family:"Verdana",sans-serif;color:#666666;background:white">model</span></span><span class="apple-converted-space"><span style="font-size:11.5pt;font-family:"Verdana",sans-serif;color:#666666;background:white"> </span></span><span class="oneclick-link"><span style="font-size:11.5pt;font-family:"Verdana",sans-serif;color:#666666;background:white">of</span></span><span class="apple-converted-space"><span style="font-size:11.5pt;font-family:"Verdana",sans-serif;color:#666666;background:white"> </span></span><span class="oneclick-link"><span style="font-size:11.5pt;font-family:"Verdana",sans-serif;color:#666666;background:white">Greek</span></span><span class="apple-converted-space"><span style="font-size:11.5pt;font-family:"Verdana",sans-serif;color:#666666;background:white"> </span></span><span class="oneclick-link"><i><span style="font-size:11.5pt;font-family:"Verdana",sans-serif;color:#666666;background:white">logik</span></i></span><span class="oneclick-link"><i><span style="font-size:11.5pt;font-family:"Calibri",sans-serif;color:#666666;background:white">ḗ</span></i></span><span class="apple-converted-space"><i><span style="font-size:11.5pt;font-family:"Verdana",sans-serif;color:#666666;background:white"> </span></i></span><a href="http://www.dictionary.com/browse/logic"><span style="font-size:11.5pt;font-family:"Verdana",sans-serif;color:#307DBC;background:white">logic</span></a><span style="font-size:11.5pt;font-family:"Verdana",sans-serif;color:#666666;background:white">,<span class="oneclick-link">etc.;</span><span class="apple-converted-space"> </span><span class="oneclick-link">see</span><span class="apple-converted-space"> </span></span><a href="http://www.dictionary.com/browse/-ic"><span style="font-size:11.5pt;font-family:"Verdana",sans-serif;color:#307DBC;background:white">-ic</span></a><span class="apple-converted-space"><span style="font-size:11.5pt;font-family:"Verdana",sans-serif;color:#666666;background:white"> </span></span><span style="font-size:11.5pt;font-family:"Verdana",sans-serif;color:#666666;background:white">)<span class="apple-converted-space"> </span><span class="oneclick-link">to</span><span class="apple-converted-space"> </span><span class="oneclick-link">mean</span><span class="apple-converted-space"> </span><span class="oneclick-link">“the</span><span class="apple-converted-space"> </span><span class="oneclick-link">doctrine</span><span class="apple-converted-space"> </span><span class="oneclick-link">of</span><span class="apple-converted-space"> </span><span class="oneclick-link">signs”;</span><span class="apple-converted-space"> </span><span class="oneclick-link">(defs</span><span class="apple-converted-space"> </span><span class="oneclick-link">1,</span><span class="apple-converted-space"> </span><span class="oneclick-link">2)</span><span class="apple-converted-space"> </span><span class="oneclick-link">based</span><span class="apple-converted-space"> </span><span class="oneclick-link">on</span><span class="apple-converted-space"> </span><span class="oneclick-link">Locke'scoinage</span><span class="apple-converted-space"> </span><span class="oneclick-link">or</span><span class="apple-converted-space"> </span><span class="oneclick-link">a</span><span class="apple-converted-space"> </span><span class="oneclick-link">reanalysis</span><span class="apple-converted-space"> </span><span class="oneclick-link">of</span><span class="apple-converted-space"> </span><span class="oneclick-link">the</span><span class="apple-converted-space"> </span><span class="oneclick-link">Gk</span><span class="apple-converted-space"> </span><span class="oneclick-link">word</span></span><span style="font-size:11.0pt;font-family:"Calibri",sans-serif;color:#1F497D;mso-fareast-language:EN-US"><o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt;font-family:"Calibri",sans-serif;color:#1F497D;mso-fareast-language:EN-US"><o:p> </o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt;font-family:"Calibri",sans-serif;color:#1F497D">Also, from a medical dictionary:<o:p></o:p></span></p>
<p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;background:white">
<span style="font-size:18.0pt;font-family:"Arial",sans-serif;color:#404040">semiotic<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:10.0pt;font-family:"Arial",sans-serif;color:#404040;background:white"> /se·mi·ot·ic/ (</span><span style="font-size:10.0pt;font-family:"Arial Unicode MS",sans-serif;color:#404040;background:white">se″me-ot´ik</span><span style="font-size:10.0pt;font-family:"Arial",sans-serif;color:#404040;background:white">)</span><o:p></o:p></p>
<p class="MsoNormal" style="line-height:14.65pt;background:white"><b><span style="font-size:10.0pt;font-family:"Arial",sans-serif;color:#404040">1. </span></b><u><span style="font-size:10.0pt;font-family:"Arial",sans-serif;color:#1D4994">pertaining</span></u><span style="font-size:10.0pt;font-family:"Arial",sans-serif;color:#404040"> to signs or symptoms.<o:p></o:p></span></p>
<p class="MsoNormal" style="line-height:14.65pt;background:white"><b><span style="font-size:10.0pt;font-family:"Arial",sans-serif;color:#404040">2. </span></b><a href="http://medical-dictionary.thefreedictionary.com/pathognomonic"><b><span style="font-size:10.0pt;font-family:"Arial",sans-serif;color:#2484C6">pathognomonic</span></b></a><span style="font-size:10.0pt;font-family:"Arial",sans-serif;color:#404040">.<o:p></o:p></span></p>
<p class="MsoNormal" style="line-height:14.65pt;background:white"><span style="font-family:"Arial",sans-serif;color:#404040">Dorland's Medical Dictionary for Health Consumers. © 2007 by Saunders, an imprint of Elsevier, Inc. All rights reserved.<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt;font-family:"Calibri",sans-serif;color:#1F497D"><o:p> </o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt;font-family:"Calibri",sans-serif;color:#1F497D">For which, if like me, you may further need:<o:p></o:p></span></p>
<p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;background:white">
<span style="font-size:18.0pt;font-family:"Arial",sans-serif;color:#404040">pathognomonic<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:10.0pt;font-family:"Arial",sans-serif;color:#404040;background:white"> [</span><span style="font-size:10.0pt;font-family:"Arial Unicode MS",sans-serif;color:#404040;background:white">path″og-no-mon´ik</span><span style="font-size:10.0pt;font-family:"Arial",sans-serif;color:#404040;background:white">]</span><o:p></o:p></p>
<p class="MsoNormal" style="line-height:14.65pt;background:white"><span style="font-size:10.0pt;font-family:"Arial",sans-serif;color:#404040">specifically </span><u><span style="font-size:10.0pt;font-family:"Arial",sans-serif;color:#1D4994">distinctive</span></u><span style="font-size:10.0pt;font-family:"Arial",sans-serif;color:#404040"> or characteristic of a disease or pathologic condition; denoting a sign or symptom on which adiagnosis can be made.<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt;font-family:"Calibri",sans-serif;color:#1F497D"><o:p> </o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt;font-family:"Calibri",sans-serif;color:#1F497D"><o:p> </o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt;font-family:"Calibri",sans-serif;color:#1F497D">John Collier<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt;font-family:"Calibri",sans-serif;color:#1F497D">Professor Emeritus and Senior Research Associate<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt;font-family:"Calibri",sans-serif;color:#1F497D">University of KwaZulu-Natal<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt;font-family:"Calibri",sans-serif;color:#1F497D">http://web.ncf.ca/collier<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt;font-family:"Calibri",sans-serif;color:#1F497D;mso-fareast-language:EN-US"><o:p> </o:p></span></p>
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<p class="MsoNormal"><b><span lang="EN-US" style="font-size:11.0pt;font-family:"Calibri",sans-serif">From:</span></b><span lang="EN-US" style="font-size:11.0pt;font-family:"Calibri",sans-serif"> Fis [mailto:fis-bounces@listas.unizar.es]
<b>On Behalf Of </b>Stanley N Salthe<br>
<b>Sent:</b> Tuesday, 17 May 2016 4:21 PM<br>
<b>To:</b> Dr. Plamen L. Simeonov <plamen.l.simeonov@gmail.com>; fis <fis@listas.unizar.es><br>
<b>Subject:</b> [Fis] _ Re: _ Re: _ Re: _ Towards a 3φ integrative medicine<o:p></o:p></span></p>
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<p class="MsoNormal"><o:p> </o:p></p>
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<p class="MsoNormal">Plamen, Pedro --<o:p></o:p></p>
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<p class="MsoNormal"><o:p> </o:p></p>
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<p class="MsoNormal">It seems to me that perhaps Medicine should not look to mathematics for support or underpinning so much as to SEMIOTICS (that is, Peircean semiotics, being worked today as biosemiotics). Biosemiotics is, in the verbal conceptual realm,
almost as complex and messy as medicine, and so the two might be matched up fruitfully!<o:p></o:p></p>
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<p class="MsoNormal"><o:p> </o:p></p>
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<p class="MsoNormal">STAN<o:p></o:p></p>
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<p class="MsoNormal"><o:p> </o:p></p>
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<p class="MsoNormal">On Tue, May 17, 2016 at 9:03 AM, Dr. Plamen L. Simeonov <<a href="mailto:plamen.l.simeonov@gmail.com" target="_blank">plamen.l.simeonov@gmail.com</a>> wrote:<o:p></o:p></p>
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<p class="MsoNormal" style="margin-bottom:12.0pt">Daer Pedro,<o:p></o:p></p>
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<p class="MsoNormal">thank you for your entertaining way of presenting my Sisyphus theme about medicine in a nutshell, which was mostly enjoyable to read. Actually, you are right, medicine is "messy", which qualifies it more like a liberal art discipline rather
than science, full of workshop type of hustle and bustle, ad hoc insights of mystic adepts followed by faithful scholars and mixed with cutting edge technology wherever possible (in the Western world). It appears that every effort to organize it in the manner
we know in mathematics and physics is doomed to failure. I realise that the subject's depth reflected in my presentation is indeed overwhelming. Yet, it was not my intention to put a Sisyphus rock upon this forum. Thank you for your and Koichiro's simplified
pedestrian analysis of the theme. We can go with thes rephrased set of questions further.
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<p class="MsoNormal">On Tue, May 17, 2016 at 12:51 PM, Pedro C. Marijuan <<a href="mailto:pcmarijuan.iacs@aragon.es" target="_blank">pcmarijuan.iacs@aragon.es</a>> wrote:<o:p></o:p></p>
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<p class="MsoNormal" style="margin-bottom:12.0pt">Dear Plamen,<br>
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Thanks for the synthetic attempt. You have put together pretty complex strands of thought that become too demanding for a general response. I will concentrate in a few points.<br>
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What is Medicine? In what extent is it amenable to "integration"? Is reductionism an anathema in medicine? Can we regularly ascend from cellular info flows to organs/systems, and to healthy individuals/environments?
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<p class="MsoNormal">These are good general questions, but I'd rather wish to focus on one specific problem, e.g. the one of the metastatic melanoma that Koichiro addressed in his example and try to "dissect" it as in the article in his example. It is clear
to me that I cannot focus on one single thing and brainstorm on it all the time. But the idea behind this concluding workshop was to be less philosophical and more practical in trying to investigate if we can reshape medicine as an extension of biology. After
all, huge amounts of money are given for research here, more than in any other field, as far as I know. Are these investments justifyable in the way this "engineering science" is performing today? Is there anything that could make this discipline more predictable,
at least at the curruculum level?<br>
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<p class="MsoNormal">The history of Medicine shows messiness in the highest degree. To note that it was not included in the Trivium/Quadrivium medieval scheme of knowledge, and was only accepted within the "mechanical arts" after Hugh of St. Victor compilation
(XIII Century), many decades after the first Faculties of Medicine were created in Italy. Why medicine is so messy? Just go the wiki pages on the topic: hundreds of subspecialties are listed, and under all those terms we imply all the internal and external
("natural") phenomena that can derail and put out of track the advancement of a life cycle. Each one of those specialties has to arrange its own world of knowledge, with lots of analytical and synthetic avenues not amenable to neat overall schemes and to formal
approaches except in some reduced pockets. Successful reductionist strategies and analytical techniques are piled up with holistic views, and reams of tacit knowledge (indeed medicine is a very stratified small world of "lords", "masters", "disciples", "servants",
and "beginners").<o:p></o:p></p>
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<p class="MsoNormal">This is all true. But it is also true that medicine has been always very important for us human beings.<br>
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So, like in engineering, one has to be suspicious of far reaching implications for the term "integrative". Not necessarily in this case with the "3φ" connotation.
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<p class="MsoNormal" style="margin-bottom:12.0pt">Indeed, there coud be a "3φ", a "4φ", or a "3φ+ 1<span lang="EN-US" style="font-size:10.0pt;font-family:"Arial",sans-serif">ψ", ... etc. Greek alphabet built polynomial connotations encoded in this prefix.
The question is wether we can use such kind of combination from the known natural science disciplines and extend them by some humanitarian fields in order to address key issues in an organised and diligent manner in medicine. We know well that there are both
serios conflicts between some branches and efforts to reconcile them. The prefix I used was to make clear that we are asking for a novel kind of integration, if possible. Yet this prefix definition should not be considered "fixed" once for ever.
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<p class="MsoNormal">But the strong reliance on criticality could be subject to scrutiny. Quite many cellular / biomolecular phenomena do not especially rely on criticality --perhaps the most essential ones, related to "codes", genomic maintenance, protein
synthesis, protein degradation, signaling, apoptosis, etc. Why the integrative strategy should rely on a term that notwithstanding strong physical grounds, has relatively thin explanatory capability in the biological?
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<p class="MsoNormal">Criticality is a phenomenon that holds both for living and non-living matter. This is something that "matters". Of course, one could take "autopoiesis" instead, which is also a good choice. I am not sure how far we can go with this this
"criticality" bus. I had to start somewhere my talk, and I made this choice to facilitate the transition to medicine. If anyone has a better suggestion, I do not mind.
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<p class="MsoNormal" style="margin-bottom:12.0pt">It is a long story of looking for responses "where the physical/math light is" and not where the biol. problems are.
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<p class="MsoNormal" style="margin-bottom:12.0pt">I agree. This is the real issue. How can ""3φ", "4φ", or "3φ+ 1<span lang="EN-US" style="font-size:10.0pt;font-family:"Arial",sans-serif">ψ +
</span><span style="color:black;background:white">µ</span> <span lang="EN-US" style="font-size:10.0pt;font-family:"Arial",sans-serif">
" help us is the question.</span><o:p></o:p></p>
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<p class="MsoNormal">My view, I can be wrong but I have worked considerably on the matter, is that cellular signaling, the crisscrossing of info flows that provide the singular intelligence and adaptability of organisms, is not well articulated yet. Neither
in evo-devo, nor in physiology, medicine and health. In this regard all the present parlance on information processing that accompanies the tremendous technological info-tech revolution does not represent a help, maybe the opposite.
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<p class="MsoNormal">Unfortunately, you appear to be right. I am also not convinced that Big Data is blessing rather than a curse.<br>
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<p class="MsoNormal">The deep info problems are taken as already solved and articulated synthesis are undertaken as mere agglutinations. Maybe the problem is too deeply complex, and medicine is as always too messy.<o:p></o:p></p>
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<p class="MsoNormal">The question we could try to answer here is: can we do something to disentangle the spaghetti dish of medicine?
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<p class="MsoNormal"><br>
Sorry if seemingly I have joined the "Cassandra" club!<o:p></o:p></p>
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<p class="MsoNormal" style="margin-bottom:12.0pt">I don't think so. Yours are fair concerns.<o:p></o:p></p>
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<p class="MsoNormal" style="margin-bottom:12.0pt">Best,<o:p></o:p></p>
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<p class="MsoNormal" style="margin-bottom:12.0pt">Plamen<o:p></o:p></p>
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<p class="MsoNormal">Best--Pedro<o:p></o:p></p>
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<br>
</span>El 14/05/2016 a las 9:49, Dr. Plamen L. Simeonov escribió:<o:p></o:p></p>
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<p class="MsoNormal"><span style="font-size:10.0pt;font-family:"Arial",sans-serif">Dear Colleagues,</span><o:p></o:p></p>
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<p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto"><span lang="EN-US" style="font-size:10.0pt;font-family:"Arial",sans-serif"> </span><o:p></o:p></p>
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<span lang="EN-US" style="font-size:10.0pt;font-family:"Arial",sans-serif">My contribution will finalize the discussion on phenomenology in the domains of biology, mathematics, cyber/biosemiotics and physics by the previous speakers (Maxine, Lou, Sœren and
Alex) with a “challenging topic” in <u>3φ integrative medicine</u>. <b>You may wish to skip the small font text notes following each underscored phrase like the one below.</b></span><o:p></o:p></p>
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<span lang="EN-US" style="font-size:10.0pt;font-family:"Arial",sans-serif"> </span><o:p></o:p></p>
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<u><span lang="EN-US" style="font-size:8.0pt;font-family:"Arial",sans-serif">Note 1:</span></u><span lang="EN-US" style="font-size:8.0pt;font-family:"Arial",sans-serif"> Although this term is often used as synonym for holistic healing (s. ref. list A), its
meaning in this context with the prefix 3φ goes much “deeper” into the disciplines’ integration leaving no room for speculations by mainstream scientists. The concept is a linguistic choice of mine for the intended merge of the complexity sciences
<u>ph</u>ysics and <u>ph</u>ysiology with <u>ph</u>enomenology for application in modern medicine along the line of integral biomathics (s. ref. list B).
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<span lang="EN-US" style="font-size:10.0pt;font-family:"Arial",sans-serif"> </span><o:p></o:p></p>
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<span lang="EN-US" style="font-size:10.0pt;font-family:"Arial",sans-serif">It is rooted in the last presentation of Alex Hankey, since it naturally provides the link from physics to physiology and medicine, and thus to an anthropocentric domain implying a leading
part of phenomenological studies. To begin, I compiled a précis of Alex’ thesis about self-organized criticality (s. ref. list C) from his paper “A New Approach to Biology and Medicine” -- the download link to it was distributed in a previous email of him
-- and extended it with my reflections including some questions I hope you will resonate on.
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<span lang="EN-US" style="font-size:10.0pt;font-family:"Arial",sans-serif">I am curious of your opinion about how to apply the scientific method, and in particular mathematics and information science, to study illness and recovery as complex phenomena.
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<b><span lang="EN-US" style="font-size:10.0pt;font-family:"Arial",sans-serif">Alex Hankey: self-organized criticality and regulation in living systems</span></b><o:p></o:p></p>
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<span lang="EN-US" style="font-size:10.0pt;font-family:"Arial",sans-serif"> </span><o:p></o:p></p>
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<b><span lang="EN-US" style="font-size:10.0pt;font-family:"Arial",sans-serif">There is a continuous growth and change at the end of a phase transition in an organism, i.e. at its critical point, which is the end point of phase equilibrium.</span></b><o:p></o:p></p>
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<b><span lang="EN-US" style="font-size:10.0pt;font-family:"Arial",sans-serif"> </span></b><o:p></o:p></p>
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<b><span lang="EN-US" style="font-size:10.0pt;font-family:"Arial",sans-serif">Both endo and exo, genetics and epigenetics are important for life.</span></b><o:p></o:p></p>
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<b><span lang="EN-US" style="font-size:10.0pt;font-family:"Arial",sans-serif"> </span></b><o:p></o:p></p>
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<b><span lang="EN-US" style="font-size:10.0pt;font-family:"Arial",sans-serif">Self-organized criticality</span></b><span lang="EN-US" style="font-size:10.0pt;font-family:"Arial",sans-serif"> is a characteristic state of a system at its critical point generated
by self-organization during a long transient period at the complexity edge between order/stability/predictability and disorder/chaos/unpredictability.</span><o:p></o:p></p>
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<span lang="EN-US" style="font-size:10.0pt;font-family:"Arial",sans-serif"> </span><o:p></o:p></p>
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<b><i><span lang="EN-US" style="font-size:10.0pt;font-family:"Arial",sans-serif">Regulation of growth, form and function as a balance between health and illness.</span></i></b><span lang="EN-US" style="font-size:10.0pt;font-family:"Arial",sans-serif"> The role
of regulation and homeostasis in maintaining the structure and function of living systems is critical. Every deviation from a regulated state of being leads to imbalances, failures and subsystem dysfunction that is usually transitory, but could also become
life-threatening, if the organism cannot find a way to restore quickly to a balanced, healthy state. Living beings are robust and fault-tolerant with respect to hazards; they possess multiple alternative pathways for supplying and maintaining their existential
functions. However, some state transitions in response to severe harms can become practically irreversible, because of the deep evolutionary interlocking between the participating entities and processes. Sometimes the normal functioning of the organism cannot
be easily restored by its natural repair processes, especially when adversities reoccur frequently, and the organism fails ill.</span><o:p></o:p></p>
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<span lang="EN-US" style="font-size:10.0pt;font-family:"Arial",sans-serif"> </span><o:p></o:p></p>
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<b><span lang="EN-US" style="font-size:10.0pt;font-family:"Arial",sans-serif">Synchronicity of action and information between the building blocks of a living system.</span></b><span lang="EN-US" style="font-size:10.0pt;font-family:"Arial",sans-serif"> There
is a need for every physiological function to be correctly coordinated with all other “peer” functions. Information flows within a living system interconnect all physiological functions and organs at multiple levels into a single mesh of regulatory interconnections.
Multiple feedback-control loops enable the cross-functional interlocking of both healthy and ill state changes of the organism. Adjacent/peripheral/secondary homeostasis processes act as fine-tuning catalyzers of substrate ratios and process rates exchanged
within the living system. Imbalances of these quantities lead to excess/blockage or scarcity/draining of essential nourishment and information exchange pathways.</span><o:p></o:p></p>
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<b><span lang="EN-US" style="font-size:10.0pt;font-family:"Arial",sans-serif"> </span></b><o:p></o:p></p>
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<b><span lang="EN-US" style="font-size:10.0pt;font-family:"Arial",sans-serif">Regulation at criticality</span></b><span lang="EN-US" style="font-size:10.0pt;font-family:"Arial",sans-serif"> not only fine-tunes a process, it
<i>optimizes</i> it for survival: with respect to a given generation’s available possibilities in the light of the past generations’ possibilities. To survive an organism or a species needs to develop optimal
<i>response-ability</i> to environmental distress.</span><o:p></o:p></p>
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<b><span lang="EN-US" style="font-size:10.0pt;font-family:"Arial",sans-serif">New ecological definition of life according to Hankey: self-regulating, self-reproducing systems that maximize efficiency of function to maximize competitiveness in their chosen environment.
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<b><span lang="EN-US" style="font-size:10.0pt;font-family:"Arial",sans-serif"> </span></b><o:p></o:p></p>
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<b><span lang="EN-US" style="font-size:10.0pt;font-family:"Arial",sans-serif">Summary: Elements of self-organized criticality</span></b><o:p></o:p></p>
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<b><span lang="EN-US" style="font-size:10.0pt;font-family:"Arial",sans-serif"> </span></b><o:p></o:p></p>
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<span lang="EN-US" style="font-size:10.0pt;font-family:"Arial",sans-serif">Criticality</span><o:p></o:p></li><li class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;text-align:justify;mso-list:l0 level1 lfo1">
<span lang="EN-US" style="font-size:10.0pt;font-family:"Arial",sans-serif">Edge of the chaos</span><o:p></o:p></li><li class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;text-align:justify;mso-list:l0 level1 lfo1">
<span lang="EN-US" style="font-size:10.0pt;font-family:"Arial",sans-serif">Self-organized criticality</span><o:p></o:p></li><li class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;text-align:justify;mso-list:l0 level1 lfo1">
<span lang="EN-US" style="font-size:10.0pt;font-family:"Arial",sans-serif">1/f fractal patterns of response
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<b><span lang="EN-US" style="font-size:10.0pt;font-family:"Arial",sans-serif">… and beyond</span></b><o:p></o:p></p>
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<span lang="EN-US" style="font-size:10.0pt;font-family:"Arial",sans-serif"> </span><o:p></o:p></p>
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<span lang="EN-US" style="font-size:10.0pt;font-family:"Arial",sans-serif">I wish to add a 5<sup>th</sup> aspect to this definition from the perspective of integral biomathics:</span><o:p></o:p></p>
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<span lang="EN-US" style="font-size:10.0pt;font-family:"Arial",sans-serif"> </span><o:p></o:p></p>
<ol start="5" type="1">
<li class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;text-align:justify;mso-list:l4 level1 lfo2">
<i><span lang="EN-US" style="font-size:10.0pt;font-family:"Arial",sans-serif">Phenomenology</span></i><o:p></o:p></li></ol>
<p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;text-align:justify">
<span lang="EN-US" style="font-size:10.0pt;font-family:"Arial",sans-serif;color:red"> </span><o:p></o:p></p>
<p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;text-align:justify">
<span lang="EN-US" style="font-size:10.0pt;font-family:"Arial",sans-serif">The latter is a largely studied matter in contemporary medicine (s. ref. list D), at least at the macro, interpersonal
<u>level</u>. </span><o:p></o:p></p>
<p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;text-align:justify">
<span lang="EN-US" style="font-size:10.0pt;font-family:"Arial",sans-serif"> </span><o:p></o:p></p>
<p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto"><u><span lang="EN-US" style="font-size:8.0pt;font-family:"Arial",sans-serif">Note 2</span></u><span lang="EN-US" style="font-size:8.0pt;font-family:"Arial",sans-serif">:
<span style="color:black">A level refers to the compositional hierarchy defining levels by scale.</span></span><o:p></o:p></p>
<p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;text-align:justify">
<span lang="EN-US" style="font-size:10.0pt;font-family:"Arial",sans-serif"> </span><o:p></o:p></p>
<p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;text-align:justify">
<b><span lang="EN-US" style="font-size:10.0pt;font-family:"Arial",sans-serif">The key question in such a “deep holistic” physically-phenomenological physiology (</span></b><span lang="EN-US" style="font-size:10.0pt;font-family:"Arial",sans-serif">3φ<u>)</u><b>
is how to define or comprehend (self-organized) criticality operationally within the unifying framework of biomathematics and biocomputation</b>. Indeed, a single temporary imbalance within a living system regarded as disease involves multiple agents, perspectives
and interpretations at all levels altogether, moreover <u>simultaneously</u>. </span>
<o:p></o:p></p>
<p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;text-align:justify">
<span lang="EN-US" style="font-size:10.0pt;font-family:"Arial",sans-serif"> </span><o:p></o:p></p>
<p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;text-align:justify">
<u><span lang="EN-US" style="font-size:8.0pt;font-family:"Arial",sans-serif">Note 3</span></u><span lang="EN-US" style="font-size:8.0pt;font-family:"Arial",sans-serif">:
<span style="color:black">Simultaneously at different levels involves very different sized 'moments' at the different scales.</span></span><o:p></o:p></p>
<p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;text-align:justify">
<span lang="EN-US" style="font-size:10.0pt;font-family:"Arial",sans-serif"> </span><o:p></o:p></p>
<p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;text-align:justify">
<span lang="EN-US" style="font-size:10.0pt;font-family:"Arial",sans-serif">So, how should we approach and take into account the other levels/scales in order to derive a reliable diagnosis and
<u>therapy</u>? </span><o:p></o:p></p>
<p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;text-align:justify">
<span lang="EN-US" style="font-size:10.0pt;font-family:"Arial",sans-serif"> </span><o:p></o:p></p>
<p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;text-align:justify">
<u><span lang="EN-US" style="font-size:8.0pt;font-family:"Arial",sans-serif">Note 4</span></u><span lang="EN-US" style="font-size:8.0pt;font-family:"Arial",sans-serif">: The notion of “subject” becomes plural (“subjects”) as superposition of quantum states
to survive the integration of the multiple first-person subjective descriptions and the standard third-person objective one.
</span><o:p></o:p></p>
<p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;text-align:justify">
<span lang="EN-US" style="font-size:10.0pt;font-family:"Arial",sans-serif"> </span><o:p></o:p></p>
<p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;text-align:justify">
<span lang="EN-US" style="font-size:10.0pt;font-family:"Arial",sans-serif">Until now criticality has been
<u>non-phenomenological</u>. </span><o:p></o:p></p>
<p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;text-align:justify">
<o:p> </o:p></p>
<p style="text-align:justify"><u><span lang="EN-US" style="font-size:8.0pt;font-family:"Arial",sans-serif">Note 5:</span></u><span lang="EN-US" style="font-size:8.0pt;font-family:"Arial",sans-serif"> In their 2012 paper “No entailing laws, but enablement in
the evolution of the biosphere” Longo, Montévil and Kauffman claim that biological evolution “marks the end of a physics world view of law entailed dynamics” (<a href="http://arxiv.org/abs/1201.2069" target="_blank">http://arxiv.org/abs/1201.2069</a>). They
argue that the evolutionary phase space or space of possibilities constituted of interactions between organisms, biological niches and ecosystems is “ever changing, intrinsically indeterminate and even (mathematically) unprestatable”.Hence, the authors' claim
that it is impossible to know “ahead of time the 'niches' which constitute the boundary conditions on selection” in order to formulate laws of motion for evolution. They call this effect “radical emergence”, from life to life. Yet this applies to abiotic dissipative
structures like tornadoes as well. Living beings are not radically different in this respect. In their study of biological evolution, Longo and colleagues carried close comparisons with physics. They investigated the mathematical constructions of phase spaces
and the role of symmetries as invariant preserving transformations, and introduced the notion of “enablement” to restrict causal analyses to Batesonian differential cases (1972: “the difference that makes a difference”). The authors have shown that mutations
or other “causal differences” at the core of evolution enable the establishment of non-conservation principles, in contrast to physical dynamics, which is largely based on conservation principles as symmetries. Their new notion of “extended criticality” also
helps to understand the distinctiveness of the living state of matter when compared to the non-animal one. However, their approach to both physics and biology is also
<i>non-phenomenological</i>. The possibility for endo states that can trigger the “(genetic/epigenetic) switches of mutation” has not been examined in their model. This is intended to be different in 3φ<i> integrative medicine</i>. </span><o:p></o:p></p>
<p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;text-align:justify">
<span lang="EN-US" style="font-size:10.0pt;font-family:"Arial",sans-serif">If we split a human body into macro (patient), mezzo (systems) and micro levels (cells) three distinct questions regarding phenomenology arise: i)
<i>how</i> these levels pervade into each other with <span style="color:black">larger scale providing context (boundary conditions) and lowest scale providing raw materials for middle scale to function,</span> monitor and control vital processes, ii)
<i>who/which</i> are the agents taking care for this to happen spontaneously, and iii)
<i>what kind and role</i> plays information in the context of i) and ii). After all w<span style="color:#1A1A1A">hat we are concerned about is modeling the agency of the systems in the mezzo level.</span>
</span><o:p></o:p></p>
<p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;text-align:justify">
<span lang="EN-US" style="font-size:10.0pt;font-family:"Arial",sans-serif;color:red"> </span><o:p></o:p></p>
<p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;text-align:justify">
<span lang="EN-US" style="font-size:10.0pt;font-family:"Arial",sans-serif">Where should we go from here?</span><o:p></o:p></p>
<p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;text-align:justify">
<o:p> </o:p></p>
<p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;text-align:justify">
<span lang="EN-US" style="font-size:10.0pt;font-family:"Arial",sans-serif">In particular, I am interested to know
<b>what kind of <i>scientific-phenomenological methodology</i> can be developed and applied for investigating
</b>the following three major groups of ailments:</span><o:p></o:p></p>
<p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;text-align:justify">
<span lang="EN-US" style="font-size:10.0pt;font-family:"Arial",sans-serif"> </span><o:p></o:p></p>
<ol start="1" type="1">
<li class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;mso-list:l1 level1 lfo3">
<b><span lang="EN-US" style="font-size:10.0pt;font-family:"Arial",sans-serif">oncological diseases</span></b><span lang="EN-US" style="font-size:10.0pt;font-family:"Arial",sans-serif"> with a particular focus on spatial and temporal heterogeneity both in terms
of flawed histological structures and biochemical reactions;</span><o:p></o:p></li></ol>
<ol start="2" type="1">
<li class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;mso-list:l2 level1 lfo4">
<b><span lang="EN-US" style="font-size:10.0pt;font-family:"Arial",sans-serif">neuro-degenerative disorders</span></b><span lang="EN-US" style="font-size:10.0pt;font-family:"Arial",sans-serif"> such as vascular dementia, Parkinson and Alzheimer diseases:</span><o:p></o:p></li></ol>
<ol start="3" type="1">
<li class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;mso-list:l3 level1 lfo5">
<b><span lang="EN-US" style="font-size:10.0pt;font-family:"Arial",sans-serif">altered organ and physiological system failures</span></b><span lang="EN-US" style="font-size:10.0pt;font-family:"Arial",sans-serif"> such as the Multiple Organ Dysfunction Syndrome
(MODS), cardiovascular and autoimmune diseases.</span><o:p></o:p></li></ol>
<p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto"><span lang="EN-US" style="font-size:10.0pt;font-family:"Arial",sans-serif;color:red"> </span><o:p></o:p></p>
<p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;text-align:justify">
<span lang="EN-US" style="font-size:10.0pt;font-family:"Arial",sans-serif;color:#1A1A1A">In the first group, the
<b>extreme diversity of cancer tissue structures and circulating tumor cells (CTC) concentrations over both spatial and temporal scales</b> makes the reliable classification, diagnosis, model/hypothesis generation, forecast and treatment of individual patients
very difficult. This is a real challenge for modern pathology. Another problem is that pathologists are actually dealing with random tissue and blood samples over irregular periods, which hinder the exact 3D histological reconstruction of the tumor formations
and tracing their development over time and space. Using additional means such as diagnostic sonography, CT, MRT and PET images do not improve sufficiently the hypotheses about the individual cancer morphology and development. All this makes tumor classification
and diagnosis, even when analyzing high-resolution digital images from biopsy slices by means of virtual microscopy, very difficult and often a guesswork also for experts. The recent advances in high-performance medical scanning and automation systems, computerized
visualization and graphical modeling tools, as well the collection of huge amounts of anonymous patient data in specialized medical databases make the impression that the solution of these problems is only a question of more automation, performance, investment
and time. However, many pathologists begin to realize a third problem, namely that
<b>tumors appear to be <i>unique</i> in their histological structure and development</b>, related to the personal history and the overall state of health of the individual patients. This argument reveals the need for developing a more personalized and differentiated
medicine that goes over scales without becoming purely symptomatic, causality-driven and reductionistic.</span><o:p></o:p></p>
<p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;text-align:justify">
<span lang="EN-US" style="font-size:10.0pt;font-family:"Arial",sans-serif"> </span><o:p></o:p></p>
<p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;text-align:justify">
<span lang="EN-US" style="font-size:10.0pt;font-family:"Arial",sans-serif">Recent research in the other two fields leads to the same conclusion. Therefore, I think that we may be able to develop and test hypotheses about emergence and development of deficiency
and illness that will lead to individual therapies in <i>3φ</i> integrative medicine. Your ideas regarding this assumption are very welcome.
</span><o:p></o:p></p>
<p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto"><span lang="EN-US" style="font-size:10.0pt;font-family:"Arial",sans-serif"> </span><o:p></o:p></p>
<p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;text-align:justify">
<span lang="EN-US" style="font-size:10.0pt;font-family:"Arial",sans-serif">Some interesting questions bridging the previous discussion sessions to this one are:
</span><o:p></o:p></p>
<p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto"><span lang="EN-US" style="font-size:10.0pt;font-family:"Arial",sans-serif"> </span><o:p></o:p></p>
<p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;margin-left:36.0pt">
<span lang="EN-US" style="font-size:10.0pt;font-family:"Arial",sans-serif">- Why does a human embryo repeat the evolutionary history of its species when going through its development stages? Is it because it is more secure to project and set up the execution
of a future life plan by tracing and bodily memorizing a series of evolutionary encoded (successful) “locks” through equilibrium states at the edge of criticality?
</span><o:p></o:p></p>
<p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto"><span lang="EN-US" style="font-size:10.0pt;font-family:"Arial",sans-serif"> </span><o:p></o:p></p>
<p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;margin-left:36.0pt">
<span lang="EN-US" style="font-size:10.0pt;font-family:"Arial",sans-serif">- Which is the
<i>vital </i>role of recursion and repetition of life processes including their material and information exchange flows in the criticality driven self-regulation for recovery from imbalances and the reversibility and healing of diseases? How can we effectively
model such processes?</span><o:p></o:p></p>
<p style="margin-left:36.0pt"><span lang="EN-US" style="font-size:10.0pt;font-family:"Arial",sans-serif">- Do we make difference between a physicist’s time and a biologist’s time in complex living systems?</span><o:p></o:p></p>
<p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto"><span lang="EN-US" style="font-size:10.0pt;font-family:"Arial",sans-serif"> </span><o:p></o:p></p>
<p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto"><b><span lang="EN-US" style="font-size:10.0pt;font-family:"Arial",sans-serif"> I look forward to your feedback and notes on the subject.</span></b><o:p></o:p></p>
<p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto"><b><span lang="EN-US" style="font-size:10.0pt;font-family:"Arial",sans-serif"> </span></b><o:p></o:p></p>
<p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto"><b><span lang="EN-US" style="font-size:10.0pt;font-family:"Arial",sans-serif">References:</span></b><o:p></o:p></p>
<p style="margin-left:36.0pt"><b><span lang="EN-US" style="font-size:9.0pt;font-family:"Arial",sans-serif">A.
<u>Integrative Medicine</u></span></b><o:p></o:p></p>
<p style="margin-left:36.0pt"><span lang="EN-US" style="font-size:9.0pt;font-family:"Arial",sans-serif">Integrative Medicine: </span><a href="http://www.wikiwand.com/en/Integrative_medicine" target="_blank"><span style="font-size:9.0pt;font-family:"Arial",sans-serif">https://en.wikipedia.org/wiki/Integrative_medicine</span></a><o:p></o:p></p>
<p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;margin-left:36.0pt">
<span lang="EN-US" style="font-size:9.0pt;font-family:"Arial",sans-serif">What Is Integrative Medicine?:</span><o:p></o:p></p>
<p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;margin-left:36.0pt">
<span lang="DE" style="font-size:9.0pt;font-family:"Arial",sans-serif"><a href="http://www.webmd.com/a-to-z-guides/features/alternative-medicine-integrative-medicine" target="_blank">http://www.webmd.com/a-to-z-guides/features/alternative-medicine-integrative-medicine</a></span><o:p></o:p></p>
<p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;margin-left:36.0pt">
<span lang="EN-US" style="font-size:9.0pt;font-family:"Arial",sans-serif"> </span><o:p></o:p></p>
<p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;margin-left:36.0pt">
<span lang="EN-US" style="font-size:9.0pt;font-family:"Arial",sans-serif">Integrative Medicine Research:</span><o:p></o:p></p>
<p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;margin-left:36.0pt">
<cite><span lang="EN-US" style="font-size:9.0pt;font-family:"Arial",sans-serif;font-style:normal"><a href="http://www.journals.elsevier.com/integrative-medicine-research/" target="_blank">http://www.journals.elsevier.com/integrative-medicine-research/</a></span></cite><o:p></o:p></p>
<p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;margin-left:36.0pt">
<cite><span lang="EN-US" style="font-size:9.0pt;font-family:"Arial",sans-serif;font-style:normal"> </span></cite><o:p></o:p></p>
<p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;margin-left:36.0pt">
<span lang="EN-US" style="font-size:9.0pt;font-family:"Arial",sans-serif">Advances in Integrative Medicine</span><o:p></o:p></p>
<p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;margin-left:36.0pt">
<cite><span lang="EN-US" style="font-size:9.0pt;font-family:"Arial",sans-serif;font-style:normal"><a href="http://www.journals.elsevier.com/advances-in-integrative-medicine" target="_blank">http://www.journals.elsevier.com/advances-in-integrative-medicine</a></span></cite><o:p></o:p></p>
<p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;margin-left:36.0pt">
<cite><span lang="EN-US" style="font-size:9.0pt;font-family:"Arial",sans-serif;font-style:normal"> </span></cite><o:p></o:p></p>
<p style="margin-left:36.0pt"><cite><b><span lang="EN-US" style="font-size:9.0pt;font-family:"Arial",sans-serif;font-style:normal">B.
<u>Integral Biomathics</u></span></b></cite><o:p></o:p></p>
<p style="margin-left:36.0pt"><cite><span lang="EN-US" style="font-size:9.0pt;font-family:"Arial",sans-serif;font-style:normal">Integral Biomathics:</span></cite><o:p></o:p></p>
<p style="margin-left:36.0pt"><span lang="EN-US" style="font-size:9.0pt;font-family:"Arial",sans-serif"><a href="https://en.wikipedia.org/wiki/Integral_Biomathics" target="_blank">https://en.wikipedia.org/wiki/Integral_Biomathics</a><b><i> </i></b></span><o:p></o:p></p>
<p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;margin-left:36.0pt">
<span lang="EN-US" style="font-size:9.0pt;font-family:"Arial",sans-serif">Integral Biomathics: A Post-Newtonian View into the Logos of Bios
</span><o:p></o:p></p>
<p style="margin-left:36.0pt"><span lang="EN-US" style="font-size:9.0pt;font-family:"Arial",sans-serif"><a href="https://arxiv.org/ftp/cs/papers/0703/0703002.pdf" target="_blank">https://arxiv.org/ftp/cs/papers/0703/0703002.pdf</a></span><o:p></o:p></p>
<p style="margin-left:36.0pt"><span lang="EN-US" style="font-size:9.0pt;font-family:"Arial",sans-serif">On Some Recent Insights in Integral Biomathics:</span><o:p></o:p></p>
<p style="margin-left:36.0pt"><span lang="EN-US" style="font-size:9.0pt;font-family:"Arial",sans-serif"><a href="https://arxiv.org/ftp/arxiv/papers/1306/1306.2843.pdf" target="_blank">https://arxiv.org/ftp/arxiv/papers/1306/1306.2843.pdf</a>.</span><o:p></o:p></p>
<p style="margin-left:36.0pt"><span lang="EN-US" style="font-size:9.0pt;font-family:"Arial",sans-serif">Integral Biomathics Reloaded: 2015 (free access until July 19<sup>th</sup> 2016):</span><o:p></o:p></p>
<p style="margin-left:36.0pt"><span lang="EN-US" style="font-size:9.0pt;font-family:"Arial",sans-serif"><a href="http://www.sciencedirect.com/science/article/pii/S0079610715001509" target="_blank">http://www.sciencedirect.com/science/article/pii/S0079610715001509</a></span><o:p></o:p></p>
<p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;text-indent:36.0pt">
<span lang="EN-US" style="font-size:9.0pt;font-family:"Arial",sans-serif"> </span><o:p></o:p></p>
<p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;margin-left:36.0pt">
<b><span lang="EN-US" style="font-size:9.0pt;font-family:"Arial",sans-serif">C.
<u>Self-organized criticality</u></span></b><u><span lang="EN-US" style="font-size:9.0pt;font-family:"Arial",sans-serif">:</span></u><o:p></o:p></p>
<p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto"><span lang="EN-US" style="font-size:9.0pt;font-family:"Arial",sans-serif"> </span><o:p></o:p></p>
<p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;margin-left:36.0pt">
<span lang="EN-US" style="font-size:9.0pt;font-family:"Arial",sans-serif">Self-organized criticality:</span><o:p></o:p></p>
<p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;margin-left:36.0pt">
<span lang="EN-US" style="font-size:9.0pt;font-family:"Arial",sans-serif"><a href="https://en.wikipedia.org/wiki/Self-organized_criticality" target="_blank">https://en.wikipedia.org/wiki/Self-organized_criticality</a></span><o:p></o:p></p>
<p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;margin-left:36.0pt">
<span lang="EN-US" style="font-size:9.0pt;font-family:"Arial",sans-serif"> </span><o:p></o:p></p>
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<span lang="EN-US" style="font-size:9.0pt;font-family:"Arial",sans-serif">Self-organized criticality (SOC):</span><o:p></o:p></p>
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<span lang="EN-US" style="font-size:9.0pt;font-family:"Arial",sans-serif"><a href="http://www.johnboccio.com/courses/SOC26/15-SOC.pdf" target="_blank">http://www.johnboccio.com/courses/SOC26/15-SOC.pdf</a></span><o:p></o:p></p>
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<span lang="EN-US" style="font-size:9.0pt;font-family:"Arial",sans-serif"> </span><o:p></o:p></p>
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<span lang="EN-US" style="font-size:9.0pt;font-family:"Arial",sans-serif">Self-organized criticality:</span><o:p></o:p></p>
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<span lang="EN-US" style="font-size:9.0pt;font-family:"Arial",sans-serif"><a href="http://web.mit.edu/8.334/www/grades/projects/projects12/V.%20A.%20Golyk.pdf" target="_blank">http://web.mit.edu/8.334/www/grades/projects/projects12/V.%20A.%20Golyk.pdf</a></span><o:p></o:p></p>
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<span lang="EN-US" style="font-size:9.0pt;font-family:"Arial",sans-serif"> </span><o:p></o:p></p>
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<span lang="EN-US" style="font-size:9.0pt;font-family:"Arial",sans-serif">Self-organized criticality – what it is and what it isn’t</span><o:p></o:p></p>
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<span lang="EN-US" style="font-size:9.0pt;font-family:"Arial",sans-serif"><a href="http://citeseerx.ist.psu.edu/viewdoc/download?doi=10.1.1.96.8017&rep=rep1&type=pdf" target="_blank">http://citeseerx.ist.psu.edu/viewdoc/download?doi=10.1.1.96.8017&rep=rep1&type=pdf</a>.
</span><o:p></o:p></p>
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<b><span lang="EN-US" style="font-size:9.0pt;font-family:"Arial",sans-serif">D.
<u>Phenomenology in Medicine</u></span></b><o:p></o:p></p>
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<span lang="EN-US" style="font-size:9.0pt;font-family:"Arial",sans-serif;color:#032511">The meaning of illness: a phenomenological approach to the physician/patient relationship:
<a href="https://baylor-ir.tdl.org/baylor-ir/handle/2104/8286" target="_blank">https://baylor-ir.tdl.org/baylor-ir/handle/2104/8286</a> ;
</span><span lang="EN-US" style="font-size:9.0pt;font-family:"Arial",sans-serif;color:#262626"><a href="http://hdl.handle.net/2104/8286" target="_blank">http://hdl.handle.net/2104/8286</a>.
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<span lang="EN-US" style="font-size:9.0pt;font-family:"Arial",sans-serif">Body Matters: A Phenomenology of Sickness, Disease, and Illness:</span><o:p></o:p></p>
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<span lang="EN-US" style="font-size:9.0pt;font-family:"Arial",sans-serif"><a href="http://philpapers.org/rec/AHOBMA" target="_blank">http://philpapers.org/rec/AHOBMA</a>.
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<span lang="EN-US" style="font-size:9.0pt;font-family:"Arial",sans-serif"> </span><o:p></o:p></p>
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<span lang="EN-US" style="font-size:9.0pt;font-family:"Arial",sans-serif">Suffering Transfigured: Phenomenological Personalism In the Doctor-Patient Relationship:
<a href="http://elischolar.library.yale.edu/cgi/viewcontent.cgi?article=1658&context=ymtdl" target="_blank">
http://elischolar.library.yale.edu/cgi/viewcontent.cgi?article=1658&context=ymtdl</a>.</span><o:p></o:p></p>
<p style="margin-left:36.0pt"><span lang="EN-US" style="font-size:9.0pt;font-family:"Arial",sans-serif">The challenge of neuroscience: Psychiatry and phenomenology today:
<a href="https://www.klinikum.uni-heidelberg.de/fileadmin/zpm/psychatrie/fuchs/Challenge_of_Neuroscience.pdf" target="_blank">
https://www.klinikum.uni-heidelberg.de/fileadmin/zpm/psychatrie/fuchs/Challenge_of_Neuroscience.pdf</a>.
</span><o:p></o:p></p>
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<span lang="EN-US" style="font-size:9.0pt;font-family:"Arial",sans-serif"> </span><o:p></o:p></p>
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<span lang="EN-US" style="font-size:9.0pt;font-family:"Arial",sans-serif">Rediscovering Psychopathology: The Epistemology and Phenomenology </span><span style="font-size:9.0pt;font-family:"Arial",sans-serif">of the Psychiatric Object:
</span><a href="http://cfs.ku.dk/staff/zahavi-publications/Rediscovering_Psychopathology.pdf" target="_blank"><span style="font-size:9.0pt;font-family:"Arial",sans-serif">http://cfs.ku.dk/staff/zahavi-publications/Rediscovering_Psychopathology.pdf</span></a><span style="font-size:9.0pt;font-family:"Arial",sans-serif">.</span><o:p></o:p></p>
<p style="margin-left:36.0pt"><span lang="EN-US" style="font-size:9.0pt;font-family:"Arial",sans-serif">PHENOMENOLOGY IN PSYCHIATRY:
<a href="http://www.wpanet.org/uploads/Sections/Philosopy_and_Humanities/Phenomenology-in-Psychiatry.pdf" target="_blank">
http://www.wpanet.org/uploads/Sections/Philosopy_and_Humanities/Phenomenology-in-Psychiatry.pdf</a>.
</span><o:p></o:p></p>
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<p class="MsoNormal"><span style="font-family:"Georgia",serif"><a href="http://www.sciencedirect.com/science/journal/00796107/119/3" target="_blank">2015 JPBMB Special Issue on Integral Biomathics: Life Sciences, Mathematics and Phenomenological Philosophy</a> </span><o:p></o:p></p>
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<p class="MsoNormal"><span style="font-family:"Georgia",serif">(note: free access to all articles until July 19th, 2016)</span><o:p></o:p></p>
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<p class="MsoNormal"><span style="font-family:"Georgia",serif"><a href="http://www.springer.com/engineering/computational+intelligence+and+complexity/book/978-3-642-28110-5" target="_blank">2012 Integral Biomathics: Tracing the Road to Reality</a></span><o:p></o:p></p>
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<p class="MsoNormal"><a href="http://www.inbiosa.eu" target="_blank"><span style="font-family:"Georgia",serif">2011 INtegral BIOmathics Support Action (INBIOSA)</span></a> <o:p></o:p></p>
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<pre><span style="color:#888888">-- <o:p></o:p></span></pre>
<pre><span style="color:#888888">-------------------------------------------------<o:p></o:p></span></pre>
<pre><span style="color:#888888">Pedro C. Marijuán<o:p></o:p></span></pre>
<pre><span style="color:#888888">Grupo de Bioinformación / Bioinformation Group<o:p></o:p></span></pre>
<pre><span style="color:#888888">Instituto Aragonés de Ciencias de la Salud<o:p></o:p></span></pre>
<pre><span style="color:#888888">Centro de Investigación Biomédica de Aragón (CIBA)<o:p></o:p></span></pre>
<pre><span style="color:#888888">Avda. San Juan Bosco, 13, planta X<o:p></o:p></span></pre>
<pre><span style="color:#888888">50009 Zaragoza, Spain<o:p></o:p></span></pre>
<pre><span style="color:#888888">Tfno. <a href="tel:%2B34%20976%2071%203526" target="_blank">+34 976 71 3526</a> (& 6818)<o:p></o:p></span></pre>
<pre><span style="color:#888888"><a href="mailto:pcmarijuan.iacs@aragon.es" target="_blank">pcmarijuan.iacs@aragon.es</a><o:p></o:p></span></pre>
<pre><span style="color:#888888"><a href="http://sites.google.com/site/pedrocmarijuan/" target="_blank">http://sites.google.com/site/pedrocmarijuan/</a><o:p></o:p></span></pre>
<pre><span style="color:#888888">-------------------------------------------------<o:p></o:p></span></pre>
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